LOCUS       NM_001347356            3200 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus TatD DNase domain containing 2 (Tatdn2), transcript
            variant 1, mRNA.
ACCESSION   NM_001347356 XM_006506335
VERSION     NM_001347356.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Hardy,M.P. and O'Neill,L.A.
  TITLE     The murine IRAK2 gene encodes four alternatively spliced isoforms,
            two of which are inhibitory
  JOURNAL   J Biol Chem 279 (26), 27699-27708 (2004)
   PUBMED   15082713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153987.4 and AC117596.6.
            
            On Sep 1, 2022 this sequence version replaced NM_001347356.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141065.1, SRR7345562.1584687.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               AC153987.4         127684-128156
            474-884             AC153987.4         128262-128672
            885-1505            AC153987.4         132656-133276
            1506-2378           AC117596.6         224748-225620       c
            2379-2506           AC117596.6         222261-222388       c
            2507-2690           AC117596.6         220011-220194       c
            2691-2864           AC117596.6         219440-219613       c
            2865-3200           AC117596.6         218585-218920       c
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.83 cM"
     gene            1..3200
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /note="TatD DNase domain containing 2"
                     /db_xref="GeneID:381801"
                     /db_xref="MGI:MGI:3576210"
     exon            1..473
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /inference="alignment:Splign:2.1.0"
     exon            474..884
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..2831
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="putative deoxyribonuclease TATDN2 isoform 1"
                     /protein_id="NP_001334285.1"
                     /db_xref="CCDS:CCDS85124.1"
                     /db_xref="GeneID:381801"
                     /db_xref="MGI:MGI:3576210"
                     /translation="MASERRKVKYHWGSTSEGCPSKRSRPREPGNVAPSSRPGRRCAS
                     RPRGASSPQRLKVRRGDDVARAPRSSVRRRTSSSSSSSSLSSGSGVGEAASPGFLIAS
                     PRRLFTSKGSPLHPAHSSLEEMASLRKEACSVKVDSKDSSCRSTNSEFATEAEGQSDA
                     MEEPNKFQKRKKDRPQDQGSRMIYLKAIQGILGKSMPKKKGEAATTQGKASLGDCPNQ
                     EGPSRKVEGPSKKVEGPARSRDGPSRSGEGRSRSREELVKSVEEGPAAKVTVTVSQKE
                     ESHTKVSVEKEASALDRSSFSDRRVIIDSVKKSSEELLGDRRTVIDKPSPALEFFDNS
                     DSHADIQKHTDREVVMEHPSSGSDWSDVDELATVRFSQEEPVPLKYSAVSESSSFPTD
                     CVMYPPHLYSSPWCDYASYWTSSHKTPGYPLVGSSNHDSAQAGKSSQDLLSVHSSKSQ
                     SISKGLDIAQEGRFQNSHSLRFSRSTEEEEVKGKRTFQEETPLHHTREHTSSSLPRSH
                     RELSLEEGFIDTHCHLDMLYSKLSFKGTFTKFRKIYSSSFPKEFQGCISDFCDPRTLT
                     DGLWEELLKEDLVWGAFGCHPHFARYYNESQERKLLHALRHPKAVAFGEMGLDYSHKC
                     TTPVPEQHQVFERQLKLAVSLKKPLVIHCREADEDLLDIMRKFVPSDYKIHRHCFTGS
                     YSVIEPLLKYFPNMSVGFTAVLTYSSAWEARDALRQIPLERIIVETDAPYFLPRQVPR
                     SLCQYAHPGLALHTVREIARVKEESLSHTLSVLRENTCRLYSL"
     exon            885..1505
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..2378
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2506
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2690
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2864
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3200
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3178..3183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /note="hexamer: AATAAA"
     polyA_site      3200
                     /gene="Tatdn2"
                     /gene_synonym="mKIAA0218"
                     /note="major polyA site"
ORIGIN      
        1 ggagctgacg ccgaggttgc gaagtaggcg gcggggccga ggccttggat gagggcgcgg
