LOCUS       NM_001310611            5662 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TBC1 domain family, member 1 (Tbc1d1), transcript
            variant 3, mRNA.
ACCESSION   NM_001310611 XM_006504035
VERSION     NM_001310611.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5662)
  AUTHORS   Larsen,J.K., Larsen,M.R., Birk,J.B., Steenberg,D.E., Hingst,J.R.,
            Hojlund,K., Chadt,A., Al-Hasani,H., Deshmukh,A.S.,
            Wojtaszewski,J.F.P. and Kjobsted,R.
  TITLE     Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome
            in Human Skeletal Muscle
  JOURNAL   Diabetes 71 (5), 906-920 (2022)
   PUBMED   35192682
REFERENCE   3  (bases 1 to 5662)
  AUTHORS   Zhang,Z., Ma,T., Fu,Z., Feng,Y., Wang,Z., Tian,S., Liu,Z., Wei,W.,
            Li,X., Chen,J. and Zhao,W.
  TITLE     TBC1Domain Family Member 25 deficiency aggravates cerebral
            ischemia-reperfusion injury via TAK1-JNK/p38 pathway
  JOURNAL   J Neurochem 160 (3), 392-411 (2022)
   PUBMED   34837397
  REMARK    GeneRIF: TBC1Domain Family Member 25 deficiency aggravates cerebral
            ischemia-reperfusion injury via TAK1-JNK/p38 pathway.
REFERENCE   4  (bases 1 to 5662)
  AUTHORS   Chen,Z.Y., Sun,Y.T., Wang,Z.M., Hong,J., Xu,M., Zhang,F.T.,
            Zhou,X.Q., Rong,P., Wang,Q., Wang,H.Y., Wang,H., Chen,S. and
            Chen,L.
  TITLE     Rab2A regulates the progression of nonalcoholic fatty liver disease
            downstream of AMPK-TBC1D1 axis by stabilizing PPARgamma
  JOURNAL   PLoS Biol 20 (1), e3001522 (2022)
   PUBMED   35061665
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5662)
  AUTHORS   de Wendt,C., Espelage,L., Eickelschulte,S., Springer,C., Toska,L.,
            Scheel,A., Bedou,A.D., Benninghoff,T., Cames,S., Stermann,T.,
            Chadt,A. and Al-Hasani,H.
  TITLE     Contraction-Mediated Glucose Transport in Skeletal Muscle Is
            Regulated by a Framework of AMPK, TBC1D1/4, and Rac1
  JOURNAL   Diabetes 70 (12), 2796-2809 (2021)
   PUBMED   34561225
REFERENCE   6  (bases 1 to 5662)
  AUTHORS   Giesen,K., Plum,L., Kluge,R., Ortlepp,J. and Joost,H.G.
  TITLE     Diet-dependent obesity and hypercholesterolemia in the New Zealand
            obese mouse: identification of a quantitative trait locus for
            elevated serum cholesterol on the distal mouse chromosome 5
  JOURNAL   Biochem Biophys Res Commun 304 (4), 812-817 (2003)
   PUBMED   12727230
REFERENCE   7  (bases 1 to 5662)
  AUTHORS   Plum,L., Giesen,K., Kluge,R., Junger,E., Linnartz,K., Schurmann,A.,
            Becker,W. and Joost,H.G.
  TITLE     Characterisation of the mouse diabetes susceptibilty locus
            Nidd/SJL: islet cell destruction, interaction with the obesity QTL
            Nob1, and effect of dietary fat
  JOURNAL   Diabetologia 45 (6), 823-830 (2002)
   PUBMED   12107726
REFERENCE   8  (bases 1 to 5662)
  AUTHORS   Kluge,R., Giesen,K., Bahrenberg,G., Plum,L., Ortlepp,J.R. and
            Joost,H.G.
  TITLE     Quantitative trait loci for obesity and insulin resistance (Nob1,
            Nob2) and their interaction with the leptin receptor allele
            (LeprA720T/T1044I) in New Zealand obese mice
  JOURNAL   Diabetologia 43 (12), 1565-1572 (2000)
   PUBMED   11151768
REFERENCE   9  (bases 1 to 5662)
  AUTHORS   White,R.A., Pasztor,L.M., Richardson,P.M. and Zon,L.I.
