LOCUS       NM_001357657            4850 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tubulin folding cofactor E-like (Tbcel), transcript
            variant 3, mRNA.
ACCESSION   NM_001357657 XM_006510394
VERSION     NM_001357657.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136903.6 and AC156631.2.
            
            On Feb 24, 2020 this sequence version replaced NM_001357657.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC136903.6         67520-67562         c
            44-193              AC136903.6         61575-61724         c
            194-333             AC136903.6         59886-60025         c
            334-515             AC136903.6         54369-54550         c
            516-772             AC136903.6         52781-53037         c
            773-899             AC136903.6         49059-49185         c
            900-1016            AC136903.6         47077-47193         c
            1017-4850           AC156631.2         150490-154323       c
FEATURES             Location/Qualifiers
     source          1..4850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 23.71 cM"
     gene            1..4850
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /note="tubulin folding cofactor E-like"
                     /db_xref="GeneID:272589"
                     /db_xref="MGI:MGI:1925543"
     exon            1..43
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /inference="alignment:Splign:2.1.0"
     exon            44..193
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1335
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /note="isoform b is encoded by transcript variant 3;
                     tubulin-specific chaperone cofactor E-like protein;
                     leucine-rich repeat-containing protein 35"
                     /codon_start=1
                     /product="tubulin-specific chaperone cofactor E-like
                     protein isoform b"
                     /protein_id="NP_001344586.1"
                     /db_xref="CCDS:CCDS23088.1"
                     /db_xref="GeneID:272589"
                     /db_xref="MGI:MGI:1925543"
                     /translation="MDQPSGRSFMQVLCEKYSPENFPYRRGPGVGVHVPATPQGSPMK
                     DRLNLPSVLVLNSCGITCAGDEREIAAFCAHVSELDLSDNKLQDWHEVSKIVSNVPQL
                     EFLNLSSNPLSLSVLERTCAGSFSGVRKLVLNNSKASWETVHTILQELPELEELFLCL
                     NDYETVSCPSVCCHSLKLLHITDNNLQDWTEIRKLGVMFPSLDTLVLANNHLNAIEEP
                     ADSLARLFPNLRSISLHKSGLQSWEDIDKLNSFPKLEEVRLLGIPLLQPYTTEERRKL
                     VVARLPSVSKLNGSVVTDGEREDSERFFIRYYVDVPQEEVPFRYHELITKYGKLEPLA
                     EVDLRPQSSAKVEVHFNDQVEEMSIRLDQTVAELKKQLKTLVQLPTSSMLLYYFDHEA
                     PFGPEEMKYSSRALHSFGIRDGDKIFVESKTK"
     exon            194..333
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /inference="alignment:Splign:2.1.0"
     exon            334..515
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /inference="alignment:Splign:2.1.0"
     exon            516..772
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /inference="alignment:Splign:2.1.0"
     exon            773..899
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1016
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..4850
