LOCUS       NM_028162               5616 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus TBC1 domain family, member 5 (Tbc1d5), transcript
            variant 2, mRNA.
ACCESSION   NM_028162
VERSION     NM_028162.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5616)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5616)
  AUTHORS   Liang,X., Wang,Y., Li,S., Fan,J., Zhou,F., Li,X., Li,S. and Li,Y.
  TITLE     Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves
            Mitophagy in Alzheimer's Disease Models
  JOURNAL   J Alzheimers Dis 100 (1), 279-296 (2024)
   PUBMED   38848175
  REMARK    GeneRIF: Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression
            Improves Mitophagy in Alzheimer's Disease Models.
REFERENCE   3  (bases 1 to 5616)
  AUTHORS   Roy,S., Leidal,A.M., Ye,J., Ronen,S.M. and Debnath,J.
  TITLE     Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane
            Translocation of GLUT1 and Glucose Uptake
  JOURNAL   Mol Cell 67 (1), 84-95 (2017)
   PUBMED   28602638
  REMARK    GeneRIF: TBC1D5 shuttling to autophagosomes during metabolic stress
            facilitates retromer-dependent GLUT1 trafficking.
REFERENCE   4  (bases 1 to 5616)
  AUTHORS   Narboux-Neme,N., Goiame,R., Mattei,M.G., Cohen-Tannoudji,M. and
            Wassef,M.
  TITLE     Integration of H-2Z1, a somatosensory cortex-expressed transgene,
            interferes with the expression of the Satb1 and Tbc1d5 flanking
            genes and affects the differentiation of a subset of cortical
            interneurons
  JOURNAL   J Neurosci 32 (21), 7287-7300 (2012)
   PUBMED   22623674
REFERENCE   5  (bases 1 to 5616)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 5616)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144467.1, BC043113.1 and AC154214.1.
            
            On Oct 26, 2013 this sequence version replaced NM_028162.3.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region compared to variant 1. The encoded protein
            (isoform b) is shorter than isoform a. Variants 2 and 3 encode the
            same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043113.1, SRR9219382.83637.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AK144467.1         2-185
            185-2657            BC043113.1         1-2473
            2658-2658           AC154214.1         72974-72974
            2659-5615           BC043113.1         2475-5431
            5616-5616           AC154214.1         75932-75932
FEATURES             Location/Qualifiers
     source          1..5616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.47 cM"
     gene            1..5616
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /note="TBC1 domain family, member 5"
                     /db_xref="GeneID:72238"
                     /db_xref="MGI:MGI:1919488"
     exon            1..253
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            254..316
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            317..447
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2798
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="TBC1 domain family member 5 isoform b"
                     /protein_id="NP_082438.3"
                     /db_xref="CCDS:CCDS37650.1"
                     /db_xref="GeneID:72238"
                     /db_xref="MGI:MGI:1919488"
                     /translation="MYKSVSETRHPLQSEEQEVGIDPLFSYSNKTRGDLSQNGRGSNS
                     TLDTEGTFNSYMKEWEELFVNNNYLATVRQKGINGQLRSSRFRSICWKLFLCVLPQDK
                     SQWISKIKELRAWYSSIKEIHITNPRKAAGQQDLMINNPLSQDEGSLWNKFFQDKELR
                     SMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLH
                     CDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGK
                     ETLMAPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRW
                     VRLLFGREFPLQDLLVVWDALFADSLNLSLVDYVFTAMLLYIRDALISSNYQTCLGLL
                     MHYPIIGDIHSLILKALFLRDPKRNPRPATYQFHPNLDYYKARGADLMNKSRTNARGA
                     PLNIHKVSNSLINFGRKLISPASAPGSMGGPVPGNNSSSSFSAAIPTRTSTEAPRHHL
                     LQQQQQQQHQQQQQQQPQQQQQQHQQQQQQQRLMKSESMPVQLNKGQSSKTISSSPSI
                     ESLPGGREFTGSPPPSATKKDSFFSNIARSRSHSKTMGRKESEEELEAQISFLQGQLN
                     DLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQS
                     QLEAGENEQITIADDHYCSSGQDQGSQVPRAAKQASSEMPGCTGGTTPDDFILVSKED
