LOCUS       NM_198664               4305 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TBC1 domain family, member 2 (Tbc1d2), mRNA.
ACCESSION   NM_198664 XM_355560
VERSION     NM_198664.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4305)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4305)
  AUTHORS   Jaber,N., Mohd-Naim,N., Wang,Z., DeLeon,J.L., Kim,S., Zhong,H.,
            Sheshadri,N., Dou,Z., Edinger,A.L., Du,G., Braga,V.M. and Zong,W.X.
  TITLE     Vps34 regulates Rab7 and late endocytic trafficking through
            recruitment of the GTPase-activating protein Armus
  JOURNAL   J Cell Sci 129 (23), 4424-4435 (2016)
   PUBMED   27793976
  REMARK    GeneRIF: Vps34 has a previously unknown role in regulating Rab7
            activity and late endosomal trafficking.
REFERENCE   3  (bases 1 to 4305)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX571848.8, BX682536.4 and AL683884.26.
            
            On Aug 1, 2006 this sequence version replaced NM_198664.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no high-quality, full-length
            transcript from the C57BL/6J reference strain was available. The
            extent of this transcript is supported by orthologous human, dog
            and chicken data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148289.1, SRR13422600.1472673.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               BX571848.8         2897-3427           c
            532-673             BX682536.4         31495-31636         c
            674-821             BX682536.4         22967-23114         c
            822-955             BX682536.4         15254-15387         c
            956-1152            BX682536.4         13719-13915         c
            1153-1527           BX682536.4         5825-6199           c
            1528-1638           AL683884.26        227448-227558       c
            1639-1820           AL683884.26        226221-226402       c
            1821-2297           AL683884.26        225142-225618       c
            2298-2418           AL683884.26        220177-220297       c
            2419-2604           AL683884.26        218164-218349       c
            2605-2726           AL683884.26        217577-217698       c
            2727-4305           AL683884.26        215584-217162       c
FEATURES             Location/Qualifiers
     source          1..4305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 25.04 cM"
     gene            1..4305
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /note="TBC1 domain family, member 2"
                     /db_xref="GeneID:381605"
                     /db_xref="MGI:MGI:2652885"
     exon            1..531
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..2934
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /note="likely ortholog of H. sapiens TBC1 domain family,
                     member 2 (TBC1D2)"
                     /codon_start=1
                     /product="TBC1 domain family member 2A"
                     /protein_id="NP_941066.3"
                     /db_xref="CCDS:CCDS18155.1"
                     /db_xref="GeneID:381605"
                     /db_xref="MGI:MGI:2652885"
                     /translation="MEDAPERTPSSSESTQPPGLAREPEVVSPGDSEGCARPLDTVPK
                     KLCGYLSKFGGKGPIKGWKCRWFFYDERKCHLYYSRTAQDANPLDSIDLSSAVFDCKA
                     DAEEEGTFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPALPATPAAALAE
                     NGPTLHLKLEQEEAELEEFLCPVKTPTGLVGAAAALQPVPAVPSALQNISLKHLGTEI
                     QNTMHNIRGNKQAQAAAHGPLVEDSPQGGEPQSGEQPSISDPSLPEKEPEDPAKSAPR
                     SSVPSGPTQKPKRQSNTFPFFSDGLARSRTAQEKVAALEQQVLMLTKELKSQKELVII