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4829..4834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /note="hexamer: ATTAAA"
     polyA_site      4850
                     /gene="Tbcel"
                     /gene_synonym="D330014K23; E130107N23Rik; Lrrc35"
                     /note="major polyA site"
ORIGIN      
        1 actcctcgct tatcccgctg ctgaagttca ctcctaggct cagacttttc agaaaagaag
       61 atggaccagc ctagtgggag aagtttcatg caagtattgt gtgaaaaata cagtcctgaa
      121 aacttccctt accgccgtgg ccctggggtg ggagtccatg tcccagccac tccccagggc
      181 tcgcctatga aagatcgcct caacctcccg agcgtgctcg tgttgaacag ctgcggcatt
      241 acctgcgcgg gagatgaaag agaaatcgca gccttctgtg ctcacgtgtc agaactcgat
      301 ctttctgaca acaagctcca agactggcat gaggtcagta agattgtgtc aaatgttcct
      361 cagctggagt ttctaaacct gagttccaat cctctgagtc tgtcagttct agaaagaaca
      421 tgtgctgggt ccttctctgg ggttcgcaaa cttgtcctca acaacagcaa agcatcatgg
      481 gaaacagtgc acaccatact gcaggagttg ccagagttgg aggagctctt cctgtgcctt
      541 aatgactatg aaacagtgtc ttgtccttct gtctgctgtc attccctcaa gctcctacac
      601 atcacagaca acaacctcca agactggact gaaatccgaa agctgggtgt aatgtttcct
      661 tcactggata ccctggtcct ggccaacaat cacttgaatg caatcgagga gcctgctgac
      721 tccctggcta ggttgttccc taatctgcgg tccatcagcc tccacaagtc aggtttgcag
      781 tcctgggaag acattgacaa actaaattca ttccccaagc ttgaagaagt gagattgcta
      841 ggaattcctc ttctacagcc gtataccacc gaggaacgca ggaaattggt ggtggccaga
      901 ttgccctccg tttccaaact caatggcagt gttgtgacgg atggtgagcg agaggattcc
      961 gagaggtttt tcatccggta ctacgtggat gttcctcagg aggaagtgcc attcaggtat
     1021 catgagctca ttacaaaata tgggaaattg gagcctttgg cagaagtgga cctaagaccc
     1081 cagagcagtg cgaaagtaga agttcacttc aatgaccaag tggaggaaat gagcatccgc
     1141 ctggaccaga cagtagccga actgaagaaa cagctaaaga ccctggtgca gttgcccacc
     1201 agcagcatgc ttctctacta ctttgaccac gaggccccgt ttggcccaga ggagatgaag
     1261 tacagctccc gggcactgca ctcctttggc attagggatg gagataaaat ttttgtggaa
     1321 tcaaaaacaa aataacctct accagccttg taaaaactca cataaggact tcctgcaggg
     1381 tgtttgtttc cagcgtgctt ttctttagga ggaaggactt ttccattttg ttttgggttt
     1441 tgtttagctt tggaggggtt ttgtatattt tcttccccta gaatggatag gtttttggta
     1501 ttttctacca cagatttttt cagatcagtt agcagacatg gctgcatctc cagtctttat
     1561 gtgagagcat gcctgtctcc ctctctccct ccccctcctc ctccctcttc cccccctctc
     1621 ccctaccccc caaagatgac agaaaccacc ggcttcttac tgtgtcattg ggatttgtca
     1681 gccactgggc tctttcctgc taagcccaaa gacagtgtgg tccctcagag gggtgatgca
     1741 gtgttcacat ccagagatgg ggtcctccta gggagggatg gggctcctcc tagggaggga
     1801 tggggtcctc ctagggaggg atgggggtcc tcctagggag ggccttctct ggctcttcct
     1861 tccctgcccc tcctcctcct cctttccatt tgggggtcct gggtctggtt ttcattctga
     1921 cttgtaccca cttacctggt agttttactc tgttcataat ttaacttggt tttgttgttg
     1981 gtgtgtctgt ttttccccct ctcgttccca gttttaagtg actttgagta ttttaagcat
     2041 ttccagtctg attctgatct caggaactcg gttaggtttt agagagaagt aggcggagtg
     2101 ttagccctgg gaaactcgct actcccctgg aagcctgcgc tgggcattct aaccgctcca
     2161 gcacctctgc gccccaggag cccctccagg gtagatcagc tgtcactccc gtcacctggc
     2221 actcgtcctg ttctaggggt tttttcttca tgttcaatga atgtacttcc tgacagcttt
