LOCUS       NM_172478               2391 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus TBC1 domain family, member 25 (Tbc1d25), transcript
            variant 1, mRNA.
ACCESSION   NM_172478
VERSION     NM_172478.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2391)
  AUTHORS   Wu,A., Ye,M., Ma,T., She,Z., Li,R., Shi,H., Yang,L., Yi,M. and
            Li,H.
  TITLE     TBC1D25 alleviates nonalcoholic steatohepatitis by inhibiting
            abnormal lipid accumulation and inflammation
  JOURNAL   J Cell Physiol 238 (2), 393-406 (2023)
   PUBMED   36710714
  REMARK    GeneRIF: TBC1D25 alleviates nonalcoholic steatohepatitis by
            inhibiting abnormal lipid accumulation and inflammation.
REFERENCE   2  (bases 1 to 2391)
  AUTHORS   Zhang,Z., Ma,T., Fu,Z., Feng,Y., Wang,Z., Tian,S., Liu,Z., Wei,W.,
            Li,X., Chen,J. and Zhao,W.
  TITLE     TBC1Domain Family Member 25 deficiency aggravates cerebral
            ischemia-reperfusion injury via TAK1-JNK/p38 pathway
  JOURNAL   J Neurochem 160 (3), 392-411 (2022)
   PUBMED   34837397
REFERENCE   3  (bases 1 to 2391)
  AUTHORS   Guo,S., Liu,Y., Gao,L., Xiao,F., Shen,J., Xing,S., Yang,F.,
            Zhang,W., Shi,Q., Li,Y. and Zhao,L.
  TITLE     TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway
  JOURNAL   Int J Biol Sci 16 (8), 1335-1348 (2020)
   PUBMED   32210723
  REMARK    GeneRIF: TBC1D25 Regulates Cardiac Remodeling Through TAK1
            Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2391)
  AUTHORS   Itoh,T., Kanno,E., Uemura,T., Waguri,S. and Fukuda,M.
  TITLE     OATL1, a novel autophagosome-resident Rab33B-GAP, regulates
            autophagosomal maturation
  JOURNAL   J Cell Biol 192 (5), 839-853 (2011)
   PUBMED   21383079
  REMARK    GeneRIF: OATL1 has a role in autophagy.
REFERENCE   5  (bases 1 to 2391)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663032.9.
            
            On Jun 1, 2019 this sequence version replaced NM_172478.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128566.1, AK040932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL663032.9         128083-128296       c
            215-324             AL663032.9         126573-126682       c
            325-479             AL663032.9         125110-125264       c
            480-607             AL663032.9         109023-109150       c
            608-796             AL663032.9         108688-108876       c
            797-2391            AL663032.9         106844-108438       c
FEATURES             Location/Qualifiers
     source          1..2391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.69 cM"
     gene            1..2391
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /note="TBC1 domain family, member 25"
                     /db_xref="GeneID:209815"
                     /db_xref="MGI:MGI:2444862"
     exon            1..214
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2158
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ornithine aminotransferase-like 1"
                     /codon_start=1
                     /product="TBC1 domain family member 25 isoform 1"
                     /protein_id="NP_766066.3"
                     /db_xref="CCDS:CCDS29988.1"
                     /db_xref="GeneID:209815"
                     /db_xref="MGI:MGI:2444862"
                     /translation="MATTSAASDSACSAAPPPVGGAQAAAAVEEEEREVVRVRVKKCE
                     SFLSPEFRSFAVDPQITSLDVLQHILIRAFDLNGKKNFGISYLARDRLGQETFLSLLS
                     DWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTT
                     AALPFTQSILSQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPE
                     ELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRV
                     NPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGM
                     SDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFY
