LOCUS       NM_001163539            3835 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus TLR adaptor interacting with endolysosomal SLC15A4
            (Tasl), mRNA.
ACCESSION   NM_001163539 XM_900683 XM_912450
VERSION     NM_001163539.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3835)
  AUTHORS   Drobek,A., Bernaleau,L., Delacretaz,M., Calderon Copete,S.,
            Royer-Chardon,C., Longepierre,M., Monguio-Tortajada,M.,
            Korzeniowski,J., Rotman,S., Marquis,J. and Rebsamen,M.
  TITLE     The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral
            responses and autoimmunity in mouse
  JOURNAL   Nat Commun 16 (1), 967 (2025)
   PUBMED   39856058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3835)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   3  (bases 1 to 3835)
  AUTHORS   Skarnes,W.C., Rosen,B., West,A.P., Koutsourakis,M., Bushell,W.,
            Iyer,V., Mujica,A.O., Thomas,M., Harrow,J., Cox,T., Jackson,D.,
            Severin,J., Biggs,P., Fu,J., Nefedov,M., de Jong,P.J., Stewart,A.F.
            and Bradley,A.
  TITLE     A conditional knockout resource for the genome-wide study of mouse
            gene function
  JOURNAL   Nature 474 (7351), 337-342 (2011)
   PUBMED   21677750
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672066.10, BY203970.1, AK155591.1 and AK017351.1.
            
            On or before Jul 26, 2009 this sequence version replaced
            XM_912450.2, XM_900683.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155591.1, SRR9219379.2852.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL672066.10        10887-10887
            2-81                BY203970.1         1-80
            82-1515             AK155591.1         8-1441
            1516-1587           AK017351.1         1458-1529
            1588-2737           AK155591.1         1514-2663
            2738-3143           AL672066.10        31016-31421
            3144-3835           AK155591.1         3070-3761
FEATURES             Location/Qualifiers
     source          1..3835
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 39.39 cM"
     gene            1..3835
                     /gene="Tasl"
                     /gene_synonym="5430427O19Rik"
                     /note="TLR adaptor interacting with endolysosomal SLC15A4"
                     /db_xref="GeneID:71398"
                     /db_xref="MGI:MGI:1918648"
     exon            1..164
                     /gene="Tasl"
                     /gene_synonym="5430427O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            165..3835
                     /gene="Tasl"
                     /gene_synonym="5430427O19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1062
                     /gene="Tasl"
                     /gene_synonym="5430427O19Rik"
                     /note="uncharacterized protein CXorf21 homolog"
                     /codon_start=1
                     /product="TLR adapter interacting with SLC15A4 on the
                     lysosome"
                     /protein_id="NP_001157011.1"
                     /db_xref="CCDS:CCDS53127.1"
                     /db_xref="GeneID:71398"
                     /db_xref="MGI:MGI:1918648"
                     /translation="MLSEGYLSGLTYWNDIHWNCASYNEPVAGDQGKETSSVAALSYS
                     SVDETQVQSLYVSCKSSGKFISSVHARASQHSRSQSRTVLQANSNPVFESPTLAAVGI
                     CRDVIRETYLVPPSCKSICKNYNDLHIAGGQVMAINSVMANFPSESSFEDGPLLKSSE
                     ISLSMEDSTSTQLTELPLKPIQRYSSYWRITSIKEKSSLQMQKPISNAVLNEYLEQKV
                     VELYKQYIMDTVFHDSSPTQILASEFIMTNVDQISLQVSKEKNLDTSKVKDIVISHLL
                     QLVSSEISTPSLHISQYSNITP"
     regulatory      1578..1583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tasl"
                     /gene_synonym="5430427O19Rik"
                     /note="hexamer: AATGAA"
     polyA_site      1594
                     /gene="Tasl"
                     /gene_synonym="5430427O19Rik"
                     /note="major polyA site"
     regulatory      3296..3301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tasl"
                     /gene_synonym="5430427O19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3321
                     /gene="Tasl"
                     /gene_synonym="5430427O19Rik"
ORIGIN      
        1 ctcttgttcc ataggatcag tgatactaag aagggggcag atcttagtag cctcttcagt
       61 gagagacttg agagcttttt gaaaagagcc ctgtctggct agttcttctc tattagatca
      121 gtcattgtgt tgctgcagga tccaaggagc agactccggt gaagaatgct atcagaagga
      181 tatctcagtg gacttaccta ctggaatgac attcattgga attgtgcatc ttataatgaa
