LOCUS       NM_199154               1032 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus taste receptor, type 2, member 107 (Tas2r107), mRNA.
ACCESSION   NM_199154
VERSION     NM_199154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Tan,X. and Sanderson,M.J.
  TITLE     Bitter tasting compounds dilate airways by inhibiting airway smooth
            muscle calcium oscillations and calcium sensitivity
  JOURNAL   Br J Pharmacol 171 (3), 646-662 (2014)
   PUBMED   24117140
  REMARK    GeneRIF: Data suggest that Tas2r107 is expressed on murine airway
            smooth muscle (ASM) cells; Tas2r107 agonists reverse
            bronchoconstriction by inhibiting agonist-induced calcium
            oscillations while simultaneously reducing calcium sensitivity of
            ASM cells.
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Vadasz,C., Saito,M., Gyetvai,B.M., Oros,M., Szakall,I.,
            Kovacs,K.M., Prasad,V.V., Morahan,G. and Toth,R.
  TITLE     Mapping of QTLs for oral alcohol self-administration in B6.C and
            B6.I quasi-congenic RQI strains
  JOURNAL   Neurochem Res 32 (7), 1099-1112 (2007)
   PUBMED   17273929
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Nelson,T.M., Munger,S.D. and Boughter,J.D. Jr.
  TITLE     Haplotypes at the Tas2r locus on distal chromosome 6 vary with
            quinine taste sensitivity in inbred mice
  JOURNAL   BMC Genet 6, 32 (2005)
   PUBMED   15938754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Scalzo,A.A., Wheat,R., Dubbelde,C., Stone,L., Clark,P., Du,Y.,
            Dong,N., Stoll,J., Yokoyama,W.M. and Brown,M.G.
  TITLE     Molecular genetic characterization of the distal NKC recombination
            hotspot and putative murine CMV resistance control locus
  JOURNAL   Immunogenetics 55 (6), 370-378 (2003)
   PUBMED   12920489
REFERENCE   5  (bases 1 to 1032)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Evolutionary relationships of the Tas2r receptor gene families in
            mouse and human
  JOURNAL   Physiol Genomics 14 (1), 73-82 (2003)
   PUBMED   12734386
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1032)
  AUTHORS   Shi,P., Zhang,J., Yang,H. and Zhang,Y.P.
  TITLE     Adaptive diversification of bitter taste receptor genes in
            Mammalian evolution
  JOURNAL   Mol Biol Evol 20 (5), 805-814 (2003)
   PUBMED   12679530
REFERENCE   7  (bases 1 to 1032)
  AUTHORS   Wu,S.V., Rozengurt,N., Yang,M., Young,S.H., Sinnett-Smith,J. and
            Rozengurt,E.
  TITLE     Expression of bitter taste receptors of the T2R family in the
            gastrointestinal tract and enteroendocrine STC-1 cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2392-2397 (2002)
   PUBMED   11854532
REFERENCE   8  (bases 1 to 1032)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   9  (bases 1 to 1032)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140204.3.
            
            On Nov 17, 2015 this sequence version replaced NM_199154.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC141027.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1032              AC140204.3         101636-102667
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.49 cM"
     gene            1..1032
                     /gene="Tas2r107"
                     /gene_synonym="mGR06; mt2r43; STC5-1; T2R07; T2R107; T2R4;
                     Tas2r7"
                     /note="taste receptor, type 2, member 107"
                     /db_xref="GeneID:387342"
                     /db_xref="MGI:MGI:2681207"
     exon            1..1032
                     /gene="Tas2r107"
                     /gene_synonym="mGR06; mt2r43; STC5-1; T2R07; T2R107; T2R4;
                     Tas2r7"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..992
                     /gene="Tas2r107"
                     /gene_synonym="mGR06; mt2r43; STC5-1; T2R07; T2R107; T2R4;
                     Tas2r7"
                     /codon_start=1
                     /product="taste receptor type 2 member 107"
                     /protein_id="NP_954605.1"
                     /db_xref="CCDS:CCDS20609.1"
                     /db_xref="GeneID:387342"
                     /db_xref="MGI:MGI:2681207"
                     /translation="MLNSAEGILLCVVTSEAVLGVLGDTYIALFNCMDYAKNKKLSKI
                     GFILIGLAISRIGVVWIIILQGYIQVFFPHMLTSGNITEYITYIWVFLNHLSVWFVTN
                     LNILYFLKIANFSNSVFLWLKRRVNAVFIFLSGCLLTSWLLCFPQMTKILQNSKMHQR
                     NTSWVHQRKNYFLINQSVTNLGIFFFIIVSLITCFLLIVFLWRHVRQMHSDVSGFRDH
                     STKVHVKAMKFLISFMVFFILHFVGLSIEVLCFILPQNKLLFITGLTATCLYPCGHSI
                     IVILGNKQLKQASLKALQQLKCCETKGNFRVK"
ORIGIN      
        1 tgggacattc tccagcagat aatttacaat agatgcagca gaagtaacct tagagatctg
       61 taaagatgct gaattcagca gaaggcatcc tcctttgtgt tgtcactagt gaggctgtgc
      121 tcggagtttt aggggacaca tatattgcac tttttaactg catggactat gctaagaaca
      181 agaagctctc taagatcggt ttcattctca ttggcttggc gatttccaga attggtgttg
      241 tatggataat aattttacaa gggtatatac aagtattttt tccacacatg cttacctctg
      301 gaaacataac tgaatatatt acttacatat gggtatttct caatcactta agtgtctggt
      361 ttgtcaccaa cctcaacatc ctctactttc taaagatagc taatttttcc aactctgtat
      421 ttctctggct gaaaaggaga gtcaatgcag tttttatctt tctgtcagga tgcttactta
      481 cctcatggtt actatgtttt ccacaaatga caaagatact tcaaaatagt aaaatgcacc
      541 agagaaacac atcttgggtc caccagcgga aaaattactt tcttattaac caaagtgtga
      601 ccaatctggg aatctttttc ttcattattg tatccctgat tacctgcttt ctgttgattg
      661 ttttcctctg gagacatgtc agacaaatgc attcagatgt ttcaggattc agagaccaca
      721 gcacaaaagt acatgtgaaa gctatgaaat ttctaatatc ttttatggtc ttctttattc
      781 tgcattttgt aggcctttcc atagaagtgc tatgctttat tctgccacaa aataaactgc
      841 tctttataac tggtttgaca gccacatgcc tctatccctg cggtcactca atcatcgtaa
      901 ttttaggaaa taagcagtta aagcaagcct ctttgaaggc actgcagcaa ctaaaatgct
      961 gtgagacaaa aggaaatttc agagtcaaat aaatgggttt gcaaataaat agctgccttg
     1021 ttcttccact gg
//
