LOCUS       NM_145556               7454 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus TAR DNA binding protein (Tardbp), transcript variant
            1, mRNA.
ACCESSION   NM_145556
VERSION     NM_145556.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7454)
  AUTHORS   Krus,K.L., Benitez,A.M., Strickland,A., Milbrandt,J., Bloom,A.J.
            and DiAntonio,A.
  TITLE     Two cardinal features of ALS, reduced STMN2 and pathogenic TDP-43,
            synergize to accelerate motor decline in mice
  JOURNAL   Exp Neurol 384, 115068 (2025)
   PUBMED   39603486
REFERENCE   2  (bases 1 to 7454)
  AUTHORS   Torres,P., Rico-Rios,S., Ceron-Codorniu,M., Santacreu-Vilaseca,M.,
            Seoane-Miraz,D., Jad,Y., Ayala,V., Marino,G., Beltran,M.,
            Miralles,M.P., Andres-Benito,P., Fernandez-Irigoyen,J.,
            Santamaria,E., Lopez-Otin,C., Soler,R.M., Povedano,M., Ferrer,I.,
            Pamplona,R., Wood,M.J.A., Varela,M.A. and Portero-Otin,M.
  TITLE     TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic
            splicing inhibition
  JOURNAL   Acta Neuropathol 148 (1), 45 (2024)
   PUBMED   39305312
  REMARK    GeneRIF: TDP-43 regulates LC3ylation in neural tissue through ATG4B
            cryptic splicing inhibition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7454)
  AUTHORS   Carmen-Orozco,R.P., Tsao,W., Ye,Y., Sinha,I.R., Chang,K.,
            Trinh,V.T., Chung,W., Bowden,K., Troncoso,J.C., Blackshaw,S.,
            Hayes,L.R., Sun,S., Wong,P.C. and Ling,J.P.
  TITLE     Elevated nuclear TDP-43 induces constitutive exon skipping
  JOURNAL   Mol Neurodegener 19 (1), 45 (2024)
   PUBMED   38853250
  REMARK    GeneRIF: Elevated nuclear TDP-43 induces constitutive exon
            skipping.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7454)
  AUTHORS   Guo,C., Wang,T., Huang,H., Wang,X., Jiang,Y. and Li,J.
  TITLE     Plasminogen degrades alpha-synuclein, Tau and TDP-43 and decreases
            dopaminergic neurodegeneration in mouse models of Parkinson's
            disease
  JOURNAL   Sci Rep 14 (1), 8581 (2024)
   PUBMED   38615036
  REMARK    GeneRIF: Plasminogen degrades alpha-synuclein, Tau and TDP-43 and
            decreases dopaminergic neurodegeneration in mouse models of
            Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7454)
  AUTHORS   Zhang,H., Chen,C., Zhang,E.E. and Huang,X.
  TITLE     TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity
            of neuroactivity in prefrontal cortex
  JOURNAL   iScience 27 (4), 109522 (2024)
   PUBMED   38585660
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7454)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 7454)
  AUTHORS   Wang,H.Y., Wang,I.F., Bose,J. and Shen,C.K.
  TITLE     Structural diversity and functional implications of the eukaryotic
            TDP gene family
  JOURNAL   Genomics 83 (1), 130-139 (2004)
   PUBMED   14667816
REFERENCE   8  (bases 1 to 7454)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7454)
  AUTHORS   Wang,I.F., Reddy,N.M. and Shen,C.K.
  TITLE     Higher order arrangement of the eukaryotic nuclear bodies
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13583-13588 (2002)
   PUBMED   12361981
REFERENCE   10 (bases 1 to 7454)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD548243.1, AK146002.1, AK146997.1, BC027105.1, AK045495.1,
            AK133207.1, CF741580.1, CK780683.1, CD353594.1, CF725038.1,
            CX202635.1, BE853411.1, BE335004.1, AK004440.1 and BF658781.1.
