LOCUS       NM_194334               5941 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TBC1 domain family, member 2B (Tbc1d2b), transcript
            variant 1, mRNA.
ACCESSION   NM_194334 XM_135076
VERSION     NM_194334.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5941)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5941)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151735.3 and AC140392.3.
            
            On Nov 9, 2022 this sequence version replaced NM_194334.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129273.1, AK156788.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               AC151735.3         166264-166686       c
            424-577             AC151735.3         145703-145856       c
            578-746             AC151735.3         136922-137090       c
            747-910             AC151735.3         124850-125013       c
            911-1155            AC151735.3         123242-123486       c
            1156-1539           AC151735.3         121933-122316       c
            1540-1650           AC151735.3         119351-119461       c
            1651-1844           AC151735.3         118219-118412       c
            1845-2339           AC151735.3         114572-115066       c
            2340-2457           AC151735.3         111390-111507       c
            2458-2643           AC151735.3         105580-105765       c
            2644-2690           AC151735.3         103760-103806       c
            2691-2765           AC140392.3         225899-225973       c
            2766-5941           AC140392.3         220173-223348       c
FEATURES             Location/Qualifiers
     source          1..5941
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.48 cM"
     gene            1..5941
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /note="TBC1 domain family, member 2B"
                     /db_xref="GeneID:67016"
                     /db_xref="MGI:MGI:1914266"
     exon            1..423
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2961
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="TBC1 domain family member 2B isoform 1"
                     /protein_id="NP_919315.2"
                     /db_xref="CCDS:CCDS23401.1"
                     /db_xref="GeneID:67016"
                     /db_xref="MGI:MGI:1914266"
                     /translation="MPGAGDGVEESCSGGEGAVPGTGSEAGAVAGREPSRLCGYLQKL
                     SGKGPLRGYRSRWFVFDSRRCYLYYFKSPQDALPLGHLDIADACFSYQGRDEAAEPGA
                     DPPTHFQVHSAGAVTVLKAPNRELMTYWLQELQQKRWEYCNSLDMMKWDSRTSPTPGD
                     FPKGLVARDTTDIISQHPNPSAEKARTVLAVEAAPGELVGDRAAHQPAPGHPNPINFY
                     SLKQWGNELKNSMSSFRPGRGHSESRRTVFYTNEEWELLDPPPKDLEESLVPEERKKP
                     MPEGSKGVASSGFPFEFGRNPYKGKRPLKDIIGSYKNRHSSSDPLLEGTATSSGSSGG
                     PTKPVPEMQLQIQSQQEELEQLKKDLSSQKELIRLLQQTVRSSQYDKYFTNPQISQGV
                     PGDTLELLHQKDEQILGLSGQLERFGLEKESLQQEVRTLKSKVGELNERLGMLMETIQ
                     AKDEVIIKLSACEGSVSSPTLGPSSPLAIPASKDQLELDRLKDSLQGYKSQNKFLNKE
                     ILELSALRRNAERRERDLMAKYSSLEAKLCQVESKYLILLQEMKTPVCSEEQGPARDV
