LOCUS       NM_029878               3870 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tubulin-specific chaperone d (Tbcd), mRNA.
ACCESSION   NM_029878
VERSION     NM_029878.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3870)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3870)
  AUTHORS   Wen,H.L., Lin,Y.T., Ting,C.H., Lin-Chao,S., Li,H. and Hsieh-Li,H.M.
  TITLE     Stathmin, a microtubule-destabilizing protein, is dysregulated in
            spinal muscular atrophy
  JOURNAL   Hum Mol Genet 19 (9), 1766-1778 (2010)
   PUBMED   20176735
REFERENCE   3  (bases 1 to 3870)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 3870)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050199.1, AK041464.1, BY513705.1 and CK622820.1.
            
            On May 17, 2018 this sequence version replaced NM_029878.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050199.1, AK054343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               AK050199.1         45-533
            490-3683            AK041464.1         480-3673
            3684-3865           BY513705.1         98-279
            3866-3870           CK622820.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..3870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 85.41 cM"
     gene            1..3870
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /note="tubulin-specific chaperone d"
                     /db_xref="GeneID:108903"
                     /db_xref="MGI:MGI:1919686"
     exon            1..238
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..3645
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /note="beta-tubulin cofactor D; tubulin-folding cofactor
                     D"
                     /codon_start=1
                     /product="tubulin-specific chaperone D"
                     /protein_id="NP_084154.1"
                     /db_xref="CCDS:CCDS25778.1"
                     /db_xref="GeneID:108903"
                     /db_xref="MGI:MGI:1919686"
                     /translation="MVLSNEPAASAAEEEVEDDALVRASALEAFGESAETRALLRSLP
                     AVHRERASREVAEERFRVIMDKYQEQPHLLDPHLEWMMNSLLDLVQDETSLPDLVHLA
                     FKFLYIITKVRGYKVFLRLFPHEVANVQPVLDMFTGQNPKDHETWETRYMLLLWLSVT
                     CLIPFDFSRLDGNLSTQTGETRVPTMDRILQIAESYLVVSDKARDAAAVLVSKFITRP
                     DVKQRKMASFLDWSLCTLAHSSFQTIEGVITMDGMLQALAQIFKHGKREDCLPYANTV
                     LQCLDGCRLPESSHTSLRKLGVKLVQRLGLTFLKPKVATWRYQRGCRSLAANLKLCAP
                     GKSDQKLLSDSLTSDGDEDYDVPEGVETVIEQLLVGLKDKDTVVRWSAAKGIGRMAGR
                     LPRELADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLSEVVTVILKAL
                     TYDEKRGACSVGANVRDAACYVCWAFARAYEPQELTPFVTAISSALVIAAVFDRNVNC
                     RRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNISNCFLIISVFIAGFQEYTKPMI
                     DHLVSMKINHWDGAIRELSAKALHNLTPQVPEYIAMHVFPALLLMTQSPDLHTRHGAI
                     LACAEVTYALYKLATQSNRLVTDYLDEKAVQSLKQIHQQLCDRHLYRGLGGELMRQAV
                     CILIEKLSLSRMPFKGDATVEGWQWLINDTLRSLHLVSSHSRQQIKEVAVSALTALCS
                     EYYVKEPGEAGSSIAKELIPQYLAELQSPEEMARCGFSSALGALPGFLLRGHLQQVLS
                     GLRRVTCISPNDVSFAEARRDGLKAISRICQTVGVNTRGPPDEVICKENISEVYAALL
                     GCMSDYTTDSRGDVGAWVREAAMTSLMDLMLLLARTEPVLIEAHICERVMCCVAQQAS
                     EKIDRFRAHAARVFLTLLHFDSPPIPHVPHRQELESLFPRSDVATVNWNAPSQAFPLI
                     TQLLGLPTYRYHVLLGLAVSVGGLTESTVRHSTQSLFEYMKGIQKDAQVLQSFSETLL
                     KVFEDNLLNDRVSVSLLKMLDQLLANGCFDIFTAEENHPFCVKLLTLCKEEIKKSKDI
                     QKLRSSIAVLCGMVQFNGDVRKKILLQLFLLLGHPFPVIRKSTASQVYEMVLTYSDLV
                     DAEVLDEVMSVLSDTAWDAELPVVREQRNRLCDLLGVPRPQLVPKPIPGS"
     exon            239..289
