LOCUS       NM_031867               2814 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus taste receptor, type 1, member 1 (Tas1r1), mRNA.
ACCESSION   NM_031867
VERSION     NM_031867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2814)
  AUTHORS   Ohmoto,M., Jyotaki,M., Yee,K.K. and Matsumoto,I.
  TITLE     A Transcription Factor Etv1/Er81 Is Involved in the Differentiation
            of Sweet, Umami, and Sodium Taste Cells
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   37045597
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2814)
  AUTHORS   Stavrou,M.R., So,S.S., Finch,A.M., Ballouz,S. and Smith,N.J.
  TITLE     Gene expression analyses of TAS1R taste receptors relevant to the
            treatment of cardiometabolic disease
  JOURNAL   Chem Senses 48 (2023)
   PUBMED   37539767
  REMARK    GeneRIF: Gene expression analyses of TAS1R taste receptors relevant
            to the treatment of cardiometabolic disease.
REFERENCE   3  (bases 1 to 2814)
  AUTHORS   Ma,L., Tian,X., Xi,F., He,Y., Li,D., Sun,J., Yuan,T., Li,K.,
            Fan,L., Zhang,C., Yang,G. and Yu,T.
  TITLE     Ablation of Tas1r1 Reduces Lipid Accumulation Through Reducing the
            de Novo Lipid Synthesis and Improving Lipid Catabolism in Mice
  JOURNAL   J Agric Food Chem 70 (33), 10248-10258 (2022)
   PUBMED   35968935
  REMARK    GeneRIF: Ablation of Tas1r1 Reduces Lipid Accumulation Through
            Reducing the de Novo Lipid Synthesis and Improving Lipid Catabolism
            in Mice.
REFERENCE   4  (bases 1 to 2814)
  AUTHORS   Murovets,V.O., Sozontov,E.A. and Zachepilo,T.G.
  TITLE     The Effect of the Taste Receptor Protein T1R3 on the Development of
            Islet Tissue of the Murine Pancreas
  JOURNAL   Dokl Biol Sci 484 (1), 1-4 (2019)
   PUBMED   31016494
  REMARK    GeneRIF: Tas1r3 knockout leads to reduction in the size of
            pancreatic islets and their density in pancreatic tissue.
REFERENCE   5  (bases 1 to 2814)
  AUTHORS   Hirata,Y., Toyono,T., Kokabu,S., Obikane,Y., Kataoka,S.,
            Nakatomi,M., Masaki,C., Hosokawa,R. and Seta,Y.
  TITLE     Kruppel-like factor 5 (Klf5) regulates expression of mouse T1R1
            amino acid receptor gene (Tas1r1) in C2C12 myoblast cells
  JOURNAL   Biomed Res 40 (2), 67-78 (2019)
   PUBMED   30982802
  REMARK    GeneRIF: RNAi-mediated depletion of Sp4 and Klf5 decreased Tas1r1
            expression, while overexpression of Klf5, but not Sp4,
            significantly increased Tas1r1 expression in the myoblast cells.
REFERENCE   6  (bases 1 to 2814)
  AUTHORS   Montmayeur,J.P., Liberles,S.D., Matsunami,H. and Buck,L.B.
  TITLE     A candidate taste receptor gene near a sweet taste locus
  JOURNAL   Nat Neurosci 4 (5), 492-498 (2001)
   PUBMED   11319557
REFERENCE   7  (bases 1 to 2814)
  AUTHORS   Kitagawa,M., Kusakabe,Y., Miura,H., Ninomiya,Y. and Hino,A.
  TITLE     Molecular genetic identification of a candidate receptor gene for
            sweet taste
  JOURNAL   Biochem Biophys Res Commun 283 (1), 236-242 (2001)
   PUBMED   11322794
REFERENCE   8  (bases 1 to 2814)
  AUTHORS   Li,X., Inoue,M., Reed,D.R., Huque,T., Puchalski,R.B., Tordoff,M.G.,
            Ninomiya,Y., Beauchamp,G.K. and Bachmanov,A.A.
  TITLE     High-resolution genetic mapping of the saccharin preference locus
            (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to
            mouse distal Chromosome 4
  JOURNAL   Mamm Genome 12 (1), 13-16 (2001)
   PUBMED   11178737
REFERENCE   9  (bases 1 to 2814)
  AUTHORS   Reed,D.R.