                     EGHRARGAFSGQAQPLLTLRSTSGKSRAPACSPLLFSDPLMGPASASASSSNPSSSPD
                     DDSSKESGFTIVSPLDI"
     exon            448..517
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            518..626
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            627..716
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            717..791
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            792..859
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            860..962
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1051
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1102
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1172
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1345
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1488
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1595
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1681
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..2010
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2174
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2274
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2354
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2498
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..5616
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4786..4791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /note="hexamer: AATACA"
     polyA_site      4812
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /note="major polyA site"
     regulatory      4894..4899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      4917
                     /gene="Tbc1d5"
                     /gene_synonym="1600014N05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccgttacgg agggagcgtg gtcacgtggc cgctggtcac cgccgccacc tcccgcccca
       61 ttctcttgct ggtcgggcca ggcccggcgt gttccacgag agcccggcag actgacgggg
      121 agagagagag agagagcgag agagcgagat aaagagagga gagagacaga gagactgaca
      181 gagagagaga gagagagaaa ggaggggagg aggattcagg gaataggagc tggggagccc
      241 tgctgcgcta cagaaaattt ctaatgactt ggtgaagata ggaaaaccgt cagaaaggct
      301 gaagtactgc catactacaa ttacttcggt gactgtctcc actctatgca atgtataagt
      361 ctgtgtctga aacgagacat cctctgcagt cagaagaaca agaagtaggc attgacccct
      421 tgttcagtta ttcaaataaa acaagaggag atctaagtca aaatggaaga ggatcaaatt
      481 ctaccttaga cactgaaggg acgttcaatt catatatgaa agaatgggaa gaactatttg
      541 taaacaacaa ttacttggca acagtaagac agaaggggat taatgggcag ctgagaagca
      601 gcaggttccg cagcatttgc tggaagctct ttctttgtgt tcttcctcaa gataaaagtc
      661 agtggataag taaaatcaaa gaactaagag cctggtatag cagtattaaa gaaatacaca
      721 tcactaaccc aaggaaggct gccggccagc aggatctgat gatcaacaac cccctatcac
      781 aggatgaagg aagtctttgg aacaagttct ttcaagataa agaactacgg tccatgattg
      841 agcaagatgt caaaagaacg tttcctgaaa tgcagttttt ccaacaagaa aatgtgagaa
      901 aaattcttac agatgttctg ttctgctatg caagagagaa cgagcagttg ctttacaaac
      961 agggtatgca tgagctacta gcgcctatca tctttaccct ccactgtgac caccaagctt
     1021 ttctacatgc cagcgagtct gcacagccca gtgaggaaat gaaaactctc ctgaaccctg
     1081 agtatctgga gcatgatgcc tatgcaatgt tctcacagct tatggaaact gctgaacctt
     1141 ggttttctac gtttgagcat gatggtcaaa agggaaaaga aactctgatg gcccccattc
     1201 cctttgctcg accacaggat ttagggccaa cagttgccat tgttacaaaa gtcaaccaga
     1261 tccaggacca tctactgaag aaacatgata ttgagctcta catgcacctg aacagactag
     1321 aaattgcacc acaaatatat gggttacgat gggtgcggct gctgtttggc agagagttcc
     1381 ctctgcagga cctgctggtg gtctgggatg ccctgtttgc ggatagcctc aacctgagct
     1441 tagtcgacta tgtcttcaca gccatgctac tctatatccg agatgctttg atttctagta
     1501 actatcagac ctgtcttggc cttctgatgc attatccaat catcggggac atacactcac
     1561 tgatactgaa ggctctgttc cttagagacc caaagagaaa tccaaggccg gcgacttacc
     1621 agttccaccc caacttagac tactacaaag cacggggagc cgaccttatg aacaaaagcc
     1681 ggaccaatgc cagaggtgct cccctgaata tacacaaggt ctccaacagc ttgattaact
     1741 ttggaagaaa gctgatttcc ccagcctcag ctccgggcag tatgggtggc cctgtacccg
     1801 gaaacaacag cagcagttcc ttctctgctg ccatccccac caggacctcc acagaagccc
     1861 caaggcatca tttgctgcag cagcaacagc agcagcagca ccagcagcag cagcagcagc
     1921 aaccacagca gcagcagcag caacaccagc agcaacagca gcagcagaga ctgatgaaat
     1981 ctgaaagcat gccggtacag ttgaacaaag ggcaaagttc gaaaaccatc agttcatctc
     2041 caagtatcga gagtttgcct gggggaagag aattcactgg ctctccacct ccatccgcta
     2101 ctaaaaagga ttcctttttc agcaacatcg cacgttcccg ttcacacagc aaaaccatgg
