LOCUS       NM_146214               2377 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tyrosine aminotransferase (Tat), mRNA.
ACCESSION   NM_146214
VERSION     NM_146214.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2377)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2377)
  AUTHORS   Jung,H.Y., Kwon,H.J., Hahn,K.R., Kim,W., Yoo,D.Y., Yoon,Y.S.,
            Kim,D.W. and Hwang,I.K.
  TITLE     Tat-heat shock protein 10 ameliorates age-related phenotypes by
            facilitating neuronal plasticity and reducing age-related genes in
            the hippocampus
  JOURNAL   Aging (Albany NY) 15 (22), 12723-12737 (2023)
   PUBMED   38011257
  REMARK    GeneRIF: Tat-heat shock protein 10 ameliorates age-related
            phenotypes by facilitating neuronal plasticity and reducing
            age-related genes in the hippocampus.
REFERENCE   3  (bases 1 to 2377)
  AUTHORS   Yeo,H.J., Shin,M.J., Yeo,E.J., Choi,Y.J., Kim,D.W., Kim,D.S.,
            Eum,W.S. and Choi,S.Y.
  TITLE     Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the
            MAPK and apoptotic signaling pathways
  JOURNAL   Free Radic Biol Med 135, 68-78 (2019)
   PUBMED   30818058
  REMARK    GeneRIF: Tat-CIAPIN1 protein transduced into HT-22cells and
            significantly inhibited cell death, DNA fragmentation, and reactive
            oxygen species (ROS) generation.
REFERENCE   4  (bases 1 to 2377)
  AUTHORS   Otani,S., Kakinuma,S., Kamiya,A., Goto,F., Kaneko,S., Miyoshi,M.,
            Tsunoda,T., Asano,Y., Kawai-Kitahata,F., Nitta,S., Nakata,T.,
            Okamoto,R., Itsui,Y., Nakagawa,M., Azuma,S., Asahina,Y.,
            Yamaguchi,T., Koshikawa,N., Seiki,M., Nakauchi,H. and Watanabe,M.
  TITLE     Matrix metalloproteinase-14 mediates formation of bile ducts and
            hepatic maturation of fetal hepatic progenitor cells
  JOURNAL   Biochem Biophys Res Commun 469 (4), 1062-1068 (2016)
   PUBMED   26724533
REFERENCE   5  (bases 1 to 2377)
  AUTHORS   Yanagida,A., Chikada,H., Ito,K., Umino,A., Kato-Itoh,M.,
            Yamazaki,Y., Sato,H., Kobayashi,T., Yamaguchi,T., Nakayama,K.I.,
            Nakauchi,H. and Kamiya,A.
  TITLE     Liver maturation deficiency in p57(Kip2)-/- mice occurs in a
            hepatocytic p57(Kip2) expression-independent manner
  JOURNAL   Dev Biol 407 (2), 331-343 (2015)
   PUBMED   26165599
REFERENCE   6  (bases 1 to 2377)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   7  (bases 1 to 2377)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Schmid,W., Aguzzi,A. and
            Schutz,G.
  TITLE     Molecular genetic analysis of glucocorticoid signaling during mouse
            development
  JOURNAL   Steroids 60 (1), 93-96 (1995)
   PUBMED   7792824
  REMARK    Review article
REFERENCE   8  (bases 1 to 2377)
  AUTHORS   Peterson,T.C., Killary,A.M. and Fournier,R.E.
  TITLE     Chromosomal assignment and trans regulation of the tyrosine
            aminotransferase structural gene in hepatoma hybrid cells
  JOURNAL   Mol Cell Biol 5 (9), 2491-2494 (1985)
   PUBMED   2874483
REFERENCE   9  (bases 1 to 2377)
  AUTHORS   Muller,G., Scherer,G., Zentgraf,H., Ruppert,S., Herrmann,B.,
            Lehrach,H. and Schutz,G.
