LOCUS       NM_025706               3779 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus TBC1 domain family, member 15 (Tbc1d15), mRNA.
ACCESSION   NM_025706
VERSION     NM_025706.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3779)
  AUTHORS   Yu W, Sun S, Xu H, Li C, Ren J and Zhang Y.
  TITLE     TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers
            cardioprotection against acute myocardial infarction-induced
            cardiac injury
  JOURNAL   Theranostics 10 (24), 11244-11263 (2020)
   PUBMED   33042281
  REMARK    GeneRIF: TBC1D15/RAB7-regulated mitochondria-lysosome interaction
            confers cardioprotection against acute myocardial
            infarction-induced cardiac injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3779)
  AUTHORS   Kwon D, Park E and Kang SJ.
  TITLE     Stimulator of IFN genes-mediated DNA-sensing pathway is suppressed
            by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15,
            mitochondrial dynamics mediators
  JOURNAL   FASEB J 31 (11), 4866-4878 (2017)
   PUBMED   28729291
  REMARK    GeneRIF: nigericin-induced mitochondria fission was rescued by
            knockdown of either dynamin-related protein 1 or TBC1 domain family
            member 15 (TBC1D15), which are two distinct mitochondria fission
            regulators, only TBC1D15 restored the activity of the STING
            pathway, which indicates that inflammasome-activating signals
            curtail STING pathway activation via TBC1D15.
REFERENCE   3  (bases 1 to 3779)
  AUTHORS   Feldman DE, Chen C, Punj V and Machida K.
  TITLE     The TBC1D15 oncoprotein controls stem cell self-renewal through
            destabilization of the Numb-p53 complex
  JOURNAL   PLoS One 8 (2), e57312 (2013)
   PUBMED   23468968
  REMARK    GeneRIF: identify TBC1D15 as a Numb-associated protein and
            demonstrate that its amino-terminal domain disengages p53 from
            Numb, triggering p53 proteolysis and promoting self-renewal and
            pluripotency
REFERENCE   4  (bases 1 to 3779)
  AUTHORS   Peralta ER, Martin BC and Edinger AL.
  TITLE     Differential effects of TBC1D15 and mammalian Vps39 on Rab7
            activation state, lysosomal morphology, and growth factor
            dependence
  JOURNAL   J Biol Chem 285 (22), 16814-16821 (2010)
   PUBMED   20363736
  REMARK    GeneRIF: although only TBC1D15/Rab7-GAP altered Rab7-GTP levels,
            both Rab7-GAP and mVps39 regulate lysosomal morphology and play a
            role in maintaining growth factor dependence
REFERENCE   5  (bases 1 to 3779)
  AUTHORS   Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J and Lickert H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3779)
  AUTHORS   Ballif BA, Villen J, Beausoleil SA, Schwartz D and Gygi SP.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 3779)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 3779)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3779)
  AUTHORS   Sandrin MS, Apostolopoulos J and McKenzie IF.
  TITLE     This is an addendum to the February 2000 article by Apostolopoulos
            et al., 'Ly6d-L, a Cell Surface Ligand for Mouse Ly6d.'
  JOURNAL   Immunity 13 (6), 853-854 (2000)
   PUBMED   11163200
REFERENCE   10 (bases 1 to 3779)
  AUTHORS   Apostolopoulos J, McKenzie IF and Sandrin MS.
  TITLE     Ly6d-L, a cell surface ligand for mouse Ly6d
  JOURNAL   Immunity 12 (2), 223-232 (2000)
   PUBMED   10714688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618866.1, BC053395.1, AK147085.1 and BY435567.1.
            
            [WARNING] On Jan 16, 2024 this sequence was replaced by
            NM_025706.4.
