LOCUS       NM_001163455            6578 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus TBC1 domain containing kinase (Tbck), mRNA.
ACCESSION   NM_001163455
VERSION     NM_001163455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6578)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6578)
  AUTHORS   Nair,D., Diaz-Rosado,A., Varella-Branco,E., Ramos,I., Black,A.,
            Angireddy,R., Park,J., Murali,S., Yoon,A., Ciesielski,B.,
            O'Brien,W.T., Passos-Bueno,M.R. and Bhoj,E.
  TITLE     Heterozygous variants in TBCK cause a mild neurologic syndrome in
            humans and mice
  JOURNAL   Am J Med Genet A 191 (10), 2508-2517 (2023)
   PUBMED   37353954
  REMARK    GeneRIF: Heterozygous variants in TBCK cause a mild neurologic
            syndrome in humans and mice.
REFERENCE   3  (bases 1 to 6578)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 6578)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
  REMARK    GeneRIF: Includes the study of an upstream ORF in this gene, and
            shows that it functions to reduce protein levels by ~49%.
REFERENCE   5  (bases 1 to 6578)
  AUTHORS   Caenepeel,S., Charydczak,G., Sudarsanam,S., Hunter,T. and
            Manning,G.
  TITLE     The mouse kinome: discovery and comparative genomics of all mouse
            protein kinases
  JOURNAL   Proc Natl Acad Sci U S A 101 (32), 11707-11712 (2004)
   PUBMED   15289607
REFERENCE   6  (bases 1 to 6578)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135118.3, AK034533.1, CN720994.1, AK007218.1, AC139942.4 and
            AK081215.1.
            
            On Dec 3, 2014 this sequence version replaced NM_001163455.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR7345562.4744447.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC135118.3         101762-101805       c
            45-1980             AK034533.1         3-1938
            1981-2573           CN720994.1         1-593
            2574-3396           AK007218.1         225-1047
            3397-5033           AC139942.4         123923-125559       c
            5034-6578           AK081215.1         2-1546
FEATURES             Location/Qualifiers
     source          1..6578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 61.49 cM"
     gene            1..6578
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /note="TBC1 domain containing kinase"
                     /db_xref="GeneID:271981"
                     /db_xref="MGI:MGI:2445052"
     exon            1..251
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            252..472
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..2961
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /note="FERRY endosomal RAB5A effector complex subunit 1"
                     /codon_start=1
                     /product="TBC domain-containing protein kinase-like
                     protein"
                     /protein_id="NP_001156927.1"
                     /db_xref="CCDS:CCDS51070.1"
                     /db_xref="GeneID:271981"
                     /db_xref="MGI:MGI:2445052"
                     /translation="MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQI
                     LKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLRERKPVSHSTVLCIAYEVLE
                     GLHYLNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPE
                     VIAQGIPKTTDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDVSERVKFLLT
                     LGCVDDTIIVLAEEHGCLDIIKELPENVINILKKCLTFHPSKRPTPDELMKDQVFSEV
                     SPLYTPFIKPASLFSSSLRCADLTLPEDISDLCKDIDNDYLAERSIEEVYYLWCLAGG
                     DLEKELINKEIIRSKPPVCTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRL
                     KDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLLK
                     AYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVD
                     IPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALA
                     YACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAI
                     PWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF
                     SDLPEIDIERCVRESVNLFCWTPKSATYRQHAQPPKPASESSVVRSSAPYFSAECTDP
                     PKTDLSRESIPLSDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVVD
                     IRNSEDFVRGHIAGSINIPFSAAFTAEGELSQGPYTTMLHNFKGKVIVVVGHVAKQTA
                     EFAAHLVKMKYPRVCILDGGINKIRPTGLLTVPSPQI"
     exon            473..545
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            546..660
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            661..734
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            735..876
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            877..937
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            938..999
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1061
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1210
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1349
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1449
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1499
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1629
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1728
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1791
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1918
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1969
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2053
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2139
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2176
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2338
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2514
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2690
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2850
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..6578
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6471..6476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /note="hexamer: AATAAA"
     polyA_site      6507
                     /gene="Tbck"
                     /gene_synonym="1700120J03Rik; 9430001M19; A630047E20Rik;
                     C030007I09Rik; Tbckl"
                     /note="major polyA site"
ORIGIN      
        1 gacccgaggc ggcggcgggg gagggggtgc tgggcgctgt cagtggagcg aggtgcgcgc
       61 tcaccctcgg gttctgagcc ggggacccgg gaggcccgcg cggacggagg cgtgtcgctc
      121 cggctgtcac cttccctagg cggcctcttg tagacgcgcc tgaaatgcag gacacggccc
      181 actaagcact gccaggcata gcttccgcgc ttaggagctc aaccccccaa tctctgcgtc
      241 cccagattca gatcatctta aaggatccaa gactacaaaa tgtttcctct gaaggatgct
      301 gagatgggcg cctttacctt ctttgcctct gctctcccac atgatgtttg tggaagcaac
      361 ggacttcctc tcacaccaaa ttccatcaaa atcttaggtc gctttcaaat ccttaagacc
      421 atcacccacc ccagactgtg ccaatatgtg gatatttcta ggggaaagca tgaaagactg
      481 gtggtggtgg cggagcactg tgagcgcagt ttggaagacc ttctacgaga aaggaagcct
      541 gtgagtcatt caacagttct gtgcatagca tatgaggtac ttgagggctt acattacttg
      601 aacaagcatg gcatagtaca ccgggccttg tctccccata atatcctgtt ggatcggaag
      661 ggccatatta aactggctaa atttggactt tatcacatga cagcccatgg tgatgatgtt
      721 gatttcccaa tagggtatcc ctcatacctg gcacctgagg taattgcaca aggaattccc
      781 aaaactactg atcatgtgcc aagtgaaaaa ccattgcctt ctggccccaa atcagatgta