  TITLE     Isolation, characterization and chromosomal mapping of the mouse
            tyrosine aminotransferase gene
  JOURNAL   J Mol Biol 184 (3), 367-373 (1985)
   PUBMED   2413215
REFERENCE   10 (bases 1 to 2377)
  AUTHORS   Schmid,W., Muller,G., Schutz,G. and Gluecksohn-Waelsch,S.
  TITLE     Deletions near the albino locus on chromosome 7 of the mouse affect
            the level of tyrosine aminotransferase mRNA
  JOURNAL   Proc Natl Acad Sci U S A 82 (9), 2866-2869 (1985)
   PUBMED   2859594
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124409.5.
            
            On Mar 23, 2010 this sequence version replaced NM_146214.2.
            
            Summary: This gene encodes a liver-specific mitochondrial enzyme
            that catalyzes the conversion of L-tyrosine into
            p-hydroxyphenylpyruvate. Regulated by glucocorticoid and
            polypeptide hormones, this gene's expression is affected by
            deletion of a regulatory region near the albino locus on chromosome
            7. Mutations in this gene cause tyrosinemia type II in humans.
            [provided by RefSeq, Mar 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030728.1, AK149383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC124409.5         150850-150934       c
            86-332              AC124409.5         149651-149897       c
            333-437             AC124409.5         149423-149527       c
            438-505             AC124409.5         148720-148787       c
            506-664             AC124409.5         147390-147548       c
            665-803             AC124409.5         146671-146809       c
            804-856             AC124409.5         146149-146201       c
            857-1009            AC124409.5         145151-145303       c
            1010-1138           AC124409.5         144448-144576       c
            1139-1222           AC124409.5         143765-143848       c
            1223-1321           AC124409.5         142975-143073       c
            1322-2377           AC124409.5         141566-142621       c
FEATURES             Location/Qualifiers
     source          1..2377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.38 cM"
     gene            1..2377
                     /gene="Tat"
                     /note="tyrosine aminotransferase"
                     /db_xref="GeneID:234724"
                     /db_xref="MGI:MGI:98487"
     exon            1..85
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            86..332
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1462
                     /gene="Tat"
                     /EC_number="2.6.1.5"
                     /note="tyrosine transaminase; L-tyrosine:2-oxoglutarate
                     aminotransferase"
                     /codon_start=1
                     /product="tyrosine aminotransferase"
                     /protein_id="NP_666326.1"
                     /db_xref="CCDS:CCDS22658.1"
                     /db_xref="GeneID:234724"
                     /db_xref="MGI:MGI:98487"
                     /translation="MDSYVIQTNVNDSLPSVLDVRVNIGGRSSVQGRAKGRKARWNVR
                     PSDMSNKTFNPIRAIVDNMKVKPNPNKTVISLSIGDPTVFGNLPTDPEVTQAMKDALD
                     SGKYNGYAPSIGYLSSREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQ
                     NILIPRPGFSLYRTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLVVNNPS
                     NPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFSDCKYEPMATLSTNVPILSCG
                     GLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILQRT
                     PQEFYQDTLSFLKSNADLCYGALSAIPGLQPVRPSGAMYLMVGIEMEHFPEFENDVEF
                     TERLIAEQSVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQE
                     ECDK"
     exon            333..437
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            438..505