  TITLE     The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene,
            BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 272-275 (2000)
   PUBMED   10965142
REFERENCE   10 (bases 1 to 5662)
  AUTHORS   Richardson,P.M. and Zon,L.I.
  TITLE     Molecular cloning of a cDNA with a novel domain present in the
            tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16
  JOURNAL   Oncogene 11 (6), 1139-1148 (1995)
   PUBMED   7566974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132271.5 and AC131679.2.
            
            On Jul 16, 2015 this sequence version replaced XM_006504035.2.
            
            Transcript Variant: This variant (3) contains two alternate
            in-frame exons compared to variant 1. The encoded isoform (3) is
            longer than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.5805.1,
                                           SRR10223969.5507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC132271.5         105483-105728
            247-755             AC132271.5         118611-119119
            756-1196            AC131679.2         46165-46605
            1197-1286           AC131679.2         49803-49892
            1287-1397           AC131679.2         52919-53029
            1398-1530           AC131679.2         53776-53908
            1531-1622           AC131679.2         60540-60631
            1623-1733           AC131679.2         64845-64955
            1734-1862           AC131679.2         67366-67494
            1863-1949           AC131679.2         68781-68867
            1950-2230           AC131679.2         71215-71495
            2231-2389           AC131679.2         73417-73575
            2390-2509           AC131679.2         74140-74259
            2510-2649           AC131679.2         75395-75534
            2650-2835           AC131679.2         100509-100694
            2836-2997           AC131679.2         105804-105965
            2998-3156           AC131679.2         113901-114059
            3157-3401           AC131679.2         122797-123041
            3402-3561           AC131679.2         124728-124887
            3562-3731           AC131679.2         129012-129181
            3732-3905           AC131679.2         134702-134875
            3906-5662           AC131679.2         139180-140936
FEATURES             Location/Qualifiers
     source          1..5662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 32.8 cM"
     gene            1..5662
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /note="TBC1 domain family, member 1"
                     /db_xref="GeneID:57915"
                     /db_xref="MGI:MGI:1889508"
     exon            1..246
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..755
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..4106
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     tre-2/USP6, BUB2, cdc16) domain family, member 1"
                     /codon_start=1
                     /product="TBC1 domain family member 1 isoform 3"
                     /protein_id="NP_001297540.1"
                     /db_xref="CCDS:CCDS80287.1"
                     /db_xref="GeneID:57915"
                     /db_xref="MGI:MGI:1889508"
                     /translation="MEAITFTARKHPFPNEVSVDFGLQLVGSLPVHSLTTMPMLPWVV
                     AEVRRLSGQCSKKEPRTKQVRLWVSPSGLRCEPDLEKSQPWDPLICSSIFECKPQRVH
