LOCUS       NM_001081499            5907 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TBC1 domain family, member 8B (Tbc1d8b), mRNA.
ACCESSION   NM_001081499 XM_621096 XM_907570 XM_977689
VERSION     NM_001081499.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5907)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5907)
  AUTHORS   Aydogdu,N., Rudat,C., Trowe,M.O., Kaiser,M., Ludtke,T.H.,
            Taketo,M.M., Christoffels,V.M., Moon,A. and Kispert,A.
  TITLE     TBX2 and TBX3 act downstream of canonical WNT signaling in
            patterning and differentiation of the mouse ureteric mesenchyme
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478225
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731648.6 and AL672243.12.
            
            On Feb 14, 2008 this sequence version replaced NM_001081499.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147581.1, SRR10223971.18941.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AL731648.6         60618-60932
            316-426             AL731648.6         76621-76731
            427-545             AL731648.6         80224-80342
            546-771             AL731648.6         81578-81803
            772-1012            AL731648.6         82739-82979
            1013-1220           AL731648.6         87876-88083
            1221-1385           AL731648.6         88877-89041
            1386-1535           AL731648.6         99525-99674
            1536-1686           AL731648.6         100700-100850
            1687-1901           AL731648.6         101286-101500
            1902-2019           AL731648.6         107880-107997
            2020-2305           AL731648.6         109577-109862
            2306-2435           AL731648.6         111911-112040
            2436-2534           AL731648.6         112576-112674
            2535-2603           AL731648.6         117549-117617
            2604-2844           AL731648.6         117774-118014
            2845-2910           AL731648.6         118978-119043
            2911-2994           AL672243.12        2835-2918
            2995-3051           AL672243.12        3978-4034
            3052-3149           AL672243.12        7575-7672
            3150-5907           AL672243.12        9088-11845
FEATURES             Location/Qualifiers
     source          1..5907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.35 cM"
     gene            1..5907
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /note="TBC1 domain family, member 8B"
                     /db_xref="GeneID:245638"
                     /db_xref="MGI:MGI:1918101"
     exon            1..315
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3530
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /codon_start=1
                     /product="TBC1 domain family member 8B"
                     /protein_id="NP_001074968.1"
                     /db_xref="CCDS:CCDS41146.1"
                     /db_xref="GeneID:245638"
                     /db_xref="MGI:MGI:1918101"
                     /translation="MWLKPEEVLLKNALKLWLMERSNEYFVLQRRRGYGEEGGGGLTG
                     LLVGTLDSVLDSTAKVAPFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTL
                     SVFDSNEDITNFVQGKIRGLIAEEGKQSFAKEDDPEKFREALLKFEKSFGLPEQEKLV
                     TYYSCSYWRGRVPCQGWLYLSTNFLSFYSFLLGSEIKLIISWDAISKLEKTSTVILTE