     2161 gcaggaaaga gtctgaagaa gaactagagg ctcagatctc cttcctacaa ggccagctga
     2221 atgacctgga tgccatgtgc aagtactgtg caaaggtcat ggacatgcat cttgtaaaca
     2281 ttcaagatgt ggtattacaa gagaatttgg aaaaagaaga tcaaattctg gtgtccttgg
     2341 caggattaaa acagatcaaa gacattctga aaggttccct gcgcttcaac cagagccagc
     2401 tggaggctgg cgagaatgag cagattacca tcgctgatga ccactactgc tccagtggcc
     2461 aggaccaggg cagccaagtt cctagggccg ccaagcaggc ctcttcagag atgccagggt
     2521 gcaccggtgg aacgacccca gatgacttca ttctggtttc caaagaagat gaggggcacc
     2581 gtgccagggg ggccttctca ggccaggccc agcctcttct caccctcaga agcacatctg
     2641 ggaaaagccg agccccagcc tgctccccac tgctgttctc agacccactg atgggcccag
     2701 cctcagcctc agcctcctcc agcaacccca gctccagccc cgatgatgac agcagcaagg
     2761 agtctggctt caccattgtg agccccttgg acatctgagc acagggcccc actggcggac
     2821 accctgctga accagtgtct ttttcccagc atgcatttgg cattggttca acccactgga
     2881 actctttaca aaaagaggca actatgcttc tttcaatgca ctatgtttac caaaatgcag
     2941 atagaggttt ccagaccctt acctgaccct gtgacccttg ttccaattag ggccaggtca
     3001 ggtccccagc tccataccca ctgtcagaca cagcagacca catcagagcc acatgtcttc
     3061 cgtcccctcc tccccagcag ctctgccagt ttacactcag aaggaaaagt tggtttcaca
     3121 acttcccctt atcaaagctt cagccacagg gaacttgttg atactgagtg aatctggcag
     3181 gcagtctcac tcctgccttg gaagcccaac atgccacaca gagggagcag agcgggtggc
     3241 tcccagggct ggagtcagag tgaattgtag gagcagggtt tcagattagg aatcagattc
     3301 ttgtttgaca caaatacagt tctggaccct gggcttccta agcttcagcc accgctgttc
     3361 ctccttgaac aactggattt ctccttccag agtccccaca gccgggagtg cagtggctcc
     3421 acgccagtct gctctgagat ggttttaaga gtcacagggc taacatcctt gaattggaga
     3481 aatgtgtcca gagctctccg gtcaggtctc tgagcatgtt tagagctaca gtggcctgtt
     3541 aaatgaggag cacagaggaa aaccacattc gcacaacccg gagtcagacc tcctgggaat
     3601 tagacctgga gttccttctg tgggagcagg tttcctgtag agcgttccag gtaccacaag
     3661 atacagggct cctattcaac ccccaacacc ctattcttgg agctcagctg taaactctgc
     3721 atccagacac tccaaggatg ggcctgcctg cctcggggcc cctgcctggg ctgggtatac
     3781 atgagacatc tccccgtcta ttggccgagt acagagctgt attgggcaca aagctaggga
     3841 cagtggaaat ggtggataga tgtagcatct gttagatgtc acctctgcct tctgtcctcc
     3901 tcagagagca gctgggcctc tgggcagtgc cccacccact aatagcattg taattctcta
     3961 cagacaggaa tgctaatgtc aggatgctct gcaggcttct tagctgtact gcatagcagg
     4021 gctggtggct cactcacatg gtggcggggc tcagtcatgg cctcatgaat tctaccccct
     4081 gcctctgacc agtcttctca gcattctgag gagcctgctt gcatacatgt cccatgaagc
     4141 tgctctgtaa gaatcagggc caccatccat ccctgctaga aggcttccag caagcattcc
     4201 acttaaagcc ttgacataac cgtgtcagta ccttagatct agtgtgggaa gtattgactg
     4261 atccatccag gtctgggaca gtgccggcca tgtctgtcac tgctgagccc tgtccccagc
     4321 atctcctttg cgttgagaat aaggtcaata gataactatc actggctacc caccaggcca
     4381 agaagatgat aggctgaccc attactgttt gaatggacat ttcataaccc ctcgacctac
     4441 ctgccctgcc catgcccgtg atgtgccccg ctcctgtgct tgtgtgggtg ccacatgaga
     4501 accccaggtt cacactgaga tgtttctatg gtccctaggc aggccactct ctccttggaa
     4561 gaaccaagga tggaaagctc ttctctaagt gactctattc ttcgttggtg accattgctt
     4621 cccttggtta cctacactgc tggtttggga tgcattccgt ccctgttatt ttatcaggta
     4681 cttctgtcta attgtacatt ttaaagtcct ggatatatag aacctttttc tttaaccaca
     4741 tggtaatcat cagttttaat ctctcacatt ttgattatag cagctaatac agttttatac
     4801 aagccaagcc tagattaagc cctactgtcg tctgcttttt tatacacatt tctgtgtttc
     4861 atgcagtcct ctctgatcag attggaagtg tgaagtaaaa catacctgtg tgccacagag
     4921 ggtcggttca gtgcctcggt tcagttctcg agaacttcct ggcttagctt ggcaagatga
     4981 ccttctgctc tgcactaact gcaacttgaa gtgaccacac tgctgctgag tgtaactctg
     5041 gagggcagct gcctccccgg agcccagttc tcgtaggggt gaatctcctc cgcacgggtt
     5101 ggctgtgctg gacaaccttg ccagccatgt ctttagtgtc agaaaggctg gacaaatgcc
     5161 aaaactctag tataacctgc tgttcagtac aggttgcttt tgcttgctaa aagctctccc
     5221 agtggccact aaagacaaag cggggagcac ctgtggccct gcaccggcca gtgccatctc
     5281 ccttccccac cctggaactg ctaggaaatg agagctgggg aagaggccat gtgcatggag
     5341 agctgtggcg gcaggctctt cacagatcac atggcctcct ccatgctagg cccaaaagct
     5401 gcttctctct tgttgaaaag aggtgtcgtt cctataacca ggctggtgtg gaagttttcc
     5461 ttcggtgcat gaggctcggc tcatctagtt gatatcccag cagtgccaac aatgtcctca
     5521 cgagccttgg tgccggagct catactgatg taggaaatgc ctccttggca gagcgagccc
     5581 acttgatgtg tactaataaa ggactactga gaactg
//
