LOCUS       NM_001358433            3697 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus TBC1 domain family, member 23 (Tbc1d23), transcript
            variant 1, mRNA.
ACCESSION   NM_001358433 XM_006522484
VERSION     NM_001358433.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3697)
  AUTHORS   Casingal,C.R., Kikkawa,T., Inada,H., Sasaki,Y. and Osumi,N.
  TITLE     Identification of FMRP target mRNAs in the developmental brain:
            FMRP might coordinate Ras/MAPK, Wnt/beta-catenin, and mTOR
            signaling during corticogenesis
  JOURNAL   Mol Brain 13 (1), 167 (2020)
   PUBMED   33323119
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3697)
  AUTHORS   Shin,J.J.H., Gillingham,A.K., Begum,F., Chadwick,J. and Munro,S.
  TITLE     TBC1D23 is a bridging factor for endosomal vesicle capture by
            golgins at the trans-Golgi
  JOURNAL   Nat Cell Biol 19 (12), 1424-1432 (2017)
   PUBMED   29084197
  REMARK    Erratum:[Nat Cell Biol. 2018 Feb;20(2):222. doi:
            10.1038/s41556-017-0026-7. PMID: 29311657]
REFERENCE   3  (bases 1 to 3697)
  AUTHORS   Ivanova,E.L., Mau-Them,F.T., Riazuddin,S., Kahrizi,K., Laugel,V.,
            Schaefer,E., de Saint Martin,A., Runge,K., Iqbal,Z., Spitz,M.A.,
            Laura,M., Drouot,N., Gerard,B., Deleuze,J.F., de Brouwer,A.P.M.,
            Razzaq,A., Dollfus,H., Assir,M.Z., Nitchke,P., Hinckelmann,M.V.,
            Ropers,H., Riazuddin,S., Najmabadi,H., van Bokhoven,H. and
            Chelly,J.
  TITLE     Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar
            Hypoplasia and Alter Cortical Development
  JOURNAL   Am J Hum Genet 101 (3), 428-440 (2017)
   PUBMED   28823707
  REMARK    GeneRIF: Homozygous Truncating Variants in TBC1D23 gene are
            associated with Pontocerebellar Hypoplasia and Alter Cortical
            Development.
REFERENCE   4  (bases 1 to 3697)
  AUTHORS   De Arras,L., Yang,I.V., Lackford,B., Riches,D.W., Prekeris,R.,
            Freedman,J.H., Schwartz,D.A. and Alper,S.
  TITLE     Spatiotemporal inhibition of innate immunity signaling by the
            Tbc1d23 RAB-GAP
  JOURNAL   J Immunol 188 (6), 2905-2913 (2012)
   PUBMED   22312129
  REMARK    GeneRIF: we now show that Tbc1d23 is a general inhibitor of innate
            immunity signaling, strongly inhibiting multiple TLR and
            dectin-signaling pathways
REFERENCE   5  (bases 1 to 3697)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154625.3.
