LOCUS       NM_053212                918 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus taste receptor, type 2, member 116 (Tas2r116), mRNA.
ACCESSION   NM_053212
VERSION     NM_053212.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 918)
  AUTHORS   Kim,D., Pauer,S.H., Yong,H.M., An,S.S. and Liggett,S.B.
  TITLE     beta2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor
            14 to the Cell Surface as a Heterodimer and Exert Unidirectional
            Desensitization of Taste Receptor Function
  JOURNAL   J Biol Chem 291 (34), 17616-17628 (2016)
   PUBMED   27342779
  REMARK    GeneRIF: Thus the beta2AR acts as a double-edged sword: increasing
            TAS2R14 cell surface expression, but when activated by
            beta-agonist, partially offsetting the expression phenotype by
            direct receptor:receptor desensitization of TAS2R14 function.
REFERENCE   3  (bases 1 to 918)
  AUTHORS   Nelson,T.M., Munger,S.D. and Boughter,J.D. Jr.
  TITLE     Haplotypes at the Tas2r locus on distal chromosome 6 vary with
            quinine taste sensitivity in inbred mice
  JOURNAL   BMC Genet 6, 32 (2005)
   PUBMED   15938754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 918)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Evolutionary relationships of the Tas2r receptor gene families in
            mouse and human
  JOURNAL   Physiol Genomics 14 (1), 73-82 (2003)
   PUBMED   12734386
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 918)
  AUTHORS   Shi,P., Zhang,J., Yang,H. and Zhang,Y.P.
  TITLE     Adaptive diversification of bitter taste receptor genes in
            Mammalian evolution
  JOURNAL   Mol Biol Evol 20 (5), 805-814 (2003)
   PUBMED   12679530
REFERENCE   6  (bases 1 to 918)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   7  (bases 1 to 918)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001084.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 64.03 cM"
     gene            1..918
                     /gene="Tas2r116"
                     /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16;
                     Tas2r7; TRB1; TRB4"
                     /note="taste receptor, type 2, member 116"
                     /db_xref="GeneID:112408"
                     /db_xref="MGI:MGI:1890258"
     CDS             1..918
                     /gene="Tas2r116"
                     /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16;
                     Tas2r7; TRB1; TRB4"
                     /note="candidate taste receptor mt2r56; T2R116; taste
                     receptor, type 2, member 7; taste receptor, type 2, member
                     14"
                     /codon_start=1
                     /product="taste receptor type 2 member 116"
                     /protein_id="NP_444442.1"
                     /db_xref="CCDS:CCDS20625.1"
                     /db_xref="GeneID:112408"
                     /db_xref="MGI:MGI:1890258"
                     /translation="MNGVLQVTFIVILSVEFIIGIFGNGFIAVVNIKDLVKGRKISSV
                     DQILTALAISRIALLWLILVSWWIFVLYPGQWMTDRRVSIMHSIWTTFNQSSLWFATS
                     LSIFYFFKIANFSNPIFLYLKVRLKKVMIGTLIMSLILFCLNIIIMNAPENILITEYN
                     VSMSYSLILNNTQLSMLFPFANTMFGFIPFAVSLVTFVLLVFSLWKHQRKMQHSAHGC
                     RDASTKAHIRALQTLIASLLLYSIFFLSHVMKVWSALLLERTLLLLITQVARTAFPSV
                     HSWVLILGNAKMRKASLYVFLWLRCRHKE"
     exon            1..918
                     /gene="Tas2r116"
                     /gene_synonym="mGR16; mt2r56; T2R16; Tas2r14; Tas2r16;
                     Tas2r7; TRB1; TRB4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatggtg tcctacaggt tacatttata gtcattttga gtgtggaatt tataattggc
       61 atctttggca atggattcat agcggtggtg aacataaagg acttggtcaa gggaaggaag
      121 atctcttcag tggatcagat cctcactgct ctggccatct ccagaattgc actgctgtgg
      181 ttaatattag taagttggtg gatatttgtg ctttacccag gacaatggat gactgataga
      241 agagttagca taatgcacag tatatggaca acattcaacc agagtagtct ctggtttgct
      301 acaagtctca gcatctttta ttttttcaag atagcaaatt tttccaaccc tatttttctt
      361 tatttaaagg tcagacttaa aaaagtcatg atagggacat tgataatgtc tttgattctc
      421 ttttgtttaa atattatcat tatgaatgca cctgagaaca ttttaatcac tgaatataat
      481 gtatctatgt cttacagctt gattttgaat aacacacagc tttctatgct gtttccattt
      541 gccaacacca tgtttgggtt catacctttt gctgtgtcac tggtcacttt tgtccttctt
      601 gttttctccc tgtggaaaca tcagagaaag atgcaacaca gtgcccatgg atgcagagat
      661 gccagcacta aggcccacat cagagccttg cagacattga ttgcctccct cctcctgtat
      721 tccattttct tcctgtctca tgttatgaag gtttggagtg ctctgcttct ggagaggaca
      781 ctcctgcttt tgatcacaca ggttgcaaga acagcttttc cgtcagtgca ctcctgggtc
      841 ctgattctgg gcaatgctaa gatgagaaag gcttctctct atgtattcct gtggctgagg
      901 tgcaggcaca aagaatga
//
