LOCUS       NM_172443               6988 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TBC1 domain family, member 16 (Tbc1d16), transcript
            variant 1, mRNA.
ACCESSION   NM_172443
VERSION     NM_172443.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6988)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6988)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047555.1, CJ111152.1, BQ831250.1 and AL662835.11.
            
            On Nov 10, 2009 this sequence version replaced NM_172443.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047555.1, SRR7345562.3224856.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AK047555.1         2-265
            265-541             CJ111152.1         237-513
            542-627             AK047555.1         543-628
            628-986             BQ831250.1         211-569
            987-2894            AK047555.1         988-2895
            2895-6988           AL662835.11        143396-147489       c
FEATURES             Location/Qualifiers
     source          1..6988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.34 cM"
     gene            1..6988
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /note="TBC1 domain family, member 16"
                     /db_xref="GeneID:207592"
                     /db_xref="MGI:MGI:2652878"
     exon            1..104
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            105..340
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2463
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="TBC1 domain family member 16 isoform 1"
                     /protein_id="NP_766031.2"
                     /db_xref="CCDS:CCDS25711.1"
                     /db_xref="GeneID:207592"
                     /db_xref="MGI:MGI:2652878"
                     /translation="MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVC
                     VHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPESS
                     PVRKAPRPRRRRTTSLGALYQPSPTEPRPPLIPKDEDILVVVQNTQDTAHISPTDEDG
                     EKLAQGPEVDGALSTSQPVHSDSGILSTVSSQDGTEDGREPRPEAVEEEGSLELSADG
                     VSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGL
                     LQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIF
                     HFHHGGLDKLSEVFQQWKFCTETHLRDQQVTDERTCMQFSIRRPKLPSSEIHPEESLY
                     RRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEER
                     EALRSQKRKEYAAIQQKRLSMTPEEQRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPN
                     VESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSP
                     RDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEAL
                     RIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVL
                     RKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTV
                     ELPSPKPSREGKKGPKAPREAFGFRR"
     exon            341..938
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1100
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1248
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1416
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1565