                     LHKALEAAQQEKRASSAYLAATEDRDRLELVRHKVRQIAELNQRVEALEQGRERLAHE
                     AGLREQQVQALQQHVQLLMDKNHAKQQVICKLTQKLTEDLAQPADATNGDFLSQQERM
                     EHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLA
                     GLRRLQEAAGAEAGDFPELLQQLIQEALQWEAGEADSVGLSPVSEYDDYGFLTVPDYE
                     MEDLKLLAKIQALEVRSHHLLAHEAVERPLRDRWATLTELTPSAELKQLLRAGVPREH
                     RPRVWRWLVHRRVRHLQAPGCYQELLARGRACEHPAARQIELDLNRTFPTNKHFTCPT
                     SSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETILPA
                     EYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQHRVDLSLITFNWFLVVFADSLISD
                     ILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILQLQDSLEIYQYLRFFTKTICDSRKL
                     MSIAFNDMNPFPMKQLRQLRAAHRERLEAELRELELLKVEYLQRRASLGRAPPEGCVS
                     EDEGEGDS"
     exon            532..673
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..821
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..955
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1152
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1527
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1638
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1820
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2297
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2418
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2604
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2726
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..4305
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4286..4291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /note="hexamer: AATAAA"
     polyA_site      4294
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
     polyA_site      4305
                     /gene="Tbc1d2"
                     /gene_synonym="A630005A06Rik; Gm1037; PARIS-1; PARIS1"
                     /note="major polyA site"
ORIGIN      
        1 tcaagtgtct aaggcgctct ctccggcgcc ggcaggggtg ctctccgcct tcttctaggg
       61 gctggaccgg accggctccg ccccagccag gtatcgccgg ttcccaggtg cccgtcggac
      121 ctcccgcatt ccagtgccgc aggcctgtgc agcgggccag cagcgatgga ggacgccccc
      181 gagcgcactc cctcttcctc ggagtccaca cagcctccgg gcttggccag ggagcccgag
      241 gtggtatctc ccggggattc ggagggctgc gcccggcctc tagacacggt ccctaagaaa
      301 ctctgtgggt atttaagtaa gtttggcggc aaaggaccca tcaagggctg gaaatgccgc
      361 tggttcttct acgatgagag gaagtgccac ctgtattatt cgcgcaccgc gcaggatgca
      421 aaccccttgg acagcatcga tctctccagt gcggtctttg actgtaaggc ggacgctgag
      481 gaggagggca cttttgaaat caagactccc agccgggtta ttaccctcaa ggctgccacc
      541 aagcaggcca tgctctactg gctacagcag ctgcagatga agcgctggga gttccacaac
      601 agcccacctg cacttcccgc cacccctgct gccgccctgg ctgagaatgg gcccaccctg
      661 cacctcaaac tagagcaaga ggaggccgag ctggaggagt tcctgtgccc tgtgaaaaca
      721 cccactggac tcgtgggtgc ggcagctgcc ttacagcctg tccctgccgt gccctcagcc
      781 cttcagaaca tctccctaaa gcatctgggc actgaaatac aaaacaccat gcacaacatc
      841 cgtggcaaca agcaggccca agcggcagcc cacgggccac tcgtggaaga ctcgcctcag
      901 ggtggagagc ctcaaagcgg ggaacagccc tcgatctctg accccagcct tccagaaaaa
      961 gagccagagg atcctgccaa gtctgcaccc aggtcctctg tgccctcagg tcccacgcag
     1021 aaacccaagc ggcaaagcaa caccttccca ttcttttccg atggactggc tcggagccgc
     1081 acagcccagg agaaggtggc ggccttggag cagcaggtgc tgatgctcac caaagagctc
     1141 aagtcacaga aggagctggt gatcatccta cacaaggccc tggaggctgc ccagcaggag
     1201 aagcgagcct ccagtgccta cctggcagcc accgaggaca gagaccggtt ggagctggtc
     1261 cggcacaagg tgcggcagat cgctgagctg aaccagaggg tggaggctct ggagcagggc
     1321 cgcgagcgcc tggcgcatga ggccggcctg cgggagcagc aggtgcaggc gctccagcag
