LOCUS       NM_001357166            1215 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TatD DNase domain containing 3 (Tatdn3), transcript
            variant 4, mRNA.
ACCESSION   NM_001357166 XM_006497203
VERSION     NM_001357166.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1215)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1215)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1215)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138229.16.
            
            On Oct 21, 2017 this sequence version replaced XM_006497203.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI328939.1, SRR5189685.114423.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC138229.16        90438-90547         c
            111-143             AC138229.16        88862-88894         c
            144-217             AC138229.16        87750-87823         c
            218-302             AC138229.16        86464-86548         c
            303-365             AC138229.16        84000-84062         c
            366-475             AC138229.16        82899-83008         c
            476-531             AC138229.16        82493-82548         c
            532-644             AC138229.16        80497-80609         c
            645-722             AC138229.16        76919-76996         c
            723-1215            AC138229.16        73465-73957         c
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..1215
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /note="TatD DNase domain containing 3"
                     /db_xref="GeneID:68972"
                     /db_xref="MGI:MGI:1916222"
     exon            1..110
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..935
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /note="isoform 4 is encoded by transcript variant 4;
                     putative deoxyribonuclease TATDN3"
                     /codon_start=1
                     /product="putative deoxyribonuclease TATDN3 isoform 4"
                     /protein_id="NP_001344095.1"
                     /db_xref="CCDS:CCDS87944.1"
                     /db_xref="GeneID:68972"
                     /db_xref="MGI:MGI:1916222"
                     /translation="MGLGLVDCHCHLSASDFDNDLDDVLEKARKANVMALVAVAEHAG
                     EFERIMQLSERYNGFVLPCLGVHPVQELSPEKPRSVTLKDLDVALPIIEKYKDRLLAI
                     GEVGLDFTPRYAGTDEEKEEQRQVLIRQVQLAKRLNVPLNVHSRSAGRPTISLLREQG
                     AKQVLLHAFDGRPSVAMEGARAGYYFSIPPSIVRSGQQKLVKQLPLSSICLETDSPAL
                     GPEKLTRNEPCNISIAAEFIAQVKGISVEEVREVTTRNAFRLFPKLQSLLQKELQSHP
                     LQAKSAQGSAGESKGLL"
     exon            111..143
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            144..217
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            218..302
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..365
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..475
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            476..531
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            532..644
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            645..722
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1215
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1201
                     /gene="Tatdn3"
                     /gene_synonym="1500010M24Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggccccagag ttccgccgcc tggcttgcag tcgagaagcc tgcaggagta gctatgggtt
       61 tggggttagt ggactgtcac tgccatctct ccgcctcgga ctttgacaac gatctggatg
      121 atgtgttgga gaaagccagg aaggctaatg tcatggccct tgtggcagtt gctgaacatg
      181 caggagaatt tgaaagaatt atgcagcttt cagaaaggta taatggattc gtcctgccat
      241 gtctgggagt tcacccagtt caagagcttt caccagaaaa accaagaagc gtgacattaa
      301 aggatttgga tgtagctttg cctattattg agaagtacaa ggatcgcttg ttggcaatcg
      361 gagaggtggg gctagacttc acccccagat atgcaggcac tgatgaggag aaggaagaac
      421 aaagacaagt cctaatcaga caagtgcaac tggccaaaag gctaaatgtg cctctaaatg
      481 tgcactcacg ctcagctgga agacccacca tcagcctctt acgtgaacaa ggtgcaaaac
      541 aggttctgct gcatgcattt gacggtcggc catcggtagc catggaaggc gccagggccg
      601 gttactactt ctccattccc ccatccatcg tacgaagtgg acagcagaag cttgtgaaac
      661 agctgcctct gagttctatc tgcttagaaa cagattcacc tgcgctagga ccagaaaagc
      721 tgacacggaa tgaaccctgc aacatttcca tcgcagcaga gttcattgcc caggtgaaag
      781 ggatttcagt ggaagaagtc cgagaagtga cgacgcggaa tgcattcaga ctgtttccca
      841 agctgcagag cctgcttcag aaagagcttc aaagtcaccc cctgcaagcc aagtcagccc
      901 agggcagcgc tggggaaagc aagggcttgc tttagtggcc tcagagaaag aagccatctt
      961 acatggctag cagtcacagt tttacagaaa tgttcctctt aaaaacaaat ttggagctgg
     1021 agagatggct ctgccattaa gagcactcag ttgctgctct tccagaggac tcgtgttcag
     1081 ttcccagcag ctatgttggg tggttcaact gcctgtaatt ccctccagcc ttctctgaca
     1141 ctagcacact ggtggcatat ctctatatag acacacggaa tataaaaatt atttctaaaa
     1201 actgtatttt taaaa
//