                     SIHVCSQGENHYFSMFLHINETYLLMEQLANYAIKRLFDKETFDNDPVLDDPLQITKR
                     GLEYRAHSEQFKAFFRLPKEETLKEVHECFLWVPFSHFSSHGKMCISENYICFASQDG
                     NLCSVIIPLREVLAIDKTDDSNRSVIISIKGKTAFRFSELKDFEQLVAKLRLKCRAAS
                     TQDDVSTEVAVSSDSTGPSENFEEQPLTCPKECSKTVNTEALMTVFHPQNLENLDSKM
                     LKEKMKEQSWNILFSECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMAT
                     NPGYYAEVVEQSLGTSNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNP
                     KIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELI
                     RDHLPQLTDHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGL
                     AILDYNLDKLLTCKDDAEAVTALNRFFDNVINKDSPLPSNVQQGSNISNEKSDHTKVD
                     ITDLIKESNEKYGSIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKMSLQEL
                     DELYVIFKKELFISCYWYLSCPGLKHHDPSLPYLEQYQIDCQQFRVLYHLLSPWAHSA
                     NRDSLALWTFRLLDENSDCLINFKEFSSAIDIMYNGSFTDKLKLLFKLHIPPAYTEVM
                     SKTSSKGDELSTEELLYFSQLQVSKPADEKETESGRNSPEKGKGKIDIQAYLSQWQDE
                     LLKKEETIKDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAIVTNLLLRMEEVGR
                     KLHSPASSASTARDSGPSEGNAESSVKKDLPSPREEHQWSFAFEQILASLLNEPALVR
                     FFERPLDLKAKLENAKSSQLRSRTKM"
     exon            316..426
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..545
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            546..771
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1012
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1220
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1385
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1535
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1686
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1901
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2019
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2305
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2435
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2534
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2603
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2844
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2910
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..2994
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3051
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3149
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..5907
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5094
                     /gene="Tbc1d8b"
                     /gene_synonym="4921505D17Rik; 9030605E16Rik"
ORIGIN      
        1 actctctctg cctacgtggg agagaaggca cggttggggg aagtgtggaa aacctccgga
       61 ggcgccgccg ccaacggaag acttggtggg aggagaagta gaggggtaaa gacaggctgg
      121 gagggtggag gtgaggagga caaataggtc gcctccgttc ccgaggcggc acaaagttct
      181 tcaagatgtg gctgaagccc gaggaagtgc tgttgaaaaa tgcgctgaag ctgtggctga
      241 tggaaagatc caacgagtac tttgtcctgc aaaggcgtcg aggctacggg gaagaaggag
      301 gagggggact tacagggctc ttggttggga ctcttgattc tgtcttagac tccactgcta
      361 aagtagctcc atttcgcatc ctacaccaga caccagattc tcaagtgtac ttgtcaattg
      421 catgtggagc caacagagaa gaaataacaa aacattggga ctggttggaa caaaatataa
      481 tgaagacttt atctgtgttt gattcaaatg aagatattac caattttgta caaggcaaaa
      541 taagaggact aatcgctgaa gaggggaaac agtcttttgc taaagaagat gatcctgaga