      241 ccggtggctg gggaccaagg caaagagaca agttctgttg ctgctctttc atattcctct
      301 gtggatgaaa cacaagttca aagtctttat gtgagctgca aatcctctgg gaagtttatt
      361 tcatcagtgc atgcaagggc gagtcagcac agcagaagcc agagcagaac agtgctgcag
      421 gcaaacagca accctgtatt tgaaagtcca actttagctg cagttggtat atgcagagat
      481 gtgatcaggg agacctactt ggttccacct tcttgtaaaa gtatttgcaa aaattacaac
      541 gacttacata ttgcaggggg acaggtgatg gccattaact cagtaatggc aaatttcccc
      601 tctgagagca gctttgaaga tggtcctttg ctaaagtcat ctgagatttc tttgtccatg
      661 gaggattcca cttccactca gctcactgaa cttcccctca aacctatcca gcggtactca
      721 tcctactgga ggataaccag catcaaagag aaaagcagcc tgcaaatgca gaagcctatt
      781 tcaaatgcag tgctcaatga gtacctggag cagaaggtgg tggaattgta taagcaatat
      841 attatggaca ctgtgtttca tgacagttct cctacccaga ttctggcatc agaattcatc
      901 atgacgaatg tagatcaaat tagtcttcaa gtgtctaaag agaagaacct ggacacttca
      961 aaagtcaagg acatagttat tagccacctg ttgcagttgg tatcatctga gatcagcacc
     1021 cctagtcttc atatttctca gtatagcaat ataactccat agagaaggct cctgtcaatt
     1081 ccccttattc ctatgaatcc caaggcacta ttgtattaat ttgatcagag gatgtgatgg
     1141 agggaattct ggaagggaat taacaactag taaaggacac tttgagaaat cacatatgga
     1201 aaggaacagg aagaggaacc aaaagaatgg tttcaaggac aagtttatac agaatcagag
     1261 caaaattaaa aatgatcaca gagagaagga aggtactgtg attcaatttt aggagttctg
     1321 aaactggaag ttaagccaaa tcaggaacaa aaggaaacac tatggcaaac tagaaagtcg
     1381 atggatttga gaattgggaa ttaaacacct gtttcctatt tagatacatt tatctaggtt
     1441 gtttcttctg gaaagaaatg gactacaaga tggttgttaa attcaggtgg actgacattt
     1501 ttccaagtat aagcttgtat ttcttttcct ctgtgctata tcagtaagtc atgtagatat
     1561 actctttata aatattaaat gaatgacaaa caaatctcag ttgtttaaac attttttttt
     1621 tttgcaacaa ggctctatta gctcaggctg gttttacaat ccttacatag ccgatgatct
     1681 tgaattcctt attctcttgc ttctatccca caagtgctgg tattataggt atgtatcatc
     1741 aaatctggat gtgtttttat ttgaaatgaa aaggttcagc cacaagacta tgacttaaat
     1801 ctcctaattc tatttagtga tagagatagc agtgtttcaa cggaaaacct cctattgtga
     1861 acattgaagc attttatttc actgagtgtg attttcatgg tgctatgagg ttcaaaagga
     1921 ttatgaatac tttgcccccc atttcccttt ttcatgtgtt cttctgacct ggagccagaa
     1981 aagggtcttc tgattgttct atacaagacc aaggactcca taatttcaat ttctgtatat
     2041 ttgtttacta aaacagtagc tttacatgtg tattactgtc ttgatctttt attcagctca
     2101 ggacttagaa aactatgagc ctttggtcaa atctaacttt atgatagctt tggactctcg
     2161 tgagctaagg ataggttttc cttttctctt ttcttttttc cctttctttt ccttttttcc
     2221 ttttcttttt cttgagggag ggcctcttta ttgtatagct ccagctgtct ggaactccct
     2281 atgtagacca ggctggtgtc taacacacag agatttgtct gcctgtgctt cccacatgct
     2341 aggaggatta agggcatgtg ccattatatc acacttggca tgttttatta tttttaattt
     2401 taatatattt taaaagccca aaagcttaag ttaaaaatac tttagagcat atgaaaatta
     2461 tatgaaattt aaaattgaaa ttcagtgtat ataaactaga ctttatttgt ttatttattt
     2521 atttatttat ttattggcag tgctggtgat ggaattcaag gccttattca tgacaggcaa
     2581 gttctataac atattccatg ctgcctacta aattttattt gtttgtttat attttatata
     2641 gtttgtagtt gcttttacat aagaatggtc gaacagacat gacggagaac atatgacaca
     2701 acaaagctta atatttcttt ttaccatctg gctgtttaca gtgatgtttg ccaactctgt
     2761 tcaatgacag tgtcttgccc aaacttgatt taggttttcc aggaagcaga ctttcgaaag
     2821 gacattgggg agcattttta tccttatggg gaataggttc cctctgtgat ggaatgaggg
     2881 aagcaaatcc agatgttacc agaaagagtt agggtgaatc ttcaaaatag ttccaaattg
     2941 aaacaagtga gtaggcgtct gttctcaagc gtctaagtgc aaggtgcata ccttgactga
     3001 tggccacagg tctatggagt ggagtggagt ggagtggagt ggagtggagt gaatagctgc
     3061 agcctctggt caggagcctg gtgtctagga gcatggaaaa aggcctacca ttccagtgca
     3121 ggctaaggtc acctgctggg ttaccggggt tttaaaccta gctcaaccag aaaccaggct
     3181 gcctctcata gtcccacaac taatgaccca aagtccatta catccacacc cagccaaatt
     3241 ttctactatc attcttgaaa ttatgtgagg ttctataact gtacataaat aaataaataa
     3301 aagcactgca gaaatctgaa atggctttag taaaattttc tgccacaatg ggactacaac
     3361 agtttagatt cagaaattca gtcttccttt ttttcttttt aaaaaatttt attgggttca
     3421 ttgattctac caagactagt ctgcacaggg gagagtgtgt cactctatga aagactaata
     3481 tttcctaaaa ttgtgaggca gagaaaattc tttccttaag ttgcttctgt gtggtgtttg
     3541 ttatggcaat aagaaattaa tcgagccatc ttagttccca gatccctctg agactatctg
     3601 cacaggtgag agtatggact acagaagcta acagcttccg ggacagaccc tgtttcaggt
     3661 tctcatcttc tgccaggagg cagatctgat tgccagatat ctgtgaacct ttcctgcaag
     3721 aggagagctt gcatgcagtg agtgctctga ccactgaaac tcagaagaga gctagtcccc
     3781 caggtctgct gatagagcgt aacagaatca cctgaggaac aagctctaac cagag
//
