LOCUS       NM_001159640            2259 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus taspase, threonine aspartase 1 (Tasp1), transcript
            variant 2, mRNA.
ACCESSION   NM_001159640
VERSION     NM_001159640.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   Niizuma,H., Searleman,A.C., Takeda,S., Armstrong,S.A., Park,C.Y.,
            Cheng,E.H. and Hsieh,J.J.
  TITLE     Taspase1 orchestrates fetal liver hematopoietic stem cell and
            vertebrae fates by cleaving TFIIA
  JOURNAL   JCI Insight 6 (15), e149382 (2021)
   PUBMED   34156981
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   Zhao,Z., Wang,L., Volk,A.G., Birch,N.W., Stoltz,K.L., Bartom,E.T.,
            Marshall,S.A., Rendleman,E.J., Nestler,C.M., Shilati,J.,
            Schiltz,G.E., Crispino,J.D. and Shilatifard,A.
  TITLE     Regulation of MLL/COMPASS stability through its proteolytic
            cleavage by taspase1 as a possible approach for clinical therapy of
            leukemia
  JOURNAL   Genes Dev 33 (1-2), 61-74 (2019)
   PUBMED   30573454
  REMARK    GeneRIF: Upon loss of taspase1, MLL1 association with chromatin is
            markedly increased due to the stabilization of its unprocessed
            version, and this stabilization of the uncleaved MLL1 can result in
            the displacement of MLL chimeras from chromatin in leukemic cells
REFERENCE   3  (bases 1 to 2259)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2259)
  AUTHORS   Takeda,S., Sasagawa,S., Oyama,T., Searleman,A.C., Westergard,T.D.,
            Cheng,E.H. and Hsieh,J.J.
  TITLE     Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by
            limiting Cdkn2a locus transcription
  JOURNAL   J Clin Invest 125 (3), 1203-1214 (2015)
   PUBMED   25664857
  REMARK    GeneRIF: TFIIA is the principal TASP1 substrate that orchestrates
            craniofacial morphogenesis.
REFERENCE   5  (bases 1 to 2259)
  AUTHORS   Dong,Y., Van Tine,B.A., Oyama,T., Wang,P.I., Cheng,E.H. and
            Hsieh,J.J.
  TITLE     Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast
            tumorigenesis
  JOURNAL   Cell Res 24 (11), 1354-1366 (2014)
   PUBMED   25267403
  REMARK    GeneRIF: Taspase1 deficiency disrupts the expression of cyclins and
            proliferation of HER2+ breast cancer cells.
REFERENCE   6  (bases 1 to 2259)
  AUTHORS   Takeda,S., Liu,H., Sasagawa,S., Dong,Y., Trainor,P.A., Cheng,E.H.
            and Hsieh,J.J.
  TITLE     HGF-MET signals via the MLL-ETS2 complex in hepatocellular
            carcinoma
  JOURNAL   J Clin Invest 123 (7), 3154-3165 (2013)
   PUBMED   23934123
REFERENCE   7  (bases 1 to 2259)
  AUTHORS   Chen,D.Y., Lee,Y., Van Tine,B.A., Searleman,A.C., Westergard,T.D.,
            Liu,H., Tu,H.C., Takeda,S., Dong,Y., Piwnica-Worms,D.R., Oh,K.J.,
            Korsmeyer,S.J., Hermone,A., Gussio,R., Shoemaker,R.H., Cheng,E.H.
            and Hsieh,J.J.
  TITLE     A pharmacologic inhibitor of the protease Taspase1 effectively
            inhibits breast and brain tumor growth
  JOURNAL   Cancer Res 72 (3), 736-746 (2012)
   PUBMED   22166309
REFERENCE   8  (bases 1 to 2259)
  AUTHORS   Niehof,M. and Borlak,J.