      601 aatttcgaga agcccttttg aaatttgaaa aatcttttgg tttaccagag caggaaaaat
      661 tagtaactta ttattcctgc agttactgga gaggacgggt cccttgtcag ggctggctct
      721 atctaagtac caactttctg agcttctatt ccttcttgct aggatcagaa attaaactca
      781 ttatctcctg ggatgcaatc tcaaaacttg aaaagacttc aactgttata ttaactgaga
      841 gcattcacgt atgttctcaa ggagagaatc actatttttc aatgtttttg cacattaatg
      901 agacatacct tcttatggaa caactggcaa actatgccat aaagagactt tttgataaag
      961 aaacatttga taatgaccca gtccttgatg atcctctaca gattaccaaa agaggtttgg
     1021 aatatcgagc ccacagtgag caattcaaag ccttttttag gctacccaaa gaagagacat
     1081 tgaaagaagt acatgagtgt ttcttatggg taccattcag ccacttcagt agtcacggaa
     1141 aaatgtgcat ttcagaaaac tatatttgct ttgctagcca ggatgggaat ctatgcagtg
     1201 taatcattcc attacgagag gtcttagcta tagataaaac tgatgactcc aacagatcgg
     1261 tcatcattag catcaaagga aaaacagctt ttcgtttcag tgagcttaaa gactttgagc
     1321 aactggtggc aaaactcagg ctcaagtgcc gggcagcttc aactcaagat gatgttagta
     1381 cagaggttgc tgttagttct gactcgacag gcccatctga gaattttgag gagcagcctt
     1441 tgacatgtcc aaaggaatgc agcaaaactg tgaacactga agccttaatg acagtatttc
     1501 accctcaaaa tctggaaaat cttgattcta aaatgttgaa agaaaagatg aaggagcaat
     1561 catggaacat cttattttca gaatgtgggc gaggtgttag catgttccgg acaaaaaaga
     1621 ctcgagatct ggtggtaaga gggattccag agacgttaag aggagagctc tggatgcttt
     1681 tctcaggtgc tgttaatgac atggcaacaa accctggcta ttatgctgaa gtggttgagc
     1741 aatccttagg gacctccaac ttggctactg aagaaattga gcgtgatttg cgtcgctctc
     1801 tgcccgaaca tccagcattt cagagtgata ctggcatatc tgctctgagg cgggtactga
     1861 cagcttatgc atataggaat cccaaaatag gatactgcca ggcaatgaac attttgactt
     1921 cagtattgct cctatatgca aaagaagaag aggctttttg gcttctggtt gctgtatgtg
     1981 aacgaatgtt gcctgattat tttaatcgtc gaatcattgg tgccttggtg gaccaggcag
     2041 tgtttgaaga acttatcagg gatcaccttc ctcagctgac agaccacatg accgacatga
     2101 ctttcttttc ctctgtttct ctttcctggt ttctcacact tttcattagt gtgctaccta
     2161 ttgaaagtgc agtgaatgtg gtggactgtt tcttctatga tggaataaaa gccattttac
     2221 aactgggatt ggcaatactt gactataatt tagacaaact tctgacatgt aaagatgatg
     2281 ctgaagcggt gacggcacta aacaggttct ttgacaatgt cattaataag gatagcccac
     2341 tgccttcaaa tgttcaacag ggttcaaata tcagtaatga aaaaagtgat catactaaag
     2401 tggatattac agatttgatt aaagagtcca atgagaaata tggtagtatc cgctatgaag
     2461 atatacatag catgcgctgt cgaaataggt tgtatgtgat ccagaccctg gaagagacaa
     2521 caaagcagaa tgtgctacgt gttgtatcgc aagacgtgaa aatgagcctt caggaactgg
     2581 acgaacttta tgtcattttt aagaaagagc tgtttatatc ttgttattgg tatttgagtt
     2641 gtccaggatt gaagcatcat gaccccagcc tgccatattt ggaacaatat cagattgact
     2701 gccagcaatt cagagtatta tatcacttgc tgagtccctg ggctcattct gcaaacagag
     2761 actcattggc tttatggaca ttccgattgt tggatgagaa ctctgattgc cttataaact
     2821 tcaaagaatt ctcctctgca atagatataa tgtacaatgg aagttttact gacaagctca
     2881 agctgctttt taagctgcat attcctccag cttatactga agtgatgtct aagacgtctt
     2941 caaagggcga tgagctttca acagaagaat tactttattt cagtcagctc caggtttcta
     3001 agcctgcaga tgagaaggaa acagaatcgg gaagaaatag ccctgaaaaa ggcaaaggaa
     3061 aaattgatat tcaagcctat ttaagtcaat ggcaagatga gcttcttaaa aaagaagaaa
     3121 ccattaaaga tttaccaaga atgaatcagt cacaatttat tcaattttca aagaccctgt
     3181 ataatttatt tcatgaggac cctgaagaag agtcgctata tcaagccatt gctattgtaa
