LOCUS       NM_001252639            1268 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus TBC1 domain family, member 7 (Tbc1d7), transcript
            variant 1, mRNA.
ACCESSION   NM_001252639
VERSION     NM_001252639.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1268)
  AUTHORS   Schrotter,S., Yuskaitis,C.J., MacArthur,M.R., Mitchell,S.J.,
            Hosios,A.M., Osipovich,M., Torrence,M.E., Mitchell,J.R., Hoxhaj,G.,
            Sahin,M. and Manning,B.D.
  TITLE     The non-essential TSC complex component TBC1D7 restricts tissue
            mTORC1 signaling and brain and neuron growth
  JOURNAL   Cell Rep 39 (7), 110824 (2022)
   PUBMED   35584673
  REMARK    GeneRIF: The non-essential TSC complex component TBC1D7 restricts
            tissue mTORC1 signaling and brain and neuron growth.
REFERENCE   2  (bases 1 to 1268)
  AUTHORS   Dibble,C.C., Elis,W., Menon,S., Qin,W., Klekota,J., Asara,J.M.,
            Finan,P.M., Kwiatkowski,D.J., Murphy,L.O. and Manning,B.D.
  TITLE     TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of
            mTORC1
  JOURNAL   Mol Cell 47 (4), 535-546 (2012)
   PUBMED   22795129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY166141.1, BC145157.1 and DN174647.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156543.1, BC145157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               BY166141.1         2-154
            154-1159            BC145157.1         1-1006
            1160-1268           DN174647.1         575-683
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 21.31 cM"
     gene            1..1268
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /note="TBC1 domain family, member 7"
                     /db_xref="GeneID:67046"
                     /db_xref="MGI:MGI:1914296"
     exon            1..193
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            194..339
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1109
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="TBC1 domain family member 7 isoform 1"
                     /protein_id="NP_001239568.1"
                     /db_xref="CCDS:CCDS26476.1"
                     /db_xref="GeneID:67046"
                     /db_xref="MGI:MGI:1914296"
                     /translation="MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCT
                     FSQRFPLPSMYRALVWKALLGILPPHHDTHSQVMAYRKDQYHDILHALTVVRFISDAT
                     PQAEVYLRMYQLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWISRCFVK
                     QLNNKYRDALPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFQRCFAGCLPES
                     SLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVS
                     KAIDLWHKHCGTPVHSA"
     exon            340..420
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            421..608
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            609..746
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            747..892
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1022
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1263
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1263
                     /gene="Tbc1d7"
                     /gene_synonym="2610009C09Rik"
                     /note="major polyA site"
ORIGIN      
        1 gacgtcacgt ccggcggcgg gagttagagg cggagagggc cgggccgggt gtctcatggc
       61 atcgctcccc tcgctcgctc ggccctgacg cttatggttc cgtctgcctg ccggtagcac
      121 agcgttgccg ggccggttct ccgccgcctc ccggatctct gagtctgagc cgggtgtgtt
      181 tgctctactc gaggctcacc taaaaaaaat ccctccaagg atgaaacatg actgacgact
      241 ctcagaggaa ctttcgatca gtctactatg agaaagtcgg gtttcgtggt gtcgaagaaa
      301 agaaatcact ggaaatcctc ctgaaagatg accgtttgga catcgagaag ctttgcacat
      361 ttagccagag gttccctctc ccatccatgt atcgcgcgtt ggtatggaag gcgcttctag
      421 gcatcttacc tccgcaccat gacactcatt cccaggtgat ggcctaccgc aaagaccagt
      481 accatgacat cctccatgcc ctgacagtcg tccgcttcat cagtgatgcc acgccacagg
      541 ctgaagtgta tcttcgcatg tatcagcttg aatcggggaa gctacctcga agtccctctt
      601 ttcctctgga gccggaggat gaagtctttc ttgccatcgc caaggccatg gaagagatgg
      661 tggaagacag tgtggactgt tactggatca gccgatgctt cgtgaagcag ttaaataaca
      721 agtacaggga cgctttacct cagctgccca aggctttcga gcagtacttg aatctggaag
      781 acagtaggct gctgagtcac ctgaagacgt gttctgcagt gtccaaactg ccttacgacc
      841 tctggttcca aaggtgcttc gcgggatgcc tccccgagtc cagtttacag agggtctggg
      901 ataaagtcgt aagtggatcc tgtaagatcc tagtttttgt agcggtagaa atactattaa
      961 cctttaaaat aaaggtcatg gcattgaaca gtgcagagaa gataacgaag ttcctggaaa
     1021 atattcctca ggacagctca gatgccatcg tgagcaaggc catcgacttg tggcacaaac
     1081 actgtgggac cccagtgcat tcggcctgac agctcgtgac tacatgggca gtctgcaggc
     1141 cctccctgag cacttcgttc acatcacctg ctctaccaac tggttagaaa caatagtctc
     1201 actgtggtgc tcaaaatgta actaccaccc cttcccccaa tcagtaaaat aatttaatca
     1261 aaaaaaaa
//
