LOCUS       NM_031873               3060 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus taste receptor, type 1, member 2 (Tas1r2), mRNA.
ACCESSION   NM_031873 XM_914879
VERSION     NM_031873.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3060)
  AUTHORS   Serrano,J., Boyd,J., Brown,I.S., Mason,C., Smith,K.R., Karolyi,K.,
            Maurya,S.K., Meshram,N.N., Serna,V., Link,G.M., Gardell,S.J. and
            Kyriazis,G.A.
  TITLE     The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor
            in skeletal muscle that regulates NAD homeostasis and mitochondrial
            capacity
  JOURNAL   Nat Commun 15 (1), 4915 (2024)
   PUBMED   38851747
  REMARK    GeneRIF: The TAS1R2 G-protein-coupled receptor is an ambient
            glucose sensor in skeletal muscle that regulates NAD homeostasis
            and mitochondrial capacity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3060)
  AUTHORS   Shi,Q., Xu,L., Cai,L., Deng,S. and Qi,X.
  TITLE     Sucralose regulates postprandial blood glucose in mice through
            intestinal sweet taste receptors Tas1r2/Tas1r3
  JOURNAL   J Sci Food Agric 104 (4), 2233-2244 (2024)
   PUBMED   37938171
  REMARK    GeneRIF: Sucralose regulates postprandial blood glucose in mice
            through intestinal sweet taste receptors Tas1r2/Tas1r3.
REFERENCE   3  (bases 1 to 3060)
  AUTHORS   Ohmoto,M., Jyotaki,M., Yee,K.K. and Matsumoto,I.
  TITLE     A Transcription Factor Etv1/Er81 Is Involved in the Differentiation
            of Sweet, Umami, and Sodium Taste Cells
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   37045597
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3060)
  AUTHORS   Serrano,J., Meshram,N.N., Soundarapandian,M.M., Smith,K.R.,
            Mason,C., Brown,I.S., Tyrberg,B. and Kyriazis,G.A.
  TITLE     Saccharin Stimulates Insulin Secretion Dependent on Sweet Taste
            Receptor-Induced Activation of PLC Signaling Axis
  JOURNAL   Biomedicines 10 (1), 120 (2022)
   PUBMED   35052799
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3060)
  AUTHORS   Zheng,X., Zhu,J., Liu,J., Wang,H., Qin,Y., Jiang,P., Xiao,L.,
            Gong,T., Li,Y., Peng,X., Xu,X., Cheng,L., Huang,L., Chen,Q.,
            Zhou,X. and Margolskee,R.F.
  TITLE     Sweet taste perception in mice is blunted by PTBP1-regulated
            skipping of Tas1r2 exon 4
  JOURNAL   Chem Senses 47 (2022)
   PUBMED   36484118
  REMARK    GeneRIF: Sweet taste perception in mice is blunted by
            PTBP1-regulated skipping of Tas1r2 exon 4.
REFERENCE   6  (bases 1 to 3060)
  AUTHORS   Bachmanov,A.A., Li,X., Reed,D.R., Ohmen,J.D., Li,S., Chen,Z.,
            Tordoff,M.G., de Jong,P.J., Wu,C., West,D.B., Chatterjee,A.,
            Ross,D.A. and Beauchamp,G.K.
  TITLE     Positional cloning of the mouse saccharin preference (Sac) locus
  JOURNAL   Chem Senses 26 (7), 925-933 (2001)
   PUBMED   11555487
REFERENCE   7  (bases 1 to 3060)
  AUTHORS   Nelson,G., Hoon,M.A., Chandrashekar,J., Zhang,Y., Ryba,N.J. and
            Zuker,C.S.
  TITLE     Mammalian sweet taste receptors
  JOURNAL   Cell 106 (3), 381-390 (2001)
   PUBMED   11509186
REFERENCE   8  (bases 1 to 3060)
  AUTHORS   Montmayeur,J.P., Liberles,S.D., Matsunami,H. and Buck,L.B.
  TITLE     A candidate taste receptor gene near a sweet taste locus
  JOURNAL   Nat Neurosci 4 (5), 492-498 (2001)
   PUBMED   11319557
REFERENCE   9  (bases 1 to 3060)
  AUTHORS   Kitagawa,M., Kusakabe,Y., Miura,H., Ninomiya,Y. and Hino,A.
  TITLE     Molecular genetic identification of a candidate receptor gene for
            sweet taste
  JOURNAL   Biochem Biophys Res Commun 283 (1), 236-242 (2001)
   PUBMED   11322794
REFERENCE   10 (bases 1 to 3060)
  AUTHORS   Hoon,M.A., Adler,E., Lindemeier,J., Battey,J.F., Ryba,N.J. and
            Zuker,C.S.
