LOCUS       NM_033074               2636 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus threonyl-tRNA synthetase 1 (Tars1), mRNA.
ACCESSION   NM_033074 XM_977343 XM_977445
VERSION     NM_033074.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Zeng,Q.Y., Zhang,F., Zhang,J.H., Hei,Z., Li,Z.H., Huang,M.H.,
            Fang,P., Wang,E.D., Sun,X.J. and Zhou,X.L.
  TITLE     Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little
            impact on protein synthesis but affects mouse development
  JOURNAL   J Biol Chem 299 (5), 104704 (2023)
   PUBMED   37059185
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Dai,C., Reyes-Ordonez,A., You,J.S. and Chen,J.
  TITLE     A non-translational role of threonyl-tRNA synthetase in regulating
            JNK signaling during myogenic differentiation
  JOURNAL   FASEB J 35 (10), e21948 (2021)
   PUBMED   34569098
  REMARK    GeneRIF: A non-translational role of threonyl-tRNA synthetase in
            regulating JNK signaling during myogenic differentiation.
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Jeong,S.J., Park,S., Nguyen,L.T., Hwang,J., Lee,E.Y., Giong,H.K.,
            Lee,J.S., Yoon,I., Lee,J.H., Kim,J.H., Kim,H.K., Kim,D., Yang,W.S.,
            Kim,S.Y., Lee,C.Y., Yu,K., Sonenberg,N., Kim,M.H. and Kim,S.
  TITLE     A threonyl-tRNA synthetase-mediated translation initiation
            machinery
  JOURNAL   Nat Commun 10 (1), 1357 (2019)
   PUBMED   30902983
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Chen,Y., Ruan,Z.R., Wang,Y., Huang,Q., Xue,M.Q., Zhou,X.L. and
            Wang,E.D.
  TITLE     A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and
            editing activities
  JOURNAL   Nucleic Acids Res 46 (7), 3643-3656 (2018)
   PUBMED   29579307
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2636)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   7  (bases 1 to 2636)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK011146.2.
            
            On Apr 5, 2007 this sequence version replaced NM_033074.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011146.2, AK167597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2636              AK011146.2         2-2637
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.6 cM"
     gene            1..2636
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /note="threonyl-tRNA synthetase 1"
                     /db_xref="GeneID:110960"
                     /db_xref="MGI:MGI:106314"
     exon            1..173
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2288
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /EC_number="6.1.1.3"
                     /note="threonyl-tRNA synthetase, cytoplasmic;
                     threonine--tRNA ligase, cytoplasmic"
                     /codon_start=1
                     /product="threonine--tRNA ligase 1, cytoplasmic"
                     /protein_id="NP_149065.2"
                     /db_xref="CCDS:CCDS27385.1"
                     /db_xref="GeneID:110960"
                     /db_xref="MGI:MGI:106314"
                     /translation="MSQEKASSPSGKMDGEKPVDASEEKRKEGGKKKSKDGGGDGGRA
                     ELNPWPEYINTRLDMYNKLKAEHDSILAEKAAKDSKPIKVTLPDGKQVDAESWKTTPY
                     QIACGISQGLADNTVVAKVNKVVWDLDRPLETDCTLELLKFEDEEAQAVYWHSSAHIM
                     GEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLETLCKKIIKEKQTFERL
                     EVKKETLLEMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKTLKI
                     HKNSSTYWEGKADMETLQRIYGISFPDPKLLKEWEKFQEEAKNRDHRKIGRDQELYFF
                     HELSPGSCFFLPKGAYIYNTLMEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYS
                     ENMFSFEVEKEQFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTG
                     LTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDI
                     EIWNQAEKQLENSLNEFGEKWELNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQL
                     PIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVP
                     VGPTCDEYAQKVRQQFHDAKFMADTDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKAS
                     GTVNIRTRDNKVHGERTVEETVRRLQQLKQTRSKQAEEEF"
     exon            174..254
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            255..445
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            446..569
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            570..691