            
            On Dec 1, 2017 this sequence version replaced XM_006522484.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.546220.1,
                                           SRR13861890.108676.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC154625.3         159408-159560       c
            154-265             AC154625.3         146403-146514       c
            266-371             AC154625.3         142258-142363       c
            372-576             AC154625.3         140465-140669       c
            577-700             AC154625.3         136298-136421       c
            701-825             AC154625.3         126953-127077       c
            826-872             AC154625.3         126818-126864       c
            873-976             AC154625.3         126375-126478       c
            977-1099            AC154625.3         120703-120825       c
            1100-1192           AC154625.3         119568-119660       c
            1193-1363           AC154625.3         117356-117526       c
            1364-1406           AC154625.3         114732-114774       c
            1407-1513           AC154625.3         112474-112580       c
            1514-1653           AC154625.3         110945-111084       c
            1654-1698           AC154625.3         109586-109630       c
            1699-1787           AC154625.3         106026-106114       c
            1788-1923           AC154625.3         101118-101253       c
            1924-2118           AC154625.3         99717-99911         c
            2119-3697           AC154625.3         96956-98534         c
FEATURES             Location/Qualifiers
     source          1..3697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.22 cM"
     gene            1..3697
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /note="TBC1 domain family, member 23"
                     /db_xref="GeneID:67581"
                     /db_xref="MGI:MGI:1914831"
     exon            1..153
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            154..265
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            266..371
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            372..576
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            577..700
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            701..825
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            826..872
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            873..976
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1099
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1192
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1363
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1406
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1513
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1653
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1698
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1787
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1923
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2118
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..3697
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3671..3676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3697
                     /gene="Tbc1d23"
                     /gene_synonym="4930451A13Rik; D030022P07Rik"
                     /note="major polyA site"
ORIGIN      
        1 caagtctcag acttcataac tccttttacg acactgaatc tctgagacag tctcggtgcc
       61 aggtccactt ttcggcaaag tgacgtggac gtcaacagca atggcggaag gagaagagct
      121 tctgccactg tcaacgtcgg gcggggacag ctgggaaaaa gatcttgaag aagcccttga
      181 agcaggaggt tgtgatcttg aaactttgag aaatataatt caagggaggc cactgcctgc
      241 tgagctgagg gccaaggttt ggaagattgc tctgaacgtt gcagggaaag gtgatagttt
      301 ggcatcatgg gatggtattt tagacttgcc tgagcagaac actattcata aagattgcct
      361 tgagtttatc gagcagctct cagtgccaga ggagaaggca gcagaattac tcctggatat
      421 tgaatctgta attacttttt actgtaaatc acgcagcgtt aaatacagca catccctgag