     1381 cacgtgcagc tgctcatgga taagaaccat gccaagcaac aggtcatctg caagctcacc
     1441 cagaagctca cggaggacct tgcccagccc gccgacgcta ccaacggcga cttcctgagc
     1501 cagcaggaga ggatggagca tctgaaggat gacatggaag catatcggac ccagaaccgc
     1561 ttcctcaact ctgagatcca ccaggtcacc aagatctgga ggaaggtggc ggagaaggag
     1621 aaagccctgc tgaccaagtg cgcctacctg caagccagga actgccaggt agaaagcaag
     1681 tacctggccg ggcttcggag gctgcaggag gcagcaggag ccgaggctgg tgacttccct
     1741 gagctgctgc agcagctgat ccaggaggcc ctgcagtggg aagccggaga ggcggacagc
     1801 gtggggctga gccccgtcag cgagtacgac gactatggct tcctgacggt gccagactac
     1861 gagatggaag acctaaaact gctagccaag atccaggcct tggaggtgcg ctcccaccac
     1921 ctgctggccc acgaggctgt ggagaggcca ctacgggacc gctgggctac cctgacggag
     1981 ctcacgccct cagctgagct caagcagctg cttcgggcag gggtgccccg agagcaccgt
     2041 ccccgagtct ggaggtggct ggtccaccgc cgtgtcaggc acctgcaggc tcccggctgc
     2101 taccaagagc ttctagcccg gggccgggca tgtgagcatc ctgcggctcg tcagatcgag
     2161 ctggacctca accggacctt ccccaccaac aagcacttca cctgcccgac ctccagtttc
     2221 cctgacaagc tccgtcgggt gcttctggcc ttctcctggc agaaccccac cattggctac
     2281 tgccaaggcc tgaacaggct ggcggccatc gccctgttgg tcctagaaga tgaggagagt
     2341 gccttctggt gcctggtggc cattgtggag accatactgc cggctgagta ctacagcaag
     2401 acactgactg catcccaggt ggaccagcgg gtgctccagg acctcctctc ggagaagctg
     2461 ccccgactga ctgcgcacct ggggcagcac cgtgtagacc tctctctcat cactttcaac
     2521 tggttcctcg tggtcttcgc cgactctctc atcagtgaca tcctcctgcg ggtctgggat
     2581 gccttcctgt atgaagggac caaggtggtg ttccgatatg ctctggccat cttcaagtac
     2641 aatgaggaag cgatcctgca actccaggac agcctggaga tctaccagta cctgcgtttc
     2701 ttcaccaaga ccatctgcga cagccggaag ctcatgagca tagccttcaa tgacatgaac
     2761 ccatttccca tgaagcaact gcggcagctg cgggcagccc accgagagcg actggaggcg
     2821 gagctgcgcg agctagagct gctgaaagtg gagtacttgc agagacgggc atccctgggc
     2881 agagcaccgc cagagggctg cgtcagcgag gacgaaggag aaggcgacag ctgaccgagc
     2941 cctctgtccc caaagccttt ctcacctttg ctggcaggaa gatagagttc agccatgggc
     3001 gggaggtgtg tgtgaccctg gaccaggcct ttgccctctc caggccttag tctcccaggc
     3061 ttgccagcct gtgtcactgc cccacagagc actttcacac acaggacagg aggcagggat
     3121 acatgctggg tcacctgacc agtctctgag aggcaccacc atttccattc cgtttggatt
     3181 tcgtcttctg accaggtctc gaggaactca ggctgacctc agactccatg caggatcctc
     3241 ctgtcagagc catgatgaca taaagcaaca tccttgcagt tgatggcgct ccacctttag
     3301 gacagaagcc gtctcattac cagggctcct cggcacaagt gtcaggaatg ttcccgctgg
     3361 caccctctgg ctccaggcct tggtcaccat tatgtggcac cccaagttca aggcctgcat
     3421 tttcagggca tctgtctttc cagacagtag cccccctgag ttgccacctg gatctgtgtg
     3481 ttgagatcgc cctgctcata gggactatct ctacagcctc atgcctaaag cttgccttct
     3541 gtttacagcc cactgggtca tcccagggga gcccctgcct gctaccctga ggaacctgat
     3601 gtggactgga cagtggacct ggagcaagca tccactctgg cctgcatctg gcctgtgggg
     3661 ccaacagggt aggcttggga ggggagcagg gcagcagccc actcggctca ccagagccag
     3721 ttggtaagca gccttacatg gaggggacat ggctaggtga tgaccggctc tcccaaaagc
     3781 caccaccaaa aagccaaaaa caggttgaac tgtgggcaca ggctgctgga taaacagtgc
     3841 cctttctact actcccccac caagccacag cccccacctc tcctcttcct caactctccc
     3901 tagaggagaa ctctgccaag cacttgcgct tctccttggg ggaccaacgc agctttctta
     3961 ccaagctgca ctgtgttcca gcagtgctgg gccttgtgtt cagctactct tggagccagg
     4021 aggcttaacc ctggggggta agtgttctgg gattaattgc ctcctccagc cctgaacgag
     4081 caggccaagc tccagtaaca ggactcagag aacttagtgt agtgtcacac agaaggggag
     4141 ggcggctctg gccgtgactg cctgtgggca tacccacagg gtcaactcta ggaaaagaaa
     4201 agggggagtc aggtgtgggg tacacacttc agatcccagc agttccaaca ctggactaca
     4261 cagccaaaca gtgtctcaaa aaccaaataa ataagagaaa aacga
//
