LOCUS       NM_025816               3307 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Tax1 (human T cell leukemia virus type I) binding
            protein 1 (Tax1bp1), transcript variant 1, mRNA.
ACCESSION   NM_025816
VERSION     NM_025816.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Zuo,G.F., Wang,L.G., Huang,L., Ren,Y.F., Ge,Z., Hu,Z.Y., Zhang,J.J.
            and Chen,S.L.
  TITLE     TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes
            to diabetes-induced heart failure with preserved ejection fraction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166979 (2024)
   PUBMED   38065272
  REMARK    GeneRIF: TAX1BP1 downregulation by STAT3 in cardiac fibroblasts
            contributes to diabetes-induced heart failure with preserved
            ejection fraction.
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   White,J., Suklabaidya,S., Vo,M.T., Choi,Y.B. and Harhaj,E.W.
  TITLE     Multifaceted roles of TAX1BP1 in autophagy
  JOURNAL   Autophagy 19 (1), 44-53 (2023)
   PUBMED   35470757
  REMARK    GeneRIF: Multifaceted roles of TAX1BP1 in autophagy.
            Review article
REFERENCE   3  (bases 1 to 3307)
  AUTHORS   Bell,S.L., Lopez,K.L., Cox,J.S., Patrick,K.L. and Watson,R.O.
  TITLE     Galectin-8 Senses Phagosomal Damage and Recruits Selective
            Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis
            Infection in Macrophages
  JOURNAL   mBio 12 (4), e0187120 (2021)
   PUBMED   34225486
  REMARK    GeneRIF: Galectin-8 Senses Phagosomal Damage and Recruits Selective
            Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis
            Infection in Macrophages.
REFERENCE   4  (bases 1 to 3307)
  AUTHORS   Sarraf,S.A., Shah,H.V., Kanfer,G., Pickrell,A.M., Holtzclaw,L.A.,
            Ward,M.E. and Youle,R.J.
  TITLE     Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate
            Accumulation in the Brain
  JOURNAL   Mol Cell 80 (5), 779-795 (2020)
   PUBMED   33207181
  REMARK    GeneRIF: Loss of TAX1BP1-Directed Autophagy Results in Protein
            Aggregate Accumulation in the Brain.
            Erratum:[Mol Cell. 2022 Apr 7;82(7):1383-1385. doi:
            10.1016/j.molcel.2022.03.020.. PMID: 35395199]
REFERENCE   5  (bases 1 to 3307)
  AUTHORS   Waidmann,O., Pleli,T., Weigert,A., Imelmann,E., Kakoschky,B.,
            Schmithals,C., Doring,C., Frank,M., Longerich,T., Koberle,V.,
            Hansmann,M.L., Brune,B., Zeuzem,S., Piiper,A. and Dikic,I.
  TITLE     Tax1BP1 limits hepatic inflammation and reduces experimental
            hepatocarcinogenesis
  JOURNAL   Sci Rep 10 (1), 16264 (2020)
   PUBMED   33004985
  REMARK    GeneRIF: Tax1BP1 limits hepatic inflammation and reduces
            experimental hepatocarcinogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3307)
  AUTHORS   Chin,K.T., Chun,A.C., Ching,Y.P., Jeang,K.T. and Jin,D.Y.
  TITLE     Human T-cell leukemia virus oncoprotein tax represses nuclear
            receptor-dependent transcription by targeting coactivator TAX1BP1
  JOURNAL   Cancer Res 67 (3), 1072-1081 (2007)
   PUBMED   17283140
REFERENCE   7  (bases 1 to 3307)
  AUTHORS   Lehoczky,J.A., Williams,M.E. and Innis,J.W.
  TITLE     Conserved expression domains for genes upstream and within the HoxA
            and HoxD clusters suggests a long-range enhancer existed before
            cluster duplication
  JOURNAL   Evol Dev 6 (6), 423-430 (2004)
   PUBMED   15509224
REFERENCE   8  (bases 1 to 3307)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 3307)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3307)
  AUTHORS   De Valck,D., Jin,D.Y., Heyninck,K., Van de Craen,M., Contreras,R.,
            Fiers,W., Jeang,K.T. and Beyaert,R.
  TITLE     The zinc finger protein A20 interacts with a novel anti-apoptotic
            protein which is cleaved by specific caspases
  JOURNAL   Oncogene 18 (29), 4182-4190 (1999)
   PUBMED   10435631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099741.4, AK146076.1 and BP754065.1.
