LOCUS       NM_178385               1843 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tubulin-specific chaperone C (Tbcc), mRNA.
ACCESSION   NM_178385
VERSION     NM_178385.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1843)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1843)
  AUTHORS   Wen,H.L., Lin,Y.T., Ting,C.H., Lin-Chao,S., Li,H. and Hsieh-Li,H.M.
  TITLE     Stathmin, a microtubule-destabilizing protein, is dysregulated in
            spinal muscular atrophy
  JOURNAL   Hum Mol Genet 19 (9), 1766-1778 (2010)
   PUBMED   20176735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY299869.1 and AK132036.1.
            
            On Feb 8, 2006 this sequence version replaced NM_178385.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY299869.1         18-73
            57-1843             AK132036.1         7-1793
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..1843
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
                     /note="tubulin-specific chaperone C"
                     /db_xref="GeneID:72726"
                     /db_xref="MGI:MGI:1919976"
     exon            1..1843
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1095
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
                     /note="CFC; tubulin-folding cofactor C"
                     /codon_start=1
                     /product="tubulin-specific chaperone C"
                     /protein_id="NP_848472.2"
                     /db_xref="CCDS:CCDS28843.1"
                     /db_xref="GeneID:72726"
                     /db_xref="MGI:MGI:1919976"
                     /translation="MEGVDCSMALADAAAGSPRDLSLVPERLQRREQERQIEVERRKQ
                     KRQDQEVEEEKSGFFAAAFARERAAVEELLRGEASAERLEEAANRLQGLRKLLNDSVL
                     FLAAYDLRQGQAALAQLQAVLTERRQELQPKKRFAFKARKKDAAGTAQVDAAPVASAA
                     PSPPVTKEEEGAPGASWACGFSNLESQDLEKRAEELHQRDVLLSDLTNCTVKLCGNPN
                     TLRLAKARGCKVLCGPVTTSVFLEDCRDCVLAVACQQLRVHTTKDTRVFLQVTSRAIV
                     EDCSGIQFAPYTWSYPGIDKDFQDSGLDRSKNNWDQVDDFNWLARNVASPNWSILPEE
                     ERDIQWD"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1222
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
                     /note="major polyA site"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
                     /note="hexamer: AATAAA"
     regulatory      1365..1370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
                     /note="hexamer: AATAAG"
     polyA_site      1380
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
     polyA_site      1383
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
     regulatory      1421..1426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
                     /note="hexamer: CATAAA"
     polyA_site      1459
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
     polyA_site      1843
                     /gene="Tbcc"
                     /gene_synonym="2810055C19Rik"
ORIGIN      
        1 ggtgggaggc ctcgcgcgga gagcgagcgc tcggaggcaa ggcggcgggg gaggaagcct
       61 ggagtcaaga tggagggtgt ggactgctcc atggctctgg ccgacgctgc cgctggctcc
      121 ccgcgggacc tgagcctggt gcccgagcga cttcagaggc gcgaacagga gaggcagata
      181 gaggtggaga gacgcaagca gaagcggcag gaccaggagg tggaggagga gaagagcggc
      241 ttcttcgccg ccgccttcgc ccgggagcgc gcagcggtcg aggagctgct gcggggcgag
      301 gcgtcggcgg agcggctgga agaggcggcc aaccggctcc agggcctgcg gaagctcctg
      361 aacgactcgg tgctcttcct cgccgcctac gacctgcggc agggccaggc ggcgttggcg
      421 cagctgcagg ctgtcctaac ggaacgtcgc caggagttgc agcccaagaa gcgcttcgcc
      481 ttcaaggcac ggaagaagga tgctgcgggg accgcccagg tagacgccgc acccgtcgcc
      541 tcggcggccc cttctccacc ggtgaccaag gaggaggagg gagctcccgg ggccagctgg
      601 gcctgtggct tctccaacct ggagtcccaa gacctggaga agagagctga agagctgcac
      661 cagcgcgacg tccttttgag cgacctgacc aactgcactg tcaaactgtg tggcaatccc
      721 aacaccttgc ggcttgcgaa ggcccgcggc tgcaaggtgc tctgcggccc agtgaccacc
      781 tctgtgtttc tggaggattg tcgagattgc gtcctggctg tggcttgcca gcagctccgt
      841 gtgcacacta ccaaagacac gcgcgtcttc ttgcaagtga ccagcagggc tatcgtggag
      901 gactgcagcg gcatccagtt tgccccttac acctggagct acccggggat cgacaaggac
      961 ttccaggact ccggtttaga taggagcaaa aataactggg accaggttga tgatttcaac
     1021 tggctggccc gaaacgtggc ctccccaaac tggagtattc ttcctgaaga ggagagagac
     1081 atccagtggg attgagcact ggccacactc agtgtgatgt cccattcggt ttacctgata
     1141 ttgtcttatg tttgcggtga taggggttag aaattgttga aactcccctc ctgtgagtcc
     1201 tattaaattc atagcagtgt aacagacttt tgctggtttg gccttcccct gcctcccttt
     1261 gagtatgaca gcgtgaagaa ttagggggag aatggaggag ctttgaggga tttgctgttc
     1321 ttaccgttga tcacagggag tgataaagtg ggtcttcaat aaataataag gatgtccgga
     1381 gaattccatt agcggacggt ttaaatggaa gaagtaggcc cataaaagct ccattaacgg
     1441 ctgttttcct cccactaaag gtttgttctg tgtctttttc agcaaggcta tgaagactcc
     1501 ttcctgaacc tctggaatcc agtgttgtgt tagggctgaa gttttgaatg gcctccaaga
     1561 ggtgtaggag ccagctagct gtaagactga aacggttaaa gtggccagct cccctccctc
     1621 cgtcttcctt gtcgagacat ggggtcacta tacaccactg gaactcacag agatgcccct
     1681 gtctctacct ctaagcatct gcaccacacc ctgctcatgt ttcttttccc tcaagagcta
     1741 caaggccatt tctattctca ccatgttcat gtgagaaaac aggtggcatc aggtcaccgc
     1801 tcatgtgatg tgctgctgga attggaaagt aggtgtggac tca
//
