LOCUS       NM_001033385            7269 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus TBC1 domain family, member 32 (Tbc1d32), mRNA.
ACCESSION   NM_001033385
VERSION     NM_001033385.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7269)
  AUTHORS   Moon,K.H., Ma,J.H., Min,H., Koo,H., Kim,H., Ko,H.W. and Bok,J.
  TITLE     Dysregulation of sonic hedgehog signaling causes hearing loss in
            ciliopathy mouse models
  JOURNAL   Elife 9, e56551 (2020)
   PUBMED   33382037
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7269)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    GeneRIF: Dzip1l interacts genetically with Bromi, and both have
            overlapping functions in ciliogenesis and neural tube patterning.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7269)
  AUTHORS   Snouffer,A., Brown,D., Lee,H., Walsh,J., Lupu,F., Norman,R.,
            Lechtreck,K., Ko,H.W. and Eggenschwiler,J.
  TITLE     Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and
            Hedgehog signaling in mice
  JOURNAL   PLoS Genet 13 (8), e1006912 (2017)
   PUBMED   28817564
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7269)
  AUTHORS   San Agustin,J.T., Klena,N., Granath,K., Panigrahy,A., Stewart,E.,
            Devine,W., Strittmatter,L., Jonassen,J.A., Liu,X., Lo,C.W. and
            Pazour,G.J.
  TITLE     Genetic link between renal birth defects and congenital heart
            disease
  JOURNAL   Nat Commun 7, 11103 (2016)
   PUBMED   27002738
  REMARK    Erratum:[Nat Commun. 2016 Jun 08;7:11910. doi:
            10.1038/ncomms11910.. PMID: 27273704]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7269)
  AUTHORS   Ko,H.W., Norman,R.X., Tran,J., Fuller,K.P., Fukuda,M. and
            Eggenschwiler,J.T.
  TITLE     Broad-minded links cell cycle-related kinase to cilia assembly and
            hedgehog signal transduction
  JOURNAL   Dev Cell 18 (2), 237-247 (2010)
   PUBMED   20159594
  REMARK    GeneRIF: Bromi, a previously uncharacterized TBC domain-containing
            protein, is required for proper cellular responses to the highest
            levels of Shh signaling in the neural tube. (bromi, broad-minded)
REFERENCE   7  (bases 1 to 7269)
  AUTHORS   Zohn,I.E., Anderson,K.V. and Niswander,L.
  TITLE     Using genomewide mutagenesis screens to identify the genes required
            for neural tube closure in the mouse
  JOURNAL   Birth Defects Res A Clin Mol Teratol 73 (9), 583-590 (2005)
   PUBMED   15971254
  REMARK    Review article
REFERENCE   8  (bases 1 to 7269)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 7269)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7269)
  AUTHORS   Rouger,K., Le Cunff,M., Steenman,M., Potier,M.C., Gibelin,N.,
            Dechesne,C.A. and Leger,J.J.
  TITLE     Global/temporal gene expression in diaphragm and hindlimb muscles
            of dystrophin-deficient (mdx) mice
  JOURNAL   Am J Physiol Cell Physiol 283 (3), C773-C784 (2002)
   PUBMED   12176734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY341016.1, CJ182214.1, CR757357.1, CR756627.1, CN536606.1,
            CN536044.1, AK141206.1, AK035346.1, AC155829.5 and BP761946.1.
