LOCUS       NM_009321                550 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus tubulin cofactor A (Tbca), mRNA.
ACCESSION   NM_009321
VERSION     NM_009321.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 550)
  AUTHORS   Nolasco,S., Bellido,J., Goncalves,J., Tavares,A., Zabala,J.C. and
            Soares,H.
  TITLE     The expression of tubulin cofactor A (TBCA) is regulated by a
            noncoding antisense Tbca RNA during testis maturation
  JOURNAL   PLoS One 7 (8), e42536 (2012)
   PUBMED   22880023
  REMARK    GeneRIF: Tbca13 mRNA levels are post-transcriptionally regulated by
            the sense and natural antisense Tbca16 mRNA levels.
REFERENCE   2  (bases 1 to 550)
  AUTHORS   Wen,H.L., Lin,Y.T., Ting,C.H., Lin-Chao,S., Li,H. and Hsieh-Li,H.M.
  TITLE     Stathmin, a microtubule-destabilizing protein, is dysregulated in
            spinal muscular atrophy
  JOURNAL   Hum Mol Genet 19 (9), 1766-1778 (2010)
   PUBMED   20176735
REFERENCE   3  (bases 1 to 550)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
REFERENCE   4  (bases 1 to 550)
  AUTHORS   Guasch,A., Aloria,K., Perez,R., Avila,J., Zabala,J.C. and Coll,M.
  TITLE     Three-dimensional structure of human tubulin chaperone cofactor A
  JOURNAL   J Mol Biol 318 (4), 1139-1149 (2002)
   PUBMED   12054808
REFERENCE   5  (bases 1 to 550)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   6  (bases 1 to 550)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   7  (bases 1 to 550)
  AUTHORS   Melki,R., Rommelaere,H., Leguy,R., Vandekerckhove,J. and Ampe,C.
  TITLE     Cofactor A is a molecular chaperone required for beta-tubulin
            folding: functional and structural characterization
  JOURNAL   Biochemistry 35 (32), 10422-10435 (1996)
   PUBMED   8756698
REFERENCE   8  (bases 1 to 550)
  AUTHORS   Gao,Y., Melki,R., Walden,P.D., Lewis,S.A., Ampe,C., Rommelaere,H.,
            Vandekerckhove,J. and Cowan,N.J.
  TITLE     A novel cochaperonin that modulates the ATPase activity of
            cytoplasmic chaperonin
  JOURNAL   J Cell Biol 125 (5), 989-996 (1994)
   PUBMED   7910827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140276.1 and BC051475.1.
            
            On Feb 8, 2019 this sequence version replaced NM_009321.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK792951.1, BC087931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               AK140276.1         2-525
            525-550             BC051475.1         510-535
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.22 cM"
     gene            1..550
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /note="tubulin cofactor A"
                     /db_xref="GeneID:21371"
                     /db_xref="MGI:MGI:107549"
     exon            1..83
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..357
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /note="CFA; TCP1-chaperonin cofactor A; tubulin-folding
                     cofactor A; co-chaperonin associated with a- & b-tubulin"
                     /codon_start=1
                     /product="tubulin-specific chaperone A"
                     /protein_id="NP_033347.1"
                     /db_xref="CCDS:CCDS26694.1"
                     /db_xref="GeneID:21371"
                     /db_xref="MGI:MGI:107549"
                     /translation="MADPRVRQIKIKTGVVRRLVKERVMYEKEAKQQEEKIEKMKAED
                     GENYAIKKQAEILQESRMMIPDCQRRLEAAYTDLQQILESEKDLEEAEEYKEARVVLD
                     SVKLEA"
     exon            84..189
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /inference="alignment:Splign:2.1.0"
     exon            190..276
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /inference="alignment:Splign:2.1.0"
     exon            277..550
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      508..513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /note="hexamer: AATAAA"
     regulatory      525..530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /note="hexamer: AATAAA"
     polyA_site      531
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
                     /note="major polyA site"
     polyA_site      550
                     /gene="Tbca"
                     /gene_synonym="Tbca13"
ORIGIN      
        1 gcctctcctt cctgcggcgc cttagggacc atggccgatc ctcgcgtgag gcagatcaag
       61 atcaagaccg gagtagtgag gcgattggtc aaagaaagag tgatgtacga aaaagaagca
      121 aagcagcaag aagaaaagat tgaaaaaatg aaggctgaag atggagagaa ctacgccatt
      181 aagaagcagg cagagatcct gcaagagtcc cggatgatga tcccagattg ccagcgtcgg
      241 ttagaggctg catatactga tcttcagcag atattagaaa gtgaaaaaga cttggaagaa
      301 gccgaggagt ataaagaagc ccgtgtagtg ctggattccg taaagctaga agcctgacat
      361 ttttctgtat gggatgtttt tttgcattaa atcctggggt ccattctaca attcattgtt
      421 ttcagccact gctgtgttta ataatatgaa aacgtggttc tttttatgca gttgcattta
      481 tttttctttg cataacttaa tgtgtcaaat aaatgagttc atctaataaa attgtttgtt
      541 ttatacttta
//
