LOCUS       NM_134023               3796 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus TBC1 domain family, member 10a (Tbc1d10a), mRNA.
ACCESSION   NM_134023
VERSION     NM_134023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Itoh,T. and Fukuda,M.
  TITLE     Identification of EPI64 as a GTPase-activating protein specific for
            Rab27A
  JOURNAL   J Biol Chem 281 (42), 31823-31831 (2006)
   PUBMED   16923811
  REMARK    GeneRIF: EPI64 is a GTPase-activating protein specific for Rab27A
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Reczek,D. and Bretscher,A.
  TITLE     Identification of EPI64, a TBC/rabGAP domain-containing microvillar
            protein that binds to the first PDZ domain of EBP50 and E3KARP
  JOURNAL   J Cell Biol 153 (1), 191-206 (2001)
   PUBMED   11285285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807825.5.
            
            On Oct 3, 2022 this sequence version replaced NM_134023.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.132842.1, BC018300.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AL807825.5         58623-58870
            249-348             AL807825.5         77528-77627
            349-456             AL807825.5         81697-81804
            457-563             AL807825.5         83912-84018
            564-678             AL807825.5         84556-84670
            679-744             AL807825.5         84749-84814
            745-934             AL807825.5         85328-85517
            935-1089            AL807825.5         85608-85762
            1090-3796           AL807825.5         86472-89178
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.92 cM"
     gene            1..3796
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /note="TBC1 domain family, member 10a"
                     /db_xref="GeneID:103724"
                     /db_xref="MGI:MGI:2144164"
     exon            1..248
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1542
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /note="EBP50-PDX interactor of 64 kDa"
                     /codon_start=1
                     /product="TBC1 domain family member 10A"
                     /protein_id="NP_598784.1"
                     /db_xref="CCDS:CCDS56756.1"
                     /db_xref="GeneID:103724"
                     /db_xref="MGI:MGI:2144164"
                     /translation="MAKSSRENGPREPAAGGSLSGTRESLAQGPDAATADELSSLGSD
                     SEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHK
                     KIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHR
                     QFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWC
                     LVQVCEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFM
                     CAFARTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKLKACQGQYETIEQL
                     RSLSPKIMQEAFLVQEVIELPVTERQIEREHLIQLRRWQETRGELECRSLPRMHGAKA
                     ILDAEPGPRPALQPSPSIRLPPDAALLSSKAKPHKQAQKEQKRTKTSAQLDKSPGLSQ
                     ATVVTAAGDACPPQGVSPKDPVPQDPTPQNLACHHSQESLTSQESEDTYL"
     exon            249..348
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     exon            349..456
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     exon            457..563
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     exon            564..678
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     exon            679..744
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     exon            745..934
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1089
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..3796
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1875..1880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /note="hexamer: AATAAA"
     polyA_site      1894
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /note="major polyA site"
     polyA_site      2097
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
     regulatory      3780..3785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
                     /note="hexamer: AATAAA"
     polyA_site      3796
                     /gene="Tbc1d10a"
                     /gene_synonym="EPI64; mFLJ00288; Tbc1d10"
ORIGIN      
        1 gaggtggccg ctggcgctct ggtggcgggc gcggccgata tggcgaaaag cagcagagag
       61 aatgggccgc gcgagcccgc agcaggcggg agcctgtctg ggacccggga aagcctggcc
      121 cagggccccg acgccgccac cgccgacgag ctgagctcgc tcggctccga ctcggaggcc
      181 aacggcttcg ccgagcgccg catcgacaag ttcggattca tcgtgggttc gcagggcgcc
