LOCUS       NM_020503               1006 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus taste receptor, type 2, member 119 (Tas2r119), mRNA.
ACCESSION   NM_020503
VERSION     NM_020503.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1006)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   3  (bases 1 to 1006)
  AUTHORS   Prandi,S., Bromke,M., Hubner,S., Voigt,A., Boehm,U., Meyerhof,W.
            and Behrens,M.
  TITLE     A subset of mouse colonic goblet cells expresses the bitter taste
            receptor Tas2r131
  JOURNAL   PLoS One 8 (12), e82820 (2013)
   PUBMED   24367558
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1006)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Evolutionary relationships of the Tas2r receptor gene families in
            mouse and human
  JOURNAL   Physiol Genomics 14 (1), 73-82 (2003)
   PUBMED   12734386
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1006)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   6  (bases 1 to 1006)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   7  (bases 1 to 1006)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   8  (bases 1 to 1006)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   9  (bases 1 to 1006)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   10 (bases 1 to 1006)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137123.7.
            
            On Jan 17, 2019 this sequence version replaced NM_020503.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC152359.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1006              AC137123.7         22043-23048
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.02 cM"
     gene            1..1006
                     /gene="Tas2r119"
                     /gene_synonym="mGR19; mt2r19; T2r19; Tas2r19"
                     /note="taste receptor, type 2, member 119"
                     /db_xref="GeneID:57254"
                     /db_xref="MGI:MGI:2681253"
     exon            1..1006
                     /gene="Tas2r119"
                     /gene_synonym="mGR19; mt2r19; T2r19; Tas2r19"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1006
                     /gene="Tas2r119"
                     /gene_synonym="mGR19; mt2r19; T2r19; Tas2r19"
                     /note="T2R119; taste receptor type 2 member 19; candidate
                     taste receptor T2R19"
                     /codon_start=1
                     /product="taste receptor type 2 member 119"
                     /protein_id="NP_065249.3"
                     /db_xref="CCDS:CCDS49590.1"
                     /db_xref="GeneID:57254"
                     /db_xref="MGI:MGI:2681253"
                     /translation="MEGHMLFFLLVVVVQFLTGVLANGLIVVVNAIDLIMWKKMAPLD
                     LLLFCLATSRIILQLCILFAQLGLSCLVRHTLFADNVTFVYIINELSLWFATWLGVFY
                     CAKIATIPHPLFLWLKMRISRLVPWLILASVVYVTVTTFIHSRETSELPKQIFISFSS
                     KNTTRVRPAHATLLSVFVFGLTLPFLIFTVAVLLLLSSLWNHSRQMRTMVGTREPSRH
                     ALVSAMLSILSFLILYLSHDMVAVLICTQGLHFGSRTFAFCLLVIGMYPSLHSIVLIL
                     GNPKLKRNAKMFIVHCKCCHCARAWVTSRNPRLSDLPVPATHHSANKTSCSEACTMPS
                     "
ORIGIN      
        1 gatggaaggt catatgctct tcttcctcct ggttgtggta gtgcagtttt taactggggt
       61 cttggcaaat ggcctcattg tggttgtcaa tgccatcgac ttgatcatgt ggaagaaaat
      121 ggccccactg gatctgcttc ttttttgcct ggcaacttct cgaatcattc ttcaattgtg
      181 tatattgttt gcacagctgg gtctatcctg tttggtgaga cacacgttat ttgctgacaa
      241 tgttaccttt gtctacatta taaatgaact gagtctctgg tttgccacat ggcttggtgt
      301 tttctactgt gccaagattg ctaccatccc tcacccactc tttctgtggc tgaagatgag
      361 gatatccagg ttggtgccat ggctgatcct ggcatctgtg gtctatgtaa ctgttactac
      421 tttcatccat agcagagaga cttcagaact tcctaagcaa atctttataa gcttttcttc
      481 taaaaataca actcgggtca gaccagcgca tgccacacta ctctcagtct ttgtctttgg
      541 tctcacacta ccatttctca tcttcactgt tgctgttctg ctcttgttgt cctccctgtg
      601 gaaccacagc cggcagatga ggactatggt gggaactagg gaacctagca gacatgccct
      661 cgtcagtgcg atgctctcca ttctgtcatt cctcatcctc tatctctccc atgacatggt
      721 agctgttctg atctgtaccc aaggcctcca ctttggaagc agaacctttg cattctgctt
      781 attggttatt ggtatgtacc cctccttaca ctcgattgtc ttaattttag gaaaccctaa
      841 gctgaaacga aatgcaaaaa tgttcattgt ccattgtaag tgttgtcatt gtgcaagagc
      901 ttgggtcacc tcaaggaacc caagactcag tgacttgcca gtgcctgcta ctcatcactc
      961 agccaacaag acatcctgct cagaagcctg tacaatgcca tcttaa
//
