LOCUS       NM_001404671            6454 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus TBC1 domain family, member 4 (Tbc1d4), transcript
            variant 1, mRNA.
ACCESSION   NM_001404671 XM_006518762
VERSION     NM_001404671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6454)
  AUTHORS   Springer,C., Binsch,C., Weide,D., Toska,L., Cremer,A.L., Backes,H.,
            Scheel,A.K., Espelage,L., Kotzka,J., Sill,S., Kurowski,A., Kim,D.,
            Karpinski,S., Schnurr,T.M., Hansen,T., Hartwig,S., Lehr,S.,
            Cames,S., Bruning,J.C., Lienhard,M., Herwig,R., Borno,S.,
            Timmermann,B., Al-Hasani,H. and Chadt,A.
  TITLE     Depletion of TBC1D4 Improves the Metabolic Exercise Response by
            Overcoming Genetically Induced Peripheral Insulin Resistance
  JOURNAL   Diabetes 73 (7), 1058-1071 (2024)
   PUBMED   38608276
  REMARK    GeneRIF: Depletion of TBC1D4 Improves the Metabolic Exercise
            Response by Overcoming Genetically Induced Peripheral Insulin
            Resistance.
REFERENCE   2  (bases 1 to 6454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6454)
  AUTHORS   Kjobsted,R., Kristensen,J.M., Eskesen,N.O., Kido,K., Fjorder,K.,
            Damgaard,D.F., Larsen,J.K., Andersen,N.R., Birk,J.B., Gudiksen,A.,
            Treebak,J.T., Schjerling,P., Pilegaard,H. and Wojtaszewski,J.F.P.
  TITLE     TBC1D4-S711 Controls Skeletal Muscle Insulin Sensitization After
            Exercise and Contraction
  JOURNAL   Diabetes 72 (7), 857-871 (2023)
   PUBMED   37074686
  REMARK    GeneRIF: TBC1D4-S711 Controls Skeletal Muscle Insulin Sensitization
            After Exercise and Contraction.
REFERENCE   4  (bases 1 to 6454)
  AUTHORS   Binsch,C., Barbosa,D.M., Hansen-Dille,G., Hubert,M., Hodge,S.M.,
            Kolasa,M., Jeruschke,K., Weiss,J., Springer,C., Gorressen,S.,
            Fischer,J.W., Lienhard,M., Herwig,R., Borno,S., Timmermann,B.,
            Cremer,A.L., Backes,H., Chadt,A. and Al-Hasani,H.
  TITLE     Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and
            increases myocardial damage after ischemia/reperfusion
  JOURNAL   Cardiovasc Diabetol 22 (1), 17 (2023)
   PUBMED   36707786
  REMARK    GeneRIF: Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake
            and increases myocardial damage after ischemia/reperfusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6454)
  AUTHORS   Larsen,J.K., Larsen,M.R., Birk,J.B., Steenberg,D.E., Hingst,J.R.,
            Hojlund,K., Chadt,A., Al-Hasani,H., Deshmukh,A.S.,
            Wojtaszewski,J.F.P. and Kjobsted,R.
  TITLE     Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome
            in Human Skeletal Muscle
  JOURNAL   Diabetes 71 (5), 906-920 (2022)
   PUBMED   35192682
REFERENCE   6  (bases 1 to 6454)
  AUTHORS   Gridley,S., Lane,W.S., Garner,C.W. and Lienhard,G.E.
  TITLE     Novel insulin-elicited phosphoproteins in adipocytes
  JOURNAL   Cell Signal 17 (1), 59-66 (2005)
   PUBMED   15451025
REFERENCE   7  (bases 1 to 6454)
  AUTHORS   Zeigerer,A., McBrayer,M.K. and McGraw,T.E.
  TITLE     Insulin stimulation of GLUT4 exocytosis, but not its inhibition of
            endocytosis, is dependent on RabGAP AS160
  JOURNAL   Mol Biol Cell 15 (10), 4406-4415 (2004)
   PUBMED   15254270
REFERENCE   8  (bases 1 to 6454)
  AUTHORS   Sano,H., Kane,S., Sano,E., Miinea,C.P., Asara,J.M., Lane,W.S.,
            Garner,C.W. and Lienhard,G.E.