     2281 atcgcataag ctattggaaa tgaaggaaga gttgtagata ctcactcctt agcagaacat
     2341 gggctgagaa gctggccagg agtgtgaagc aagtggtggg actggggaga aagcttgcag
     2401 gctttccacc tgtgcggcat ccttgtgaag gaagcggcgc tctcggctct ctaacgggag
     2461 agatttaatc acagggagct gaggcccacc tttttcttgg gactttgtga tgatgcgtct
     2521 gaacaactct ttttgttttg tattttatgt cccccgtgga atgatttttg cctaatctgt
     2581 gagtgaactt tcagtgtcac ccccccaggt gttttttgca ggggtgtgtg tgtataaagc
     2641 acttgacctt tgacacagcc cctcacctac tctcctattc tgaaatcttt ttctttggcc
     2701 ttccattctt tgttaatctg gatggtttcc ttgctgtttc tatttagttc tgttctagtt
     2761 cttgttttgt tctggctttt aacatttgat atgtgattcc ccccctcctc caaacttact
     2821 gtggagtaaa cgctttaggt gacccatgtg acctcttcac ggatgggagg tgtagtcttt
     2881 aagttccctc ctccgccatg tggcaggtgt ttgctctctt gccaccgcac ttcaggttca
     2941 gcatctctaa ggctgctgcc ccgggcctcc tgaggcaggc ccgaattcac tgcagcacta
     3001 agggtgaaag ccaaagggtt tagaaagatg aatgaagccg ggtctcctgc tgcagacttt
     3061 gtctcagaat cctaaaaaaa gaaaaagaaa aaagaaaaga aaaatgagca gcggggatca
     3121 ggccagtata gacgaggaca gttattttgc aattgcattt tcttgacaga gttttggaaa
     3181 tagaaaaaaa aaaagagtat ggcagccgtg tcccgaggat gaagattggt tgctttgtgt
     3241 atgtgcgtgc gagtgcggag gaatttgcaa gagaaactgt aatggagacg ttgctttgtc
     3301 agcctgggaa acagttgcac tcttattttt gaactttgga gccactgttg tcccagggca
     3361 gaaggcagag tgagcgctta cactttggtc acaatgagat attttctata tgacagagtt
     3421 ctctgagagg cttttttacg ctttgaaact cgtatcttct gttattactc aacagtgttt
     3481 ctctgctgca ggcctaatcc tttattacag ctgcgtggaa aaggagtctc atccaaccca
     3541 accggcgtgg gtgtttccag agcattgtca ttggcggttt gaataattgc cgaatctttt
     3601 ccaattaaga aaatcttaag tacagtcctt ggccttttag aattaacagc agtaaatgag
     3661 gaagccgttt gcgcatgcgt ctttccagat tcacttgggt ggctgaggaa agaagctggt
     3721 tttgaaataa aatcggtgct gtgtagacat ttataaccaa aattattttt ataacagacc
     3781 cagaaggagg agagaaaaga ccgtggacct ttgagcctgc atgttatccg tcgtgcttgt
     3841 ttgtatgtaa cattgatttc atcagattga gtggaagcat atggttggca gttaggaggc
     3901 gaaaagctgc cctcgctggt atacagagcg cgccttgggc acggcaggga gaacatgcct
     3961 ttctaaagca gaaagtcttt tcggttgtgg ggaaggaaag gagtaacacg agaaagccaa
     4021 acctaagccc agggtcctcc tgtgggcaga gctgctgaag ctgtgctcca gagggatctc
     4081 ttagtttggg ttgttgagat accctggatt gttttaaatc gggggagtcc acagttgcct
     4141 gtgtctgcag cccattgcca taaatgcaca agacagcagc agagctgaac gccccttgtt
     4201 cttagagacc ctctggtgaa aatgaagcca cgtagccgag ggctgcagtg ctaccccgag
     4261 aaaaagaagg agctgtgtga gggaacgaag agcagatgca gttccaactg ggattttcag
     4321 caatgtcacc ctaccggccc tgctgggagc agagaacact tggttgtgca gtattggtca
     4381 ccacgggagc cttgccacca atagcttttc ctaacacatg tgagtgtggc tctccctccg
     4441 cactgtagct taggccctgg gcaagtaggg cgtgactcca gaatgctctg tagtttgtat
     4501 gtacgataat ttctgtttat gaatttcact tttcctttca tttcatgtaa aactaaaatg
     4561 caaacaatct gctttcaaga atgcccagaa gctctgtgtc cccaactgtt gttgtgaact
     4621 ctaccatttc tcataggtgc ttccttaaaa tgtatgttta ttctagtgac cgagagggga
     4681 ctggactctc aggcccttta cagttgtctc ctgcagttaa tggaaatata aatatatata
     4741 tatattttat tttagaatat aatttaaaca tgaaggtcta ttctttgcac tttttattaa
     4801 tatatataga gagagaatct ttaaaaaaat taaaaataca agtccattta
//