     3241 ccaaccttct gctcaggatg gaagaagttg gaaggaaact ccatagcccg gcatcatcag
     3301 ccagtacagc tcgtgattct ggacccagtg aagggaatgc agagagcagt gtgaagaaag
     3361 atcttccctc tcccagggaa gaacatcagt ggtcgtttgc atttgagcag attcttgctt
     3421 ccctgttaaa tgaaccagcc ttggtgaggt tttttgagag acccttagat ttaaaagcca
     3481 agctagaaaa tgcgaaaagc tcccagctaa ggtctagaac caagatgtaa atctctgcca
     3541 tcatcagctt tgccaagatt cctgcactat cagcctgatt cctgggaata cttctcaggg
     3601 atatgttgca ttactgatgt gctccaaggc agaagaaaaa gatactcaga agcacaatgg
     3661 ttcattcctt tgtattaaat gcacttttaa aaaattctcc ccctgtcaca agataagcag
     3721 catcagggtc acatgctcag tgggaccacc agagggcgcc accatatcac tttagtgagt
     3781 cagtcacaag tttgtcctgc tgtttccatg agattgctgg tcttttgaaa ggtggtagga
     3841 tatttattat aatgctgtta tggcaaattg gtaagccttg tttttcaaat gaccccagtc
     3901 ttataaaaac tttacaaaac tgggctttag aactgtagcc ttaattatct aggaagttgc
     3961 cttttagggc cctgatttcc aagttatata actaaaagat ttacttctaa aacgtaattt
     4021 tattcagtac agtaatacat ggttttacag taatacatgc aacttctgca ttctctgctc
     4081 tcgagggatt gagcactcgg tgtttaacgc tactaactct gttgctgata aacacaaatc
     4141 aagaagtcta aattctgggc tgatataaag aaaaacaaca ccagatttag acttaaatca
     4201 aataaagcca gcattttgaa aagaaaggtt agaagacagt ttagttaact atatagctct
     4261 ttcagttaga ctgagacaca aataaaaatt ctctagagtg gcattgttta ttgctttggt
     4321 ttcagaatag cttctgattg cttgtgtccc agctttgtag tttgaatttt tacccattgt
     4381 attttaattt atagtaggta gtgtggaaga gtttcactaa gactgaattg ctgtattagt
     4441 ctggcaagca tgtaaagtat acttcatgta atacttacta gggtactata tagaattgcc
     4501 agcatctacc taaaaaggtt agacttagat gtgcaatttt tacatacttt atgctttttc
     4561 tatggcagtc catttaaata tatatggacg ctgatagcac tttcaaaaga acaaaacaac
     4621 aaacaaacaa aaacaagcaa tccatgcaga cctgacctgt cttctgccgc ttttgaagag
     4681 ggacttattt agcagttgac ttgggaaatg gggcaggaac cagtgtgtgg agcttctgtc
     4741 ttcacactag acttggattt cgagcctctg acttggctag aagggaaaca atgaaaggat
     4801 agacttcctt catggtgacc aaacaagtct ccctttctgg gaaagaattg gcatggtcag
     4861 tctttgacaa gaacgtactg tgactaaaac ctaactgtgt taccatacca catactattt
     4921 tcagtgaagc taagcacttc tcaaattgtg tctttgaaaa ttcctatgta tcaggagatg
     4981 gcctaatcgg ccatcagtag aaagagaggc ccattggtcg tgcaaacttt atatgcccca
     5041 gtacagggga acaccagggc caaaaagtgg gagtggcggg gggagggtat gggggacttt
     5101 tgggatagca ttgtaaatgt aaatgaagaa aatacctaat taaaattaaa aaaaaataaa
     5161 tttaaaaaat cccttaatgt aatccactat ataaacaaac tcaaaggaaa aaaaaaaaga
     5221 aagaaaattc ctaagttgaa tttggtcaaa tgctggtagc atctttaaga tttgattatg
     5281 ctgtcttttc aaggacatga ctacttaaaa gagatagttg aaaactaagc ctttctgcct
     5341 caactcagag atgattagct aaaatatgtc ccaattttca atcctagttg atagtttatg
     5401 tgagaaccat cacacatcta ccattatgca atgattgtta aattatacga tgatagctct
     5461 agaaaaacat atggtccgcg cttgtataca aagatactgt tatacacact ttgttgaata
     5521 ttttgtcagt tgtatttaca acagatactt tcttaagaga atatgttgtt agtttttgat
     5581 attattttaa agtcaaaatg gtaaagatta ctgaatattg tattttagtc ttgatcaata
     5641 aaaaataaat aaagagattt tttgaatttc aagaagatta taaatgaaag caagacaaca
     5701 atgtattttc cgagtctgca ggagaaggaa gcaaaacatg ttctagtttt atagctgctg
     5761 ctttgttaag caaatgagtt gttcacaata ttcaaaatat tttgttgtgt caaactggac
     5821 cagtgcatta tgccttttac cttaaatgtt ataacatgac tttgtcttta taaaactaag
     5881 tattaaaaat ctattatatt aaatatg
//
