LOCUS       NM_031872               3514 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus taste receptor, type 1, member 3 (Tas1r3), mRNA.
ACCESSION   NM_031872
VERSION     NM_031872.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3514)
  AUTHORS   Seong,H., Song,J.W., Lee,K.H., Jang,G., Shin,D.M. and Shon,W.J.
  TITLE     Taste receptor type 1 member 3 regulates Western diet-induced male
            infertility
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (3), 159433 (2024)
   PUBMED   38007088
REFERENCE   2  (bases 1 to 3514)
  AUTHORS   Shi,Q., Xu,L., Cai,L., Deng,S. and Qi,X.
  TITLE     Sucralose regulates postprandial blood glucose in mice through
            intestinal sweet taste receptors Tas1r2/Tas1r3
  JOURNAL   J Sci Food Agric 104 (4), 2233-2244 (2024)
   PUBMED   37938171
  REMARK    GeneRIF: Sucralose regulates postprandial blood glucose in mice
            through intestinal sweet taste receptors Tas1r2/Tas1r3.
REFERENCE   3  (bases 1 to 3514)
  AUTHORS   Shon,W.J., Seong,H., Song,J.W. and Shin,D.M.
  TITLE     Taste receptor type 1 member 3 is required for the fertility of
            male mice
  JOURNAL   Heliyon 10 (2), e24577 (2024)
   PUBMED   38312691
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3514)
  AUTHORS   Lee,K.H., Song,J.W., Kim,C.S., Seong,H., Shin,D.M. and Shon,W.J.
  TITLE     Taste receptor type 1 member 3 mediates diet-induced cognitive
            impairment in mice
  JOURNAL   Life Sci 334, 122194 (2023)
   PUBMED   37865176
  REMARK    GeneRIF: Taste receptor type 1 member 3 mediates diet-induced
            cognitive impairment in mice.
REFERENCE   5  (bases 1 to 3514)
  AUTHORS   Song,J.W., Lee,K.H., Seong,H., Shin,D.M. and Shon,W.J.
  TITLE     Taste receptor type 1 member 3 enables western diet-induced anxiety
            in mice
  JOURNAL   BMC Biol 21 (1), 243 (2023)
   PUBMED   37926812
  REMARK    GeneRIF: Taste receptor type 1 member 3 enables western
            diet-induced anxiety in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3514)
  AUTHORS   Capeless,C.G. and Whitney,G.
  TITLE     The genetic basis of preference for sweet substances among inbred
            strains of mice: preference ratio phenotypes and the alleles of the
            Sac and dpa loci
  JOURNAL   Chem Senses 20 (3), 291-298 (1995)
   PUBMED   7552037
REFERENCE   7  (bases 1 to 3514)
  AUTHORS   Belknap,J.K., Crabbe,J.C., Plomin,R., McClearn,G.E., Sampson,K.E.,
            O'Toole,L.A. and Gora-Maslak,G.
  TITLE     Single-locus control of saccharin intake in BXD/Ty recombinant
            inbred (RI) mice: some methodological implications for RI strain
            analysis
  JOURNAL   Behav Genet 22 (1), 81-100 (1992)
   PUBMED   1590732
REFERENCE   8  (bases 1 to 3514)
  AUTHORS   Lush,I.E.
  TITLE     The genetics of tasting in mice. VI. Saccharin, acesulfame, dulcin
            and sucrose
  JOURNAL   Genet Res 53 (2), 95-99 (1989)
   PUBMED   2744455
REFERENCE   9  (bases 1 to 3514)
  AUTHORS   Galbraith,D.B. and Wolff,G.L.
  TITLE     Aberrant regulation of the Agouti pigment pattern in the viable
            yellow mouse
  JOURNAL   J Hered 65 (3), 137-140 (1974)
   PUBMED   4847754
REFERENCE   10 (bases 1 to 3514)
  AUTHORS   Fuller,J.L.
  TITLE     Single-locus control of saccharin preference in mice
  JOURNAL   J Hered 65 (1), 33-36 (1974)
   PUBMED   4847746
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL670236.9.