  TITLE     Insulin-stimulated phosphorylation of a Rab GTPase-activating
            protein regulates GLUT4 translocation
  JOURNAL   J Biol Chem 278 (17), 14599-14602 (2003)
   PUBMED   12637568
REFERENCE   9  (bases 1 to 6454)
  AUTHORS   Kane,S., Sano,H., Liu,S.C., Asara,J.M., Lane,W.S., Garner,C.C. and
            Lienhard,G.E.
  TITLE     A method to identify serine kinase substrates. Akt phosphorylates a
            novel adipocyte protein with a Rab GTPase-activating protein (GAP)
            domain
  JOURNAL   J Biol Chem 277 (25), 22115-22118 (2002)
   PUBMED   11994271
  REMARK    GeneRIF: AS160 was shown to be a substrate for Akt, and two sites
            of phosphorylation, both in RXRXXS/T motifs, were identified by
            mass spectrometry and mutation
REFERENCE   10 (bases 1 to 6454)
  AUTHORS   Kurihara,L.J., Semenova,E., Miller,W., Ingram,R.S., Guan,X.J. and
            Tilghman,S.M.
  TITLE     Candidate genes required for embryonic development: a comparative
            analysis of distal mouse chromosome 14 and human chromosome 13q22
  JOURNAL   Genomics 79 (2), 154-161 (2002)
   PUBMED   11829485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025630.9, CT573033.14 and CT573019.12.
            
            On Apr 13, 2022 this sequence version replaced XM_006518762.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.17230.1,
                                           SRR10223971.14948.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-884               CT025630.9         52262-53145         c
            885-1487            CT573033.14        62652-63254         c
            1488-1577           CT573033.14        60672-60761         c
            1578-1682           CT573033.14        56576-56680         c
            1683-1815           CT573033.14        49910-50042         c
            1816-1907           CT573033.14        45417-45508         c
            1908-2018           CT573033.14        45076-45186         c
            2019-2138           CT573033.14        42992-43111         c
            2139-2213           CT573033.14        34695-34769         c
            2214-2440           CT573033.14        32544-32770         c
            2441-2605           CT573033.14        30641-30805         c
            2606-2769           CT573033.14        21165-21328         c
            2770-2979           CT573033.14        18439-18648         c
            2980-3138           CT573033.14        14299-14457         c
            3139-3297           CT573033.14        13630-13788         c
            3298-3542           CT573033.14        10411-10655         c
            3543-3702           CT573033.14        7982-8141           c
            3703-3872           CT573033.14        4766-4935           c
            3873-4049           CT573033.14        3091-3267           c
            4050-6454           CT573019.12        132119-134523       c
FEATURES             Location/Qualifiers
     source          1..6454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 50.9 cM"
     gene            1..6454
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /note="TBC1 domain family, member 4"
                     /db_xref="GeneID:210789"