                     KLIHNSHDPSYFACLIKEDAAHRQSLCYVFKADDQTKVPEIISSIRQAGKIARQEELR
                     CPSEFDDTFAKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSCGRRTDWEAPTGQP
                     SAPGPRPMRKSFSQPGLRSLAFRKEFQDASLRSSTFSSFDNDIENHLIGGHNVVQPTD
                     MEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRECSGG
                     GSGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQGLHKL
                     CERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLY
                     EEKQKEHSHTGEPKQTLQVAAENIGSDLPPSASRFRLDSLKNRAKRSLTESLESILSR
                     GNKARGLQDHSASVDLDSSTSSTLSNTSKELSMGDKEAFPVSETSFKLLGSSDDLSSD
                     SEGHIAEESALLSPQQAFRRRANTLSHFPVECPAPPEPAQSSPGVSQRKLMRYHSVST
                     ETPHERNVDHLPGGESQGCPGQPSAPPPPRLNPSASSPNFFKYLKHNSSGEQSGNAVP
                     KSVSYRNALRKKLHSSSSVPNFLKFLAPVDENNTCDFKNTNRDFESKANHLGDTDGTP
                     VKTRRHSWRQQIFLRVATPQKACDSPSRYEDYSELGELPPRSPLEPVCEDGPFGPVQE
                     EKRKTSRELRELWKKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKE
                     VTTVWEKMLSTPGRSKIKFDMEKVHSAVGQGVPRHHRGEIWKFLAEQFHLKHPFPSKQ
                     QPKDVPYKELLKKLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQ
                     EVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRL
                     LHDYHRDLYNHLEEHEIGPSLYAAPWFLTVFASQFPLGFVARVFDMIFLQGSEVIFKV
                     ALSLLGSHKPLILQHENLETIVDFIKNTLPNLGLVQMEKTISQVFEMDIAKQLQAYEV
                     EYHVLQEELIESSPLSDNQRMEKLEKTNSSLRKQNLDLLEQLQVANARIQSLEATVEK
                     LLTSESKLKQAALTLEVERSALLQMVEELRRQSARPSTPEPDCTQLEPTGD"
     exon            756..1196
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1286
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1397
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1530
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1622
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1733
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1862
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1949
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2230
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2389
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2509
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2649
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2835
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2997
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3156
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3401
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3561
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3731
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3905
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..5662
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5638..5643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /note="hexamer: AATAAA"
     polyA_site      5657
                     /gene="Tbc1d1"
                     /gene_synonym="1110062G02Rik; mKIAA1108; Nob1; Nobq1;
                     Tbc1"
                     /note="major polyA site"
ORIGIN      
        1 ctgctgtcgc cgccgccggc cacaccgcgg tgcctgttgc tgcaagccac ctcggaccga
       61 ccgtctcttc aacccgcaag agaagcagag actgtggagt ggacccccac cccagcagcg
      121 tggggcggca agagcacagc cagctgagga ccatggacgc cccgcccgcc caggccatct
      181 tctgggtgcc cgggagcacc tgcgcgccct agctcagccc ggagttctga gcgtgccacc