            
            On Jun 14, 2007 this sequence version replaced NM_001033385.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BY341016.1         3-37
            36-425              CJ182214.1         2-391
            426-664             CR757357.1         9-247
            665-847             CR756627.1         77-259              c
            848-1170            CN536606.1         1-323
            1171-1805           CN536044.1         1-635
            1806-3255           AK141206.1         1-1450
            3256-4109           AK035346.1         1036-1889
            4110-7059           AC155829.5         155982-158931       c
            7060-7269           BP761946.1         1-210               c
FEATURES             Location/Qualifiers
     source          1..7269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 28.45 cM"
     gene            1..7269
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /note="TBC1 domain family, member 32"
                     /db_xref="GeneID:544696"
                     /db_xref="MGI:MGI:2442827"
     exon            1..212
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            213..374
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            375..543
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            544..612
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            613..738
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            739..817
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            818..921
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            922..983
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1128
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1188
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1279
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1420
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1513
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1656
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1784
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1986
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2069
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2208
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2296
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2415
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2532
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2621
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2744
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2853
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2947
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3073
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3157
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3227
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3343
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3498
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3639
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3828
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..7240
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4087..4092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /note="hexamer: AATATA"
     polyA_site      4112
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /note="major polyA site"
     regulatory      7137..7142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      7157
                     /gene="Tbc1d32"
                     /gene_synonym="b2b2284Clo; Bromi; C6orf170; D630037F22Rik"
ORIGIN      
        1 gtgcgctttg ttggtggcga ccccgcggtg gttgcggaga tttgactgct gcaaggcatg
       61 gcccatttct ccagcgagga tgaggtgatg ctgcaggcga tgctccggca gctgttccag
      121 agcgtgaagg agaaaatcac cggagctccc tccttggagt gcgcagagga gatcctcttg
      181 cggctggagg agactgacga aaattttcac aactatgaat ttgtgaaata cctcagacag
      241 cacatatgta acatgttggg gtctatgatt gaagaagaaa tggaaaaatg cacatctgat
      301 cagaatcagg gggaggattc tggctatgac acggttgttc agcatgttac caaaagaacg
      361 caggaatcta aagagtataa ggaaatgatg cattccctga agaacattat gatggtggtg
      421 gtcgaggcga tgatcaacaa gtttgaggaa gacgagacac ggagtgagga caggcagagg
      481 aaaatgcaga gtggcagctg ctgcacagac aactgctccg acagtgactc ctccttcaat