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1700
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1887
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2067
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2214
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..6988
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6967..6972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /note="hexamer: AATAAA"
     polyA_site      6986
                     /gene="Tbc1d16"
                     /gene_synonym="B930087K01; Tcd1d16"
                     /note="major polyA site"
ORIGIN      
        1 atattccctc cccgccgcgc ctcgctttcg gcggcggtgg cagtggcggc ggcggtggtg
       61 gctcctggag ccggcgcgtg tccagccctc gcggcgggac ccgggtcctg ataagccctg
      121 cctgggctca agcgtgcgga gaatggaaac gcgcgctcag ccatgtctct gggccgcctc
      181 cttcgtcggg cctcctccaa ggcctcagac ctcctgaccc taaccacggg gggcagtggc
      241 gggtccctct ccgtcctgga tggagaggtc atctactcca agaacaatgt ctgcgtgcat
      301 gcacccgagg ggctgcaggg ccctggggag caccacccag ggtatctgtg cctgtacatg
      361 gagaaagatg agctgctggg agctaccctc atcctggcat gggttcccaa ctctcgcatc
      421 cagagacagg acgaggaggc cctacgctat atcactcccg agagctctcc tgtgcgcaag
      481 gcaccccgtc ctcggcggcg gcgcaccaca agcctggggg ccctctacca accctctccc
      541 acagagccaa ggcctcccct gattcccaaa gacgaggaca tcctggtggt ggtccagaac
      601 acgcaggata ctgcgcacat cagccctaca gatgaagatg gggaaaagct ggcccagggc
      661 ccagaggtgg atggggccct gtccacctca cagcctgtgc atagtgactc agggatcctg
      721 tctacagtca gctcccagga tgggacggag gatggccggg agcctcggcc cgaggctgtg
      781 gaggaagagg gctctttgga gttgtcggcc gatggcgtga gcagggatag ctcctttgac
      841 tcggactctg acgccttctc ttcgcccttc tgcctctccc ccatcagtgc ggcccttgcg
      901 gaggggaaca gctctgcatt cctggagagc gagggcagct ccccctccag ctccgatgcc
      961 aacctgcggt tccctgacag caatggcctc ctgcagacgc ctcgctggga tgagccccag
     1021 cggggatgtg ctctggagca gatctgtggt gtgttccgag tggacctggg ccacatgcgc
     1081 tccctgcggc tcttcttcag tgacgaggct tgcacgagtg gccagctggt ggtggccagc
     1141 cgagagagcc aatacaagat ttttcacttt caccacggcg gcctggacaa gctctccgag
     1201 gtgttccagc aatggaaatt ctgcacggag acacacctca gggaccagca ggtcacggat
     1261 gagaggacat gtatgcagtt ctccatccga aggcccaagc tgccgtcctc tgaaatccac
     1321 cctgaggaga gcctgtaccg gaggctggac gtgtctgcct ggctcaacca cctgaatgac
     1381 ctgggccagg tggaggagga gtacaagcta cgccaggcca ttttctttgg tggcattgat
     1441 gtgtcgatcc gtggggaggt ctggcctttt ctgctgcact attatagcca cgagtccacg
     1501 tcggaggaac gcgaggcact tcggtcgcag aagcgaaagg aatacgcagc catccagcaa
     1561 aagaggctct ccatgactcc agaggagcag agagccttct ggcgtaatgt gcagttcact
     1621 gtggacaaag acgtggttcg gacagatagg aacaaccagt tcttccgagg ggaggacaat
     1681 ccaaacgtgg agagcatgag gaggatcctg ttgaactatg ctgtgtacaa cccagccatc
     1741 ggctactcac agggcatgtc agatctggtg gcgcctatcc tggctgaagt cttggatgaa
     1801 tcagacacct tctggtgctt cgtgggtttg atgcagaaca ccatctttgt cagctctccc
     1861 agggatgagg acatggagag acagctgctg tacctgcggg agctgctgcg gctgacacac
     1921 cagcgcttct accaacacct ggtgtccctg ggtgaggacg gcctccagat gctcttctgc
