LOCUS       NM_144522               3614 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TBC1 domain family, member 10b (Tbc1d10b), mRNA.
ACCESSION   NM_144522
VERSION     NM_144522.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3614)
  AUTHORS   Egami,Y., Kawai,K. and Araki,N.
  TITLE     Rit1-TBC1D10B signaling modulates FcgammaR-mediated phagosome
            formation in RAW264 macrophages
  JOURNAL   Life Sci Alliance 7 (10), e202402651 (2024)
   PUBMED   39084876
  REMARK    GeneRIF: Rit1-TBC1D10B signaling modulates FcgammaR-mediated
            phagosome formation in RAW264 macrophages.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3614)
  AUTHORS   Hou,Y., Chen,X., Tolmachova,T., Ernst,S.A. and Williams,J.A.
  TITLE     EPI64B acts as a GTPase-activating protein for Rab27B in pancreatic
            acinar cells
  JOURNAL   J Biol Chem 288 (27), 19548-19557 (2013)
   PUBMED   23671284
  REMARK    GeneRIF: EPI64B can serve as a potential physiological GAP for
            Rab27B and thereby participate in the regulation of exocytosis in
            pancreatic acinar cells.
REFERENCE   3  (bases 1 to 3614)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047320.1 and AC122537.4.
            
            On Feb 11, 2008 this sequence version replaced NM_144522.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047320.1, AK047327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AK047320.1         2-196
            196-196             AC122537.4         183342-183342       c
            197-3280            AK047320.1         198-3281
            3281-3281           AC122537.4         172861-172861       c
            3282-3608           AK047320.1         3283-3609
            3609-3614           AC122537.4         172528-172533       c
FEATURES             Location/Qualifiers
     source          1..3614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.38 cM"
     gene            1..3614
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /note="TBC1 domain family, member 10b"
                     /db_xref="GeneID:68449"
                     /db_xref="MGI:MGI:1915699"
     exon            1..1019
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2502
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /note="protein wz3-85"
                     /codon_start=1
                     /product="TBC1 domain family member 10B"
                     /protein_id="NP_653105.3"
                     /db_xref="CCDS:CCDS40139.2"
                     /db_xref="GeneID:68449"
                     /db_xref="MGI:MGI:1915699"
                     /translation="METGPAPLVAPPRRHGAPAAPSPPPRGSRAGSHLVVEPGPPVTT
                     ATSAPVELVAPGEARPACVPGSSQTSASTPTTATSSTVVMLTLEASPEAAKTQEFPAP
                     AAETGAETSVALALGTDTQKTEEVRASPVPGPGTPTRTPSRMAPGALTAKPPLAPKPG
                     TTVASGVTARGGVGQVAGGHEAATSASAGSVPEDPSGPVTGPPGTCEAPAPTPVAVVT
                     VTPAPEPVENFQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLPDDVSSM
                     GSDSEINGMALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLEMFSNWDKWLSR
                     RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAAGDPKWLDVIEKD
                     LHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQA
                     FWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRVSPLAHRHLRRQRIDPVLYMTE
                     WFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETM
                     EQLRNLPQQCMQEDFLVHEVTNLPVTEAWIERENAAQLKKWRETRGELQYRPSRRLHG
                     SRAIHEERRRQQPPLGPSSSLLSLPSLKSRGSRAVGGAPSPPPPVRRASAGPVPGAVV
                     IAEGLHPSLPSPTGNSTPLGTSKEIRRQEKERQKQEKDREKERQRQEKERERQEKERQ
                     KWEKEQEKEQQKQEKERQKLEKKGQGRKLSLRRRADGPPASHDGGDRSAAEARQDAYF
                     "
     exon            1020..1119
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1227
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1334
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1449
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1515
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1705
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1860
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..3614
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /note="hexamer: AATGAA"
     polyA_site      3276
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /note="major polyA site"
     polyA_site      3506
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3614
                     /gene="Tbc1d10b"
                     /gene_synonym="1110003P22Rik"
ORIGIN      