            
            On Aug 14, 2009 this sequence version replaced NM_025706.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147085.1, BC053395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BB618866.1         5-32
            29-243              BC053395.1         10-224
            244-3412            AK147085.1         207-3375
            3413-3496           AK147085.1         3377-3460
            3497-3773           AK147085.1         3462-3738
            3774-3779           BY435567.1         424-429
FEATURES             Location/Qualifiers
     source          1..3779
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 63.51 cM"
     gene            1..3779
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /note="TBC1 domain family, member 15"
                     /db_xref="GeneID:66687"
                     /db_xref="MGI:MGI:1913937"
     exon            1..112
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2098
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /EC_number="1.15.1.1"
                     /note="GAP for RAB7; GTPase-activating protein RAB7;
                     lymphocyte antigen 6, locus D ligand"
                     /codon_start=1
                     /product="TBC1 domain family member 15"
                     /protein_id="NP_079982.3"
                     /db_xref="CCDS:CCDS24176.1"
                     /db_xref="GeneID:66687"
                     /db_xref="MGI:MGI:1913937"
                     /translation="MAAAGVVSGKIIYEQEGVYIHSSCGKANDQDSLISGILRVLEKD
                     AEVIVDWRPLDDALDSSSILCAGKDSSSVVEWTQAPKERAHRGSDQQSSYEAEWDMVT
                     TVSFKKKPHTNGDAPGHRNGKSKWSFLFSLADLKSVKQSKEGMGWSYLVFCLKDDVML
                     PALHFHQGDSKLLIESLEKYVVLCESPQDSRTLLVNCQNKSLSQSFENLLDEPAYGLI
                     QKIKKDPYTATMVGFSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQE
                     EPGFEVITRIDLGERPVVQRREPVSLEEWNKSLDPEGRLVAVESMKQKIFRGGLSHSL
                     RKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSVSEAQEKRNSRLRDYRS
                     LIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVM
                     ENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYL
                     YFCFRWLLIRFKREFSFLDILRLWEVMWTELPCKNFHLLLCCAILESEKQQIMAKHYG
                     FNEILKHINELSMKIDVEDILCKAEAISLQMAQCKELPQAVCEILGLQDSEITTPDSD
                     TDENVGSPCPVSAFPSSTLPILAASEAKDDSPTQTLASPNACRLTPA"
     exon            113..211
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            212..286
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            287..425
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            426..636
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            637..739
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            740..937
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1066
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1170
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1265
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1382
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1483
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1583
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1681
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1798
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1885
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..3779
                     /gene="Tbc1d15"
                     /gene_synonym="4432405K22Rik; Ly6dl; Rab7-GAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttagcccg accggatgtt gttgtgagtc cgagagccac gtgaggttgt gctacgtcat
       61 caccaggcac gcgcggggga acatggcggc ggcgggtgtt gtgagcggga agattatata
      121 tgaacaagaa ggagtatata ttcactcatc ttgcggaaag gcaaatgacc aagacagctt
      181 gatttcagga atattgcgtg ttttagaaaa ggatgctgaa gtaatagtgg actggagacc
      241 attggatgat gcattagatt cttccagtat tctgtgtgct ggaaaggact ccagctcagt
      301 cgtagagtgg actcaggctc caaaggaaag agctcatcgg gggtcggacc agcagagcag
      361 ctatgaagcg gagtgggaca tggttactac agtgtccttt aagaagaaac cacacaccaa
      421 tggagatgct ccaggccata ggaacgggaa aagcaaatgg tcgttcctgt tcagcctggc
