LOCUS       NM_001017433            1545 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus thymus, brain and testes associated (Tbata),
            transcript variant 1, mRNA.
ACCESSION   NM_001017433
VERSION     NM_001017433.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1545)
  AUTHORS   Yammine,M., Saade,M., Chauvet,S. and Nguyen,C.
  TITLE     Spatial gene's (Tbata) implication in neurite outgrowth and
            dendrite patterning in hippocampal neurons
  JOURNAL   Mol Cell Neurosci 59, 1-9 (2014)
   PUBMED   24361585
  REMARK    GeneRIF: Spatial, through its transport by Kif17, is crucial for
            neuronal polarization.
REFERENCE   2  (bases 1 to 1545)
  AUTHORS   Flomerfelt,F.A., El Kassar,N., Gurunathan,C., Chua,K.S.,
            League,S.C., Schmitz,S., Gershon,T.R., Kapoor,V., Yan,X.Y.,
            Schwartz,R.H. and Gress,R.E.
  TITLE     Tbata modulates thymic stromal cell proliferation and thymus
            function
  JOURNAL   J Exp Med 207 (11), 2521-2532 (2010)
   PUBMED   20937703
  REMARK    GeneRIF: Tbata modulates thymus function by regulating stromal cell
            proliferation via the Nedd8 pathway.
REFERENCE   3  (bases 1 to 1545)
  AUTHORS   Saade,M., Irla,M., Yammine,M., Boulanger,N., Victorero,G.,
            Vincentelli,R., Penninger,J.M., Hollander,G.A., Chauvet,S. and
            Nguyen,C.
  TITLE     Spatial (Tbata) expression in mature medullary thymic epithelial
            cells
  JOURNAL   Eur J Immunol 40 (2), 530-538 (2010)
   PUBMED   19918778
  REMARK    GeneRIF: Data show that Spatial expression is independent of
            thymocyte-derived signals during thymus organogenesis.
REFERENCE   4  (bases 1 to 1545)
  AUTHORS   Irla,M., Saade,M., Fernandez,C., Chasson,L., Victorero,G.,
            Dahmane,N., Chazal,G. and Nguyen,C.
  TITLE     Neuronal distribution of spatial in the developing cerebellum and
            hippocampus and its somatodendritic association with the kinesin
            motor KIF17
  JOURNAL   Exp Cell Res 313 (20), 4107-4119 (2007)
   PUBMED   17961552
  REMARK    GeneRIF: These findings suggest that Spatial may play a role in
            neuronal morphogenesis and synaptic plasticity through its
            interaction with the kinesin motor KIF17 in dendrites.
REFERENCE   5  (bases 1 to 1545)
  AUTHORS   Saade,M., Irla,M., Govin,J., Victorero,G., Samson,M. and Nguyen,C.
  TITLE     Dynamic distribution of Spatial during mouse spermatogenesis and
            its interaction with the kinesin KIF17b
  JOURNAL   Exp Cell Res 313 (3), 614-626 (2007)
   PUBMED   17196196
  REMARK    GeneRIF: Together, these findings imply a function of Spatial in
            spermatid differentiation as a new cargo of kinesin KIF17b, in a
            microtubule-dependent mechanism specific to the manchette and the
            principal piece of the sperm tail.
REFERENCE   6  (bases 1 to 1545)
  AUTHORS   Li,Q., Ishikawa,T.O., Miyoshi,H., Oshima,M. and Taketo,M.M.
  TITLE     A targeted mutation of Nkd1 impairs mouse spermatogenesis
  JOURNAL   J Biol Chem 280 (4), 2831-2839 (2005)
   PUBMED   15546883
REFERENCE   7  (bases 1 to 1545)
  AUTHORS   Irla,M., Puthier,D., Granjeaud,S., Saade,M., Victorero,G.,
            Mattei,M.G. and Nguyen,C.
  TITLE     Genomic organization and the tissue distribution of alternatively
            spliced isoforms of the mouse Spatial gene
  JOURNAL   BMC Genomics 5 (1), 41 (2004)
   PUBMED   15236666
  REMARK    GeneRIF: A new short thymus isoform, Spatial-beta, differs from
            other isoforms by an additional alternative exon of 69 bases. This
            new exon encodes an interesting proline-rich signature that could
            confer to the 34 kDa Spatial-beta protein a particular function.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1545)
  AUTHORS   Irla,M., Puthier,D., Le Goffic,R., Victorero,G., Freeman,T.,
            Naquet,P., Samson,M. and Nguyen,C.
  TITLE     Spatial, a new nuclear factor tightly regulated during mouse
            spermatogenesis
  JOURNAL   Gene Expr Patterns 3 (2), 135-138 (2003)
   PUBMED   12711538
  REMARK    Erratum:[Gene Expr Patterns. 2003 Aug;3(4):539]
REFERENCE   9  (bases 1 to 1545)
  AUTHORS   Flomerfelt,F.A., Kim,M.G. and Schwartz,R.H.