  TITLE     EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted
            by HNF4alpha splice variants in hepatocellular carcinomas
  JOURNAL   Gastroenterology 134 (4), 1191-1202 (2008)
   PUBMED   18395097
  REMARK    GeneRIF: TASP1, EPS15R, and PRPF3 expression were significantly
            induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven
            HNF4alpha
REFERENCE   9  (bases 1 to 2259)
  AUTHORS   Takeda,S., Chen,D.Y., Westergard,T.D., Fisher,J.K., Rubens,J.A.,
            Sasagawa,S., Kan,J.T., Korsmeyer,S.J., Cheng,E.H. and Hsieh,J.J.
  TITLE     Proteolysis of MLL family proteins is essential for
            taspase1-orchestrated cell cycle progression
  JOURNAL   Genes Dev 20 (17), 2397-2409 (2006)
   PUBMED   16951254
  REMARK    GeneRIF: This paper describes the quintessential function of
            Taspase1 in orchestrating cell cycle progression.
REFERENCE   10 (bases 1 to 2259)
  AUTHORS   Cho,S., Attaya,M., Brown,M.G. and Monaco,J.J.
  TITLE     A cluster of transcribed sequences between the Pb and Ob genes of
            the murine major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5197-5201 (1991)
   PUBMED   1711220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK015624.1, BC024597.1 and BB791136.1.
            
            On Jan 24, 2014 this sequence version replaced NM_001159640.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (a).
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024597.1, SRR17253011.5699938.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK015624.1         1-13
            14-2181             BC024597.1         1-2168
            2182-2259           BB791136.1         296-373
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 69.2 cM"
     gene            1..2259
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /note="taspase, threonine aspartase 1"
                     /db_xref="GeneID:75812"
                     /db_xref="MGI:MGI:1923062"
     exon            1..52
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            53..265
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1383
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /EC_number="3.4.25.-"
                     /note="isoform a is encoded by transcript variant 2;
                     threonine aspartase 1; taspase-1"
                     /codon_start=1
                     /product="threonine aspartase 1 isoform a"
                     /protein_id="NP_001153112.1"
                     /db_xref="CCDS:CCDS16802.1"
                     /db_xref="GeneID:75812"
                     /db_xref="MGI:MGI:1923062"
                     /translation="MIMEKGMNSGEGLPSRSSQASAAKVTVKELETQQPCKEKRGGFV
                     LVHAGAGYHSESKAKEYKHVCKRACQKAIEKLQAGALATDAVAAALVELEDSPFTNAG
                     IGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVAHRLLCEGQKGKLSAGRI
                     PPCFLVGEGAYRWAVDHGIPSCPPSTMTTRFSLAAFKRNKRKLELAERVETDFIQLKR
                     RRQSSAKENDSGTLDTVGAVVVDHEGNVAAAVSSGGLALKHPGRVGQAALYGCGCWAE
                     NTGAQNPYSTAVSTSGCGEHLVRTILARECSHALQAEDAHQALLETMQNKFISSPFLA
                     CEDGVLGGVIVLRSCRCSSESDSSQDKQTLLVEFLWSHTTESMCVGYMSAQDGKAKTH
                     ISRLPPGAVAGQSVAIEGGVCRLESPVN"
     exon            266..333
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            334..402
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            403..523
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            524..608
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            609..688
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..795
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            796..915