                     IAQLLEDALQVESQEQPEQAFVKPHLVSEFDIYGFRTVPDDDEEEKLVAKVRALDLKT
                     LYLTDNQEVSTGVKWENYFASTMNREMACSPELKNLIRAGIPHEHRSKVWKWCVDRHT
                     RKFKDSMEPDYFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSSPTSEGIQKLRSV
                     LLAFSWRNPDIGYCQGLNRLVAVALLYLDQEDAFWCLVTIVEVFMPRDYYTKTLLGSQ
                     VDQRVFRDLLSEKLPRLHTHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLY
                     EGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDARKLISISFGDLNPF
                     PLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDEEEDT"
     exon            424..577
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            578..746
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            747..910
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1155
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1539
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1650
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1844
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2339
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2457
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2643
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2765
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..5941
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5908..5913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /note="hexamer: AATAAA"
     regulatory      5923..5928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /note="hexamer: ATTACA"
     polyA_site      5928
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /note="major polyA site"
     polyA_site      5941
                     /gene="Tbc1d2b"
                     /gene_synonym="1810061M12Rik; mKIAA1055"
                     /note="major polyA site"
ORIGIN      
        1 gctgcggcgg cggcccggag gagcgcgggg cgggagcgcg ggcgcgggcg ccggcggcag
       61 gccatgccgg gggccgggga cggcgtggag gagagctgca gtggtggtga gggagcggta
      121 ccgggaacag gctcggaggc tggggcggtg gcgggacggg agccctcgcg gctgtgcggc
      181 tacctgcaga agctgtcggg caagggcccg ttgcgcggct accgcagccg ctggttcgtg
      241 tttgactcgc gccgctgcta cctctactac ttcaagagtc cccaggacgc tctgccgctc
      301 ggccacctgg acatcgccga cgcctgcttc agctaccagg gccgcgatga ggctgcggag
      361 cccggagcag atccgcccac acacttccag gtgcacagcg ccggtgcagt caccgtgctc
      421 aaggctccta atcgtgagct catgacttac tggctacagg agcttcagca gaaaagatgg
      481 gaatattgca acagccttga catgatgaag tgggacagca ggacttcccc gactccaggg
      541 gattttccca agggccttgt ggccagagat accacagata taatttccca gcacccaaat
      601 ccttctgcag aaaaagccag aactgtgctc gctgtggaag ctgcccctgg agagctggtg
      661 ggagaccggg ctgctcatca gccagctccc gggcatccga atcccatcaa cttttactct
      721 ctgaagcagt ggggaaatga gctcaaaaat tcaatgtcat cattccgtcc tgggagaggg
      781 cacagtgaga gtcgcaggac cgtgttttac accaatgaag agtgggaact tctagacccg
      841 cctcctaagg acctggagga gtccctggta ccagaagaga ggaagaagcc gatgcctgag
      901 ggcagtaaag gagtcgctag ttcaggattc ccctttgaat ttggacggaa cccttacaaa
      961 ggaaagcgcc ccttgaaaga tataattggg tcatacaaaa accgccacag cagtagtgat