            
            On Nov 17, 2006 this sequence version replaced NM_031872.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF337039.1, AB049994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AL670236.9         169734-169943       c
            211-511             AL670236.9         169325-169625       c
            512-1315            AL670236.9         168441-169244       c
            1316-1513           AL670236.9         168132-168329       c
            1514-1634           AL670236.9         167913-168033       c
            1635-3514           AL670236.9         165858-167737       c
FEATURES             Location/Qualifiers
     source          1..3514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.65 cM"
     gene            1..3514
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /note="taste receptor, type 1, member 3"
                     /db_xref="GeneID:83771"
                     /db_xref="MGI:MGI:1933547"
     exon            1..210
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2596
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /note="sweet taste receptor T1R3; saccharin preference
                     protein"
                     /codon_start=1
                     /product="taste receptor type 1 member 3 precursor"
                     /protein_id="NP_114078.1"
                     /db_xref="CCDS:CCDS19046.1"
                     /db_xref="GeneID:83771"
                     /db_xref="MGI:MGI:1933547"
                     /translation="MPALAIMGLSLAAFLELGMGASLCLSQQFKAQGDYILGGLFPLG
                     STEEATLNQRTQPNSIPCNRFSPLGLFLAMAMKMAVEEINNGSALLPGLRLGYDLFDT
                     CSEPVVTMKSSLMFLAKVGSQSIAAYCNYTQYQPRVLAVIGPHSSELALITGKFFSFF
                     LMPQVSYSASMDRLSDRETFPSFFRTVPSDRVQLQAVVTLLQNFSWNWVAALGSDDDY
                     GREGLSIFSSLANARGICIAHEGLVPQHDTSGQQLGKVLDVLRQVNQSKVQVVVLFAS
                     ARAVYSLFSYSIHHGLSPKVWVASESWLTSDLVMTLPNIARVGTVLGFLQRGALLPEF
                     SHYVETHLALAADPAFCASLNAELDLEEHVMGQRCPRCDDIMLQNLSSGLLQNLSAGQ
                     LHHQIFATYAAVYSVAQALHNTLQCNVSHCHVSEHVLPWQLLENMYNMSFHARDLTLQ
                     FDAEGNVDMEYDLKMWVWQSPTPVLHTVGTFNGTLQLQQSKMYWPGNQVPVSQCSRQC
                     KDGQVRRVKGFHSCCYDCVDCKAGSYRKHPDDFTCTPCNQDQWSPEKSTACLPRRPKF
                     LAWGEPVVLSLLLLLCLVLGLALAALGLSVHHWDSPLVQASGGSQFCFGLICLGLFCL
                     SVLLFPGRPSSASCLAQQPMAHLPLTGCLSTLFLQAAETFVESELPLSWANWLCSYLR
                     GLWAWLVVLLATFVEAALCAWYLIAFPPEVVTDWSVLPTEVLEHCHVRSWVSLGLVHI
                     TNAMLAFLCFLGTFLVQSQPGRYNRARGLTFAMLAYFITWVSFVPLLANVQVAYQPAV
                     QMGAILVCALGILVTFHLPKCYVLLWLPKLNTQEFFLGRNAKKAADENSGGGEAAQGH
                     NE"
     exon            211..511
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..1315
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1513
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1634
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..3514
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3488..3493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /note="hexamer: ATTAAA"
     polyA_site      3514
                     /gene="Tas1r3"
                     /gene_synonym="Sac; T1r3"
                     /note="major polyA site"
ORIGIN      
        1 ctggagactt ctacctacca tgccagcttt ggctatcatg ggtctcagcc tggctgcttt
       61 cctggagctt gggatggggg cctctttgtg tctgtcacag caattcaagg cacaagggga
      121 ctacatactg ggcgggctat ttcccctggg ctcaaccgag gaggccactc tcaaccagag
      181 aacacaaccc aacagcatcc cgtgcaacag gttctcaccc cttggtttgt tcctggccat
      241 ggctatgaag atggctgtgg aggagatcaa caatggatct gccttgctcc ctgggctgcg
      301 gctgggctat gacctatttg acacatgctc cgagccagtg gtcaccatga aatccagtct
      361 catgttcctg gccaaggtgg gcagtcaaag cattgctgcc tactgcaact acacacagta
      421 ccaaccccgt gtgctggctg tcatcggccc ccactcatca gagcttgccc tcattacagg