     1981 caccgatggc tcctgctctg cttcaagcga gagtttcctg aggccgaggc cctgcgtatc
     2041 tgggaggcct gctgggccca ctaccagacg gactacttcc acctgttcat ctgtgtggcc
     2101 atcgtcgcca tctacgggga tgatgtcatc gagcagcagc tggccacgga tcagatgctg
     2161 ctgcacttcg gaaacctggc catgcatatg aatggagagc tggtgctcag gaaggccagg
     2221 agcctcctgt accagttccg ccttctacca cggataccct gcagcctcca tgacctgtgt
     2281 aagctgtgtg ggacaggcat gtgggacagt gggtacatgc cagctgtgga gtgtgctggc
     2341 caccacccag gctcagagag ctgtccctat gggggcacag tggagttgcc atcacccaag
     2401 ccttcaagag aaggcaagaa aggcccaaag gcaccgcggg aggcctttgg tttccgaaga
     2461 tagaaaagcc cctgcccttg accatcgacg aggggaccgc catgaggtcc tgggcaaggg
     2521 ggtgggggag gggatggata tggcgaggac acaaggaaaa gcctctggcc agggtgaagg
     2581 gaaccttgtc atgatgacaa aatcgggctc tagaactgac attaggtatc agctgtccct
     2641 ggagttcagc tcctgaaagg ctagcccagg gtgtctggct agccactgga atgcaggctg
     2701 ctggctggct ggggtgttcc agcagagacc aggagtctct ccgcaagctg tgggcaaggc
     2761 agggtctaga aagggcctcg tgctcacacc catgccaggg gacagagagg agcaggattg
     2821 ttgtctgagt gaaccaagca cacttgcgaa gcttcatggt cacagctgca agactggcat
     2881 gaagactcct gtccaaaaga gaaagaaaag gaagggaggg gggagggagg gagggagggg
     2941 gagagggtgg gggaagaaaa gcttatgagg gcaggtgttc tggcctggcc ttctcacagt
     3001 gtccatatga gtgttctgtg tcctgcaatg tatgggaagg acacgcctac cccgagccaa
     3061 gtgtcagatg caccctccac tgggatcctc ccctgaggat ctaaggtgtg tgcagaaaca
     3121 gcaacccact ggggcctgaa taggttgatg ggtgtggtgt gcgcagccac gatgtcctct
     3181 gaatacttgg tcccggagaa gggggagaat ataactcccc agccaagaca aaggcatctg
     3241 gcctggcttg gaagctgcct ccgccgccat gctggaccta gggaacttct gggatgctct
     3301 cttcctttta ataaggaaaa cgcccacact ccatcctcca aagctgagga ttgtggttgg
     3361 ataaaagtgt gttccagagc tttcctagcc agtgtcccaa aagctggtgc aagcaaggag
     3421 cctggattcc tccacggagg gctgaatcct catagtgggt gcaggcggca gggtcggtgg
     3481 agatgcctct gccttttggc ttttctcact aagagtggtg ctgcaggaca gtgccacgtt
     3541 taaaggtgct gaccagaata agagggggcg gagcctcaga atgagaaggg tgggccctca
     3601 gaatgagaga gggcgaggcc tcaaaatgag atgggcggga tcaccgattg aaagggcggg
     3661 gcctcggaat gagaggggcg ggccttcaaa atgagagggg gcaaggcctc agaatgagga
     3721 gaggctcagc ataagagagg cggggcttca gaacgagggg cggggcctct aggcctcctt
     3781 tctcagcttc ccttgctccg tgagctcatc ccctatctga aggccctcct gagaatgtga
     3841 gtccttctag gaagagactt tggaagtgga tgtgctaatc ttggggggta ctgtcctttg
     3901 tgagcaacag tgcagtcctg ggagtggcct ttcatctgaa ttgctttcta tactggcttc
     3961 tgactcttcc tggaagctag agccacaaac aggtatatcc acactgccta tcaccccagt
     4021 aacagaaatg cagggcagag cctcagtgac ctagaactct gtgcacctgg ctggcacaga
     4081 ctgcagtcca ggttgggtgg ttctggtctt gtgtagtttg cctcatcact tctggggttg
     4141 tcgccatctc tgaaatcccc gtgggtaggt atatgggtga gacagcactg gcctctgggt
     4201 cttaggtcac cccatgacgg tagaggcaga aatgggtggt gtttttttag taagtggata
     4261 cccccacttg ctaaccatgt caaagcaagt tgaacggctg aagccagcat ccagccctgg
     4321 gaaggtgaac ccttgtcttg gggtcttctc ttggtagtca tgtgacagaa gcctggtaat
     4381 tcagaggggg tcccataagc ctacctcccc aggatcacac ttctgtcctg caccccagta
     4441 tctacactcc aatgttttga ttggggacag ctggagcaga tccaaagact tactggccat