  TITLE     Gene mapping for taste related phenotypes in humans and mice
  JOURNAL   Appetite 35 (2), 189-190 (2000)
   PUBMED   10986112
REFERENCE   10 (bases 1 to 2814)
  AUTHORS   Hoon,M.A., Adler,E., Lindemeier,J., Battey,J.F., Ryba,N.J. and
            Zuker,C.S.
  TITLE     Putative mammalian taste receptors: a class of taste-specific GPCRs
            with distinct topographic selectivity
  JOURNAL   Cell 96 (4), 541-551 (1999)
   PUBMED   10052456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF337040.1.
            
            On Jul 14, 2009 this sequence version replaced NM_031867.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF337040.1, AY032622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AF337040.1         78-110
            34-2814             AF337040.1         112-2892
FEATURES             Location/Qualifiers
     source          1..2814
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 82.83 cM"
     gene            1..2814
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /note="taste receptor, type 1, member 1"
                     /db_xref="GeneID:110326"
                     /db_xref="MGI:MGI:1927505"
     exon            1..298
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2633
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /note="candidate taste receptor T1R1; G-protein coupled
                     receptor 70"
                     /codon_start=1
                     /product="taste receptor type 1 member 1 precursor"
                     /protein_id="NP_114073.1"
                     /db_xref="CCDS:CCDS18985.1"
                     /db_xref="GeneID:110326"
                     /db_xref="MGI:MGI:1927505"
                     /translation="MLFWAAHLLLSLQLAVAYCWAFSCQRTESSPGFSLPGDFLLAGL
                     FSLHADCLQVRHRPLVTSCDRSDSFNGHGYHLFQAMRFTVEEINNSTALLPNITLGYE
                     LYDVCSESSNVYATLRVLAQQGTGHLEMQRDLRNHSSKVVALIGPDNTDHAVTTAALL
                     SPFLMPLVSYEASSVILSGKRKFPSFLRTIPSDKYQVEVIVRLLQSFGWVWISLVGSY
                     GDYGQLGVQALEELATPRGICVAFKDVVPLSAQAGDPRMQRMMLRLARARTTVVVVFS
                     NRHLAGVFFRSVVLANLTGKVWIASEDWAISTYITNVPGIQGIGTVLGVAIQQRQVPG
                     LKEFEESYVQAVMGAPRTCPEGSWCGTNQLCRECHAFTTWNMPELGAFSMSAAYNVYE
                     AVYAVAHGLHQLLGCTSGTCARGPVYPWQLLQQIYKVNFLLHKKTVAFDDKGDPLGYY
                     DIIAWDWNGPEWTFEVIGSASLSPVHLDINKTKIQWHGKNNQVPVSVCTRDCLEGHHR
                     LVMGSHHCCFECMPCEAGTFLNTSELHTCQPCGTEEWAPEGSSACFSRTVEFLGWHEP
                     ISLVLLAANTLLLLLLIGTAGLFAWRLHTPVVRSAGGRLCFLMLGSLVAGSCSLYSFF
                     GKPTVPACLLRQPLFSLGFAIFLSCLTIRSFQLVIIFKFSTKVPTFYHTWAQNHGAGI
                     FVIVSSTVHLFLCLTWLAMWTPRPTREYQRFPHLVILECTEVNSVGFLVAFAHNILLS
                     ISTFVCSYLGKELPENYNEAKCVTFSLLLHFVSWIAFFTMSSIYQGSYLPAVNVLAGL
                     ATLSGGFSGYFLPKCYVILCRPELNNTEHFQASIQDYTRRCGTT"
     exon            299..605
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1367
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1580
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1701
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2785
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /note="hexamer: AATAAA"
     polyA_site      2785
                     /gene="Tas1r1"
                     /gene_synonym="Gpr70; T1r1; TR1"
                     /note="major polyA site"
ORIGIN      
        1 gtcccacccc tttcaggggc atgcagttat gaagcgtctg ggcagctgcc attccctgtc
