LOCUS       NM_020501                903 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus taste receptor, type 2, member 105 (Tas2r105), mRNA.
ACCESSION   NM_020501
VERSION     NM_020501.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 903)
  AUTHORS   Ohmoto,M., Jyotaki,M., Yee,K.K. and Matsumoto,I.
  TITLE     A Transcription Factor Etv1/Er81 Is Involved in the Differentiation
            of Sweet, Umami, and Sodium Taste Cells
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   37045597
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 903)
  AUTHORS   Narukawa,M., Kamiyoshihara,A., Kawae,M., Kohta,R. and Misaka,T.
  TITLE     Analysis of aging-dependent changes in taste sensitivities of the
            senescence-accelerated mouse SAMP1
  JOURNAL   Exp Gerontol 113, 64-73 (2018)
   PUBMED   30243894
  REMARK    GeneRIF: The mRNA expressions of the bitter taste receptor Tas2r105
            and its coupled G protein gustducin were significantly decreased
            with aging. However, the majority of molecules tested did not show
            significant expression changes.
REFERENCE   3  (bases 1 to 903)
  AUTHORS   Gu,F., Liu,X., Liang,J., Chen,J., Chen,F. and Li,F.
  TITLE     Bitter taste receptor mTas2r105 is expressed in small intestinal
            villus and crypts
  JOURNAL   Biochem Biophys Res Commun 463 (4), 934-941 (2015)
   PUBMED   26071358
  REMARK    GeneRIF: Tas2Rs and taste-related signaling transduction cascades
            are also observed in mouse small intestine including duodenum,
            jejunum and ileum by RT-PCR and Western Blot
REFERENCE   4  (bases 1 to 903)
  AUTHORS   Liu,X., Gu,F., Jiang,L., Chen,F. and Li,F.
  TITLE     Expression of bitter taste receptor Tas2r105 in mouse kidney
  JOURNAL   Biochem Biophys Res Commun 458 (4), 733-738 (2015)
   PUBMED   25681767
  REMARK    GeneRIF: The bitter taste receptors Tas2r105 and Tas2r106 are
            expressed in the renal corpuscle and the renal tubule, including
            the proximal tubule and distal tubule.
REFERENCE   5  (bases 1 to 903)
  AUTHORS   Koudelka,J., Horn,J.M., Vatanashevanopakorn,C. and Minichiello,L.
  TITLE     Genetic dissection of TrkB activated signalling pathways required
            for specific aspects of the taste system
  JOURNAL   Neural Dev 9, 21 (2014)
   PUBMED   25256039
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 903)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   7  (bases 1 to 903)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   8  (bases 1 to 903)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   9  (bases 1 to 903)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   10 (bases 1 to 903)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF227147.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC125515.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/SvJ"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.53 cM"
     gene            1..903
                     /gene="Tas2r105"
                     /gene_synonym="mGR05; mt2r5; T2R05; T2r5; T2R9; Tas2r5"
                     /note="taste receptor, type 2, member 105"
                     /db_xref="GeneID:57252"
                     /db_xref="MGI:MGI:2681195"
     CDS             1..903
                     /gene="Tas2r105"
                     /gene_synonym="mGR05; mt2r5; T2R05; T2r5; T2R9; Tas2r5"
                     /note="taste receptor T2R5; T2R105; taste receptor type 2
                     member 5; taste receptor type 2 member 9; candidate taste
                     receptor T2R5"
                     /codon_start=1
                     /product="taste receptor type 2 member 105"
                     /protein_id="NP_065247.1"
                     /db_xref="CCDS:CCDS20612.1"
                     /db_xref="GeneID:57252"
                     /db_xref="MGI:MGI:2681195"
                     /translation="MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNNKLSMT
                     GFLLIGLATSRIFIVWLLTLDAYAKLFYPSKYFSSSLIEIISYIWMTVNHLTVWFATS
                     LSIFYFLKIANFSDCVFLWLKRRTDKAFVFLLGCLLTSWVISFSFVVKVMKDGKVNHR
                     NRTSEMYWEKRQFTINYVFLNIGVISLFMMTLTACFLLIMSLWRHSRQMQSGVSGFRD
                     LNTEAHVKAIKFLISFIILFVLYFIGVSIEIICIFIPENKLLFIFGFTTASIYPCCHS
                     FILILSNSQLKQAFVKVLQGLKFF"
     exon            1..903
                     /gene="Tas2r105"
                     /gene_synonym="mGR05; mt2r5; T2R05; T2r5; T2R9; Tas2r5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgagtg cggcagaagg catcctcctt tccattgcaa ctgttgaagc tgggctggga
       61 gttttaggga acacatttat tgcactggta aactgcatgg actgggccaa gaacaataag
      121 ctttctatga ctggcttcct tctcatcggc ttagcaactt ccaggatttt tattgtgtgg
      181 ctattaactt tagatgcata tgcaaagcta ttctatccaa gtaagtattt ttctagtagt
      241 ctgattgaaa tcatctctta tatatggatg actgtgaatc acctgactgt ctggtttgcc
      301 accagcctaa gcatcttcta tttcctgaag atagccaatt tttccgactg tgtatttctc
      361 tggttgaaga ggagaactga taaagctttt gtttttctct tggggtgttt gctaacttca
      421 tgggtaatct ccttctcatt tgttgtgaag gtgatgaagg acggtaaagt gaatcataga
      481 aacaggacct cggagatgta ctgggagaaa aggcaattca ctattaacta cgttttcctc
      541 aatattggag tcatttctct ctttatgatg accttaactg catgtttctt gttaattatg
      601 tcactttgga gacacagcag gcagatgcag tctggtgttt caggattcag agacctcaac
      661 acagaagctc atgtgaaagc cataaaattt ttaatttcat ttatcatcct tttcgtcttg
      721 tattttatag gtgtttcaat agaaattatc tgcatattta taccagaaaa caaactgcta
      781 tttatttttg gtttcacaac tgcatccata tatccttgct gtcactcatt tattctaatt
      841 ctatctaaca gccagctaaa gcaagccttt gtaaaggtac tgcaaggatt aaagttcttt
      901 tag
//