       61 tgcggcgctg ggccgggtca gctggaggag cggaggtgac ttccggcgcg cggctccgga
      121 ggccagtggc tccctcaggc ccggggcggg acggggcggc gggaggcgag cggccacccc
      181 gcccgcggcc cgcccttggc gtccggggcc tgcgggcgcg tgcggcccaa aaggcggctc
      241 cgcacgcgct cggccccccg cgcagggctt cggaaggcag accgctgcac cgcgccgcgc
      301 cgcgccggaa gcgcctcggc gtctcgggag tggcgcgctg ttgacagccg cgctcgcgga
      361 cttgggctgc gcgttgttcg ggctcggcgc tcggcccgcg gacgcttctc ggagcgctgt
      421 ggcgtccccg aagcccgtag cactggaatg ggcagacgac aggaacggga aaggtgccca
      481 tggcgtcgga gcggcgcaag gtcaagtatc actggggcag cacgtcggaa gggtgtccca
      541 gcaagcgcag ccgcccccgg gagcccggca atgtggcccc ctccagccgg ccaggtcgca
      601 ggtgtgcgtc gcgtcctcga ggggccagca gcccccagcg tctgaaagtc cggcgcgggg
      661 acgatgtggc ccgcgctcct cggagctcag tccgccgtcg cacctcctct tcctcttctt
      721 cgtcctctct ctcttcgggc tcaggtgtgg gtgaggccgc ttcccctggc ttcctgattg
      781 cgagccctcg gagactattt acgtccaagg ggtcccctct gcaccctgcc cactcctctc
      841 tagaagaaat ggcttctcta cggaaggaag cttgtagcgt taaggttgat tctaaagata
      901 gttcttgccg ctctacgaac tctgaatttg caacagaagc tgagggtcag agtgatgcta
      961 tggaggaacc caacaagttc cagaaaagga agaaggacag gcctcaagac cagggctcaa
     1021 gaatgatcta cctgaaggcc atccagggca tcctggggaa gtcaatgccc aagaagaagg
     1081 gagaagctgc caccactcag gggaaggcaa gcttgggaga ctgtcctaat caggaaggac
     1141 caagcaggaa ggtggaagga ccaagcaaga aggtggaagg accagccagg agcagggacg
     1201 gaccgtccag gagtggggaa ggacggtcca ggagccggga agaactggtc aagagcgttg
     1261 aggagggacc agctgcaaag gttacagtta ctgtttctca gaaagaagag tcacatacga
     1321 aggtcagtgt ggagaaggaa gcgtctgcgc tagacaggag cagcttcagt gacagaagag
     1381 tgatcataga ttctgtgaag aaaagtagtg aggagctgct tggggaccga aggacagtta
     1441 ttgacaaacc ctctccagcc ctagaatttt ttgataactc tgactctcat gcagatattc
     1501 aaaagcacac agacagagag gtggtgatgg agcatccctc ttcagggagt gactggtcag
     1561 atgtggatga gctggccact gtgaggttct cccaagagga acctgtccca ctgaaatact
     1621 cagcagtttc agaatcctct tccttcccca ctgactgtgt aatgtaccct cctcatttgt
     1681 atagtagccc atggtgtgac tatgccagct actggactag cagccataag acacctggtt
     1741 atccattagt gggatccagc aaccatgact cggcacaggc tgggaagagc agccaggatc
     1801 ttctgagtgt tcactcctcc aagtcccaga gcatctccaa aggcctagac attgcccagg
     1861 aaggtaggtt ccagaattcc cactcacttc ggttctccag aagcacagag gaggaggagg
     1921 tgaaggggaa gaggacattc caagaggaga caccacttca ccacaccaga gaacacacat
     1981 ccagctcttt gccaaggagc cacagagagc tgagcctgga agagggcttc atcgataccc
     2041 actgtcatct agacatgctc tactccaagc tgtctttcaa ggggaccttt acaaagttca
     2101 gaaagattta tagcagctcc ttccctaagg agtttcaagg ctgcatctct gacttctgtg
     2161 atccaaggac actgactgat ggcctatggg aggaacttct gaaagaagat ctggtttggg
     2221 gggcttttgg ctgtcaccct cattttgcac gatactataa tgagagtcaa gaaagaaagc
     2281 ttttgcatgc cttacgccac cccaaggctg tggcatttgg ggaaatgggg ctggactact
     2341 ctcacaagtg tactactcca gttcctgaac agcaccaggt gtttgagagg cagctgaagc
     2401 tggctgtgtc tctgaagaag cccttggtca ttcactgccg tgaagctgat gaagatttgt
     2461 tggatatcat gagaaaattt gtgccctctg actacaagat ccataggcac tgcttcactg
     2521 gcagctactc agtcattgag cccttgttga agtacttccc taacatgtcc gtgggcttca
     2581 cagcagtgct gacctactct tccgcctggg aggctcggga tgcccttaga cagatcccgt
     2641 tggagaggat cattgtggaa acagacgcac cctactttct ccctcgccag gtgccgagaa
     2701 gtctttgcca gtatgctcat ccaggcttgg ccttgcacac agttcgagag attgccaggg
     2761 tcaaagagga gtcactttcc cacactctgt cagttctccg agagaatact tgtcgcctct
     2821 acagtctttg agcagggagc acgagcagtc atcttctggc aaaggatgac cagtggcctg
     2881 atagcatagg agggctccgt ctgtctgtgt ccaaggtgaa ggatgtgttg gagatcctgt
     2941 caaaactcag cgcaccagga tgttaccttg gaccctcatc acaaggcttc acttgctggt
     3001 tgctgggtgg gtgggtgggt actgtggaat ggatttgggg tgaggagtag ttttgcctgc
     3061 tggtcacaag gccctagggt aatcagtgag caacagaaaa aaaacattat gacacagtgt
     3121 acaatgagat ggccagtctg gatccctgcc ctttggcctg ggtttcccag cagtctgaat
     3181 aaagtcacct ctttatctga
//