  TITLE     Putative mammalian taste receptors: a class of taste-specific GPCRs
            with distinct topographic selectivity
  JOURNAL   Cell 96 (4), 541-551 (1999)
   PUBMED   10052456
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF337041.1.
            
            On Dec 7, 2005 this sequence version replaced XM_914879.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF337041.1, AY032623.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.82 cM"
     gene            1..3060
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /note="taste receptor, type 1, member 2"
                     /db_xref="GeneID:83770"
                     /db_xref="MGI:MGI:1933546"
     exon            1..222
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2563
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /note="sweet taste receptor T1R2; G-protein coupled
                     receptor 71; candidate taste receptor T1R2"
                     /codon_start=1
                     /product="taste receptor type 1 member 2 precursor"
                     /protein_id="NP_114079.1"
                     /db_xref="CCDS:CCDS18849.1"
                     /db_xref="GeneID:83770"
                     /db_xref="MGI:MGI:1933546"
                     /translation="MGPQARTLHLLFLLLHALPKPVMLVGNSDFHLAGDYLLGGLFTL
                     HANVKSVSHLSYLQVPKCNEYNMKVLGYNLMQAMRFAVEEINNCSSLLPGVLLGYEMV
                     DVCYLSNNIQPGLYFLSQIDDFLPILKDYSQYRPQVVAVIGPDNSESAITVSNILSYF
                     LVPQVTYSAITDKLRDKRRFPAMLRTVPSATHHIEAMVQLMVHFQWNWIVVLVSDDDY
                     GRENSHLLSQRLTNTGDICIAFQEVLPVPEPNQAVRPEEQDQLDNILDKLRRTSARVV
                     VIFSPELSLHNFFREVLRWNFTGFVWIASESWAIDPVLHNLTELRHTGTFLGVTIQRV
                     SIPGFSQFRVRHDKPEYPMPNETSLRTTCNQDCDACMNITESFNNVLMLSGERVVYSV
                     YSAVYAVAHTLHRLLHCNQVRCTKQIVYPWQLLREIWHVNFTLLGNQLFFDEQGDMPM
                     LLDIIQWQWGLSQNPFQSIASYSPTETRLTYISNVSWYTPNNTVPISMCSKSCQPGQM
                     KKPIGLHPCCFECVDCPPGTYLNRSVDEFNCLSCPGSMWSYKNNIACFKRRLAFLEWH
                     EVPTIVVTILAALGFISTLAILLIFWRHFQTPMVRSAGGPMCFLMLVPLLLAFGMVPV
                     YVGPPTVFSCFCRQAFFTVCFSVCLSCITVRSFQIVCVFKMARRLPSAYGFWMRYHGP
                     YVFVAFITAVKVALVAGNMLATTINPIGRTDPDDPNIIILSCHPNYRNGLLFNTSMDL
                     LLSVLGFSFAYVGKELPTNYNEAKFITLSMTFSFTSSISLCTFMSVHDGVLVTIMDLL
                     VTVLNFLAIGLGYFGPKCYMILFYPERNTSAYFNSMIQGYTMRKS"
     exon            223..523
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1300
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1510
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1634
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..3047
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3026..3031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /note="hexamer: AATAAA"
     polyA_site      3047
                     /gene="Tas1r2"
                     /gene_synonym="Gpr71; T1r2; TR2"
                     /note="major polyA site"
ORIGIN      
        1 gggcatcgtc taaggctgtt acttggctgg catgggaccc caggcgagga cactccattt
       61 gctgtttctc ctgctgcatg ctctgcctaa gccagtcatg ctggtaggga actccgactt
      121 tcacctggct ggggactacc tcctgggtgg cctctttacc ctccatgcca acgtgaagag
      181 cgtctctcac ctcagctacc tgcaggtgcc caagtgcaat gagtacaaca tgaaggtctt
      241 gggctacaac ctcatgcagg ccatgcgatt cgccgtggag gaaatcaaca actgtagctc
      301 tctgctgccc ggcgtgctgc tcggctacga gatggtggat gtctgctacc tctccaacaa
