LOCUS       NM_207030                933 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus taste receptor, type 2, member 131 (Tas2r131), mRNA.
ACCESSION   NM_207030
VERSION     NM_207030.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 933)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 933)
  AUTHORS   Prandi,S., Voigt,A., Meyerhof,W. and Behrens,M.
  TITLE     Expression profiling of Tas2r genes reveals a complex pattern along
            the mouse GI tract and the presence of Tas2r131 in a subset of
            intestinal Paneth cells
  JOURNAL   Cell Mol Life Sci 75 (1), 49-65 (2018)
   PUBMED   28801754
  REMARK    GeneRIF: Results show that taste receptor type 2 member 131
            (Tas2r131(+)) cells appear in the jejunum and the ileum.
REFERENCE   3  (bases 1 to 933)
  AUTHORS   Voigt,A., Hubner,S., Doring,L., Perlach,N., Hermans-Borgmeyer,I.,
            Boehm,U. and Meyerhof,W.
  TITLE     Cre-Mediated Recombination in Tas2r131 Cells-A Unique Way to
            Explore Bitter Taste Receptor Function Inside and Outside of the
            Taste System
  JOURNAL   Chem Senses 40 (9), 627-639 (2015)
   PUBMED   26377344
REFERENCE   4  (bases 1 to 933)
  AUTHORS   Soultanova,A., Voigt,A., Chubanov,V., Gudermann,T., Meyerhof,W.,
            Boehm,U. and Kummer,W.
  TITLE     Cholinergic chemosensory cells of the thymic medulla express the
            bitter receptor Tas2r131
  JOURNAL   Int Immunopharmacol 29 (1), 143-147 (2015)
   PUBMED   26102274
  REMARK    GeneRIF: These data demonstrate the presence of bitter
            taste-sensing signaling in cholinergic epithelial cells in the
            thymic medulla and opens a discussion as to what is the
            physiological role of this pathway.
REFERENCE   5  (bases 1 to 933)
  AUTHORS   Voigt,A., Bojahr,J., Narukawa,M., Hubner,S., Boehm,U. and
            Meyerhof,W.
  TITLE     Transsynaptic Tracing from Taste Receptor Cells Reveals Local Taste
            Receptor Gene Expression in Gustatory Ganglia and Brain
  JOURNAL   J Neurosci 35 (26), 9717-9729 (2015)
   PUBMED   26134654
  REMARK    GeneRIF: This study demonstrated that that genetic transsynaptic
            tracing from bitter and umami receptor cells does not selectively
            label taste-specific neuronal circuits and reveal local taste
            receptor gene expression in the gustatory ganglia and the brain.
REFERENCE   6  (bases 1 to 933)
  AUTHORS   Voigt,A., Hubner,S., Lossow,K., Hermans-Borgmeyer,I., Boehm,U. and
            Meyerhof,W.
  TITLE     Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in
            mice
  JOURNAL   Chem Senses 37 (9), 897-911 (2012)
   PUBMED   23010799
REFERENCE   7  (bases 1 to 933)
  AUTHORS   Nelson,T.M., Munger,S.D. and Boughter,J.D. Jr.
  TITLE     Haplotypes at the Tas2r locus on distal chromosome 6 vary with
            quinine taste sensitivity in inbred mice
  JOURNAL   BMC Genet 6, 32 (2005)
   PUBMED   15938754
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 933)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Evolutionary relationships of the Tas2r receptor gene families in
            mouse and human
  JOURNAL   Physiol Genomics 14 (1), 73-82 (2003)
   PUBMED   12734386
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 933)
  AUTHORS   Shi,P., Zhang,J., Yang,H. and Zhang,Y.P.
  TITLE     Adaptive diversification of bitter taste receptor genes in
            Mammalian evolution
  JOURNAL   Mol Biol Evol 20 (5), 805-814 (2003)
   PUBMED   12679530
REFERENCE   10 (bases 1 to 933)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001089.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 64.03 cM"
     gene            1..933
                     /gene="Tas2r131"
                     /gene_synonym="mGR31; mt2r61; T2R31; Tas2r31"
                     /note="taste receptor, type 2, member 131"
                     /db_xref="GeneID:387356"
                     /db_xref="MGI:MGI:2681280"
     CDS             1..933
                     /gene="Tas2r131"
                     /gene_synonym="mGR31; mt2r61; T2R31; Tas2r31"
                     /codon_start=1
                     /product="taste receptor type 2 member 42"
                     /protein_id="NP_996913.1"
                     /db_xref="CCDS:CCDS20630.1"
                     /db_xref="GeneID:387356"
                     /db_xref="MGI:MGI:2681280"
                     /translation="MYMILVRAVFITGMLGNMFIGLANCSDWVKNQKITFINFIMVCL
                     AASRISSVLMLFIDATIQELAPHFYYSYRLVKCSDIFWVITDQLSTWLATCLSIFYLF
                     KVAHISHPLFLWFKWRLRGVLVVFLVFSLFLLISYFLLLETLPIWGDIYVTLKNNLTL
                     FSGTIKTTAFQKIIVFDIIYLVPFLVSLASLLLLFLSLVKHSRSLDLISTTSEDSRTK
                     IHKKAMKMLVSFLILFIIHIFFMQLARWLLFLFPMSRPINFILTLNIFALTHSFILIL
                     GNSNLRQRAMRILQHLKSQLQELILSLHRFSSLY"
     exon            1..933
                     /gene="Tas2r131"
                     /gene_synonym="mGR31; mt2r61; T2R31; Tas2r31"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtatatga tactggtaag agcagtattt ataactggaa tgctgggaaa tatgttcatt
       61 ggactggcaa actgctctga ctgggtcaag aaccagaaaa tcaccttcat caacttcatc
      121 atggtctgtt tggcagcttc cagaatcagc tctgtgctga tgttatttat tgatgcaacc
      181 atacaagaac tagcgcctca tttctattat tcttaccgtc tagtaaaatg ctctgatata
      241 ttctgggtta taactgatca actatcaaca tggcttgcca cctgcctgag catattctac
      301 ttattcaaag tagcccacat ttcccatccc cttttcctct ggtttaagtg gagattgaga
      361 ggtgtgcttg ttgtttttct tgtattttct ttgttcttat tgatttctta ttttctactg
      421 cttgaaacac ttcctatttg gggagatatt tatgtaaccc ttaaaaacaa tctgacctta
      481 ttttcaggta caattaagac cactgctttt caaaagataa ttgtttttga tataatatat
      541 ttagtcccat ttcttgtgtc cctagcatca ttgctccttt tatttttgtc cttggtgaaa
      601 cactcccgaa gccttgacct gatttctacc acttctgaag attccagaac caagattcat
      661 aagaaggcca tgaaaatgct ggtgtctttc ctcattctct ttataattca catttttttc
      721 atgcagttag cacggtggtt attatttttg tttccaatga gcaggccaat taatttcatc
      781 ttaacattaa atatctttgc cttaactcac tcatttattc tcatcctggg aaatagcaat
      841 cttcgacaga gagcaatgag gatcctgcaa catcttaaaa gccagcttca agagctgatc
      901 ctctcccttc atagattctc cagtctttac tag
//