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            506..664
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            665..803
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            804..856
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1009
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1138
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1222
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1321
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..2377
                     /gene="Tat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tat"
                     /note="hexamer: AATAAA"
     polyA_site      2083
                     /gene="Tat"
     regulatory      2356..2361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tat"
                     /note="hexamer: AATAAA"
     polyA_site      2374
                     /gene="Tat"
                     /note="major polyA site"
ORIGIN      
        1 ctcatcatca gaggacttgg tggaggagcg ctcgtgggcc ttataggttt ggctgcttgg
       61 agactgcttt gcctggacga ggaaggcttt gtgagccatg gactcctacg taatccagac
      121 gaatgtcaat gacagcctac cttcagtgct ggatgttcgc gtcaatattg gcgggagaag
      181 ctcggtgcaa gggagagcga agggcaggaa ggccaggtgg aatgtgaggc cctctgacat
      241 gtccaataaa accttcaatc ccatccgagc cattgtggac aacatgaagg tgaagccgaa
      301 tccgaacaaa accgtgatct ctctgtcaat tggggaccct actgtgtttg ggaacctgcc
      361 cacagaccct gaagtgaccc aagccatgaa ggatgccctg gactccggga agtacaatgg
      421 ctatgcccca tctatcggct acctatccag tcgggaggag gtcgcttcct attaccactg
      481 tcctgaggct cctctggaag ctaaggatgt cattctgacg agtggctgca gtcaggccat
      541 tgagctgtgt ctagccgtgt tggccaatcc tggacagaac atcctcattc cgaggcccgg
      601 gttttccctc tacaggacat tggctgagtc tatggggatt gaggtcaagc tctacaatct
      661 attgcctgag aagtcttggg aaattgatct aaaacaactg gaatctctga tcgacgaaaa
      721 aacagcttgt ctcgtggtca acaacccgtc caatccctgt ggctctgtgt tcagtaagcg
      781 gcaccttcag aagattttgg cagtggctga aaggcaatgc gtccccatct tagccgatga
      841 gatctatggt gacatggtgt tttcagattg caaatatgaa ccaatggcca ccctcagcac
      901 caatgtcccc atcctgtcct gtggtgggct ggccaagcgc tggctggttc ctggctggag
      961 gctgggctgg atccttatcc atgatcgaag agacattttt ggcaatgaga ttcgggacgg
     1021 gctggtgaag ctgagtcagc ggatcctggg cccgtgcacc atcgtccaag gtgccctgaa
     1081 gagcatcctt cagcgcaccc ctcaggagtt ctaccaggac actttaagct tccttaagtc
     1141 caatgcggac ctctgctatg gggcgttgtc tgccattcct ggactccagc cagtccgccc
     1201 atctggagcc atgtacctta tggtgggaat tgagatggag cacttcccag aatttgagaa
     1261 tgacgtggaa ttcacagagc ggttaattgc ggagcagtct gtccactgcc tcccagccac
     1321 gtgcttcgag tacccaaatt tcttccgggt tgtcatcaca gtccccgagg tgatgatgct
     1381 ggaggcttgt agccggatcc aggagttctg tgaacagcac taccactgtg ctgaaggcag
     1441 ccaggaggag tgtgacaaat aggccctcat gcatcctcct gaagacatgt cccactcaag
     1501 gagagttggg ctgctcctcc tcaggacgac agatgtccct tcttcgagag ggacctccaa
     1561 agcaccgcat caagatttga agattatttc ttcttccccc agtcacatcc aacacatgcc
     1621 tggaacccca gattctccca ttattcggct ctgctggagc gactcatgag ccctttaccc
     1681 ctagctacac gcacgcacgc acggacgcac gcactcacgc acgcaggcag gcaccatata
     1741 cttctttatc ctgagggtac cagtttacca gaaggaagct gggatgggaa aagccagagc
     1801 tcaggatgag agaagcagaa ggttgcctcc cccaccattt cctcgagctg acacaggagt
     1861 gtcctcttca gtcaggtcgg aagtcacctt ggttcctgcc tcacttcagc aatacctcac
     1921 gccctgcggt agagctacac cagagagaag tcgaagactt gtaaatttgg ttaactgtat
     1981 tctaagtgca ttgggaaact tgatatttaa aggatccttg atagaatttt ttttgtaaaa
     2041 aaattatttt gcggtgcaaa taaataccag cttcctaaac tgattagatc tgcttgtatc
     2101 aggttttctt aaaataggag cacacctcat tgaaggagaa agaagggaca ggaggcctct
     2161 ccagagacat tgctgcggac cggaaagcat cttcctcctc accttcttgt agaatcattg
     2221 ccacttttgc tgtcatgtga atattgattt attaatattt gtaatattat cttttcatat
     2281 attttctaag aaacatttat attataagat cttttatttt gtcaagggta taaattatta
     2341 ttctcttttt ttttaaataa aattttatca agtatgc
//
