LOCUS       NM_021562                939 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus taste receptor, type 2, member 140 (Tas2r140), mRNA.
ACCESSION   NM_021562
VERSION     NM_021562.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Nelson,T.M., Munger,S.D. and Boughter,J.D. Jr.
  TITLE     Haplotypes at the Tas2r locus on distal chromosome 6 vary with
            quinine taste sensitivity in inbred mice
  JOURNAL   BMC Genet 6, 32 (2005)
   PUBMED   15938754
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Evolutionary relationships of the Tas2r receptor gene families in
            mouse and human
  JOURNAL   Physiol Genomics 14 (1), 73-82 (2003)
   PUBMED   12734386
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Shi,P., Zhang,J., Yang,H. and Zhang,Y.P.
  TITLE     Adaptive diversification of bitter taste receptor genes in
            Mammalian evolution
  JOURNAL   Mol Biol Evol 20 (5), 805-814 (2003)
   PUBMED   12679530
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001092.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC145965.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 64.03 cM"
     gene            1..939
                     /gene="Tas2r140"
                     /gene_synonym="mt2r64; mTRB3; T2r34; T2R40; Tas2r13;
                     Tas2r137; Tas2r40; Tas2r8; TRB3; TRB5"
                     /note="taste receptor, type 2, member 140"
                     /db_xref="GeneID:387616"
                     /db_xref="MGI:MGI:2681298"
     CDS             1..939
                     /gene="Tas2r140"
                     /gene_synonym="mt2r64; mTRB3; T2r34; T2R40; Tas2r13;
                     Tas2r137; Tas2r40; Tas2r8; TRB3; TRB5"
                     /note="T2R8; T2R13; mTRB5; T2R140; taste receptor type 2
                     member 40; taste receptor family B member 3"
                     /codon_start=1
                     /product="taste receptor type 2 member 140"
                     /protein_id="NP_067537.1"
                     /db_xref="CCDS:CCDS20633.1"
                     /db_xref="GeneID:387616"
                     /db_xref="MGI:MGI:2681298"
                     /translation="MNATVKCTLLIILGVEIIIGCLGNGFIAVVNIMDWAKRRKISLV
                     DQIFTALAISRLAFVWSLLTVLFTSELYSALMTTRKVLIIFNNSWTVINHFNIWLATC
                     LSIFYFLMIANFSNSIFLSLRWRVKTVVSVTLLMSLLLLFVNVLVINTFIVISVDVYK
                     VNTSYSSHSDNNIHISRIFLFTNTIFTFIPFSVTLTIFLLLIFSLWTHLKNMQHNAKD
                     SRDPSTTAHIKALQMMVTFLLLYTIFFLALVMQSSKMKFLSSTVFNYFFEVISLAFPS
                     GHSCVLILGNSKLRQTFISTVWWLKSSFNAAELPGP"
     exon            1..939
                     /gene="Tas2r140"
                     /gene_synonym="mt2r64; mTRB3; T2r34; T2R40; Tas2r13;
                     Tas2r137; Tas2r40; Tas2r8; TRB3; TRB5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatgcta ctgtgaagtg tacattatta atcatcttag gtgtagaaat cattataggg
       61 tgtttaggaa atggattcat agctgtggtg aacattatgg actgggccaa gagaagaaag
      121 atctccttag tggatcagat attcactgct ctggccatct ccagacttgc ttttgtgtgg
      181 tcactactca cagttttatt cacatctgag ctgtactcag cattaatgac aacaagaaaa
      241 gtgttgataa tatttaataa ttcctggaca gtgatcaatc atttcaatat ttggcttgct
      301 acatgtctca gcatctttta ttttctcatg atagctaatt tttcaaattc tatttttctt
      361 tccctaaggt ggagggtaaa aactgtggtt tcagtaacac tattgatgtc acttctcctc
      421 ttgtttgtaa acgttttagt cataaacaca tttattgtta tctcagttga tgtatataaa
      481 gtaaatacgt cctacagttc tcattcagat aacaatatac atatttctag gattttttta
      541 tttaccaaca ctatattcac attcataccc ttcagtgtga cgctgacaat ttttctcctg
      601 ctcatcttct cactatggac tcatctgaag aacatgcaac acaatgccaa agactccaga
      661 gaccccagca ccacagccca tattaaggcc ctgcaaatga tggtcacctt tctcttatta
      721 tacaccattt tctttctggc acttgtcatg caatcttcaa aaatgaagtt tctttcgagc
      781 actgtgttca attatttttt tgaggttata tcacttgctt ttccttcggg ccactcttgt
      841 gtcctaattc tgggaaattc taagctcaga cagactttta tatccacagt atggtggctg
      901 aagtccagtt ttaatgctgc agaactccca ggtccttag
//