                     QYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPS
                     QVADTGFGSHRGRPVRQRHMLRPAGGGGGAFEDAVVHLAASSQGPSGGGRLLRQASLD
                     GLQQLRDNMGLRKDHLVQLSHPATLISSKSLSEPLLNSPDPLLSTSSRPDSPSSSSPP
                     STQEASPSGDIAVGSPLMQEVGSPRDPGKPVPPPPPMGLPPPQEFGRGNPFMLFLCLA
                     ILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRAKALFADYLQSEVWDSEEGA
                     EATAPS"
     exon            215..324
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..479
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..607
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..796
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..2391
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2380
                     /gene="Tbc1d25"
                     /gene_synonym="6330576A08Rik; DXHXS7927e; Oatl1"
                     /note="major polyA site"
ORIGIN      
        1 aaggtggggc cgcgggcgcc cgcactgttg ggtgtacgtt agggtacggg taactatcgg
       61 ttatcacctg gacagagacg acagcggcgg gatggcaacc acctccgcgg cctcggactc
      121 ggcgtgctcg gcagcgcccc cgcccgtcgg aggtgcccag gcggccgcgg cggttgagga
      181 ggaggagcgt gaggtggtac gggtccgagt caagaaatgt gagagcttct tgtcccctga
      241 gttccgctct tttgcggtgg atcctcagat cacctcgctg gacgtgttgc agcacatcct
      301 catccgagcc tttgacttaa atgggaagaa gaactttggc atcagctacc tggctcgaga
      361 ccggctagga caggaaactt tcctctccct cctttctgat tgggacctca gcacagcttt
      421 cgccactgcc tccaaacctt atctgcagtt gcgtgtagac attcggccct cagaggacag
      481 cccattgctg gaagactggg acataattag ccccaaagat gtcattggat ctgatgtgct
      541 actggctgag aagcgatcat cactgacgac agctgccttg ccttttacac agtccatcct
      601 ctctcaggtg ggtcgtacac tgtctaaggt ccagcaggtg ctgagttggt cttatgggga
      661 agatgtgaag ccttttaagc cccccctgag tgatgctgag ttccacacgt acctgaatca
      721 tgaaggtcag ctctcccggc ctgaggagtt gcgtttgagg atctaccacg gcggtgtgga
      781 gccttcactt cgaaaagtag tatggcggta cctccttaat gtgtacccag atgggctgac
      841 tggccgtgag cggatggact acatgaaacg taagagccga gagtacgagc agctcaaaag
      901 tgagtgggcc cagcgagtga accctgagga cctggaattc atccgcagca cagtcctcaa
      961 ggatgtgctc cgcacagacc gagcccatcc ctactacgca gggcctgagg atggcccaca
     1021 cctacgggcc ctacacgact tgctcaccac ctatgccgtt acccatccac aggtatcata
     1081 ctgccagggg atgagtgacc tggcctcacc aattcttgct gtcatggacc atgaaggcca
     1141 tgcctttgta tgcttctgtg gcatcatgaa gcgcttagct gccaacttcc accctgatgg
     1201 ccgtgccatg gccaccaagt ttgcccacct caagctgcta ttgagacatg ctgacccaga
     1261 cttctatcag tacctgcaag aagcaggtgc cgatgacctc tttttctgtt accgctggct
     1321 gctgctggag ctcaagcgtg aattcgcctt cgatgatgct ctccgaatgc tagaagtcac
     1381 ctggagttca ctgccccctg accctcctga acacgaagtg gagctcgtcg gacctcccag
     1441 ccaagtagca gacactggct ttggtagcca caggggacgg ccagtacgtc agaggcacat
     1501 gctgaggcct gctggtggag gaggcggtgc ttttgaagat gctgttgtcc acttagctgc
     1561 atctagccag ggacctagtg gtggggggcg tctcctaaga caagccagtc tggatggtct
     1621 ccaacaactc agggataaca tgggcctcag gaaggaccat ctggtccaac tatcccaccc
     1681 agctaccctc attagctcta agtccctctc tgagcccttg ctgaattccc cagatccact
     1741 cctctccacc tcttctcggc ccgattcccc atcttcgtca tctcctccat ctacccagga
     1801 ggcttctcct tctggtgaca tagctgtagg atccccctta atgcaagagg taggttctcc
     1861 cagagaccct gggaagcctg taccacctcc acctccaatg ggccttcccc caccccagga
     1921 gtttggccga gggaacccat tcatgctctt cctctgcttg gctatcctgc tggagcatcg
     1981 tgaccacatc atgcgcaatg ggctggatta caatgagcta gccatgcatt ttgaccgcct
     2041 ggttcgtaaa caccatctag ggcgtgtctt gcgtagggcc aaagcactct ttgctgatta
     2101 cctacagtct gaagtgtggg actctgagga gggggctgag gccacagctc catcttgatt
     2161 atactccctc caacgctcca accccaatgg tactccattc tttgccatga gggcctacac
     2221 atgagacctt attccctgcc tgccatcccc agacatgttg gagcctgagg ccctctctcc
     2281 ccagatttga gtatgtgtgg ctcagccttg gcactgcccc acagaggcca cagcctcgtt
     2341 ctgtttttgt tgtttctaaa ctatactttc catatacaaa ggtcactgtg g
//
