LOCUS       NM_020502                894 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus taste receptor, type 2, member 108 (Tas2r108), mRNA.
ACCESSION   NM_020502
VERSION     NM_020502.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 894)
  AUTHORS   Avau,B., Bauters,D., Steensels,S., Vancleef,L., Laermans,J.,
            Lesuisse,J., Buyse,J., Lijnen,H.R., Tack,J. and Depoortere,I.
  TITLE     The Gustatory Signaling Pathway and Bitter Taste Receptors Affect
            the Development of Obesity and Adipocyte Metabolism in Mice
  JOURNAL   PLoS One 10 (12), e0145538 (2015)
   PUBMED   26692363
  REMARK    GeneRIF: The role of Tas2R108 in the development of obesity and
            adipocyte metabolism
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 894)
  AUTHORS   Yamaguchi,T., Yamashita,J., Ohmoto,M., Aoude,I., Ogura,T., Luo,W.,
            Bachmanov,A.A., Lin,W., Matsumoto,I. and Hirota,J.
  TITLE     Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing
            microvillous cells in the mouse main olfactory epithelium
  JOURNAL   BMC Neurosci 15, 13 (2014)
   PUBMED   24428937
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 894)
  AUTHORS   Prandi,S., Bromke,M., Hubner,S., Voigt,A., Boehm,U., Meyerhof,W.
            and Behrens,M.
  TITLE     A subset of mouse colonic goblet cells expresses the bitter taste
            receptor Tas2r131
  JOURNAL   PLoS One 8 (12), e82820 (2013)
   PUBMED   24367558
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 894)
  AUTHORS   Krasteva,G., Canning,B.J., Hartmann,P., Veres,T.Z., Papadakis,T.,
            Muhlfeld,C., Schliecker,K., Tallini,Y.N., Braun,A., Hackstein,H.,
            Baal,N., Weihe,E., Schutz,B., Kotlikoff,M., Ibanez-Tallon,I. and
            Kummer,W.
  TITLE     Cholinergic chemosensory cells in the trachea regulate breathing
  JOURNAL   Proc Natl Acad Sci U S A 108 (23), 9478-9483 (2011)
   PUBMED   21606356
  REMARK    GeneRIF: Data show that brush cells of the mouse trachea express
            the receptors Tas2R105 and Tas2R108.
REFERENCE   5  (bases 1 to 894)
  AUTHORS   Wu,S.V., Chen,M.C. and Rozengurt,E.
  TITLE     Genomic organization, expression, and function of bitter taste
            receptors (T2R) in mouse and rat
  JOURNAL   Physiol Genomics 22 (2), 139-149 (2005)
   PUBMED   15886333
REFERENCE   6  (bases 1 to 894)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   7  (bases 1 to 894)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   8  (bases 1 to 894)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   9  (bases 1 to 894)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   10 (bases 1 to 894)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF227148.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY916507.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/SvJ"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.82 cM"
     gene            1..894
                     /gene="Tas2r108"
                     /gene_synonym="mGR08; mt2r8; T2R108; T2r8; Tas2r4; Tas2r8"
                     /note="taste receptor, type 2, member 108"
                     /db_xref="GeneID:57253"
                     /db_xref="MGI:MGI:2681210"
     CDS             1..894
                     /gene="Tas2r108"
                     /gene_synonym="mGR08; mt2r8; T2R108; T2r8; Tas2r4; Tas2r8"
                     /note="taste receptor T2R8; T2R4; taste receptor type 2
                     member 8; candidate taste receptor T2R8"
                     /codon_start=1
                     /product="taste receptor type 2 member 4"
                     /protein_id="NP_065248.1"
                     /db_xref="CCDS:CCDS20032.1"
                     /db_xref="GeneID:57253"
                     /db_xref="MGI:MGI:2681210"
                     /translation="MLWELYVFVFAASVFLNFVGIIANLFIIVIIIKTWVNSRRIASP
                     DRILFSLAITRFLTLGLFLLNSVYIATNTGRSVYFSTFFLLCWKFLDANSLWLVTILN
                     SLYCVKITNFQHPVFLLLKRTISMKTTSLLLACLLISALTTLLYYMLSQISRFPEHII
                     GRNDTSFDLSDGILTLVASLVLNSLLQFMLNVTFASLLIHSLRRHIQKMQRNRTSFWN
                     PQTEAHMGAMRLMICFLVLYIPYSIATLLYLPSYMRKNLRAQAICMIITAAYPPGHSV
                     LLIITHHKLKAKAKKIFCFYK"
     exon            1..894
                     /gene="Tas2r108"
                     /gene_synonym="mGR08; mt2r8; T2R108; T2r8; Tas2r4; Tas2r8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctctggg aactgtatgt atttgtgttt gctgcctcgg tttttttaaa ttttgtagga
       61 atcattgcaa atctatttat tatagtgata attattaaga cttgggtcaa cagtcgcaga
      121 attgcctctc cggataggat cctgttcagc ttggccatca ctagattcct gactttgggg
      181 ttgtttctac tgaacagtgt ctacattgct acaaatactg gaaggtcagt ctacttttcc
      241 acattttttc tattgtgttg gaagtttctg gatgcaaaca gtctctggtt agtgaccatt
      301 ctgaacagct tgtattgtgt gaagattact aattttcaac acccagtgtt tctcctgttg
      361 aaacggacta tctctatgaa gaccaccagc ctgctgttgg cctgtcttct gatttcagcc
      421 ctcaccactc tcctatatta tatgctctca cagatatcac gttttcctga acacataatt
      481 gggagaaatg acacgtcatt tgacctcagt gatggtatct tgacgttagt agcctctttg
      541 gtcctgaact cacttctaca gtttatgctc aatgtgactt ttgcttcctt gttaatacat
      601 tccttgagaa gacatataca gaagatgcag agaaacagga ccagcttttg gaatccccag
      661 acggaggctc acatgggtgc tatgaggctg atgatctgtt tcctcgtgct ctacattcca
      721 tattcaattg ctaccctgct ctatcttcct tcctatatga ggaagaatct gagagcccag
      781 gccatttgca tgattattac tgctgcttac cctccaggac attctgtcct cctcattatc
      841 acacatcata aactgaaagc taaagcaaag aagattttct gtttctacaa gtag
//
