LOCUS       NM_177363               1036 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus T cell-interacting, activating receptor on myeloid
            cells 1 (Tarm1), transcript variant 1, mRNA.
ACCESSION   NM_177363
VERSION     NM_177363.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1036)
  AUTHORS   Yabe,R., Chung,S.H., Murayama,M.A., Kubo,S., Shimizu,K.,
            Akahori,Y., Maruhashi,T., Seno,A., Kaifu,T., Saijo,S. and
            Iwakura,Y.
  TITLE     TARM1 contributes to development of arthritis by activating
            dendritic cells through recognition of collagens
  JOURNAL   Nat Commun 12 (1), 94 (2021)
   PUBMED   33397982
  REMARK    GeneRIF: TARM1 contributes to development of arthritis by
            activating dendritic cells through recognition of collagens.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1036)
  AUTHORS   Radjabova,V., Mastroeni,P., Skjodt,K., Zaccone,P., de Bono,B.,
            Goodall,J.C., Chilvers,E.R., Juss,J.K., Jones,D.C., Trowsdale,J.
            and Barrow,A.D.
  TITLE     TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor
            That Costimulates Proinflammatory Cytokine Secretion by Macrophages
            and Neutrophils
  JOURNAL   J Immunol 195 (7), 3149-3159 (2015)
   PUBMED   26311901
  REMARK    GeneRIF: The results suggest a putative T cell ligand can interact
            with TARM1 receptor, resulting in bidirectional signaling and
            raising the T cell activation threshold while costimulating the
            release of proinflammatory cytokines by macrophages and
            neutrophils.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY209831.1, AK036904.1 and AC240460.2.
            
            On Apr 6, 2018 this sequence version replaced NM_177363.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036904.1, DQ973493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                BY209831.1         2-73
            73-1029             AK036904.1         2-958
            1030-1036           AC240460.2         151095-151101       c
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.04 cM"
     gene            1..1036
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /note="T cell-interacting, activating receptor on myeloid
                     cells 1"
                     /db_xref="GeneID:245126"
                     /db_xref="MGI:MGI:2442280"
     exon            1..193
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            194..229
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            230..520
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..817
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..883
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1036
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1012..1017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="Tarm1"
                     /gene_synonym="9930022N03Rik; Gm9904; OLT-2"
                     /note="major polyA site"
ORIGIN      
        1 agcacatttc ctgcgagtga acgtgtgagg aaggaactga gcagcgatct caaaaccaat
       61 cctgcctact ccctgagctt ggggatgctg atgtcctggc cactttcttc tgctgatagt
      121 agacctgctg aagacctttg gaccagccgc tgagccacca tgatctctag gctcctttcc
      181 cttctctgcc tccggctgtg tgttgggcaa acagacattc ctgaaaatgg gtctcctccc
      241 aagcccagcc tcagtgcctg gcccagcaca gtgcttccca ccaagagcca cgtgacaatg
      301 caatgtaaga gccccacccc gagtaaatac ttcatcctca aaaaggaagg tttcgctttg
      361 aattctgtga agccatataa tttgacagag gagacggctg attttcattt caccgaccta
      421 cgacagaatg atggcggaca ctacacctgt gaatactata gcaaatggcc ccatgacaca
      481 ccgtcacacc ccagcaatgc ccttttcttg ttggtcacag ggtacttacc tcagccctcc
      541 tttcaagccc accaccgggg tacagtgact gcaggaagca aggtgacttt gcagtgccag
      601 aaagcaggca gtgtcctcgg acccgtaaag tttgcgttac tgaaggtggg acactcaact
      661 cctgtgcaga caaggagctc aacaggaatg gtatcagact tctctcttca gaatgtgaca
      721 gccagagact cgggggaata cagctgtgtt tactatcagg caaaggctcc ctatcgggcc
      781 tcagggccca gcaatctcct tgagatctct gtgatagaca accatctgcc tcaagatctt
      841 gctgcctcga ctttcccacc gcaactgaca gcaacctcac ccaagacccc gggtacaatg
      901 acagaaggct acactgtgga taatctcatc cgggtcggtg tggctgctgc aatcctgcta
      961 atagtgggag gcttcctggt tgaagcctgg cacagtgagc ggctgtctcc aaataaaccc
     1021 tggtaaaata actgaa
//