      481 agacctgaag tcagtcaagc agagcaagga gggcatgggc tggtcgtacc tggtcttctg
      541 cctgaaggat gacgtcatgc tgcctgccct gcacttccat caaggagaca gcaaactgct
      601 gatcgagtct cttgagaaat acgtggtatt gtgtgagtca ccacaagata gtagaacact
      661 tctagtcaat tgtcagaata agagtctctc acagtctttt gaaaatcttc ttgatgaacc
      721 agcatatggc ttaatacaaa aaattaaaaa ggatccttat acagcaacca tggtaggatt
      781 ttccaaagtt acaaactaca tttttgacag tttgcgaggc agcgatccct ctacacatca
      841 acgaccacct tcagaaatgg cagattttct tagtgacgct atcccaggac tcaagataaa
      901 ccagcaagaa gagccaggat ttgaagtcat cactagaatt gatttgggag agcgacctgt
      961 tgtgcaaagg cgggagccag tgtccctgga agaatggaac aagagccttg accctgaagg
     1021 aagactcgta gccgtggaga gcatgaagca aaagatattc agagggggtc ttagtcattc
     1081 attaagaaag caagcatgga aatttctcct gggttatttt ccttgggata gtaccaaaga
     1141 ggaaagaact cagttacaaa aacaaaaaac tgatgagtac ttcaggatga aactgcagtg
     1201 gaagtctgtc agtgaggctc aggagaagag aaactcacgc ctgagagact acagaagtct
     1261 gatcgagaaa gatgtcaaca gaacagatcg aacgaacaag ttttatgaag gccaagataa
     1321 cccagggctg attctgcttc acgacatttt gatgacctac tgtatgtatg actttgattt
     1381 aggatatgta caaggaatga gcgacttact ttccccactt ttgtatgtga tggagaatga
     1441 agtggatgcc ttttggtgct ttgcctctta catggaccag atgcatcaaa attttgaaga
     1501 acaaatgcag ggcatgaaga cgcagttaat ccagttgagt accttactca ggttactgga
     1561 cagtggattt tgtagctatt tagaatccca ggactctgga tatctatatt tttgcttcag
     1621 atggctttta atcagattta aaagggaatt tagttttcta gatatacttc gattatggga
     1681 ggtaatgtgg actgaactgc cctgtaagaa ttttcatctt cttctgtgtt gtgccatcct
     1741 ggaatcagaa aagcaacaga taatggcaaa gcactatggc ttcaatgaaa tccttaagca
     1801 catcaatgag ttgtccatga agattgatgt ggaagatata ctctgtaaag cagaagcaat
     1861 ttccctacag atggcacaat gcaaggaatt gccacaagca gtttgtgaga tcctgggact
     1921 tcaggacagt gaaattacaa cgccagattc cgacactgat gaaaatgttg gcagcccttg
     1981 tcctgtatct gcgtttccaa gtagcacctt gcccatcctt gctgccagtg aagccaaaga
     2041 tgacagtcca acacagacat tagcatcccc gaatgcctgc agattaacac ctgcatgatc
     2101 atttgtctta cagtttttga gatactttgt tgcaattcct ttttaagtac atgaaagata
     2161 gacattcacg gtcttggtat tgatcatgct ttaagtttta tggagagaca gtgtactgat
     2221 gttcttgcat taaagcttta caaagtttta aactaattat ttttgtagtt acttctacca
     2281 aatagccttt ccttttcaat aacattcctt agtattttta tagccaagca cattttattt
     2341 tgttgctgat gaactgggat tggataaata cttcaagtgg aagctttgga aattatgcac
     2401 ttggaaaagc actcactgtt tattctttag agggctttgg acttgattac attaaatgtt
     2461 gagcctttat aaagcattct aagctgagaa gtacattgtt actcagagat gaaatttaaa
     2521 atacaaattt ggcttttcta ttgtttacaa caatattcag cttaactatt tatgctggtt
     2581 gaatgtgatt taaataagac atttttacca acgtagttaa acgtgtggat aaagaactgt
     2641 ttcaacctta gcaactggat tggcagtctg ggttttttac aaagaacttt tcttcacttg
     2701 tatataggct atatatatgt actatttatg agtataagaa agcatagtcc tattttcttt
     2761 aactgaataa acttgactat tgatttatat aagctgattc aacaaaatta atacatggct
     2821 tcaatataag atctttttca aaactatttt cttaactgaa catttattta atgagactac
     2881 attgagccct gtctatacct ggtataaatc actgtaacct ctttactaat aatgtttatt
     2941 atctttccta atactgcact aattggttaa tcagatcgtt acatttttaa aaatattctt
     3001 tgcaaaaagc ttatgtcaga agtttccagg cactgtcatg agtcggaaag gaatattttt
     3061 ttgtatatga atgaagctgt ttttaccatg cagtgttgca tgtttttaag ttctgtggaa
     3121 ttgccataac aaattccgtt ttaattgtaa tttgttaact cttgtacata tcattaaatg
     3181 aaatcaaagc tattttagtg ttttcagtta cattgcactt agaaacggct gcttcttcat
     3241 cagagcgtgc acctcagcat gtcacagcca ccaagccagt gagtcatggg cgcaccaaca
     3301 tgcacaactc ctccatacgt gagcacactg ttcagaagtg tgcatgctca tggcgtgtca
     3361 ccgaagcagc tgtcttgtga tgcttgtata cattgtttgt ttggtttttt ttcttcccca
     3421 gaaagtaaag gaacttgccc actagctgag tattaacgga cagtcgtggc cctagagcca
     3481 tcagatgtgg gtttttaata ttgtgtgtta tctctcatca gttaataatg agtaagccca
     3541 tttagaagag taaactgctc acaagcgcat catctccagc ctttcatttc ctgccatgca
     3601 ggaaattgct cagaacatct tgatgtcctc ctcgttcttc ctggacagtg ggtgttcgga
     3661 cgtctttcta cgtaatacaa tatctacttc agattaaaga aaatttaata tgtttcataa
     3721 gttgaacttt tgtcaagttt tggtatgaaa ctgcttgtta aaatattttt actaaaaat
//