            
            On Aug 30, 2007 this sequence version replaced NM_145556.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.181684.1,
                                           SRR1660811.239321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               CD548243.1         1-231
            232-2965            AK146002.1         2-2735
            2966-2969           AK146997.1         2645-2648
            2970-3110           BC027105.1         1764-1904
            3111-3917           AK045495.1         1201-2007
            3918-4366           AK133207.1         3694-4142
            4367-4627           CF741580.1         317-577
            4628-5225           CK780683.1         91-688
            5226-5424           CD353594.1         416-614
            5425-6037           CF725038.1         36-648
            6038-6373           CX202635.1         366-701
            6374-6888           BE853411.1         33-547
            6889-7350           BE335004.1         52-513
            7351-7446           AK004440.1         1042-1137
            7447-7454           BF658781.1         4-11                c
FEATURES             Location/Qualifiers
     source          1..7454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.77 cM"
     gene            1..7454
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /note="TAR DNA binding protein"
                     /db_xref="GeneID:230908"
                     /db_xref="MGI:MGI:2387629"
     exon            1..316
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /inference="alignment:Splign:2.1.0"
     exon            317..568
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1575
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /note="isoform 1 is encoded by transcript variant 1; TAR
                     DNA-binding protein 43"
                     /codon_start=1
                     /product="TAR DNA-binding protein 43 isoform 1"
                     /protein_id="NP_663531.1"
                     /db_xref="CCDS:CCDS38971.1"
                     /db_xref="GeneID:230908"
                     /db_xref="MGI:MGI:2387629"
                     /translation="MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYR
                     NPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQK
                     TSDLIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVK
                     VMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVV
                     DVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRF
                     GGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSW
                     GMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAG
                     SGSGFNGGFGSSMDSKSSGWGM"
     exon            569..732
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /inference="alignment:Splign:2.1.0"
     exon            733..873
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1044
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..7454
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2952..2957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /note="hexamer: AATAAA"
     polyA_site      2973
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /note="major polyA site"
     regulatory      4345..4350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /note="hexamer: AATAAA"
     polyA_site      4368
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
     regulatory      7430..7435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /note="hexamer: ATTAAA"
     polyA_site      7449
                     /gene="Tardbp"
                     /gene_synonym="1190002A23Rik; TDP-43; Tdp43"
                     /note="major polyA site"
ORIGIN      
        1 ctcggaaggc cgagtggccg ttctgtcctt catctgtcag tttttcagac ccagctgttt
       61 tcattgttgc gtttctttac ttttttctat acgccgaaga gcctgctagc atccgagcct
      121 ctgggaggag agagcgcctg tggcttccct cggagagcgc ccctcctgca gggaagccag
      181 tgggagaggc cgaaggcggg cgagggcggg aggcggccct agcgccattt tgtgggcacg
      241 gagcggtagc gcggctgttg tcggattcct tcccgtctgt gcttcctcct tgtgcttcct
      301 agcagtggcc tagcggagat ttaagcaaag atgtctgaat atattcgggt aacagaagat
      361 gagaacgatg aacccattga aataccatca gaagacgatg ggacggtgtt gctgtccaca
      421 gttacagccc agtttccagg ggcatgcggc ctgcgctacc ggaatcccgt gtctcagtgt
      481 atgagaggag tccgactggt ggaaggaatt ctgcatgccc cagatgctgg ctggggcaat
      541 ctggtatatg ttgtcaacta tcccaaagat aacaaaagga aaatggatga gacagatgct
      601 tcctctgcag tgaaagtgaa aagagcagtc cagaaaacat ctgacctcat agtgttgggt
