LOCUS       NM_178650               1781 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TBC1 domain family, member 10c (Tbc1d10c), mRNA.
ACCESSION   NM_178650
VERSION     NM_178650.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Pane,R., Laib,L., Formoso,K., Detrait,M., Sainte-Marie,Y.,
            Bourgailh,F., Ruffenach,N., Faugeras,H., Simon,I., Lhuillier,E.,
            Lezoualc'h,F. and Conte,C.
  TITLE     Macromolecular Complex Including MLL3, Carabin and Calcineurin
            Regulates Cardiac Remodeling
  JOURNAL   Circ Res 134 (1), 100-113 (2024)
   PUBMED   38084599
  REMARK    GeneRIF: Macromolecular Complex Including MLL3, Carabin and
            Calcineurin Regulates Cardiac Remodeling.
            Erratum:[Circ Res. 2024 Feb 16;134(4):e2. doi:
            10.1161/RES.0000000000000658.. PMID: 38359097]
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Cohen,A.O., Woo,S.H., Zhang,J., Cho,J., Ruiz,M.E., Gong,J., Du,R.,
            Yarygina,O., Jafri,D.Z., Bachelor,M.A., Finlayson,M.O., Soni,R.K.,
            Hayden,M.S. and Owens,D.M.
  TITLE     Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell
            anti-tumor response
  JOURNAL   Oncoimmunology 11 (1), 2141011 (2022)
   PUBMED   36338148
  REMARK    GeneRIF: Tbc1d10c is a selective, constitutive suppressor of the
            CD8 T-cell anti-tumor response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Ni,X., Wu,X., Zhu,X.X., Li,J.H., Yin,X.Y. and Lu,L.
  TITLE     Carabin Deficiency Aggravates Hepatic Ischemia-Reperfusion Injury
            Through Promoting Neutrophil Trafficking via Ras and Calcineurin
            Signaling
  JOURNAL   Front Immunol 13, 773291 (2022)
   PUBMED   35265067
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Villagomez,F.R., Diaz-Valencia,J.D., Ovalle-Garcia,E., Antillon,A.,
            Ortega-Blake,I., Romero-Ramirez,H., Cerna-Cortes,J.F.,
            Rosales-Reyes,R., Santos-Argumedo,L. and Patino-Lopez,G.
  TITLE     TBC1D10C is a cytoskeletal functional linker that modulates cell
            spreading and phagocytosis in macrophages
  JOURNAL   Sci Rep 11 (1), 20946 (2021)
   PUBMED   34686741
  REMARK    GeneRIF: TBC1D10C is a cytoskeletal functional linker that
            modulates cell spreading and phagocytosis in macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Bisserier,M., Berthouze-Duquesnes,M., Breckler,M., Tortosa,F.,
            Fazal,L., de Regibus,A., Laurent,A.C., Varin,A., Lucas,A.,
            Branchereau,M., Marck,P., Schickel,J.N., Delomenie,C., Cazorla,O.,
            Soulas-Sprauel,P., Crozatier,B., Morel,E., Heymes,C. and
            Lezoualc'h,F.
  TITLE     Carabin protects against cardiac hypertrophy by blocking
            calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II
            signaling
  JOURNAL   Circulation 131 (4), 390-400 (2015)
   PUBMED   25369805
  REMARK    GeneRIF: Carabin functions as an endogenous inhibitor of
            calcineurin, Ras and CamKII kinase which resulted in protection
            against cardiac hypertrophy.
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Schickel,J.N., Pasquali,J.L., Soley,A., Knapp,A.M., Decossas,M.,
            Kern,A., Fauny,J.D., Marcellin,L., Korganow,A.S., Martin,T. and
            Soulas-Sprauel,P.
  TITLE     Carabin deficiency in B cells increases BCR-TLR9
            costimulation-induced autoimmunity
  JOURNAL   EMBO Mol Med 4 (12), 1261-1275 (2012)
   PUBMED   23109291
  REMARK    GeneRIF: Carabin as a new negative regulator of B-cell function,
            whose deficiency in B cells speeds up early B-cell responses
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ829173.1, AK040487.1 and AA217314.1.