      241 tcactggatt ctgccctcag aagcacgtga aatagatcac ttcatttaaa gtaggaaaat
      301 agtagcacgt tttcctggct ctccagacct ctcccaggat ggaggcaatc acattcacag
      361 cgaggaagca tccgttccct aacgaagtct ccgtggactt cggcttgcag ctggtgggct
      421 ccttacccgt gcattctctc accactatgc ccatgctgcc gtgggtggta gccgaggtac
      481 gaagactcag tggccagtgc tctaaaaagg agcctaggac aaagcaagtc cgcctttggg
      541 tttcgccctc cggactgcgg tgcgagcctg acctggagaa aagtcaacca tgggacccgc
      601 tcatctgttc cagcatcttt gagtgcaagc ctcagcgtgt gcacaaactg attcacaaca
      661 gtcacgaccc gagctacttt gcttgcctca ttaaggagga tgctgcgcac aggcagagcc
      721 tctgctatgt gtttaaagca gacgatcaaa caaaagtgcc tgagatcatc agctccatcc
      781 ggcaggccgg gaagattgcc cgccaggaag agctgcgttg cccctccgag ttcgacgata
      841 ccttcgccaa aaagttcgag gtgctcttct gtggccgggt gactgtggct cacaagaagg
      901 ccccacccgc actgattgac gagtgtatcg agaagttcaa ccatgtgagc tgtggtcgca
      961 gaacggactg ggaagcgccc accgggcagc catcagcgcc tggccccagg cccatgcgca
     1021 aatccttctc acagcctgga ctgcgctcgc tggccttcag gaaggagttc caggacgcta
     1081 gcctccgcag tagcaccttt agctcctttg acaatgacat agagaaccac ctcatcggtg
     1141 ggcacaatgt ggttcagccc acagacatgg aggagaaccg aactatgctg ttcacgattg
     1201 gccaatctga agtttacctc atcagtcctg acaccaaaaa gattgcactg gagaaaaatt
     1261 ttaaggagat atccttttgc tctcagggca tcagacatgt ggaccacttt ggattcatct
     1321 gccgagagtg ctcgggtggc ggcagtggcg gctttcattt tgtctgttac gtgttccagt
     1381 gcacaaatga agctctggtt gacgagatca tgatgactct gaagcaggct ttcacggtag
     1441 ctgcggtgca gcagacggct aaggcaccag cccagctctg tgagggctgc cccttgcaag
     1501 gcctgcacaa gctctgcgaa aggatagagg gaatgaattc atctaaaacc aaattagaac
     1561 tccagaagca cttgaccaca ctgaccaatc aggagcaggc caccatattc gaggaggttc
     1621 agaaattgag accaagaaac gagcagcgag agaatgaatt aattatttct tttctgaggt
     1681 gcttatatga agagaagcaa aaagagcaca gccacactgg ggagccaaag cagacactac
     1741 aggtggcagc agagaatatt gggagtgacc tgccacccag tgctagccgg ttcaggttag
     1801 attcgctgaa gaacagagca aagaggtcct taacagagtc cctagagagc attctgtccc
     1861 ggggtaataa agccagaggc ctgcaggacc attccgccag tgtggatctg gacagctcca
     1921 cttctagtac tctaagtaac accagcaaag agctgtccat gggtgacaag gaggccttcc
     1981 ccgtctctga gacctccttc aagctccttg gctcctcaga tgacctgtcc agtgactcag
     2041 agggccacat tgcagaagag tctgccctgt tgtcacccca gcaggcgttc agaaggagag
     2101 ccaacaccct gagtcatttc ccagtagagt gccctgcgcc tccagaacct gcccagagct
     2161 ctccaggggt ctctcaaagg aaactcatgc ggtaccactc cgtgagcaca gagacgcctc
     2221 atgaacgcaa tgtggaccat cttcctgggg gtgagtctca gggctgccca gggcagcctt
     2281 cagctccgcc tccacctcgt cttaacccct ccgcctcctc accaaacttc tttaagtacc
     2341 taaaacacaa ttccagtgga gagcaaagtg ggaatgctgt gccaaaaagt gtctcctacc
     2401 gtaatgccct gcggaaaaaa ctccattctt cctcctctgt gccaaatttt ctaaaatttc
     2461 tggctcccgt agatgaaaat aacacctgtg actttaagaa cacgaacagg gactttgaat
     2521 ccaaagcaaa ccacctgggt gacacagatg ggacccccgt gaagacccgg cggcactcgt
     2581 ggagacagca gatattcctt cgagtggcca ctccacagaa ggcttgtgac tccccgagca
     2641 gatatgaaga ttattccgag ctgggagagc tccctccacg ctccccttta gaaccggtgt
     2701 gtgaggacgg cccatttggc ccagtacagg aagaaaagag gaagacgtca cgcgagcttc
     2761 gagagctgtg gaaaaaggcc atcttgcagc agatcctgct gctcaggatg gagaaggaga
     2821 atcagaagct acaagcctct gaaaacgatt tgctgaacaa acgcctcaag cttgactatg
     2881 aagaaatcac tccgtgtctt aaagaagtca ctacagtgtg ggaaaagatg cttagcactc