      481 caagttcttc agcttcttcc tcatgccaca ggtcagctat agtgccagca tggatcggct
      541 aagtgaccgg gaaacgtttc catccttctt ccgcacagtg cccagtgacc gggtgcagct
      601 gcaggcagtt gtgactctgt tgcagaactt cagctggaac tgggtggccg ccttagggag
      661 tgatgatgac tatggccggg aaggtctgag catcttttct agtctggcca atgcacgagg
      721 tatctgcatc gcacatgagg gcctggtgcc acaacatgac actagtggcc aacagttggg
      781 caaggtgctg gatgtactac gccaagtgaa ccaaagtaaa gtacaagtgg tggtgctgtt
      841 tgcctctgcc cgtgctgtct actccctttt tagttacagc atccatcatg gcctctcacc
      901 caaggtatgg gtggccagtg agtcttggct gacatctgac ctggtcatga cacttcccaa
      961 tattgcccgt gtgggcactg tgcttgggtt tttgcagcgg ggtgccctac tgcctgaatt
     1021 ttcccattat gtggagactc accttgccct ggccgctgac ccagcattct gtgcctcact
     1081 gaatgcggag ttggatctgg aggaacatgt gatggggcaa cgctgtccac ggtgtgacga
     1141 catcatgctg cagaacctat catctgggct gttgcagaac ctatcagctg ggcaattgca
     1201 ccaccaaata tttgcaacct atgcagctgt gtacagtgtg gctcaagccc ttcacaacac
     1261 cctacagtgc aatgtctcac attgccacgt atcagaacat gttctaccct ggcagctcct
     1321 ggagaacatg tacaatatga gtttccatgc tcgagacttg acactacagt ttgatgctga
     1381 agggaatgta gacatggaat atgacctgaa gatgtgggtg tggcagagcc ctacacctgt
     1441 attacatact gtgggcacct tcaacggcac ccttcagctg cagcagtcta aaatgtactg
     1501 gccaggcaac caggtgccag tctcccagtg ttcccgccag tgcaaagatg gccaggttcg
     1561 ccgagtaaag ggctttcatt cctgctgcta tgactgcgtg gactgcaagg cgggcagcta
     1621 ccggaagcat ccagatgact tcacctgtac tccatgtaac caggaccagt ggtccccaga
     1681 gaaaagcaca gcctgcttac ctcgcaggcc caagtttctg gcttgggggg agccagttgt
     1741 gctgtcactc ctcctgctgc tttgcctggt gctgggtcta gcactggctg ctctggggct
     1801 ctctgtccac cactgggaca gccctcttgt ccaggcctca ggtggctcac agttctgctt
     1861 tggcctgatc tgcctaggcc tcttctgcct cagtgtcctt ctgttcccag ggcggccaag
     1921 ctctgccagc tgccttgcac aacaaccaat ggctcacctc cctctcacag gctgcctgag
     1981 cacactcttc ctgcaagcag ctgagacctt tgtggagtct gagctgccac tgagctgggc
     2041 aaactggcta tgcagctacc ttcggggact ctgggcctgg ctagtggtac tgttggccac
     2101 ttttgtggag gcagcactat gtgcctggta tttgatcgct ttcccaccag aggtggtgac
     2161 agactggtca gtgctgccca cagaggtact ggagcactgc cacgtgcgtt cctgggtcag
     2221 cctgggcttg gtgcacatca ccaatgcaat gttagctttc ctctgctttc tgggcacttt
     2281 cctggtacag agccagcctg gccgctacaa ccgtgcccgt ggtctcacct tcgccatgct
     2341 agcttatttc atcacctggg tctcttttgt gcccctcctg gccaatgtgc aggtggccta
     2401 ccagccagct gtgcagatgg gtgctatcct agtctgtgcc ctgggcatcc tggtcacctt
     2461 ccacctgccc aagtgctatg tgcttctttg gctgccaaag ctcaacaccc aggagttctt
     2521 cctgggaagg aatgccaaga aagcagcaga tgagaacagt ggcggtggtg aggcagctca
     2581 gggacacaat gaatgaccac tgacccgtga ccttcccttt agggaaccta gccctaccag
     2641 aaatctccta agccaacaag ccccgaatag tacctcagcc tgagacgtga gacacttaac
     2701 tatagacttg gactccactg accttagcct cacagtgacc ccttccccaa acccccaagg
     2761 cctgcagtgc acaagatgga ccctatgagc ccacctatcc tttcaaagca agattatcct
     2821 tgatcctatt atgcccacct aaggcctgcc caggtgaccc acaaaaggtt ctttgggact
     2881 tcatagccat actttgaatt cagaaattcc ccaggcagac catgggagac cagaaggtac
     2941 tgcttgcctg aacatgccca gccctgagcc ctcactcagc accctgtcca ggcgtcccag
     3001 gaatagaagg ctgggcatgt atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3061 gtgtatgtac gtatgtatgt atgtatcagg acagaacaag aaagacatca ggcagaggac
     3121 actcaggagg taggcaacat ccagccttct ccatccctag ctgagcccta gcctgtagga
     3181 gagaaccagg tcgccgccag caccttggac agatcacaca cagggtgcgg gtcagcacca
     3241 cggccagcgc cagccacgcg ggacccctgg aatcagcttc tagtaccaag gacagaaaag
     3301 ttgccgcaag gccccttact ggccagcacc agggacagag ccacatgcct aagcggcaag
     3361 ggacaagagc atcgtccatc tgcaggcagg atcagacccg ggtcagttct ggactggccc
     3421 ccacacctga atcccggagc agctcagctg gagaaaagag aaacaagcca cacatcagtc
     3481 ccataaaatt aaacgctttt tttagtgttt aaaa
//