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            290..387
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            388..489
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            490..636
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            637..692
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            693..825
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            826..871
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1004
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1147
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1208
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1283
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1378
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1535
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1593
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1623
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1709
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1790
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1864
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1982
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2043
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2066
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2098
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2161
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2238
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2320
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2439
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2531
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2672
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2756
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2915
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3054
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3176
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3254
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3344
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3432
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3542
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3627
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3870
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3845..3850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /note="hexamer: ATTAAA"
     polyA_site      3864
                     /gene="Tbcd"
                     /gene_synonym="2310057L06Rik; A030005L14Rik; mKIAA0988"
                     /note="major polyA site"
ORIGIN      
        1 gtatctcttt tcttcccggt tgccggtagg gttcttacgg aagctgctgg caggatggta
       61 ctgagcaatg agccggctgc gagcgccgcc gaggaggagg tggaggatga tgcgcttgtt
      121 cgcgcctccg ccctggaagc gttcggcgag agtgcggaga cccgcgcgct gctccgcagc
      181 ttgccggcgg tgcacagaga gcgcgcgtcc cgggaggtgg cggaggagcg gttccgcgta
      241 attatggaca aataccagga gcagccccac ctcctggatc cacaccttga gtggatgatg
      301 aactcactgt tggacctggt acaggatgag acatctctgc ccgaccttgt ccatctggct
      361 tttaagtttc tttatatcat caccaaggtt cgtggatata aagtgtttct gcgtctgttt
      421 cctcacgaag tggctaatgt tcagcctgtg ttagatatgt tcacaggtca gaaccctaaa
      481 gaccatgaga cgtgggaaac acgctacatg cttctactgt ggctctctgt gacctgcttg
      541 atcccttttg atttttcacg ccttgatggg aacctgtcta ctcaaactgg agaaacacga
      601 gtacccacca tggaccgaat tctgcaaata gcagagtctt acttggtggt cagtgacaag
      661 gcgcgagatg cagctgctgt ccttgtgtcc aaatttatca cacgtcccga tgtcaagcag
      721 agaaagatgg ccagctttct ggactggagc ctttgcacct tggcccactc ttccttccag
      781 accatcgagg gtgtcattac catggatggg atgctgcagg ccctggctca aatatttaag
      841 catggaaaac gtgaagactg ccttccctat gccaacactg tgctccagtg cctcgacggc