      241 gagggcgcac tggaggaagt tcccctggag gtgctgaggc agagggagtc caagtggctg
      301 gacatgctca acaactggga caaatggatg gccaagaagc acaaaaagat tcgtcttcga
      361 tgccagaagg gcatcccacc ttctctgcgc ggacgggctt ggcagtacct gtcgggaggc
      421 aaggtgaaac ttcagcagaa ccctgggaag tttgatgagc tggacatgtc tcctggggac
      481 cccaagtggc tagatgtgat tgagcgtgac ctgcaccggc agttcccatt ccatgagatg
      541 ttcgtgtccc gaggaggcca tggccagcag gacctgttcc gtgtgctgaa ggcctacacg
      601 ctgtaccgcc ctgaggaggg ctactgccag gcgcaggcac ccattgctgc tgtgctcctc
      661 atgcacatgc ctgctgagca agccttctgg tgtctggtac aagtctgtga gaagtacctg
      721 cctggctact acagtgagaa actggaggca atccagctgg acggcgagat cctcttctca
      781 ctgctacaga aggtgtcccc tgtggctcac aagcacctca gccgccagaa gattgatccc
      841 ctgctgtaca tgacagagtg gttcatgtgt gcttttgccc gcacgctgcc ctggagctct
      901 gtgctgcgag tttgggacat gttcttttgt gaaggagtca agatcatctt ccgcgtgggg
      961 ctggtactac tgaagcatgc actgggctcc ccagagaagc tcaaagcctg ccagggccag
     1021 tatgaaacca tcgagcagct gcggagcctc agccccaaga tcatgcagga agccttcctg
     1081 gttcaggagg tgatagagct gcctgtgacg gagcgccaga ttgagcggga gcacctcatc
     1141 cagctgcggc gctggcaaga gacgcgtggt gagctggagt gccgctctct gcccaggatg
     1201 catggtgcca aagccatcct ggatgcagag cctggtccca ggcctgccct gcaaccttca
     1261 ccttccatcc gcctaccgcc agatgcagcc ctcctcagct ccaaggctaa gccgcacaag
     1321 caggcccaga aggagcagaa gcggacaaag accagtgcgc aactggacaa gtccccaggc
     1381 ctcagtcaag ccacagtggt gactgctgca ggagatgcat gtcctcctca gggtgtgtcc
     1441 ccaaaggacc cggtccccca ggaccctact cctcagaact tagcctgcca ccattcccag
     1501 gagagcctga cctcccagga gagtgaggac acctacttgt aaccccggga gctcaggcct
     1561 ccgcgggggt cttctcacgt cttacacggt tcaaagactg acaacactcc aggtcctctg
     1621 cgcctgagga gccaactgct tggcccgtgg gctgggatag gatctggctg gtccagtaca
     1681 gagtctgcct gggcctcctt atttattttc tcttgagttg agctggtcca gccagcacag
     1741 gcagaagctg tggccaaagg ggttgggtct cagccccatc cttctgggga gatgttaccc
     1801 aggggtaggg tgctggcatg cggggaggcg gtggggtact ctttgtgtaa aatagatata
     1861 tggttttgta cggaaataaa caggcttgtg tatagagctg tgtatagtta ggacccaaag
     1921 ggctatcgcc cttcatcccg ggagcccccc tgaaacatac aggagcacgg agtccagagc
     1981 caattactgt tcttggctct tctctctcga cccatctttc ttccatgttc acctctacac
     2041 agaagagtca gtccaggcta aagcccacca ctgggcagaa caggaaatag tccccaaggc
     2101 cttgctctgt gcttctttat tggggattgg gggtaagatc ctgaagaggt agctaaaggc
     2161 tccaaggcca gacctagatg ctgaccatag cagggagtag ggagaaacag acttggagga
     2221 gcttccaggc gttgcctggg cctaggctgc attgtcctgg tacagctggg aatactgagt
     2281 ctggagaggc gaatggttac ctgaggttca gggcagcttc acattctctg cctcctgctt
     2341 ctcagccctg tggctctcca ctctgtccac acttgccgtg gtgagatgag gagctcactt
     2401 aagaccccag ttaacttgtg agcactcaca cagtatcagg ggctgccgcc agggcaaggt
     2461 actgcaggcg cctgacacaa gcctccacca aagaaagaca ggtgagggga gaagtgggcc
     2521 tccttgataa agcgctactt tctgttggct gacacggtcc acatgccagg ctgggcttgt
     2581 gtctgacata agaggagttc aatgtcctcc tcctccaagt gccacatttg cacccaagcc
     2641 cctcacccaa gtgagcagag ggcggtggag ggtcaggcag gtgctcagct acaacctgat
     2701 agttggcggt gaggagaaca gggtgtccct gggagaggcc ccccttctgc tgaggaagca
     2761 gcttttctag tcaaacaata gtggttgttc ctggcctgag accaagctgg gccagaccat
     2821 agcaggggac agggagggag ggacagactc acagggagct tttaggcatt gcctgggcct
     2881 agcacgtgtt gtcctggtac aactggggag actgaggcta gaaaggcaaa cggttaccag
     2941 agactctggg cagcttgcac actctccacc tcctgcctct cactcctgtg gtttcctact
     3001 ctgttcacac ttgctgtggt gaaatgggct cagcctttga aaagcacccc ccaaccccct
     3061 tagttctcca ggggacaggc caggatgtga cggctgcaca ctgttccatg agaattatct
     3121 ggagctagca aagccaggaa caggactgag cccagcttcc ttctgcctgt gatgcagggt
     3181 ctggagcatc aagtcctgcg tgggcctgtt gggtcttgat cacacccaag gcctgcttta
     3241 aactaccttg tttaaagcct ccaacctgaa gccgagtgtc tgggccaaac aagggccctt
     3301 tggagcatgc cccatcctgc cgtgaaatca acctgtgctt gctcgtttct gctcagcctt
     3361 ggggttttct taaaccttga tcactggggt gtctgccagt gcttaggggc cttcttggat
     3421 ctgtagctaa tttagatgtg ttcaggccag ttgagttctg caaatgatga gacgctttaa
     3481 gaaaacttca acagggaggt ctctggtttg atacccaggg aacctcaaat actatggcct
     3541 gtcccctcag tgtctgagcc ctgggcattc tcacttcagg tacttagggt tgtccctgga
     3601 ataagattca gaatctaggg gtaagggctg gagagatggc tcagcagtta agagcactga
     3661 ctgctcttcc gaaggtcccg agttcaaatc ccagcaacca cgtggttcac aaccatccga
     3721 aatgagatct gataccctct tctggtgtgc ctgaagacac agtatactta catataataa
     3781 ataaaattta aaaaaa
//