                     /db_xref="MGI:MGI:2429660"
     exon            1..884
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1487
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1577
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1682
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1815
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1907
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2018
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2138
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2213
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2440
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2605
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2769
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2979
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3138
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3297
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3542
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3702
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3872
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4049
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     exon            4050..6454
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6436..6441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /note="hexamer: AATAAA"
     polyA_site      6454
                     /gene="Tbc1d4"
                     /gene_synonym="5930406J04Rik; A930035N22; As160"
                     /note="major polyA site"
ORIGIN      
        1 agccttcccg tgccagcgct gggtgagcgc gccggccgca gcgggctgca ggagcaggag
       61 cccgagcagg atcgagagac cgcggctgcc ctggtcccgg accccaagga cggaccggcg
      121 gctggagaac agacctgccc tggggcgcga tctccaggaa ggaggatgcg cgcgtgagcc
      181 tgggtctccc gctagtccac tgagctgcag ccaaaggctc ggagccgcgc ccggggaagt
      241 gtcgcatggg gcagggccgc tgaagcacgg actttaagaa ctggtggcac caaggcaggc
      301 gcgggggcct ggggcgacag ttagcagttt cctcggctcc tgcacagtga gagttggggg
      361 cgcggtgccc tcgctaggcg cgagttatgg agtcgcctag ctgcattcag gatgagcctt
      421 tcccgcaccc cctggagcct gagccgagtg ccccagcaca gccaggtgcc accaagcctg
      481 gcgacaagcg cttccggcta tggtacgtgg gagggtcttg cttggatcgc aggaccacgc
      541 tacccatgct cccttggctc atggccgaga tccgtcggcg cagccagaag cccgatgcgg
      601 gcggctgcgg ggcgcccgca gcccgggagg tgatcctggt gctcagcgcc ccctttctgc
      661 gttgtgtccc tgcgccgggt gccggggtcg gcgggggcgc aggctccggg gctgtgcagc
      721 ccaacaccgg ggtgttcatc ttcgagcaca aggctcagca catctcgcgc ttcatccaca
      781 acagtcacga cctcacctac tttgcctatt tgatcaaggc gcagcccgac gaccccgagt
      841 cacagatggc ctgccacgtt ttccgcgcca cggatcctaa ccaggttcca gatgtgatca
      901 gtagcatcag gcagttatcc aaggctgcca tgaaggagga ctccaaaccc agcaaagata
      961 acgaggatgc cttctacaac tctcagaaat tcgaagtgct ttactgtggg cgggtgatcg
     1021 tgacccataa gaaggcgccc tccagcctca ttgatgactg caaggacaag ttcagcctgc
     1081 atgagcagca gcgactgaag ctgcaaggcg agagaggtgg tgaccctggc gacgagatgg
     1141 gtgtccttga ggtcgagtct cctgtgtctc cagatgacag cctgcccgag aaggcagatg
     1201 gtacagtcaa cagcccccgt gccctgccct ctctggctag ccttcctgcc ttggccagcc
     1261 aacccgcact agccagctct cgggtttgct tcccagagag gattttggaa gactgtggct