        1 gcccttcgcc ctctctgcag ccccggcggg ctgctccggg cggcctgagg ggcggcgcct
       61 tctgcggcct ccccggcggg gggatgtgag gggccgcccg cagctatgga gacgggtccg
      121 gcgccccttg tggccccgcc gcgccgccac ggcgcccccg ctgccccttc gcccccgccc
      181 cggggctccc gggccggatc gcacttagtg gtggaaccgg gaccgccagt gactacagcc
      241 acttcggccc cagtcgaatt ggtggccccc ggggaggctc ggcccgcctg cgtcccagga
      301 tcatcacaga cctcggcctc tacacccacg acagctacga gcagcacggt agtgatgctg
      361 accctggagg cctcacccga agccgcgaag acgcaagagt tccccgcacc agcggcagaa
      421 acaggagccg agacgtcggt ggctttggct ttggggacag acactcaaaa gacggaagag
      481 gttcgagcct ctcctgtccc aggaccaggg acccccactc ggacaccttc cagaatggcg
      541 cctggagccc tgactgccaa acccccgctt gcccccaagc cggggaccac agtggcttca
      601 ggagtgactg cacggggtgg agtaggacag gtggcaggtg ggcatgaagc tgcgacctca
      661 gcatcagcag ggtcggtgcc tgaggacccc tcagggcctg tcacaggccc tcccgggaca
      721 tgcgaggctc cggctccgac tccggtggct gtggtgacag tgaccccagc tccggagcct
      781 gttgaaaact ttcaagacct gggctccacg tccagtctag gacctggcat ctcggggcct
      841 cggggtcagg ccccagacac cctgagctac ttggactccg tgagcctcat gtcagggacc
      901 ttggagtcct tgccggatga tgtgagctcc atgggttcag actcggagat aaatgggatg
      961 gccctgcgca agacggacaa gtatggtttc cttgggggca gccagtactc aggcagccta
     1021 gagagctcta ttccggtgga tgtggctcgc cagcgggagc tcaagtggct ggagatgttc
     1081 agtaactggg ataagtggct gtcacggcgt ttccagaagg taaagctgcg ctgccggaaa
     1141 ggaatcccct cctctctgag agccaaggcc tggcagtacc tgtctaatag caaggaactc
     1201 ctggagcaga accctggcaa gtttgaggag ctggagcggg ctgctgggga ccccaagtgg
     1261 ctcgatgtga ttgagaagga cctgcatcgc cagttccctt tccatgagat gtttgctgct
     1321 cgaggagggc atgggcaaca ggacctgtac cgaatcctga aggcctatac catctacagg
     1381 cctgacgagg gctactgtca ggcccaggcc ccagtggctg cggtgttgct aatgcacatg
     1441 cctgctgagc aagcgttttg gtgcctggta cagatctgcg acaagtacct cccaggttac
     1501 tacagtgcag ggctggaagc cattcagttg gatggagaaa tcttttttgc actcctgcgc
     1561 cgggtctctc cgctggcaca tcgtcacctt cggcggcagc gcattgaccc tgtgctctac
     1621 atgacagagt ggttcatgtg catctttgcc cgcaccctcc cctgggcttc agtgctgcgt
     1681 gtctgggaca tgtttttctg tgaaggcgtt aagatcatct tccgagtggc tctggtttta
     1741 ctgcggcaca cactgggttc tgtggaaaag ctgcgctcat gtcaaggcat gtatgaaacc
     1801 atggagcagc ttcgaaacct accacaacag tgtatgcagg aggacttcct ggtgcatgag
     1861 gtaaccaacc tcccagtgac agaagcatgg attgagcggg agaatgcagc ccaactgaag
     1921 aagtggcgag aaactagagg agagctgcag tatcggccct cacggcgact acacggctcc
     1981 cgagccatcc atgaggaacg caggcggcag cagccacccc tgggcccttc ctctagcctc
     2041 ctcagcctcc ctagtctcaa gagcagaggc tcccgggcag ttggaggggc tccttcccca
     2101 ccacctcctg tccgcagggc tagtgctggg cccgtccctg gggctgtcgt cattgctgag
     2161 ggactgcatc catcccttcc ttcacctact ggtaacagca ccccactagg caccagcaag
     2221 gagatcaggc ggcaggagaa agagcggcag aaacaggaga aagatcgaga gaaggagcgg
     2281 cagagacaag agaaggagcg ggaaaggcag gagaaggagc ggcagaagtg ggaaaaggag
     2341 caagagaagg aacagcagaa gcaggagaag gagcggcaga agctggagaa gaaaggccaa
     2401 ggccggaaac tgtccttgcg tcgaagggca gatgggcccc cggcatccca tgatggtggg
     2461 gacaggtcag cagctgaggc ccggcaggat gcttactttt gacctctggt tggatctgga
     2521 tggcatggcc ctcctccttc ccctcatcga gagcagccct ggcaggctct cccagctccc
     2581 cttggcaggc tcttcctttt tctgaggaaa gtggcttgat tcccctgact ccttgccagc
     2641 tgctgatccg tacatggcca ggacagccac agtgcaaggg acagctgcat tacctagggt
     2701 aacagtgacc aagtctggag acccttttgt ccagttaggc tcagcttggg tctctgtcac
     2761 acctatgaaa tccttctggg gtgctgtctt acactccggt ggcttccctt agatggtgga
     2821 gctaggttcc ttttcctgtc ttggggccct gcctgtcacc ccactgccta ctgggggcca
     2881 aggctgtttt ctctcctgga tatccttgtg ttgtaattat gtacagaagg tcaggttggc
     2941 ctggggtggg tgctgtcctt tcccctctcc acagcgctgc ttcactccag tttatttaag
     3001 aggatatgct aggaagtgtc ctccgtctcc ttcccacccg tgccctgctc tctcctaact
     3061 cacttgcttt gtatgctcag gcctctctgc tgcagtcaca aagtctgtct tcgattttgt
     3121 tcctttctag ccatcaagcc cctctctgaa taagggtctt cccttgagtc caggggtgga
     3181 acccaatgtt tacattctct tctgtcttgg tcccacctca gtggcagttt tgtggcgctt
     3241 tgaggaaccg gaaaatgaac ctgctgttat atctgtctcc cgccttgtta tttgaagagt
     3301 gctgtagagt aaggggagtg ggggaggcag gcacaaagtc tgactttcca taggttcagt
     3361 ctgcaggtct tggcaggaac atctggacca ctggttctca atcttcctaa tgctgtgacc
     3421 ctttaataca gttctttata ttgtggtgac tccaaccata aaattatttt cattattact
     3481 taataacagt atactactgc tatgaatcat aatgtacgtc tctgttttct gatagtctta
     3541 ggcaacctct gtgaatagta ttcgaccccc aaaaggagtc acagtaaacg ctcacttcat
     3601 ctctcatcaa caaa
//