  TITLE     Spatial, a gene expressed in thymic stromal cells, depends on
            three-dimensional thymus organization for its expression
  JOURNAL   Genes Immun 1 (6), 391-401 (2000)
   PUBMED   11196687
  REMARK    GeneRIF: provides evidence for non-AUG translation initiation site
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK132793.1, AF521592.1 and
            AW490515.1.
            
            On Apr 2, 2008 this sequence version replaced NM_001017433.1.
            
            Summary: This gene encodes a putative transcription factor that is
            highly expressed in thymic cortical stromal cells, and may be
            involved in T-cell development. Its expression is developmentally
            regulated in the testis, where it is restricted to the haploid
            round spermatids during spermatogenesis, and thus this gene may
            also have a role in the control of male germ cell development.
            Alternative splicing of this gene results in two sets of transcript
            variants: the variants containing 5 additional exons at the 3' end
            encode long isoforms that are highly expressed in the testis, while
            the variants lacking the 3' end exons encode short isoforms that
            are highly expressed in the thymus. Most of the transcripts
            encoding the short isoforms have been shown to initiate translation
            from non-AUG (CUG) start sites. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as Spatial-epsilon) that is highly expressed in the
            testis.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF521592.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AK132793.1         2-70
            70-1523             AF521592.1         1-1454
            1524-1545           AW490515.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.16 cM"
     gene            1..1545
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /note="thymus, brain and testes associated"
                     /db_xref="GeneID:65971"
                     /db_xref="MGI:MGI:1923820"
     exon            1..69
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            70..224
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            225..472
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            473..733
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            734..813
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1005
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1087
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1229
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1282
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1528
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /note="hexamer: AATAAA"
     polyA_site      1526
                     /gene="Tbata"
                     /gene_synonym="1700021K02Rik; Spatial; Titest"
                     /note="major polyA site"
ORIGIN      
        1 agtcttcttc tccatcttgg tcaggcacca ggggcttctt gctcatatgc tatagtggac
       61 atcttcctga tcgcatgttc cagtttatac acccgccacc aggccaccag agctgtgcca
      121 tccatcaaag acacggacat tccgagtcta gtctttacat ctcttattgc aaaccctgat
      181 atgactacag aggtgaacca gctgtctgag catcctctag tgagtccaaa ggcagagccc
      241 cagccagaga cgaagccgga gaaccttcca aggagccacg gggatgttgg gctccagaaa
      301 gagactgtgg tcccaggcat tgtggatttc gagctgatcc atgaggagct gaagaccaca
      361 aagccccaaa catcacaacc aacacccagt gcctaccgct ttggacgcct aagccaccat
      421 tccttcttct cgaggcacca cccccaacca cagcgagtga ctcatatcca agttacagga
      481 agagaggacc tggagcactc cctgcccctc accacctctt tccagctcct tcaagctcct
      541 ggggtccagc ccatggatct cactccctct gcagatatcg ctgggaagcc tgtctgcgtg
      601 gtcagggacg agttctctct gtcggccttg actcagccca cattcttatc ccgctgtctg
      661 atggggatgc ccaccatctc tgtccccatt ggggatccac agtccaatcg gaacccccag
      721 ctttctactt ctgacacctg gaggaagaaa ctgaaggacc tggcttcccg agtgactgtc
      781 ttcactaagg aaatccagcc aaagcccgat gagcagaagg aagagccacc tctgagggaa
      841 cctcctccga gagagcaggg ggccaaatac tcagctgaga ccggtaggct tatccctgct
      901 tccagccaag ccctcacccg tcgcaaccgc cagggccagc gggtccaccc ttctagcaaa
      961 gatggaggag tccaagcctc cattctgcag gaccaggagc tgctgatttt ggagctcctt
     1021 tgtcaaattc tacaaacaga ttctctaagg gctattcagt tctggctgct ttatgctcca
     1081 tcaaaagaaa aagatttagc tctggggctt ctgcaaactg ccgtggctca gcttatcccc
     1141 cagccccttt cctccatccc agcagagaag ctctggaacc atctccaaga gcttcaagag
     1201 cctcaagaga cacaagaggc agcctacagt ccatccctga agaagactag gtcaccacct
     1261 ctacccaaaa cagacaaacc agagtacata ggcaaagccc aagtcctcct ggtgcatccc
     1321 agcgaggacc cagaggagaa aacgaccaag gctgaaagct gaagagccca gaccagagca
     1381 cggagacttc tgcctagctc caaggcagcc gctcagcttg gggaggggag gggctcctgt
     1441 ccttctacct tgactccagc ccctggcctc caacagtact aaataaaatc ctgccctccc
     1501 tcttggatga gggcagttcc accctcccaa aaaaaaaaaa aaaaa
//
