LOCUS       NM_145476               3242 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus TBC1 domain family, member 22a (Tbc1d22a), transcript
            variant 1, mRNA.
ACCESSION   NM_145476
VERSION     NM_145476.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3242)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3242)
  AUTHORS   van der Weyden,L., Swiatkowska,A., Iyer,V., Speak,A.O. and
            Adams,D.J.
  TITLE     A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators
            of Pulmonary Metastatic Colonisation
  JOURNAL   G3 (Bethesda) 10 (6), 1869-1877 (2020)
   PUBMED   32245826
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3242)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3242)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 3242)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116764.10, AC115755.8, AC146911.11 and AC163400.3.
            
            On Jul 12, 2022 this sequence version replaced NM_145476.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066009.1, AK146872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC116764.10        17257-17447         c
            192-248             AC115755.8         84795-84851         c
            249-586             AC115755.8         83728-84065         c
            587-763             AC115755.8         80288-80464         c
            764-834             AC115755.8         27377-27447         c
            835-963             AC115755.8         19806-19934         c
            964-1026            AC115755.8         17973-18035         c
            1027-1141           AC115755.8         7740-7854           c
            1142-1251           AC146911.11        145687-145796       c
            1252-1327           AC146911.11        130770-130845       c
            1328-1455           AC146911.11        106246-106373       c
            1456-1551           AC146911.11        48163-48258         c
            1552-2188           AC146911.11        1-637               c
            2189-3242           AC163400.3         9184-10237
FEATURES             Location/Qualifiers
     source          1..3242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.56 cM"
     gene            1..3242
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /note="TBC1 domain family, member 22a"
                     /db_xref="GeneID:223754"
                     /db_xref="MGI:MGI:1289265"
     exon            1..191
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            192..248
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            249..586
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            587..763
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            764..834
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            835..963
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1026
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1141
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1251
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1327
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1455
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1551
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..3242
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3221..3226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /note="hexamer: AATAAA"
     polyA_site      3242
                     /gene="Tbc1d22a"
                     /gene_synonym="D15Ertd781e"
                     /note="major polyA site"
ORIGIN      
        1 ctctcggctc tacgcttcgg agtcctggtg tctctgaggg ggccgccggg gcacaggaga
       61 gggccgctgg aggtgtggcc gaccgctctc gggtgtcagg gttgcggatc tgagggatga
      121 ggagcggcca tggccagcga cggggccagg aagcagttct ggaagcgcag caacagcaag
      181 gtcccgggca gcatccagca tgtgtatgga gcccagcacc caccgtttga tccgctgtta