      901 tgcagactcc ccgagagcag tcatacctcg ctgcggaagc ttggtgtgaa gcttgtccag
      961 aggctggggc tgactttcct gaagccaaag gtggccacgt ggaggtatca gcgtggctgt
     1021 cggtctttgg ctgctaacct gaagctctgt gccccgggta agagtgacca gaagctgctg
     1081 tctgatagtt tgacctctga tggtgatgaa gactatgatg tcccagaggg ggtagaaact
     1141 gtgatagagc agctactggt tgggttgaag gacaaggaca ctgtggtgcg gtggtctgca
     1201 gcgaaaggaa ttggtaggat ggctggaagg cttcccagag agctggccga tgatgtggtg
     1261 gggtctgtgt tggactgttt cagttttcag gagacggata aggcatggca tggtggatgt
     1321 ctggcattgg cagagctggg tagacgaggc ctgttgctac catccagact ctcagaggtt
     1381 gtcacggtga tcctgaaggc ccttacctac gatgagaagc ggggtgcctg cagcgttggg
     1441 gccaatgtca gggatgctgc ctgttatgtg tgctgggctt ttgcacgtgc ctatgaacct
     1501 caggagttga caccttttgt gactgccatt tcaagtgccc tggtcattgc tgctgtattt
     1561 gaccgaaatg tgaactgcag aagagcagcc tctgctgcct tccaggagaa cgtggggaga
     1621 cagggtactt tccctcatgg aattgatatt ttgactacag cagactattt tgcagttggt
     1681 aacatatcta actgtttcct gattataagt gtgtttattg ctggcttcca ggaatacacc
     1741 aagcccatga ttgatcacct ggtctccatg aaaatcaacc attgggatgg ggccatccga
     1801 gaactgtctg caaaggcatt gcacaacctg actccacaag tacccgagta catagccatg
     1861 cacgtattcc ctgcactact gttgatgaca cagagtccag atctacacac gagacatggt
     1921 gccatccttg cctgtgcaga ggtcacctat gccctgtaca agctggccac acagagtaac
     1981 aggcttgtca cagactatct ggatgagaag gcagtgcaaa gcctgaagca gatccaccag
     2041 cagctttgtg accgccatct ctataggggt cttggaggag agcttatgag acaagcagtg
     2101 tgcatcttaa tagagaagct gtcactttcc agaatgccat ttaaagggga cgccactgtc
     2161 gaaggttggc agtggctgat aaatgacact ctcaggagtc ttcaccttgt ttcaagccat
     2221 tccagacaac agatcaagga ggtggctgtc tctgccctga ctgccctctg cagtgaatac
     2281 tacgtgaagg agcctgggga ggcaggctcc tccatcgcga aggagctgat tccccagtac
     2341 cttgctgagc tccagagccc agaggagatg gcccgttgtg gcttttcctc agccttgggt
     2401 gccctcccag gtttccttct caggggccat ctgcagcagg ttctctcagg tctgagaaga
     2461 gtcacctgta tttctcccaa tgatgtgagc tttgctgaag cccggagaga tggtttgaaa
     2521 gcaatctcaa gaatttgcca gacggttggt gtgaacacac gggggcctcc agatgaagtc
     2581 atatgcaaag agaacatctc tgaggtttat gctgcattgc tgggctgcat gagtgattac
     2641 accacagaca gcagagggga tgtgggagcc tgggttcgtg aggctgccat gaccagcctc
     2701 atggatttga tgcttttgct ggcacggaca gagccggtgc tgattgaggc ccacatctgt
     2761 gagcgcgtca tgtgttgcgt tgcccagcaa gcaagtgaga agattgatcg gttccgtgct
     2821 catgctgccc gggtgttcct gactctcttg cacttcgaca gccctcccat tccccatgtt
     2881 ccccaccgcc aagaactgga aagtctgttt cccaggtctg atgtggccac tgtgaactgg
     2941 aacgcacctt cccaggcctt ccctctcatc acccagctct tgggattgcc tacctataga
     3001 taccatgtcc tgctggggct ggctgtgtct gtgggtggct tgacagagtc tacggtcaga
     3061 cattctacac agagcctctt tgagtacatg aaggggattc agaaggatgc tcaggtcctg
     3121 cagagcttca gtgagaccct cctgaaggtc tttgaggaca accttttgaa tgatagggtg
     3181 tctgtatcac tgctgaaaat gctggaccag ctgttggcta atgggtgctt tgacatcttt
     3241 actgccgagg agaaccaccc cttttgtgtg aagttgctca cactttgtaa ggaagaaatc
     3301 aagaagtcaa aagacatcca gaaacttcgg tcaagcatcg cagtgctctg tgggatggtg
     3361 cagttcaatg gtgatgtgag aaagaagatt cttcttcagc tgttcctcct cctcggccac
     3421 cctttccctg tgatccggaa gagcacagcg agccaggtct acgagatggt gcttacctac
     3481 agcgacctgg tagatgccga ggtgcttgat gaggtcatgt ctgtgctcag tgacacagcc
     3541 tgggacgcag agcttccagt tgtaagagaa cagcggaatc gcctgtgtga ccttcttggc
     3601 gtgcccagac cccagctggt tccaaagcct attccaggaa gctgagcctt gcctacctag
     3661 ctgggatgtc tcgccctgag gctccacaac aagctttacc atcatggaaa cttggtgcca
     3721 cagacatctg aggaaggtag caccttcatt gggaggccat ccctggagag cagtaattcc
     3781 tcatgcgtgc tttgctctgg tggccgggac tgcccatacg tttgctgtca cagacgtgct
     3841 tctcattaaa tcatgtatca cacagcccag
//