     4501 ggagagtctc agcatttatt ctaagtctct agctcccaca gtcctccccc ctccagtgct
     4561 ccccaagacc tgacccaacc tgttcagtga cagccttgtg ccaggtatgt cccctctagt
     4621 cctatggact actggacctt ggtgttacct caggccagct ggggcctctg cagccagaca
     4681 tggtgtgtgg gctctcggag ccctgctctg ctctgaggac gagagaggcc ccgcgcagag
     4741 cagcaacctt aatctggatg caattagagg aaaccagcca aatgccctgt ggcagctgtt
     4801 accccaggat tattcccagt cagcaaaagg cattagagtg ataattcagt cattagactt
     4861 ctagctgtct cacagccagg acgtacaaat cacgggtaat cagcaagtac accgtcccct
     4921 ggccacgagg cttatttaac ccattttttt aaaaaaatga tgcttaatgc tattggccgg
     4981 gcgcatctgt gtgcgcatgc cccaccgata atgtctgtgc tgacgacatt gcttaatgtc
     5041 accaaggcct tgtcatctag ggctctggga gagaaggacg cctttgatgt gcgtgtgtgc
     5101 tgtcactgct gagacatgat gcctaccttg gaaagggcgc cctcacttct gactcaccct
     5161 ccaaggagaa gggagagggc aagggagggg gcagcagcag aatgtgtcct cctctctctg
     5221 ggttagagga tgtcttcact gggcacagga aagacattgc ctgcctagaa agttgcacct
     5281 ggagtgccag ccaagaggcc tagctgtttc tgcagaggag ggccgaagtc cccagagagg
     5341 ctctgttagt aaccttgagc tgggcgatct gttgcagagc tatgtggttg ctgatcaaac
     5401 cgacccgggt tagggagggg cacatgctac attcagaagg ggatgactgg gggcctggct
     5461 ttgagtgcag gacaccagcc caagagaggc tctggagctg gtgccttcga tggccagggc
     5521 aggatggcag taaataagtg ggaagaggaa tgcttgctgt cagggtcagc tcctgaaagg
     5581 ctcctttgac ctctggcctg tatttgtgtt ttccttactg ctttgctggg gttttgctgt
     5641 gctggggagg ggggagtagg gggtgcagta cgtggaactt gctaggccat aagcgatgca
     5701 gtcgtctttg acaacattaa tttagatggc gatcaacccc agggttcctg gaatccacct
     5761 gtgacctccc tccgctctgt cagttccctt ctactgcagt caggccagga gtgtcaggca
     5821 tacccggggc tggccagaca gagggaagga acctggcaga gatccctgga ggccaccctg
     5881 cctagaacgg agacgatgat gacaggttcc cccagaaaac ttatgcaggg ctatgctatg
     5941 gcctgggtta taggggagcc aggactgcca cccagctggg ccaccagaga cgacataggg
     6001 aaactggcta gcctgaggct ggacctggca gatccctgga gtctctgaag agacaagtgg
     6061 cctctgggtg ttagtgttgt gtttctacag aagctgtgat gtgttttgtc atgggctagc
     6121 ctggtctagc cggattgtga caccccaaat ctaagaagcc agtttctccc agagcttctg
     6181 cagcagggag caaggggttc ccccagccca cttccttgcc tataaaagga gaacaaggcc
     6241 ctcccacaga ctccttcaaa agacttctct gaggctgcca tgagggtggc taactatggc
     6301 ccagggactt cacccgccac tcagggacga gcccactggc cttagccttc cgcagcattg
     6361 accgagaggg gttgtccact cccagtcgaa tgccctccca ggtctgaagt cagcaaacca
     6421 atgcctctcc tgcacttcta ccttgctgag tgtcctccgc agagggcaaa tctctctgta
     6481 acgttcactc tgtgccaccc acgcctaccc tgaagaaaaa tgagccacaa agccgcctca
     6541 gcggtctcgg tctgcgccta gctatgcaca taggtgtttg cagagctctt ccatggacgg
     6601 ccctcggagg gggagaccct ttctgaggac tctgcacttt ctgagcagct gcgtgcagat
     6661 gcctgctgcc accaggcctt taaatacatt gtgttcaatt ccaggtggga agatagcatt
     6721 tcaggtttgc agaaatcaag tcacatgact gtcttccttc cacactttga ggataaggag
     6781 gacagctttt ttgtgtgttt cgttttgttt ttaaagtaag gaaatacccc cattgctgat
     6841 gtctatagca agtgattcgt ttctctgttg cattttgttt ttttaagcag tccccttccg
     6901 gtcaaggtca ggactggtca ccatgacccc tgtgaataat gattctcatg gattcctcac
     6961 aaaacaaata aaatagtatc accacaca
//