       61 aggggtgtgc tcagccatgc tggacagagg gacgtctggc cagcatgctt ttctgggcag
      121 ctcacctgct gctcagcctg cagctggccg ttgcttactg ctgggctttc agctgccaaa
      181 ggacagaatc ctctccaggt ttcagcctcc ctggggactt cctcctggca ggcctgttct
      241 ccctccatgc tgactgtctg caggtgagac acagacctct ggtgacaagt tgtgacaggt
      301 ctgacagctt caacggccat ggctatcacc tcttccaagc catgcggttc accgttgagg
      361 agataaacaa ctccacagct ctgcttccca acatcaccct ggggtatgaa ctgtatgacg
      421 tgtgctcaga gtcttccaat gtctatgcca ccctgagggt gctcgcccag caagggacag
      481 gccacctaga gatgcagaga gatcttcgca accactcctc caaggtggtg gcactcattg
      541 ggcctgataa cactgaccac gctgtcacca ctgctgccct gctgagccct tttctgatgc
      601 ccctggtcag ctatgaggcg agcagcgtga tcctcagtgg gaagcgcaag ttcccgtcct
      661 tcttgcgcac catccccagc gataagtacc aggtggaagt catagtgcgg ctgctgcaga
      721 gcttcggctg ggtctggatc tcgctcgttg gcagctatgg tgactacggg cagctgggcg
      781 tacaggcgct ggaggagctg gccactccac ggggcatctg cgtcgccttc aaggacgtgg
      841 tgcctctctc cgcccaggcg ggtgacccaa ggatgcagcg catgatgctg cgtctggctc
      901 gagccaggac caccgtggtc gtggtcttct ctaaccggca cctggctgga gtgttcttca
      961 ggtctgtggt gctggccaac ctgactggca aagtgtggat cgcctccgaa gactgggcca
     1021 tctccacgta catcaccaat gtgcccggga tccagggcat tgggacggtg ctgggggtgg
     1081 ccatccagca gagacaagtc cctggcctga aggagtttga agagtcctat gtccaggcag
     1141 tgatgggtgc tcccagaact tgcccagagg ggtcctggtg cggcactaac cagctgtgca
     1201 gggagtgtca cgctttcacg acatggaaca tgcccgagct tggagccttc tccatgagcg
     1261 ctgcctacaa tgtgtatgag gctgtgtatg ctgtggccca cggcctccac cagctcctgg
     1321 gatgtacctc tgggacctgt gccagaggcc cagtctaccc ctggcagctt cttcagcaga
     1381 tctacaaggt gaatttcctt ctacataaga agactgtagc attcgatgac aagggggacc
     1441 ctctaggtta ttatgacatc atcgcctggg actggaatgg acctgaatgg acctttgagg
     1501 tcattggttc tgcctcactg tctccagttc atctagacat aaataagaca aaaatccagt
     1561 ggcacgggaa gaacaatcag gtgcctgtgt cagtgtgtac cagggactgt ctcgaagggc
     1621 accacaggtt ggtcatgggt tcccaccact gctgcttcga gtgcatgccc tgtgaagctg
     1681 ggacatttct caacacgagt gagcttcaca cctgccagcc ttgtggaaca gaagaatggg
     1741 cccctgaggg gagctcagcc tgcttctcac gcaccgtgga gttcttgggg tggcatgaac
     1801 ccatctcttt ggtgctatta gcagctaaca cgctattgct gctgctgctg attgggactg
     1861 ctggcctgtt tgcctggcgt cttcacacgc ctgttgtgag gtcagctggg ggtaggctgt
     1921 gcttcctcat gctgggttcc ttggtagctg ggagttgcag cctctacagc ttcttcggga
     1981 agcccacggt gcccgcgtgc ttgctgcgtc agcccctctt ttctctcggg tttgccattt
     2041 tcctctcctg tctgacaatc cgctccttcc aactggtcat catcttcaag ttttctacca
     2101 aggtacccac attctaccac acttgggccc aaaaccatgg tgccggaata ttcgtcattg
     2161 tcagctccac ggtccatttg ttcctctgtc tcacgtggct tgcaatgtgg accccacggc
     2221 ccaccaggga gtaccagcgc ttcccccatc tggtgattct tgagtgcaca gaggtcaact
     2281 ctgtgggctt cctggtggct ttcgcacaca acatcctcct ctccatcagc acctttgtct
     2341 gcagctacct gggtaaggaa ctgccggaga actataacga agccaaatgt gtcaccttca
     2401 gcctgctcct ccacttcgta tcctggatcg ctttcttcac catgtccagc atttaccagg
     2461 gcagctacct acccgcggtc aatgtgctgg cagggctggc cactctgagt ggcggcttca
     2521 gcggctattt cctccctaaa tgctacgtga ttctctgccg tccagaactc aacaacacag
     2581 aacactttca ggcctccatc caggactaca cgaggcgctg cggcactacc tgatccgctg
     2641 gggctgttga gaatgggcag atgagatggg ctgaaggtgg cgggtcgagt ggggcggaga
     2701 gcttgaggtg tctgggagag ctcagccacg gcttgcgatg tataagcaca cagaaggatc
     2761 cagtgcaata aagacgtgaa acgtgaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