     1021 cctttgctcg agggaacggc gacatcatca ggcagcagcg gaggtcccac taagccagtc
     1081 cccgaaatgc agctgcagat tcaaagccag caggaggagc tggagcaact caagaaggac
     1141 ctatccagtc agaaggagct cattcggctg ctccagcaga cagtccggtc atcccaatat
     1201 gacaagtatt tcacgaaccc ccagatcagc cagggggtcc ccggggacac actggagctc
     1261 ctgcaccaga aggacgagca gatcctgggc ctcagcggcc agctggagag gttcggcctg
     1321 gagaaggaaa gcctccagca ggaagtgagg acgctgaaga gcaaggtggg cgagctcaac
     1381 gagcggctcg gcatgctgat ggagaccatc caggccaagg acgaggtcat catcaagctc
     1441 agcgcctgtg agggcagcgt gtcatcaccc accctggggc ccagctctcc tttggccatc
     1501 ccagccagca aggaccagct ggagctggac aggctaaaag atagtctgca agggtacaaa
     1561 agccaaaata aatttctaaa caaggaaatt ttggaactct cggctctacg aagaaatgca
     1621 gaaaggagag agagggatct gatggctaag tactctagcc tggaagccaa gctctgccag
     1681 gttgaaagta aatacttgat actgctccaa gaaatgaaga caccagtttg ctcagaggaa
     1741 cagggccctg ccagggatgt catagcccag ttgttggagg atgctctgca ggtcgagagc
     1801 caagagcagc cggagcaagc attcgttaag cctcatctgg tcagtgagtt tgatatctac
     1861 gggtttagga ctgtccctga tgatgatgag gaagagaagt tggtcgccaa ggtccgagca
     1921 ctggacctga agactctgta cctcacagac aaccaggagg tttccactgg ggtcaagtgg
     1981 gaaaactatt ttgcgagcac aatgaacagg gagatggcat gctctccgga gctgaaaaac
     2041 ctgatccgag caggcattcc ccacgagcac cgctccaagg tgtggaagtg gtgtgttgac
     2101 cgtcacacca ggaagttcaa ggacagcatg gagccagact acttccagac cttgctgcag
     2161 aaggctctgg agaaacagaa cccggcctcc aagcagatcg agctggacct gctccggact
     2221 ctgcccaaca acaagcacta ctccagcccc acgtcggagg gcatacagaa gctgcgcagt
     2281 gtcctgctcg ccttctcctg gcggaatccc gatatcggct actgccaagg cctgaacagg
     2341 ttggtggcag tggctctcct ttacctggat caagaagatg ccttctggtg tctcgttacc
     2401 atcgtggaag tcttcatgcc ccgagactat tacacaaaga ctcttttagg atcccaggtg
     2461 gaccagcggg tgttcagaga cctcctgagt gagaagctgc ctcgactgca cacccatttt
     2521 gaacagtaca aagtggacta caccctcatc accttcaact ggtttctggt ggtatttgtg
     2581 gacagcgttg tcagcgacat cctctttaaa atatgggact ctttccttta tgagggacca
     2641 aaggttattt tccgttttgc cctggcactt tttaaatata aggaagagga gatcctgaaa
     2701 ttgcaagatt cgatgtccat attcaagtat ctgcgttact tcactcggac tatcctcgat
     2761 gccaggaagc tgatcagcat ctcctttggg gatctgaacc ccttccccct gcgccagatc
     2821 cggaaccgga gagcctacca cctggagaag gtccggctgg agctgacaga gctggaggcc
     2881 attcgagagg acttcctgcg tgagcgggac actagccctg acaaaggcga gctagttagc
     2941 gatgaggagg aagacacttg aatggatccc caccctagga tgctgctctt cttgccttcc
     3001 ttcataacca aaagtagcaa aggcacatca ctgcacatca gctgtcagat tgtaacatct
     3061 acagcctctg gcttctgctg ggcagatgtc cagagctaag ctgcactttc tcatctccca
     3121 tttcggggca gggggcaggt ggctttacag ccatttccgt gtcacatgca tcatatgctt
     3181 gctgcctgat tggtgactca ccgggtgact gtttccaagg gcctgtttac agcatctgcc
     3241 agttgtgtgc gtgtttcgcc ccacaaaaac tatgttccac atctccctat gctctttctt
     3301 ttacccaagg gcagcactgt ggaggaatgt gcagggcgcc acagtgtggc tgcttccagg
     3361 gtcacaaggt caccataaga agagggacct ctttaaaaag caagcacaca actggcctcc
     3421 caggctggcg tgggagccct ctgctggtgg cttggcactg ccagccgcag tcccttctgg