     1321 ttgacgagca gcaagagttc cgatctcggt gcagcagcgt cacaggcgtc atgcaaaaga
     1381 aggttcatga gaacaaccag aaaacacagc caagaaggag gcacgcgagc gcgcccagtc
     1441 acgtgcagcc ctcagactcg gagaagaatc ggaccatgct cttccaggtc ggccgctttg
     1501 agattaacct catcagtccc gacactaaat cagtcgtgct ggagaagaat ttcaaagata
     1561 tctcctcttg ttctcaggga ataaagcatg ttgatcactt tggctttatc tgtcgggagt
     1621 ctccggagcc ggggctgagc cagtacatct gttatgtgtt ccagtgcgcc aacgaatctc
     1681 tggtggatga ggtcatgctg actctgaagc aagctttcag cacggctgct gcgctgcaga
     1741 gtgccaagac gcagattaaa ctgtgcgaga cctgccccat gcactctttg cataagctct
     1801 gtgagagaat cgaaggtctc tacccacctc gagccaagct ggtaatccag aggcacctct
     1861 cttcgctgac ggataacgag caagctgaca tctttgaacg ggttcagaag atgaagccca
     1921 tcagcgacca ggaggagaac gaacttgtga ttctgcacct gaggcagctc tgtgaagcca
     1981 agcagaggac ccacgtgcac atcggggaag ggccggcgat tatttcaaat agtacaatcc
     2041 cagaaaatgt gacaagcggt gggaggttca agcttgatgt tctgaaaaac aaagcgaaga
     2101 gatccttaac ttcctccctg gaaaatatct tctccagggg agctaacagg atgagaggtc
     2161 ggcttggaag tatggacagc tttgaacgcg ccaacagtct tgcctcagag aaggacttct
     2221 caccagggga ctctcctcct gggacaccgc cagcctcccc actgtcctcc gcctggcacg
     2281 ccttcccaga ggaggactcc gactctccac agttccgaag acgggctcac acattcagcc
     2341 atccaccttc aagttcaagg aggaagctga acttgcaaga tggcaaggcc cacggcctac
     2401 ggtcccctct actgaggcag agctccagcg aacaatgcag cattgtcccg tcagcccggc
     2461 gcatgtacaa ggagagtaat tcttcctgca gccttccaag ccttcacaca tccttctctg
     2521 ccccttcctt cactgctccc tctttcctga aaagctttta tcagaattca ggtagactgt
     2581 ccccacagta tgaaaatgaa atcagtgatg gagaagggag aaagaggacg tcatccacct
     2641 gcagcaacga gtccctaaat gccggaggaa ccccggtcac tcctcgcaga gtctcctgga
     2701 gacagcggat tttcctccgg gttgcatctc ctgtgaacaa gtccccttca gcaatgcagc
     2761 agcaaaaaga tgggctagac aggactgagc tgctcccgtt gtctcctctc tctcccacca
     2821 tggaggaaga gcctctcatt atcttcttgt ctggtgacga ggacacagaa aaagttgaag
     2881 aaaaaaagaa atcaaaggag ctcaagagtc tgtggaaaaa agctatacac cagcaaatcc
     2941 tgctgcttcg aatggagaag gaaaaccaga aactggaagc aagaagagat gagctccaat
     3001 ctagaaaagt caagttggac tatgaagaag ttgggacatg tcagaaggag atcttaatag
     3061 catgggacaa gaagctgtta aattgcagaa ctaaaatcag gtgtgacatg gaagatatcc
     3121 atacgtccct taaagaaggg gtccctaaaa gtcggcgagg ggaaatttgg caatttctag
     3181 cattacaata tcgcctaaga cacagattgc ccaacaaaca ccagcctcca gacacctcct
     3241 ataaggagct tttgaagcag ctcactgctc agcagcacgc catccttgtg gatttgggga
     3301 ggacttttcc cacccaccct tacttttcag tgcagcttgg ggcaggacag ctgtccctct
     3361 ttaacctgct gaaagcctac tctctgctgg acaaagaggt aggctactgt cagggcatca
     3421 gctttgtggc cggagtcctg cttctgcaca tgagtgaaga gcaagccttt gaaatgctca
     3481 agttcctaat gtacgacctg ggcttccgaa agcagtaccg accggatatg atgtcacttc
     3541 agattcagat gtaccaactg tccagactcc ttcatgacta ccaccgagaa ctctacaatc
     3601 atcttgagga aaatgagatc agccccagtc tgtacgctgc tccctggttc ctcacactct
     3661 ttgcctctca gtttccctta ggattcgtag ccagagtttt tgatattatt ttccttcaag
     3721 gaactgaagt tatattcaag gttgctctca gcttactgag cagccaggag gcacttataa
     3781 tggagtgtga aaactttgaa aatattgttg aatttctcaa aagtacatta cctgatatga
     3841 ataccactga aatggaaaaa attattaccc aggtttttga gatggatatt tccaaacagt