      841 tggtctcttg ggataatttt atttgagctt tgtgtgggga gaaaattgtt tcagagcttg
      901 gatgtttctg aaagagtaaa atttttgctt actttgggct gtgtagatga tactataata
      961 gttctcgctg aggagcatgg gtgtctggac attatcaagg agcttcctga aaatgtgata
     1021 aatattttga agaagtgcct caccttccat ccttctaaga ggccaacccc agatgagtta
     1081 atgaaggacc aggtgttcag tgaagtgtca cctttataca ccccctttat caaacctgcc
     1141 agtctgtttt catcttctct gagatgcgct gatctaactc tgcctgagga tatcagtgac
     1201 ttgtgtaaag atatagacaa tgattacctg gcagagagat ctattgagga agtttactac
     1261 ctttggtgtt tggctggagg ggacctggaa aaggagctta taaacaagga aattattcgc
     1321 tccaagccac ctgtctgcac actcccgaat tttctctttg aagatggaga aagttttgga
     1381 caaggtcgag atagaagctc actcttagat gacaccacag tcacgttgtc tttgtgccag
     1441 ctaagaaaca gattaaaaga tgttggtgga gaagcgtttt acccattgct ggaggatgac
     1501 cagtcaaatt tgccacattc aaacagcaat aatgagttgt ctgcagctgc taccctgcct
     1561 ttaatcatca gagagaggga tacagaatat cagctcaaca ggattattct ctttgacagg
     1621 ctgttgaagg cttacccata caaaaaaaat caaatctgga aagaagcaag agttgacatc
     1681 cctccactta tgagaggttt aacctgggct gctcttctgg gagttgaggg agctattcat
     1741 gccaagtatg acgccattga caaagacact ccgattccta cagatagaca aattgaggta
     1801 gacatccctc gctgtcatca gtatgacgag ctgttgtcat caccagaagg ccatgcaaag
     1861 ttccggcgtg tactgaaagc ctgggtggtt tctcatcctg atcttgtgta ctggcaaggt
     1921 cttgactcac tctgtgctcc attcctgtat ctaaatttca acaatgaagc cttggcatat
     1981 gcgtgcatgt ctgcttttat tcccaaatac ctgtataact tcttcttgaa ggacaactct
     2041 catgtaatac aagagtacct gaccgtgttc tcccagatga tcgccttcca tgatccagag
     2101 ctgagtaatc acctcaacga gattggcttc attcccgatc tctacgccat cccttggttt
     2161 ctcaccatgt ttactcatgt atttccactg cacaaaattt tccacctctg ggatacatta
     2221 ctgctcggaa attcctcttt cccattctgc attggagtag ccatcctcca gcagctgcgg
     2281 gaccgtcttt tggccaatgg cttcaatgaa tgcatccttc tcttctctga cttaccagaa
     2341 attgacattg aacgctgcgt acgtgagtcg gtcaatctgt tttgctggac tcctaaaagt
     2401 gctacataca gacagcatgc tcagcctcca aagccagcct cggagagcag tgtagtgcga
     2461 agctcagcgc cttacttctc tgctgagtgt acagatcctc caaagacaga cctgtcaaga
     2521 gaatccatcc ctttaagtga cctgaaatca gaagtatcac cccggatttc agcagaggac
     2581 ctgatcgatt tgtgtgagct cacagtgaca ggccacttca aaacccccac caagaaaacc
     2641 aagtccagta aaccaaagct cctggtggtg gacatccgaa acagtgagga cttcgttcgc
     2701 gggcacattg caggcagcat caacatccca ttcagcgcag cgttcacggc agaaggagag
     2761 ctcagccaag gcccttacac caccatgctg cacaacttca aggggaaagt cattgtggtt
     2821 gtaggccacg tggctaagca aacagctgag tttgcagctc atctggtgaa gatgaaatac
     2881 ccaagagtct gcattctaga tggcggcatt aacaagatca ggccaacagg cctcctcacg
     2941 gtcccctctc ctcagatatg aaggaccaag tccacggctg acaagacaga gtaccatcac
     3001 cccctcacag cccgtcacac tgagacacaa gtggacatca gaccactgca ttgcgaagtt
     3061 ttctcatgag atgcttttgg aaatcgtgac tcaaatggtc gcctagctag gcaagaaatt
     3121 tgattgctca tgtattgatt gctaaaagac ttttcttaat agtgaaatct gatcatgcca
     3181 tataaatcca cactgccaca taaagccaga agaattcagc cgacagggca aatttggcac
     3241 tctcaagaat ccacaatgaa ctgagaaagc tgccgtccag tgcactgagc agactgtctt
     3301 aacaaaggtg tttagaaaat gtgatgtgtt tcaccacctc ttccttatgg cagaaagtag
     3361 aaagctagtc acagtaaatg tgacatttgt taactcacaa acaaggggtg tgtgtgtaca
     3421 tgtgtatgtg tttagaccat tgtgaacagt ggtagcagca atctcagaga atggaccttc
     3481 agagactggt catatttggt aacatatttg tccacttgta tagcaagaaa ctcgaagaat
     3541 gactgaaaca gcttttctga tctaacacac tcagtcttca tgggcagcga cggcttcctt
     3601 gcctgcacaa cggtacagag ctgatagctt ctgctgcttt gccacagaac acttttctcc
     3661 ttgtgagcac gaaagctcct gagactgtgg cagcagacag aggcccgagc ccggtggttt