     3481 actagccttt gctctcctat gtagcctttc agactgcagc actccccctg atctgcagca
     3541 gtgcccacac ttctcactgc cagctgcttt gccagctgtc tgtcccagat tgcagtgggg
     3601 ctaaacacat ctccaggagc tgctgtagga agctcttcta gctgggagct gacttgtaga
     3661 caccattctc caactctggc tggcttgggg ttccaaaggg accttgcagt agacccagcc
     3721 ctgcataagg gaacatagga aactctcaga tctgtggctt gtgggctcct ggattcaggg
     3781 ctctagaatc tctcctgcct gacagctgga gtggggctga ctgccagctt cctgcatctg
     3841 gaagcacctg gagtggtgag ttctagtctc tgtgttgcct ggattatcct tgtcttcaac
     3901 agggatctgg ggccactatg gcctctggaa tagcagactc tggggacttg gaacacttct
     3961 ttcttgaagc ccagagaggg tttgaacaag aaaggttatt tttgctcagt cccagcgcat
     4021 cgctgatggg tgactgtcat gagaaagcat gttacacagt attatgggag cacaagggaa
     4081 acagccttgg actactttac actacctggg ggaaaattgg aaacaatcct tagtgtaaac
     4141 acactcagac tcaggagcgg agcaagacag tttcgagaag cgctttttcc atgacccatt
     4201 ttcctgtttt tgctgtctgc tttctagcac ttgagtggct gagtccattt ttcagtatct
     4261 agactatgct taacttctcc aaaagttgct tcatttatta ccatgtaaaa ggagctggtc
     4321 tctctattta gccaatggcc tttgcctatc ttcaggtatc aaaaatgtca tccttgtgtc
     4381 tttaggatgg tggtttgagg cctggtttct tcaggaagct tgtctggagc tggacagtgg
     4441 tcttactgct attccagagc ctccctgaga ccaaatgcag ggagatgccc cacccccttg
     4501 gaagtgccgg ctctcagcct tggggacagc tgttaggaag tgccgcaggg tagggttgcc
     4561 ccagggctca gttgccatgt cagtttcgta ccagaagatg ccagtccaga tgtgcatttg
     4621 gtgtaaattt actggcgggt tgcttttgtc ctgtatgctg gtggaggagt ctttaaagca
     4681 cctggtgatg ccggggacat ggcttagaac atgtgcctgg tgtgtgggac tctgggttcc
     4741 agcccagtga ttggaaacga aaatctccaa tatgcatggg gtcctgttct gccattccct
     4801 gagagacggc attagtttct caagcagtta gcatcagtgc tcaggtaaaa gtctcaagag
     4861 gccccaaggg gaatgcacaa atgcacactt agaggctctc atccctggat aaatgactca
     4921 gtggcttcag agctgagaag gagggcttgc cctctttcca gtttggggac aaaatggcag
     4981 atgcttgtcc cagaggcaag gctccggtga ctgagccatc ttctcccatt ccctcatcac
     5041 ggagactgtc tttaccctcc tctagtgttc ctgaggttcc agacttctcc cagccaccgt
     5101 ggcaggtacc cctcatgtca gggactgcct cgtgctgctt ttcatctgaa cctttaccca
     5161 gcatgcaacg catggctcct gcctggtgag cctcgtgggc tgagaaagcc aaagcacagc
     5221 ctccagcgtg tgggtccaaa tgcacgtgcc acagtagagg agcaccctgc gcttggcgcc
     5281 ccgtctggtg ggacctaccg atattccaac cgttgacact tttatatttt cactacattt
     5341 tatattttta tagactattt tatattaagg tttttctaga tcctgtacaa cttttatata
     5401 acaagttcta ttttgtgtgc acgactcccc tgtatgtatt tatatcaacc cgagcctccc
     5461 agattgcagg tccctcttgt gccacctttt cctcttagcc ttgactgtcc ctctcctctg
     5521 ctcacccagg tagcctcagg ggctacttct agccgtgata acacccgaac agcagtcact
     5581 ggtcagcatg tacttctctg gtgtttgtta gctgtggtct gttgatacag gaagtactct
     5641 gggcagtacc cagtcaggtt accacactat gttaccgcac aaacccctct ccctcagtac
     5701 agtgggtgtc ctgatgcagc gacctctggg tgggtggctg gtcaggaaag tcctcgaaga
     5761 cagaggctag atgcaagccc gatgtatgag gctctgctcc tgtgggcaac taggggactt
     5821 gagggcacac tgccaaatga ctgtcctttc atatcacagc agcttccctg ctcatccttg
     5881 agttaaatgt agacttgtaa aggaagaaat aaactaattt ttattacatt ctgcctcaaa
     5941 a
//