            
            On Mar 2, 2007 this sequence version replaced NM_178650.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040487.1, AK153836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               BQ829173.1         237-563
            328-1744            AK040487.1         329-1745
            1745-1781           AA217314.1         232-268
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.88 cM"
     gene            1..1781
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /note="TBC1 domain family, member 10c"
                     /db_xref="GeneID:108995"
                     /db_xref="MGI:MGI:1922072"
     exon            1..29
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            30..201
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1390
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /note="EBP50-PDZ interactor of 64 kD"
                     /codon_start=1
                     /product="carabin"
                     /protein_id="NP_848765.2"
                     /db_xref="CCDS:CCDS37885.1"
                     /db_xref="GeneID:108995"
                     /db_xref="MGI:MGI:1922072"
                     /translation="MAQALGEDLLSELQDDSSSLGSDSELSGPSPYRQADRYGFIGGN
                     SGELRLCQPSADLIRQREMKWVEMTLHWEKTMSRRYKKVKIQCRKGIPSALRARCWPL
                     LCGARMCQKNNPGTYQELAAAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQ
                     VLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVQ
                     LDAEVFMALLRRQLPRVYKHLQQVGVGPLLYLPEWFLCLFTRSLPFPTVLRIWDAFLS
                     EGAKVLFRVGLTLMRLALGTVEQRTACPGLLETLGALRAIPPTQLQEEVFMSQVHSVT
                     LSERVLQQEIRIQLAQLSKSLPGPAPLPQARLPGAQAIFESQQLAGVRESTKPEIPRI
                     VVQPPEEPKPPRRKPQTRGKTFHGLLIRARGPPIEGPSRSQRGSASFLDTRF"
     exon            202..301
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            302..409
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            410..516
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            517..631
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            632..697
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            698..887
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1042
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1759
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1700..1705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /note="hexamer: AATAAA"
     regulatory      1726..1731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /note="hexamer: GATAAA"
     polyA_site      1727
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /note="major polyA site"
     polyA_site      1747
                     /gene="Tbc1d10c"
                     /gene_synonym="1810062O14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagaagaaga ggtgaggtgc agcaaggagc ctgtgacact ggggtccagg gcagaatggc
       61 ccaggccctg ggagaggact tgttatcaga actacaggat gattctagct ccctagggtc
      121 tgactcagag ctgagtgggc ccagtccata tcgccaggct gaccgttatg gcttcattgg
      181 gggcaactca ggtgaactga ggctttgtca accctctgca gacctcatcc gccagcgaga
      241 gatgaaatgg gtggaaatga ccttacactg ggagaagacc atgtcccgac gatacaagaa
      301 ggtaaagatc cagtgccgca agggcatccc ctcagccctg cgtgcccggt gttggcccct
      361 cctgtgtggg gcccggatgt gtcagaagaa caaccctggc acctaccagg agctggcagc
      421 agcccccggg gacccgcagt ggatggagac cattggcaga gacttgcacc gtcagtttcc
      481 tctgcatgag atgtttgtgt caccccaggg acacgggcag caggggctgc tgcaggttct
      541 caaggcctac accctgtacc ggccagagca gggatactgc caggctcagg gacctgtagc
      601 tgctgtgctg ctcatgcatc tacccccaga ggaggccttc tggtgcttgg tgcagatctg
      661 cgaggtctac ctccctggct actatgggcc ccacatggag gccgtacagc tggatgctga
      721 agtgttcatg gcccttctga ggcggcagct cccacgagtg tacaagcacc tgcagcaggt
      781 aggcgtcggc cccctgctct acctgcctga gtggttcctg tgcctcttca ctcggtcgct
      841 gcccttcccc acagtactgc gcatctggga tgccttcctc agtgaggggg ctaaggtact
      901 gttccgcgtg gggctgacac tgatgcgcct ggcactgggc actgtagaac agcgcacagc
      961 atgcccaggg ctcctggaga cattgggggc cctacgagcc attcccccta cccagctgca
     1021 ggaagaggtc ttcatgtccc aggtgcacag tgtaaccctg tctgagcgag tcctgcaaca
     1081 ggaaatcagg atccagctag cccagctttc gaagtcactc cctgggccag cccctctgcc
     1141 acaggcccgc cttcctgggg cccaagccat cttcgagtcc cagcagctgg caggggttcg
     1201 agaaagcacc aaacctgaga tacctcgaat tgtggtgcag cctccagagg agcccaagcc
     1261 accacggcgc aagccacaga cccggggtaa gactttccat ggactcctga taagggccag
     1321 gggaccccct attgagggcc cctccaggtc ccaacgaggc tctgcctctt tcctggacac
     1381 ccgattctaa gtgcaccata cacttagtgc caccatatct caatcatctg agcagtgatg
     1441 ccagccccag gcatgtatcc tctattgctg tgctatgtga caatgctgtt tccagcaagg
     1501 accaccgtga ggagtggagt gtctcctcac tttaaggact gtatcaggca caaagataaa
     1561 gaaggatgct gagtggagct tgtggggagc tgtttggtgc ttgccattgc cagcatcaaa
     1621 gccagcactg aaggattgtg ggaataaagc ctctggctga gatatggtac cccatgggct
     1681 tcttgcaagg gaatcctcaa ataaagcctg actgagaaga tactagataa agttggatca
     1741 aatattcctc cactctccaa aaaaaaaaaa aaaaaaaaaa a
//