            
            On Aug 28, 2009 this sequence version replaced NM_025816.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146076.1, BC014798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC099741.4         213724-213745
            23-1418             AK146076.1         3-1398
            1419-1419           AC099741.4         242708-242708
            1420-3282           AK146076.1         1400-3262
            3283-3307           BP754065.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.7 cM"
     gene            1..3307
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /note="Tax1 (human T cell leukemia virus type I) binding
                     protein 1"
                     /db_xref="GeneID:52440"
                     /db_xref="MGI:MGI:1289308"
     exon            1..127
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            128..296
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2579
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TRAF6-binding protein homolog; tax1-binding protein 1
                     homolog"
                     /codon_start=1
                     /product="tax1-binding protein 1 homolog isoform 1"
                     /protein_id="NP_080092.2"
                     /db_xref="CCDS:CCDS39490.1"
                     /db_xref="GeneID:52440"
                     /db_xref="MGI:MGI:1289308"
                     /translation="MTSFQEVQLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHP
                     HSKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQF
                     CYVTHKGEIRGASTPFQFRAASPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTLKE
                     KEELLKLIAVLEKETAQLREQVGRMERELSQEKGRCEQLQAEQKGLLEVSQSLRVENE
                     EFMKRYSDATAKVQQLEEDIVSVTHKAIEKETDLDSLKDKLRKAQHEREQLECQLQTE
                     KDEKELYKVHLKNTEIENTKLVSEIQTLKNLDGNKESMITHFKEEISKLQSCLADKEN
                     LYRALLLTTSNKEDTLFLKEQLRKAEEQVQATRQELIFLTKELSDAVNVRDKTMADLH
                     TARLENERVKKQLADTLAELQLHAVKKDQEKTDTLEHELRREVEDLKLRLQMAADHYR
                     EKFKECQRLQKQINKLSDQAASTNSVFTKKMGSQQKVNDASINTDPAASTSASAVDVK
                     PAASCAETGFDMSTKDHVCEMTKEIAEKIEKYNKCKQLLQDEKTKCNKYAEELAKMEL
                     KWKEQVKIAENVKLELAEVEDNYKVQLAEKEKEINGLASYLENLSREKELTKSLEDQK
                     GRKLEGQSPQQVSRCLNTCSEQNGLLPPLSSAQPVLQYGNPYSAQETRDGADGAFYPD
                     EIQRPPVRVPSWEDNVVCSQPARNLSRPDGLEDPEDSREDENVPIPPDPANQHLRSHG
                     AGFCFDSSFDVHKKCPLCELMFPPNYDQTKFEEHVESHWKVCPMCSEQFPPDYDQQGF
                     ERHVQTHFDQNVLNFD"
     exon            297..399
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            400..587
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            588..746
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            747..895
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            896..986
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1172
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1397
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1544
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1677
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1778
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1904
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..1976
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2151
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2294
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2377
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..3285
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2973..2978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /note="hexamer: AATAAA"
     polyA_site      2993
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /note="major polyA site"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
                     /note="hexamer: AATAAA"
     polyA_site      3285
                     /gene="Tax1bp1"
                     /gene_synonym="1200003J11Rik; 1700069J21Rik; D6Ertd404e;
                     D6Ertd772e; T6bp; TXBP151"
ORIGIN      
        1 ggggcggaag tgacgcaccg ccggctctcc gcttagagaa ggtgtagccg gtctacgctg