      361 tatccagcct gggctctact tcctgtcaca gatagatgac ttcctgccca tcctcaaaga
      421 ctacagccag tacaggcccc aagtggtggc cgtcattggc ccagacaact ctgagtccgc
      481 catcaccgtg tccaacattc tctcctactt cctcgtgcca caggtcacat atagcgccat
      541 caccgacaag ctgcgagaca agcggcgctt ccctgccatg ctgcgcactg tgcccagcgc
      601 cacccaccac atcgaggcca tggtgcaact gatggttcac ttccagtgga actggatcgt
      661 ggtgctggtg agcgatgacg attatggccg agagaacagc cacctgctga gccagcgtct
      721 gaccaacact ggcgatatct gcattgcctt ccaggaggtt ctgcctgtac cagaacccaa
      781 ccaggccgtg aggcctgagg agcaggacca actggacaac atcctggaca agctgcggcg
      841 gacctcggcg cgtgtggtgg tgatattctc gccagagctg agcctgcaca acttcttccg
      901 cgaggtgctg cgctggaact tcacaggctt tgtgtggatt gcctctgagt cctgggccat
      961 cgaccctgtt ctacacaacc tcacagagct gcgccacacg ggcactttcc tgggcgtcac
     1021 catccagagg gtgtccatcc ctggcttcag ccagttccga gtgcgccacg acaagccaga
     1081 gtatcccatg cctaacgaga ccagcctgag gactacctgt aaccaggact gtgacgcctg
     1141 catgaacatc accgagtcct ttaacaacgt tctcatgctt tcgggggagc gtgtggtcta
     1201 cagtgtgtac tcggccgtct acgcggtagc ccacaccctc cacagactcc tccactgcaa
     1261 ccaggtccgc tgcaccaagc aaatcgtcta tccatggcag ctactcaggg agatctggca
     1321 tgtcaacttc acgctcctgg gcaaccagct cttcttcgac gaacaagggg acatgccgat
     1381 gctcctggac atcatccagt ggcaatgggg cctgagccag aaccccttcc aaagcatcgc
     1441 ctcctactcc cccaccgaga cgaggctgac ctacattagc aatgtgtcct ggtacacccc
     1501 caacaacacg gtccccatat ccatgtgttc taagagttgc cagcctgggc aaatgaaaaa
     1561 acccataggc ctccacccgt gctgcttcga gtgtgtggac tgtccgccgg gcacctacct
     1621 caaccgatca gtagatgagt ttaactgtct gtcctgcccg ggttccatgt ggtcttacaa
     1681 gaacaacatc gcttgcttca agcggcggct ggccttcctg gagtggcacg aagtgcccac
     1741 tatcgtggtg accatcctgg ccgccctggg cttcatcagt acgctggcca ttctgctcat
     1801 cttctggaga catttccaga cgcccatggt gcgctcggcg ggcggcccca tgtgcttcct
     1861 gatgctggtg cccctgctgc tggcgttcgg gatggtcccc gtgtatgtgg gcccccccac
     1921 ggtcttctcc tgtttctgcc gccaggcttt cttcaccgtt tgcttctccg tctgcctctc
     1981 ctgcatcacg gtgcgctcct tccagattgt gtgcgtcttc aagatggcca gacgcctgcc
     2041 aagcgcctac ggtttctgga tgcgttacca cgggccctac gtctttgtgg ccttcatcac
     2101 ggccgtcaag gtggccctgg tggcaggcaa catgctggcc accaccatca accccattgg
     2161 ccggaccgac cccgatgacc ccaatatcat aatcctctcc tgccacccta actaccgcaa
     2221 cgggctactc ttcaacacca gcatggactt gctgctgtcc gtgctgggtt tcagcttcgc
     2281 gtacgtgggc aaggaactgc ccaccaacta caacgaagcc aagttcatca ccctcagcat
     2341 gaccttctcc ttcacctcct ccatctccct ctgcacgttc atgtctgtcc acgatggcgt
     2401 gctggtcacc atcatggatc tcctggtcac tgtgctcaac tttctggcca tcggcttggg
     2461 gtactttggc cccaagtgtt acatgatcct tttctacccg gagcgcaaca cttcagctta
     2521 tttcaatagc atgattcagg gctacacgat gaggaagagc tagtcccacc caccgcctca
     2581 gcagcagagc ccccagccac gctcccggtg ttccttgttc ctcagcattc tttgcagtgt
     2641 agctattttt tttacccaca tagctcttga aattacccat aatgcactcc cactgccccc
     2701 tcctccaatc cccgaacccc gcccgagcgg ggggttcact ggctaggacc taccacccac
     2761 ttatggaaga aaccaccaag gtgacctatg tggctccaag gatggcccac cactgccatc
     2821 tggtggccat agagagcacc tgcggggctg tggcccatgc cttcctgctc atggctagtg
     2881 tggctgtgag accaaccatg gtggctactg tgctctccag atgtctgtta atctgtgttt
     2941 cattccggtt cctggggagc acagactggg actcctgtgt tctaatggtc agatgagcat
     3001 catgggtcct ccattgttgc ttatgaataa atttcccttg ggtgaaaaaa aaaaaaaaaa
//