      541 cagagttaca aattctgtca agggaaacta cggttgattt tagaccagtt ggatcctggc
      601 caacctaaag aggtgagata tgaagcttta caaacattgt gctcagctcc cccatccgac
      661 gtcctgagct gtgagaactg gaccactctc tgtgaaaagc tgaccacatc tctgtctgat
      721 ccagatccta tgttcactga ccggatttta aagttctacg cacagacttt taccctctca
      781 ccgttacata tgaccaagga gatttataca agcttagcta aatatctgga ggtatatttt
      841 ctttctagag aaaatcacct tcctactctt tcaactggag tagacataac cagtcccaat
      901 gtgacccgct tactgaaaaa ggttcgcctt ctgaatgagt accagaaaga ggctccatct
      961 ttttggattc gtcacccaga gaagtatatg gaggaaattg tggagagtac tctgtccttg
     1021 ctctcagtca aacacgagca aagccacctg gtgccacaga agattttgga tcccatctat
     1081 tttttcgcat tagttgatac taaggctgtg tggttcaaaa agtggatgca tgcatattac
     1141 agcagaactg cagtactgag acttcttgaa aagaaatata aatgtctgat aactacagca
     1201 gttcagcaat gtgttcagta cttggagtta tgtgaagcta tgaaagctga tgaaattctg
     1261 agacatccaa aacattgtgg aaccaagcaa aagagtttct actattcagg acaagaattg
     1321 caatatattt atttcattca ctcactgtgc cttttaggaa gattgttgat ctatacacag
     1381 ggcaggaaat tattccccat aaagctgaag aatagaaaag attcagtatc cctgacaaat
     1441 ctgctggttt tgtttactca acttatctat tattcaccaa gttgtccaaa gatgacctcc
     1501 atcatgtgtt cagagaacta ttctcctgca agtatggtga ctgacgttct gcggatgctc
     1561 tgcgaccaga aagaatgtgc agtcgagtgc ttatacaaca gcacagtgac agaggcgctt
     1621 ctcctgccca ttcataacct gacgaaagga actgcggctg ctccagattg ctctgagaca
     1681 gctctaattc atatagctga tattttggca agaatcgctt ctgtcgagga aggactcatc
     1741 ttacttctgt atggagaaaa tatgaactct tctgaagaag aaagtcttac aggtgctcat
     1801 ataatagcca agttttcaaa gaaacttctt gaagaagata tttctatttt ttctggatcg
     1861 gaaatgttgc ctgtagttaa aggagctttt atttctgtgt gtcgtcagat ctacggtacc
     1921 tgcgaaggct tacaggtgtt gcttccttat ggtttacatg aatccatagc aaaggcatgg
     1981 aagaagacaa gcttgctatc agaaaggatc cccactccag tagagggctc tgattctgtt
     2041 tcctcagtga gccaggtgtc tccgaacagt gtggcttggg aagacaattt gttggatgat
     2101 ttactgaatt ttgcagccac ccccaaagga ctgctgcttc ttcagagaac aggcgccatc
     2161 aatgaatgtg tgacgtttat gctcagccag tatgcaaaaa agccacaggt caacaggcag
     2221 aagaagtttg gctatgaagt cttggttgta caggtggcat cgacagcagc aggtgcagtg
     2281 gctctacaga attcaggctt tattagtgca cttataactg agttatggtc caaccttgaa
     2341 tgtggaagag atgatgtaag gctaactcat cccagagcta ccccagtgga cccaattgac
     2401 cgaagctgtc agaagtcctt ccttgcactg gtgaacctgc tgtcctaccc tgctgtgtat
     2461 gagctaacag ccaatcagga gcttcctaat aaggcagagt attctcttcg tgaagttccc
     2521 acatgcatca tcgatataat ggataggctt attgttttga actctgaagc caagatccgg
     2581 tctttactga attatgaaca gtcgcacacc tttggtctaa ggttactaag tgtggtgtgc
     2641 tgtgatctgg atgcgcttct cttactggag gctcagtatc aagtatctaa catgttatta
     2701 catgctcaag aagaaaatac ctttgagatc tctgagaacc acaggaactt tataattgat
     2761 ggattatcag tagagagaaa tcatgttctc gtaaggatta atcttattgg tggtccttca
     2821 gagcggatat tgcctccaag gatgcttgag aagggggatg acccatatcc ttggccaatg
     2881 ttttcttcat atccattgcc acactgctat cagtcagaag gtccacgaag tgctgatcta
     2941 aaacaagaca atgatattgg aaacctgtta tcatgcttca aaatgtccga taaacaaaca
     3001 gagtggatag agaactgccg aagacagttt tgtaaaacaa tgaagtccaa gcctgatgca
     3061 gtccatggaa gtgccttagg agaactactg gaaaaatttg tgctgcttct caccgaaaac
     3121 ccatctgaat gttacttccc ttcagtggaa tacacagcta ctgatgcaaa tgtgaagaat
     3181 gaaagtctct catctgtgca gcagcttggc atgaaaatga ctgtcaggta tgggaggttt
     3241 ctcaatttgt taaaagatgg tgcagaaaat gagcttgctt tggtcttaaa gcattgtgag
     3301 aaattcctga aacaacagca gtcaccggtc acttcttctc tcctgtgcct gcaagggaac
     3361 tacgcaggcc atgactggtt tgtgtcttct ctgttcatga taatgctggg agacaaaggg
     3421 aagaccttcc actttctcca gcatttctcc aggctgctga cctctgcctt cctttgggtg
     3481 ccacggctgc ataattctag gtaccttcct gtcgacaccc tagggaccgg catccatccc
     3541 atctactttt gcagtgctca ctacattgaa atgctgctga aggctgaggt gccgcttgtg
     3601 ttttcggctt tccacatgtc tggttttgct ccatcccaga tttgcctgca gtggataact
     3661 cagtgttttt ggaattactt agattggata gaaatatgcc actatattgc tacttgtgtt
     3721 gtccttggtc ctgattatca agtgtatgtc tgcatagccg ttctcaaaca tctgcagcga
     3781 gatattctcc agcataccca gactcaagat ctgcaagtct ttctcaaaga agaagcactg
     3841 catgggtttc gagtgagcaa ctattttgaa tacatggaga atttggagca aaactaccga