     3901 tacacgccta tgaggtagaa tatcacgtgc tgcaggatga gctgctagaa tcttcctatg
     3961 cctgtgagga caatgaatct ctggagaagc tggagagagc caacaaccaa ttgaaaagac
     4021 agaacatgga cctcttggaa aaactccagg tggctcatgc taaaattcag gccttggaat
     4081 ccaacctaga aactcttttg accagagaaa ccaaaatgaa ggctttaatc cggaccctgg
     4141 aacaagataa aatggcatat caaaagacag tggaacagat ccggaagctg ctaccagcag
     4201 atgcgctggc caactgtgaa ttgctgttga aagacttaac tcatccaacg aatgacaaag
     4261 ccaaggcagg aaataagcca tagtttcaga catggcctca gcagacagct tcctttaaaa
     4321 tatctggacc ctgtgtaagg ttgatcagaa agctggtagg acagctacta ctggtggtag
     4381 gatcatcaga aggcgatgta gctctcctca gagcactcca ctcttaagcc atcacagaca
     4441 tccagactgt atttccttct ggttgttgcc aactatgtac ataactatat ctaagtggac
     4501 ataaagattc atgctttcaa gtcaaacagt aggcgtatgt taggagaaac tttctttttc
     4561 agtcagaact tcatgaaaat cacatcaaag gggagttcaa gtgagattct ccttggatac
     4621 acctgaaatc cttttggttt tctagtgaaa caaatctaga atatctttgt atattgaaat
     4681 atacttgaac aacaaaaaaa gatgaatgta tttttccctg cccccaaaga ttagcatgct
     4741 tcactcagtg tggtaggcag acacatttct ttagctatgt gtctatctat aagggacatg
     4801 attggcttcc agtctcactc ccgtgagtct cctaggaagg tggggctctt ctgccctgcc
     4861 tgctgtgtga caaccagcat gtctaacctt tgaggatcct gaccctggtt aggctttgct
     4921 ttagatacac acagggagaa agcaggacac tgtggctgag tcaacccctc tcagggtgaa
     4981 gagggctgtt gctaattttc tagcagatta gaccagcatt gatatttaag ccgaaaatac
     5041 gaggcctcaa acacaccatt aagctcctga attgcctagg gtagcctttt gccattttac
     5101 ttaagtgact tctacacagg caaacagttg cttggtgctg tatttaccaa gtgagagggt
     5161 ttgctatttt ctcacaaaag tatgggagca ttctatgtag tccttgcgac cttcggtgtt
     5221 agaataggga aataaaatta ggatttccca aagatgatat accacgttga gttgcttttc
     5281 tattttttgc tcaatgccag aacccatttt taatcacttt cccctttcat gtgaaaattt
     5341 agaactgtga actatttagg aaccaatcat gaaaagcaca caggaagggc tggaagcgtc
     5401 tccgccccag ggtaaaacct acaattctgt gtttggactc ctggcttctg ctgcgtacag
     5461 gtaggatact agaggatgtt cgtgcaagct gggtgcatgg atggcaagtc attttcccag
     5521 gacatgttca gtccctacag cagagatggc tttacaatag tgcctctgaa cactgggaca
     5581 gcattctgtt tggcctttgt aaacagtgtt tactgttgct gctctttcag ccattgtctt
     5641 tttgcagatg ggttgcttgg gggtattttt cctcaaagag agttgattat acacgagatg
     5701 aaatgttatc atagtgcttt tgagtcaaga tgtaaagctt ccaaagacat ggaaacgtgc
     5761 ggatgaacag catctaggct gttctccact tgaatgtcac aaggatcaca gggtcagagt
     5821 agccttggat ctagggggtt ttctccttta aaaaagtctt attagccagg agagttgatg
     5881 tacgttctag attctaggaa gtgctgatta ttgattctcc gtttggttga gggccattag
     5941 ttgatctgtt gcttggatct cttgaaaaat gtcttcattt gtagtatctc tattcagcat
     6001 tactgtctga tggttgaaat cattgccttg tggtggctga aggatcctta tgtcagggaa
     6061 ggaaatagtt tctttccatt tctccattaa aagtaatgtc ttcatttgta gtatctctat
     6121 tcagcattac tgtctgatgg ttgaaatgat ggttgaaatc attgccaggt ggtggctgag
     6181 ggatccttat gtcagggaag gaaatatttt cttttcattt ctccattaaa agtaaactgt
     6241 gttccggatg ttgggagcca gcagtatggg ttgtttatgg tattcagtga ttaagacaac
     6301 gtggatgtgg tattttcttg tgaaaatgac ttttctttct cattggtgat tttttaaaaa
     6361 aaaaatatgt tactcctgtt tcgctttgta atattacatc tccatcaggt tcctgtaacg
     6421 tctagaatta tttccaataa atatgttgct gcca
//