      481 ctggattcat ctactgaaac cattgatctg tctccagctg cctcgcagcg acctatacaa
      541 ctgcttctat gccgtcatga ataagtacat tcccagggat tgttccctga aggggaggcc
      601 atttcatctc ttccggttgc tcatccagta ccacgagcct gagctttgtt cttttcttga
      661 cacaaagaaa atcactccag actcctatgc actcaactgg ctcgggagcc tttttgcaca
      721 ttactgttcc actgaggtca cccaggcaat atgggacgga tatctacagc aagcggaccc
      781 gttttttatt tatttcttaa tgttaattat ccttgttaat acaaaagaag ttattttagc
      841 acaagagtct gacagcaaag aagaagttat ccgctttttg gaaagtaccc cggccagcct
      901 gaatctggaa gacatagaag acctgttctc tttggctcag tattactgta gtaagacgcc
      961 agcttctttt aggaaggata accatcatct cttcggtagc accctgctgg ggatcaagga
     1021 cgacgaggca gatctgagcc aggctctgtg tctggctgtt tcagtatcag agatccttca
     1081 agctaatcag ctgcaagggg aaggagtccg gttcttcgtg gtggactgcc gtcctgcgga
     1141 gcagtacaat gctgggcatt tggcaaccgc gttccaccta gactcagact tgatgctcca
     1201 gaatccatct gagtttgcac agtcagtaaa gtccttgcta gaagcacaga aacagtccat
     1261 tgagtctggc tccatagcag gcggggagca cctctgtttt atgggcagtg gcagagagga
     1321 agaagacatg tacatgaaca tggtcctcgc acacttctta cagaaaaaca aagaatatgt
     1381 tagcattgcc agtggaggat ttatggccct tcagcagcac ctggcagaca taaatgtaga
     1441 gggaccagaa agtggatacg gccattggat tgccagtacc tcagggtcaa ggggcagcat
     1501 cagctctgtc gatggtgaat cctgtaatgg ctccaatgat agaggaatga aatccctggt
     1561 cagtaaaatg actgtggctc taaagacaaa atccgttacc gttagggaaa aggtcatcag
     1621 ctttattgag aactcgtcga ctcctgtgga ccgaatgtct ttcaatcttc cctggccaga
     1681 cagatcatgt acagagcggc acgtgagcag cagcgacaga gtgggcaagc cttaccgtgg
     1741 agtgaagcct gtgttcagca tcggcgatga agaggaatat gacacagatg aaatcgacag
     1801 ctcgtccatg tcagatgatg ataggaaaga ggttgtcaac atccagacct ggatcaacaa
     1861 gccggacatc aagcatcact ttccctgtaa agaagttaaa gaaagtggac atatgtttcc
     1921 tagccatctg ctggttaccg ccacccatat gtactgctta agggagattc tttcaaggaa
     1981 aggcctggct tacatccagt ctcggcaagc actaaattct gtagtgaaaa ttacgtccaa
     2041 aaaaaaacat cccgagctaa ttaccttcaa gtatggaaac agcagtgctt ccgggataga
     2101 aatcttggct attgaaaggt atttgattcc aaatgcagga gatgctacca gagccataaa
     2161 acagcagatc atgaaagtgt tggatgcttt ggaaagttaa tgtaaaagaa agttatttaa
     2221 gtgaaattaa ggcaacgaag agaaatatga aaatatattt cctgactcaa tactaagcag
     2281 agacctttga tttgctcatg gggtgcctga gtagagggtc taaatgcaaa ttattgtaat
     2341 caataccggg atgggttcac ttttttaaca gtttcttttg catctttggt tttatataat
     2401 gatttattat aaaggtcagt tattaaatga ctttgaagta actggccttg tgccctatgg
     2461 atccaagggc acagaatgca gttctgtttt gaagagctgt tttaaaggac atgcatcatt
     2521 ttcaggtttt aaaacaactg tacacataca tatttgcaat gtcttcactg aaatttaggg
     2581 atagaattag ttgaagagat ttaattgcta cattgagttt tactacaatg agcattatcg
     2641 aaaataaacg gttagactaa tgattagctc actgttctgt tcttaaaaag attgaagtct
     2701 gttggatgga atggatggag atcatagcaa ctcaaaacac agcccagagt gagacaccga
     2761 aggtcagctt ccccatcttc cttcctccag taggtaatta tccagagact aattgcctca
     2821 gagatagtga gcctcacccc aagttgctaa ggaacagtta acagcactag aagtaagtag
     2881 gcatgttaag gttaaaatta gcatttgggg gacagaattg tatctgtaaa aatgtccttg
     2941 gtctttatta caaatgggtc atttggtcta ggctgtttca aaatgctttg ccacactgat
     3001 tatcctcctt gaaatgatca cccgtgacca cactaatgtc cagtttttaa aagaaagata
     3061 atcagagagc tgtaggaatt tcccattgtt tctctatcac tttctaaaag ttccccggtt
     3121 tttgccgtcg cagtaaagtt tgcgtggttg gcacttgttc catccttact ctctgaaaga
     3181 cggacgccgt ctgctttgtt tcgcagcttg ctcagactag tcactgtgct gagagagccg
     3241 gaacagcttc cgaccatggg atgattttta taaaatctgt ctgaaaaata gtaaatagaa
     3301 cctgccatgt cataacatgt aatagatttt ttccaagggg ttggttgata gaaatatcta
     3361 gatgtacccc accagtagcc agtgttttaa tttgcttaat ggaaatcaag tgaatggtaa
     3421 cataattaaa agaactctat tctgatatct aaataaaaac aatgtatttg agtggttgaa
     3481 gacatttgca tgaaattgca ccttgtacgg tacttgatat ttataactct tcccccaaac
     3541 tgttgtattt catttcttcc attttctcga caccctcttt gagatgtcct gaagtctctc
     3601 agctatggga ctttttttca taatattaat gtaaagatgt ttgtgttact gtttataaat
     3661 tacaattgta aataaactga tacaagtttg ctcaaaa
//