     3721 cccggtgctg agaggggaaa tggatgcaag cccgtccctc accaagaagc tatctccagt
     3781 tggtagccac tcacaaagaa aaatgagttt cggcagagcc atctccctgg ggtacaaacc
     3841 acagagtcag accccatgcc cagcagttga tggccaacaa aataggaact caactgtatt
     3901 tttagatttt ttttctgtct gatattgctt tgtttgtcat tttttacctt tatttttttc
     3961 tcaagtggta ttgtttctga ttttgtggtt ttattggttt tgtgtgtacg tgtatataag
     4021 tgtatttctt tgtgctgttt ttgtttgttt tgttctggtg tgttttctaa atgatgaaaa
     4081 agaaagggtg gcgttggaaa gaactgggag acaggggaat ctgagcagag catattaaat
     4141 gagaagtttt ttgttttttg gttttttttt tttttttttt tttttttttt ggtttttcga
     4201 ggcagggttt ctctgtatag ccctggctgt cctggacctc actttgtaga ccaggctggc
     4261 ctcgaactca gaaatccgcc tgcctctgcc tcccgagtgc tgggattaaa ggcgtgcacc
     4321 accacgcccg gaagttattt tcaatttaaa aaaaaaggct cctccacttc catcattata
     4381 tccgaaatct agaaggaaag aaatgaaaga gggaaggcaa gacagagaag gcagaagtag
     4441 gaagaaatca ggaagaaaag gtgagcagga aagagaagga agaggcatcg cattcccttc
     4501 aaagacacga gctgacgctg cacactccct ccactgcctc accggtgacc agcctggact
     4561 cgcatggcag cacccaggga atgctgaggg aagctgggat ggcagcctct gggttgccag
     4621 agctccccag ctccgaaagc ctgactgcag tgtgaggaga agagaatgtg tacggagagc
     4681 cagcagcagc ctctgcccca gggttggaaa agttatgtcc tgagctctac cgaatctaaa
     4741 aatccacaat tgtgtgagac cacaatatgg agtcagaaag acaaaggcat tcatcatttg
     4801 taagaggaac ttttttttca gatttctgaa atgggaacat tactgaaata tatcctttga
     4861 ctattttgaa tgttgtttca aaagtgtcca ctcttggtcc cttctattcc ccgtcagtgt
     4921 gacgactctg aacatctgta cagaaacctc aagcgtctgg gcctggactt cattctacaa
     4981 ctgttgccgc ctttatttta cttgcatctg tttttaattt gtgagtacac aggtgtgggt
     5041 gcaggtaccc tatggtggta cacctatggg gtcacctact tattctccaa cttttctttg
     5101 gtatttttgt ttggggctgt agactagaat gttaatagct cagcagtagg ccagcaagct
     5161 cctggggtca tgctgtatcc aaccttccgc actaggatta cacaccacta ccgcgcccaa
     5221 ctacttagtt gggttctggg catctgaact caggtttcca tacttgaaag gcaagcactc
     5281 tacccactga gccatctcct cagcttacat ctatgtaaaa ctatactttg caaaccataa
     5341 aattcacctt tttatcctag gtgattcagt gacttgttat attcataaca ttgtactggt
     5401 agtagttaat tccagaacat tttcatgacc caaaaccaaa atattgtatt tatttgcagc
     5461 cattttgcca atagcctcta cttggtcttt gatttcattt ttgtgcctgg agtaaaacag
     5521 ggacctaact tcacttttgc gtaaagatat ccaggtcaat taaattatac ttggttatcc
     5581 accaaatatc ttttgaatta tttactatgc aagatactaa tgtgaccaat aactatcatt
     5641 ttgtgatttt tacatagttt gtaaaggaaa acaaatagga ttagagaaaa aaaaaaacga
     5701 ctaccattgt ctagcgccat ttcctgacca acatgagcct cgccagcgct cctggttttc
     5761 ttcggtcttt ggtggtttaa ctgtctccac aggaagaaga atgcagcact gataatccac
     5821 tcagaattgt tcccatctta cctttctcac agtggccccg gtttgactgg tcacagtgac
     5881 agatgggaga gggtgaagac atgagcgttg taaagaaaac tataagggag agttatggtt
     5941 cacctccatc agggtctttc atgtgatttt ttttttctta aaataacata tttaggcttg
     6001 ttctaaatga cagggaaatg ttttaacaga taaattttaa gtaatattta atattctcaa
     6061 ctacaacatt cgaggtgtct atgatggtta atattgtcaa cttgacaggt tctacactta
     6121 cctaggagac actcctctta ggcatgtcca tgcgggagtt gccagattgg gttgattgaa
     6181 atgggatgtc ccatcctaac tatgagtggt cctgttccag tagctggggt cagaatggaa
     6241 taaagggaga aagaacgctg cgcaccatca ttcatctccc tgtgtcctga ctgaggatgt
     6301 aatgtgacca gcaagcctga gcttctgtta ttacaacttt ctttctgtga tattctgtat
     6361 tctaaaactg tgagcaaaaa taccccctat cctatgctgt ttctgtcagg gtattttacc
     6421 ccagacacag aacaagtaat acagcatgct gacctgtggc agatcatctc aataaagtgg
     6481 accttagcaa gtgtttctta aagtaaacct gtggtgtata ggagtccttt atggtatatt
     6541 attgacccct actctgtcac tattaaagcc acttctgg
//