     3901 ccagtgctgc tgcgagacat gcgcagcatc agagtgcaga acacatagat caggagaagc
     3961 acactcccat tttatgtcct attcatttgt aaaggagaca aagcaacttg atggtgttct
     4021 gtctacatct gtaagatcct ttgtgcgtcc acgcactgta aatcagcact gtggggttgg
     4081 gaacagaata tattcatctt gttgtttgct cagtgtgtgg aacgaagtga ggtcatttgt
     4141 gaagtccctt gttctttaaa tgtttagaat ctgctctagg ttatactttt tattttatgt
     4201 ttggcttaca aagggatcaa agacattaat gtaaaaccta aatatttgaa actactagaa
     4261 gaaacactct tgaaaaatat gaacatagcc aatggcttct gagtgagatc ccaatagctg
     4321 aggaaataaa agcaggcata gatagattgt acaacatacg tgtgaaataa aagaaaggga
     4381 agctagggta taaaccatgt aaaatcctcg ccaattattc aaccaatgaa ggaataagat
     4441 ttagaacatg tgttgaactt aattactaaa tagtaaaaga ccaaaaagac tccagtcaaa
     4501 tgggcaaaga aaggagcagg cccttcacac gatgaagtag ccattgtaaa caagcacatg
     4561 aagcgaggct ctctgccgtt acccacctgg agactgctca tccaaactac ttcacttcat
     4621 caagcaaacc aatgccagtc agaactggtg ggagaagagg cttagaagtt actagtggct
     4681 atgtgtattc atctagctac tatgggaatc ggtgtggagg agcctcaaaa agctaaaact
     4741 tgacctagcc atacaactta catgacataa ataaatacat aaatatcagg tggcagtgga
     4801 tatttctgca catctttgtt tttcatgaca ctactcacaa tagccaggtt atggaatatg
     4861 ccaaagtatt catggtgcgt gaacacaata gggatttacc cagccacaaa gaatgaaatt
     4921 aagcatttgc aggaaattgg gatcagagat catgttaggt aataaaaggc agacacctaa
     4981 agacatgtac acatgtttta tctcctttgt ggatgctgtg ggaggggtag taatataaaa
     5041 gaattagcag tgggaaagat acagggatta tatgaatgta gtggaggtct gaggaccaca
     5101 gacgtggctc agtggataaa ggcacttgcc tccaagcctg acaacttggt gtcattccct
     5161 caaatccgtg tggtcaaaaa ggagaactga ctctcaagag ctgacctctg acctccagat
     5221 gcacatggta gacgtgcctg gaaccgtgaa gtaaaatgtt tctaaaaata gaagtaatgt
     5281 gagacacaga atcaaagaat attacatgtg tgttgggaat gttatgaaac cctttataca
     5341 attaatacaa gttttaaatt aaatgtccca gcacctgtgt catttctatt gtggtaatat
     5401 tttttcctaa tgatcttggg aagaagcaat atttttggaa ggagcaagga aggaaggaag
     5461 ggaggaagga aggaaggaaa gaagggaaag ggggagaagg gacaaaaacc agagtactag
     5521 aaagagtcta tagagatgga acaaaagcct tcatttgtgt gtctgtgctg aaggaagaac
     5581 acagacaaca gcatggttgc ttatttctcc catggagaaa caaaggatcc tactggaaca
     5641 ttgtcctcac acctgatggt ctttctaaga ggcactttta atattgctat cactttctgt
     5701 tttttgtttt tttcacttga aatataaaac tcagcatggt tcatttagaa gacggattga
     5761 ctcccttgtg ttgataagca ttctgctatt attttttggc atttcttggt gatagatttg
     5821 atctgcactg aacttgaaaa cattaaaaag aatagatttt taaattgaaa tgattcacac
     5881 tatgttttat ttaaacagaa ctctctgtgt gtgcccataa gattaacctg gaagggcctg
     5941 ttttttcttt tttcttctta ttttgagtaa ctgtccattt actgtttaaa agccaatacc
     6001 caacaagcta ttaatttacc aatttcagtt tttaaaaaaa tcacatgggt tattatgtat
     6061 tcttagctta tataaccata cattttaaac taatactact tttttctttc ttctaccaaa
     6121 atggaccatg cccaatttta tttttgtcag catgtgaggc aactggttct gtaaagattt
     6181 aaatttaggg acatttaggc atttgaagaa tgtttcttcc caaataagtt tttgtactgt
     6241 ccatgccacc atttccagta atggtgttgt tagagggcat tgtaaattgg aggaaggtag
     6301 atcgaacaag ttaactagat tcagtgcaca ttggctcctg ctgagtgagt gaagtgggca
     6361 atggccctaa caagttcgct gtctgcagag tacctctgtg gagccagagt acatgctgaa
     6421 ggttccaacg ccctgtactc cagagtgatg cccttagtgc ttagaagcca gaactttttc
     6481 tcatcggaaa gctctaaaga gagaaacaca tcattggcga cagatggctt tcgttggaaa
     6541 ttcaggaaat atctatatta tgacaattac atcttgcaaa aagtgatgtc atctggttct
     6601 gattttcctt tgataaatta gaaactagac atggtggttc acattggtga tcccaatgct
     6661 cccgaaacag aagcagtcca tcaatgcaat gtacaggcca agtaggactt catagtaaag
     6721 ccctatctca aaaaaggaaa gtaagtacaa ataataaatt agtaagtaaa aatgaactaa
     6781 agtaataaga gtgggcaaga tgtctcaaca gataaagatg tctagtgtca aacctaggag
     6841 ctagagtttg atgcctatca cctacacagt agcagaacaa cacctagttg cccctcaccc
     6901 tccacaacag tcctcaacca aagacaatgt aatatttaaa aaataaaata aaaatcaaga
     6961 aacaaaaaac aatcaaaacg taaaaataaa taataaatgt cttaggaaga atgacttaca
     7021 ttggtttcat ggaagtaaac ataaaacaga gtttgtgcag ctacccttgt aatttgtgat
     7081 tccatttatt ttgagaataa tggccttaaa gaatactttc ctgcctctat tgtgtaatta
     7141 aagagtctgg actcttagaa cagactttgt ctcttatttg tgaagatcta gttcatatgt
     7201 tttacagaat ttaatgataa ataaaatttt atgatataaa aaaaaaaaaa aaaaaaaaaa
     7261 aaaaaaaaa
//