       61 agaggcagtg gtggtggccg cggaggttcg gggcgcggcg tagcgtgcgg ggcggaggcc
      121 ctgaccgatt cacaatgaca tcctttcaag aagtccaatt gcagacttcc aattttgccc
      181 atgtcatctt tcaaaatgtg gctaaaagtt accttcctaa tgcacacttg gagtgccatt
      241 acaccttaac tccgtatatc catccacact ccaaagattg ggttggtata ttcaaggttg
      301 gatggagtac tgctcgtgac tattacacat ttttatggtc tcctatgcct gaacattatg
      361 tggaaggatc aacagtcaat tgtgtactag catttcaagg atattacctt ccaaatgatg
      421 atggagaatt ttatcagttc tgttacgtca cccataaggg tgaaattcgt ggagcaagta
      481 ctcctttcca gttccgagct gcttctccag ttgaagagct gctcactatg gaagatgaag
      541 gcaattccga tatgttggtg gtaaccacaa aagctggcct tcttgagctg aaaattgaga
      601 agaccctgaa agaaaaagaa gaattgttaa agttgatagc tgttcttgaa aaagaaacag
      661 cacagctgag agaacaagtt ggaagaatgg agagagaact gagccaggag aaagggcggt
      721 gtgagcaatt gcaggctgag cagaagggcc ttcttgaagt atcacaaagt ttgagagtgg
      781 aaaacgaaga gtttatgaag agatacagtg atgctacagc taaagttcaa cagcttgaag
      841 aggacattgt atcagtgaca cataaagcca ttgaaaaaga aactgaccta gacagtttga
      901 aggataagct caggaaggca cagcatgaga gagagcagct tgaatgtcag ctgcagacag
      961 aaaaggatga gaaggagctg tataaggtac atttgaagaa tacagaaata gaaaatacga
     1021 agcttgtgtc agagatacag actttaaaga atttagatgg aaacaaagaa agcatgatta
     1081 cccatttcaa agaagagatt agcaaactgc agtcctgctt ggctgacaag gaaaatttgt
     1141 acagagctct cctgcttaca acctcaaata aagaagatac attattttta aaggagcaac
     1201 ttcgcaaagc ggaggaacaa gtccaggcaa cacggcaaga acttatcttt ctgactaaag
     1261 agctcagtga tgcagtgaat gtgcgagata aaactatggc agatctgcat actgcacgct
     1321 tagaaaatga gagagtgaag aagcagctag ccgacacact ggcagagctg cagctacatg
     1381 ctgtaaagaa agatcaggaa aagactgata ccctggaaca tgaactgaga agagaagttg
     1441 aagatctgaa actccgtctt cagatggctg cagatcatta cagagaaaag tttaaggagt
     1501 gccagaggct ccaaaagcaa ataaacaaac tttcagacca ggcagcgagt actaacagtg
     1561 tcttcacaaa gaaaatgggg agtcagcaga aagtgaacga tgcttcaata aatacagacc
     1621 cggctgcctc tacttctgct tctgccgtgg atgtaaagcc agcagcgtca tgtgcagaga
     1681 caggctttga tatgtcaaca aaggatcatg tctgtgaaat gactaaagaa attgctgaga
     1741 aaatagaaaa gtataataag tgtaaacaac tcttgcagga tgagaaaact aagtgcaata
     1801 aatacgctga agaacttgcc aaaatggagc tgaagtggaa agaacaagtg aaaattgctg
     1861 aaaatgtaaa acttgaacta gctgaagtag aggataacta caaagttcag ctggcggaga
     1921 aagagaaaga aataaatggt ctggcttcat atttggaaaa tctctccagg gagaaggaac
     1981 ttacaaagag tttagaagat caaaaaggaa ggaaattgga aggccagagc cctcaacaag
     2041 tctcaaggtg tctcaacaca tgttctgagc aaaatgggct ccttcctcca ctgtcaagtg
     2101 cacagccagt tcttcagtat ggcaaccctt actcagcaca ggaaacaaga gatggagcag
     2161 atggtgcttt ttatccagat gaaatccaaa ggccacctgt gcgagtccca tcttgggaag
     2221 acaatgttgt ctgtagccag cctgctcgaa accttagccg gccggatggt ttagaggacc
     2281 ccgaagacag cagagaagac gaaaatgtgc ccattcctcc tgatccagca aaccagcact
     2341 tacgtagtca tggagcaggc ttttgctttg attccagctt tgatgttcac aagaaatgtc
     2401 ccctctgtga attaatgttc cctcctaact acgatcagac caaatttgaa gaacacgttg
     2461 aaagtcactg gaaggtgtgt ccaatgtgca gcgagcagtt cccgccggac tacgaccagc
     2521 aggggtttga aaggcatgtt cagacccatt ttgatcagaa tgttctcaac ttcgactagc
     2581 ttgtaataag aggtagtaca atttagcaat tacaaaacaa accacatctc agaggctaag
     2641 gagatgccag gtgtcacttt caggttcctc ctccacactt tcctgatgat ggagaacttc
     2701 tttagcgtgt gctgtcacta gggccagggt acagctgtga ctacatacaa tgaatacagt
     2761 tttaatctct gttaatcttg tctgctgtaa gaagagtgct tctgggtttg catctctgtc
     2821 tatcctccag ttagcagaag tgtgtgaaga acacaagaat tattttaatg ttaccgaatt
     2881 gcaaacataa acatgtagta gttagatcct cagcacaatc acacttacaa gtttctgtac
     2941 accttggcga ttgagcatga ccactgatat gtaataaaaa gcattgatca taacagttct
     3001 gtgaaataat tctttgaata tagaaaaacc cttactcaat gaaatgataa attttaaaat
     3061 cgtacttaga tgtggagctg caagaagaat gagataagtg gtgtgaagaa acccttttta
     3121 tatgggaacg ctggcttatg gcatatttag ataattttat gataacattt tagcataatc
     3181 tagatgacta tttttaaatg attgagtttg tatttataac tagctataat tgtatttaac
     3241 tataatggac caaaataaat caaggcatta tctgttctca ttaaaaaaaa aaaaaaaaaa
     3301 aaaaaaa
//