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            692..809
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            810..874
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            875..953
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1100
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1199
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1366
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1529
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1667
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1745
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1846
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1951
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2024
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2139
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2636
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2561..2566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
                     /note="hexamer: AATAAA"
     polyA_site      2594
                     /gene="Tars1"
                     /gene_synonym="D15Wsu59e; Tars; ThrRS"
ORIGIN      
        1 agctggttcc gcctgtggcc acgtggcgca cgcgcagtgc ggaattgtag gtctacaccg
       61 ccggcttggg gtcttctctg cggtgcagct cacgggtttt gtctctctgt ggtccttcca
      121 tgtcgcagga gaaggctagc agcccttcgg ggaagatgga cggcgagaag ccggtggatg
      181 ccagcgagga gaagcggaaa gaaggaggca agaagaagag caaagatgga ggtggagatg
      241 gaggtcgagc agagttgaat ccctggcctg aatacattaa cacacgcctt gatatgtaca
      301 acaaactcaa agcagaacac gattctatcc tggccgaaaa ggcagcaaaa gatagcaagc
      361 cgattaaagt caccctgcct gacggcaagc aggtggatgc ggagtcctgg aaaaccacgc
      421 cgtatcagat tgcttgtgga attagtcagg gcctggctga caacaccgtt gttgctaagg
      481 tgaacaaagt cgtttgggac ctggaccgcc cgctggagac agattgcacg ttggagctgc
      541 tcaagtttga ggacgaggaa gcgcaggccg tatactggca ctccagtgcc cacataatgg
      601 gcgaggccat ggagagagtc tatggcggat gtctatgtta cggcccacca atagaaaacg
      661 gcttctatta tgatatgtac cttgaagaag ggggcgtgtc cagcaatgac ttctcttccc
      721 tggaaacttt gtgcaagaaa atcattaaag agaaacaaac tttcgaaaga ttggaagtta
      781 aaaaggaaac attactagaa atgtttaagt acaacaagtt caagtgccgg atattgaatg
      841 agaaagtgaa tactccgacc acgactgtct acagatgtgg ccctctgata gatctctgcc
      901 ggggtcctca tgtccgacac accggcaaga ttaagacttt gaagatacac aagaattctt
      961 ccacgtactg ggaaggcaaa gcagacatgg agacgctcca gcggatctat ggcatttcat
     1021 tccctgaccc caagctactg aaagagtggg agaagttcca agaggaagcc aaaaaccgag
     1081 accacaggaa aatcgggagg gaccaagaac tatatttctt ccatgaactt agccctggaa
     1141 gttgcttttt cctgcccaaa ggagcctaca tttataatac actaatggaa tttatcagga
     1201 gtgaatatag gaaaagaggg ttccaggagg tcgtcactcc caacatcttc aatagccggc
     1261 tctggatgac ctctggccac tggcagcact acagcgagaa catgttctcc tttgaggtgg
     1321 agaaggagca gtttgcactt aagcccatga actgcccggg acactgcctg atgttcgatc
     1381 accggccacg gtcctggcga gagctgcccc tgcggctagc tgactttggt gtgctgcata
     1441 ggaatgagct ctcgggggct ctcaccgggc tcacacgggt ccgaagattc cagcaggatg
     1501 acgcacacat cttctgtgcc atggagcaga ttgaagatga aatcaaaggt tgtttggatt
     1561 ttcttcgcac agtatatagt gtctttggat tttcatttaa attgaatctt tctactcgcc
     1621 cagaaaaatt ccttggagat attgaaatat ggaaccaagc tgagaaacaa cttgaaaaca
     1681 gtttgaatga gttcggtgag aagtgggaac taaatcctgg agatggagcc ttctatgggc
     1741 caaagattga catacagata aaagatgcca tcggtcgcta ccaccagtgt gcaaccatcc
     1801 agctggactt tcagttgccc atcaggttta accttactta cgtcagccac gatggcgatg
     1861 ataagaaaag gccagtgatt gttcacagag ccatcctggg gtcggtggaa agaatgattg
     1921 ccatcctcac agaaaactat gggggcaaat ggcctttctg gctctctcct cgccaggtga
     1981 tggtggtccc agtgggaccg acatgtgatg aatatgccca aaaggtacgg caacaattcc
     2041 atgatgctaa attcatggcg gacactgacc tggatccagg ctgtaccttg aataagaaga
     2101 tcagaaacgc acagttagca cagtataact tcatccttgt tgttggtgaa aaagagaaag
     2161 ccagtggcac ggtgaacatc cgcacgagag acaataaggt ccacggagag cggacagtgg
     2221 aggagacggt gcggcggctg cagcagctca agcagacgcg cagcaagcag gcagaggagg
     2281 agttctagca ggcacacgct gtgcccgagc tggcgccgtg tcagggaaga ccttgtacac
     2341 cgggaagcaa gcgtggcttc aggccgagcg tggagtagct ctgcagtctg catgaatcgg
     2401 cctttgatct ggccaagtct tagagaatgt tgtagatggg ggttaagaga accatttaaa
     2461 gtattttgtt cattaaatgc ctctttccaa aaatggaaga tccaaaaatg gggatgtttt
     2521 atgtacccgg gttattttgt atgaattcaa tcaattagga aataaaaaga ttttaaatgt
     2581 gtctaaggag aaaacagagt tgaattatgg cgttaaaata aaatttacta ccaaag
//