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            916..994
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1105
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1216
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1290
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..2259
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1463
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /note="major polyA site"
     regulatory      1958..1963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1983
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
     regulatory      2236..2241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2258
                     /gene="Tasp1"
                     /gene_synonym="4930485D02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcaacgggc gaacgactac ttcctgtgtg tgagtgctct gcgctgacgc gggttgactc
       61 cctttgcaca gttggatgga aggatgctct tttcctgata gaagatgatg atcttggaga
      121 atgatcatgg agaaggggat gaattctgga gaaggactgc cttccagatc atctcaggca
      181 tctgctgcta aagtaacagt caaggagtta gaaacacagc agccctgtaa ggagaaacga
      241 gggggctttg tgctggtgca tgcaggtgca ggctatcatt ctgaatccaa agccaaggaa
      301 tataaacatg tatgcaaacg agcttgtcag aaggcaattg agaagctaca ggctggtgct
      361 cttgctacag atgcagtggc tgctgctctg gtggaacttg aggattctcc ttttacaaat
      421 gcaggaatag gatctaatct aaatctctta ggagagattg aatgtgatgc cagcataatg
      481 gatggaaagt ccttaaactt tggagccgtt ggagcactga gtggaatcaa gaatccagtc
      541 tcagttgctc acaggctctt gtgtgaaggg cagaagggca agctctctgc aggcagaatt
      601 cctccctgct ttttagttgg agaaggagcc tacagatggg cagtggatca tgggataccc
      661 tcttgccctc ctagcaccat gaccacaaga ttcagcttag ctgcatttaa aaggaacaag
      721 aggaaactag agctggcaga aagggtggaa acagacttca tccagctgaa gagaagacga
      781 caatcaagcg caaaggaaaa tgactcaggc actttggaca cggtgggtgc tgtggtcgtg
      841 gatcacgaag ggaatgttgc tgctgctgtc tccagtgggg gcttggcctt gaaacatcca
      901 gggagagttg ggcaggctgc tctttatgga tgtggctgct gggctgagaa tactggcgct
      961 cagaacccct actccacagc tgtgagtacc tcaggatgtg gcgagcatct tgtgcgcacc
     1021 atactggcta gagaatgttc acacgcttta caagctgaag atgctcacca agctctgttg
     1081 gagactatgc aaaacaagtt tatcagttca cctttccttg cctgtgaaga tggcgtgctc
     1141 ggtggagtga tcgttctccg gtcatgcaga tgttcttcag agtctgactc ctcccaagat
     1201 aaacagacac tgcttgtgga atttctgtgg agccatacta cagagagcat gtgcgtggga
     1261 tatatgtcag cccaggacgg caaagccaag actcacattt cacgactccc tcctggtgct
     1321 gtggcaggac agtctgttgc catcgaaggt ggggtttgcc gcctggagag ccccgtgaac
     1381 tgactccagg ctgaatatga agtgtctgag aggcatttca gagcctgagc tttgggctgt
     1441 ttaattgaag ttgggtgttt taatcttctt gttttgtaat ttttattgca acctcgggca
     1501 ctgcttggga cacaagtgct gctatactta gtgctggttg acactcgagt cttagatggg
     1561 tgagcggaag tctgtgtggg tgtgtatccg tgtgcagtgt gtgcgcttgc ttcccccgga
     1621 tgggatgagt tctccttaag tgcaacctat gaatgagaat gatggaatct ttacaaaatg
     1681 tgtgctttaa ctgtttacaa ggaaacctaa agttgtagaa aacttttatt tcttcaagag
     1741 gtaccaacta tggttgatac aatgtgtctg aactgaagag tgaatctgct tgtttaaaca
     1801 acttgacctt gattgtagtc catttaataa cagtaatcag taatatggtg tcagtttaag
     1861 tggatggtgt ggtaacttaa actcttgttc tcatccctca gacagggcat ttttccttga
     1921 acacagaatg gtttcagtga aaccattcta gcagagaatt aaagtcagaa cgttttaaag
     1981 taatggtctt attggtgaag tttgtgcttc tttcctgagc tatttgaagc ttaagtattg
     2041 catagctttg cgccgtgtgt actatattat gaaagaatat gtaaagaaag tgttcagtaa
     2101 cacacagttt taatttgtgt ataatggaat gttatttaca atgtaacact gtaaataaga
     2161 aagcaaaagt ttatgggaaa attcaatatt atctttgttt cttgtttaaa tatattttta
     2221 agataaaggt acaaaaataa aagaagccta ttactgggt
//