     2941 caggaagatc caaaattaag tttgacatgg aaaaagtgca ctcagctgtt gggcaaggtg
     3001 tgccacgtca tcaccgaggt gagatctgga aatttctagc tgagcagttc caccttaaac
     3061 acccatttcc tagtaaacag cagccaaagg acgtgcccta caaagagctc ctgaagaagc
     3121 tgacctcgca gcagcacgcc attctcatcg acctcgggcg aacctttcca acacatccat
     3181 acttctctgc ccagcttgga gcaggtcagc tgtcacttta caacattctg aaggcctact
     3241 cgcttctgga ccaggaggtt ggatactgcc aaggtctcag ctttgtggca ggcattttgc
     3301 ttcttcacat gagtgaggaa gaggcgttca agatgctcaa gttcctgatg tttgacatgg
     3361 ggctgcggaa acagtatcgg ccagacatga ttattttgca gatccagatg taccagctgt
     3421 cacggctcct ccacgattac caccgagacc tctacaacca cctggaagag cacgagatcg
     3481 gccccagcct ctacgcggct ccctggtttc tcactgtgtt cgcctcacag ttcccactcg
     3541 gctttgtagc cagagtcttt gatatgatct tccttcaggg atcagaggtc atatttaaag
     3601 tagctttaag tcttttgggg agccataagc ccttgattct acagcatgag aacctggaaa
     3661 ccatagtgga cttcataaag aacacactcc ccaacctggg cctggtgcag atggagaaga
     3721 ccatcagtca ggtgtttgag atggacatcg ccaagcagct ccaggcctat gaggtcgagt
     3781 accacgtgct ccaggaggag cttattgagt cctcgcctct cagtgacaac caaagaatgg
     3841 agaaattgga gaaaaccaac agcagcttgc gcaaacagaa ccttgacctc ctggagcagt
     3901 tgcaggtggc aaatgctagg atccaaagcc ttgaagccac ggtagagaaa cttcttacca
     3961 gcgagagtaa gctgaagcag gctgcgctga ccctggaggt ggagcgctcc gccctgctgc
     4021 agatggtgga ggagctgcgg aggcaaagcg cccggcccag cactccagag ccagactgca
     4081 cccagctgga gcccacaggc gattgaccgc tgccagaaga gactgtgcac cattaacact
     4141 gtccaagcct taatcaagag agatggaagt cagaggcaga gaagagagaa cttctcaggg
     4201 aggaaactgg ctgaccagcc tgcagatcct tttgagctca gaacttggga ttggaggaca
     4261 aaagtctcag agttattgtt gtttttggtt ctaatccgtc ccctttccag tcctggttgt
     4321 tgtagcttta gatggcatgg acatgaataa attacattta tggttcctcc tccttcttgc
     4381 agagacacag tgtgtggaaa gagcattcat gactgcagtg ttccaaaaac aagatgggtc
     4441 tgaaataatt cctcaggcag aagaaacgtg accctttgtc agtctgcaag aaaggttcct
     4501 gggagggtgc ccttgatgtc acctgaggtg cagtgggccc ttgtccattt ttattatggg
     4561 acctaaggtg accatgagga aggaagaaag gggtttattt aaatcagata tattggttgt
     4621 tcctgaatcc acggtcactc ccattggtac tgaagagagc tcatctttta caaactcagt
     4681 gttttagtat ggtttttgct taccctttca agtcacaggt aaatgtttca taaggaaatc
     4741 acagttttta gattccctgt tattgctagt gtgggacctg tagctgtggg gtctgacata
     4801 tttatttctt tttgattgtt tcatatccac actatagggt cacatattta tttttgtctg
     4861 ttgataaatg atgtaccact gccacatctt cctttgagcc ttgaacccct tggaaatctg
     4921 atttctcata gaaggaacaa aacataccaa gatttccagg ggctcctaag atgctgaaac
     4981 attgcaaaag aaaccagatt gcaatcaggt gtatggcagc tgacagcttt tcagaagtag
     5041 gaagtgtgtt ttgaaagtac tcaaacacac gcacgccttc cttgggatgg cgaggaccct
     5101 gtgccttcaa gcagagtgca gctcacactc accctgcttc tagctggtcc tgtgtagagc
     5161 atcacccatg tgtgcaacag cttttttttt tcttttaaca tacacacaaa ggcttaggtt
     5221 agggaagacc accagccagg agccctggct atcggaattg gtcctgcctt gggctctgtt
     5281 ggccctcctg ttcctggagg tctgctgcag cgctgttggt aggaaaggag ccttgtaagt
     5341 ctgggctgta aggagagacc atcaccgttg gggtcatttg ggatctccta gccctatcaa
     5401 agggacacta aatggccagg agggatgtaa gactcccaca tggtcttggg tcagaggaga
     5461 ggtctctcca taaaccaaca tgcccagtcc cagttggttg gagcaggggt tgtcagagga
     5521 gggtgacagt ggacagcttc tttccacatt gtattttatt atttgaatgt tttaatgttg
     5581 aattttggac atgttattac tgttcaaaaa acactgactc tacagtaaga aaagagcaat
     5641 aaaacagatt attcacacct gt
//