      241 catggcacct tgctcaagtc cacgcccaag gtgcccacca ctccggtgaa ggccaagcgg
      301 gtcagcacct tccaggagtt tgagagcaac accagtgatg cttgggatgc cggtgaagac
      361 gatgatgagc tcctggccat ggcgacagag agcctgaact ctgaggtggt catggagaca
      421 gcacatcgtg tcctgcgcaa tcacagccag aggcagagcc agccttcaca gaagacgaca
      481 gaaccagagc cagagcctca gcccatagca gagcctcctg tacctcccag tggtgacctt
      541 cgcctggtga agtctgtcag tgagagccac actccttgtc cttcagagag caccggtgat
      601 acagtccctc tgcaacggtc ccagtctctt ccccactcgg ccacagtgac actgagtggg
      661 acatctgacc cacatgccct tgctgactca gccctgagta agagagagac ctctcggctg
      721 gacaagttca aacagctgct tgctggcccc aacacagacc ttgaggaatt acggaagctg
      781 agctggtccg gaatcccaaa gccagttcgt ccaatgacat ggaaacttct ctcaggttac
      841 cttcctgcca atgttgaccg aagaccagcc acgctgcaga ggaaacagaa ggaatacttt
      901 gctttcattg agcattatta cagctctagg aatgacgaag ttcaccagga cacgtatcgc
      961 cagatccata tcgacatccc tcggatgagc ccggaagcgc tgattcttca gcccaaggtg
     1021 acagagattt tcgaaaggat cttgtttata tgggcaatcc gacaccctgc cagtggatac
     1081 gttcagggaa taaatgacct ggtcactccg ttcttcgtgg tcttcatttg cgagtacaca
     1141 gaccgggagg acgtggacaa ggtcgatgtc tccagtgtgc ctgcagaggt gcttcgcaac
     1201 attgaggctg acacctactg gtgcatgagc aagcttctgg atggcattca ggacaactac
     1261 acctttgccc aacctgggat tcagatgaaa gtgaagatgc tggaagagct tgtgagccgg
     1321 attgatgagc gagtccaccg gcatctggac gggcatgagg tgcggtacct gcagtttgcc
     1381 ttccgctgga tgaacaacct gctgatgagg gagctgcccc tgcgctgcac catccgcctg
     1441 tgggacactt accagtctga acccgagggc ttttctcatt tccacttata tgtttgtgct
     1501 gctttcctcg tgagatggag gagagaaatt ctagaagaaa gagattttca agagttgctg
     1561 ctcttcctcc agaacctgcc tactgcccgc tgggatgacc aggatgtcag cctgctgctg
     1621 gctgaggcct atcgcctcaa gtttgccttc gcagacgccc ccaatcacta caagaagtga
     1681 gcctggggcc catggcagtg gcctcaccct agggatagca tcccctctct gcctgggcag
     1741 ttgctggcct ctggactggt cctttcctgg tgtgacctag cagagtggac ccagcatggt
     1801 ccagggctgg caggataggc agcctagttt gatgagatac caaagagagc ccaggagaga
     1861 ctcctagctt cagaagctca gtgtggccag gagtgccctc accctggccc tgccttgcca
     1921 aatgccctcc ctacagcccc cagtccagac agccaagagg aagtccctca gagagccctg
     1981 ctgtacgtac gggtgccagg cagaggtggg cagccatctc aagcctgctc tcaattgcac
     2041 aaatctattc tgtcaagtga aagaataaag tccagaaaac aatgccgagc atgacttagg
     2101 ctgagctagg agttctgcac acagagcctt taatggcccc atgtttaggt tgacttggtt
     2161 taaacagggc taggtcagga gttagatcct gggagactgt ggaacaagag gaggccaggg
     2221 caggctgagg cttctcacgg tcaccttact ttctgttttt aattaactgg ttccctgtcc
     2281 gggtgaggaa aagggtcaag gaacccccag gtgggcaggg gtttttgtca gtcagggttc
     2341 cagagattgt ctcatgggcc caaacttgac cgcaacaggg cagaaattag tggttctaaa
     2401 gtcccagcca tgtgtagggg gcttcttcct aacaccaccc agatggcaat agccaggagc
     2461 tgctgggctg gcctctcttc atgccctact gccctttcca gagccactgg gttagagcct
     2521 ttgccccgtt gctggccttc tccagggccc tcagactggc ttctcacatg tatatcccac
     2581 agatgccccc accaggctgc ctggcctctg tgatgtggga tccccaagga ccaccaggcc
     2641 acctgtagga caagagccta gactcctaga gcagcctcct gtcctcagtt acccactgca
     2701 gcccactctg acctgtccct tctttaggag cagcgcaaca ctgcccaggc actaggactc
     2761 tgcccagagg ctgtggggaa gacataggga agacgtgtgc ctgcttctgt tcagatgatc
     2821 ctgggtcagg tgggatgtga catcagcaga gtgctgtgca ggcaatccga tgtcctggat
     2881 cagcagaggg acatgctccc tcagaccagt gcctgtcctg ggtgagaggc acccagttat
     2941 aaggaaagct acctctgtgg ctctggagaa gcaccatctt ccctgatcct tccatggtgc
     3001 ggatcacccc tcagccagaa gggtaggccc ataacgatct gccccatggt gtttttatga
     3061 gatgacaagg acccatgagg ttaacttaag ccctgaatgt atttttatgt gtgcaaatgc
     3121 ttgactgggt gtacgagacg ctggcgacag tcctgtgtct gagcccatga gctgagccgg
     3181 gcaggatgtg tgctttgaat gtgatgtgtt ggaaacacga aataaagatg cttcatatgg
     3241 cc
//