      661 ctcccctgga aaacaactga gcaggatctg aaagactatt tcagtacttt tggagaggtt
      721 cttatggttc aggtcaagaa agatcttaaa actggtcact cgaaagggtt tggctttgtt
      781 cgatttacag aatatgaaac ccaagtgaaa gtaatgtcac aacgacatat gatagatggg
      841 cgatggtgtg actgtaaact tcccaactct aagcaaagcc cagacgagcc tttgagaagc
      901 agaaaggtgt ttgttggacg ttgtacagag gacatgactg ctgaagagct tcagcagttt
      961 ttctgtcagt atggagaagt ggtagatgtc ttcattccca aaccattcag agcttttgcc
     1021 ttcgtcacct ttgcagatga taaggttgcc cagtctcttt gtggagagga tttgatcatt
     1081 aaaggaatca gcgtgcatat atccaatgct gaacctaagc ataatagcaa tagacagtta
     1141 gaaagaagtg gaagatttgg tggtaatcca ggtggctttg ggaatcaggg tgggtttggt
     1201 aacagtagag ggggtggagc tggcttggga aataaccagg gtggtaatat gggtggaggg
     1261 atgaactttg gtgcttttag cattaaccca gcgatgatgg ctgcggctca ggcagcgttg
     1321 cagagcagtt ggggtatgat gggcatgtta gccagccagc agaaccagtc gggcccatct
     1381 gggaataacc aaagccaggg cagcatgcag agggaaccaa atcaggcttt tggttctgga
     1441 aataattcct acagtggttc taattctggt gccccccttg gttgggggtc agcatcaaat
     1501 gcaggatcgg gcagtggttt taatgggggc tttggctcga gcatggattc taagtcttct
     1561 ggctggggaa tgtaggtggt ggggggtggt tagtaggttg gttattaggt taggtagatt
     1621 tagaatggtg ggattcaaat ttttctaaac tcatggtaag tatattgtaa aatacatatg
     1681 tactaaaatt ttcagattgg tttgttcagt gtggagtata ttcagcagta tttttgacat
     1741 ttttctttag aaaaaaagag gggaaagcta aatgaatttt ataagttttg ttatataaag
     1801 ggttaaaata ctgagtgggt gaaagtgaac tgctgtttgc ctaattggta aaccaacact
     1861 acaattgatc tcagaaggtt tctctgtaat attctatcat tgaaattgtt aatgaattct
     1921 ttgcatgttc agagtagaaa ccattggtta gaactacatt cttttctcct tattttaatt
     1981 tgaatcccac cctatgaatt ttttccttag gaaaatctcc atttgggaga tcatgatgtc
     2041 atggtgtttg attcttttgg ttttgttttt aacacttgtc ttccttcata tacgaaagta
     2101 caatatgaag ccttcattta atctctgcag ttcatctcat ttcaaatgtt tatggaagaa
     2161 gcacttcatt gaaagtagtg ctgtaaatat tctgccatag gaatacttct gtctacatgc
     2221 tttctcatcc aagaattcgt catcacgctg cacaggctgc gtctttgacg gtgggtgttc
     2281 catttttatc cgctactctt tatttcatgg agtcgtatca acgctatgaa cgcaaggctg
     2341 tgatatggaa ccagaaggct gtttgaactt ttgaaacctt gtgtgggatt gatggtggtg
     2401 ccgaggcatg aaaggctagt atgagcgaga aaaggagagc gcgtgcagag acttggtggt
     2461 ggaaaatgga tattttttaa cttggagaga tgtgtcactc aatcctgtgg ctttggtgag
     2521 agagtgtgca gagagcaatg atagcaaata acgtacgaat gttttacatc aaaggacatc
     2581 cacatcagtt ggaagacttt gagttttgtt cttaggaaac ccactttagt tgaatgtgtt
     2641 aagtgaaata cttgtacttc cctccccctc tgtcaactgc tgtgaatgct gtatggtgtg
     2701 tgttctcctc tgttactgat ctggaagtgt gggaacgtga actgaagctg atgggctgcg
     2761 aacatggact gagcttgtgg tgtgctttgc aggagaactt ggaagcagag ttcaccagtg
     2821 agctcaggtg tctcaaagaa gggtggaagt tctcatgtct gttagctatt cataagaatg
     2881 ctgtttgctg cagttctgtg tcctgtgctt ggatgctttt ttataagagt tgtcattgtt
     2941 ggaaattctt aaataaaact gatttaaata atatgtgtct ttgttttgca gccctgaatg
     3001 caaagaattc atagcagtta attccccttt ttgacccttt tgagatggaa ctttcataaa
     3061 gtttcttggc agtagtttat tttgcttcaa ataaacttat ttgaaaagtt gtctcaagtc
     3121 aaatggattc atcacctgtc atgcattgac acctgatacc cagacttaat tgctatttgt
     3181 tcttgcattg tccaaagtga aagtttttct ttggtttgtt tttaatttag tttttcttaa
     3241 gtctgggtga ccgcacctaa aatggtaagc agttaccctc tggcttgttc tgagtgcctc
     3301 tgtgcatttg attttctatt tacatgctgt ataaatctcc actggggaat catgccttct
     3361 aaaaatattt gggagagggc aaaagagttg atttctaatg ctttgtagca gagcatatca
     3421 atgggaaaga aggttaagca cctttctgtt tgggatttga aaagtggaat taattgcaat
     3481 agggatgaag tagaagaaac caagaaacca tgtgcctgaa atacattaag aagcctgatt
     3541 gatagcttta agaactagta gggtgggttg tcttacctgt ggcagtctta agtgaggtag
     3601 gcttttgccc tcctgaatgt gggggttatg tagtgatgaa tatgctcaca aaatcagatt
     3661 agactgtcaa tgcattgtta atgtaaaagc aataatacat tgattattgt acttttcctg
     3721 taactactga gaccggaggc gctccttttc taactggaag aatgggacag tttttgtgtt
     3781 ggtagttttt cctaatgccc ttacctaaat agattatgat aaataggttt gtcattttgc
     3841 aagttgcgtg ttttaaaatt ttatatccgt tagagacttg ttatgaacac attgtttcat
     3901 tatacagtat cctctgtaaa aggatcgtga gttattgtaa gtttttttct ctgcatctaa
     3961 ccctgcatga tttccaaacc ctgtgcatct gaattttgca ttttagcact gtttgcactg
     4021 ttactcagca gcagtaacat ggtaacatta aaatggtttt cggggacctc caaagacggc
     4081 caggagtcct ggggtaagtt acttgtcaat ggcatggttt tgatcccttt tttacacttg
     4141 ttaaagactt actggtcata gaagtctttc agtgttgatc agccttttaa catgtttatg
     4201 gatgacatag ctgtagttag ttacttgccg taaatgaggt tttagaaata aactacttgg
     4261 caaagatttg gttttgaaag tctggtcatc aaaacgcgtt cattccttag aaataatgaa
     4321 gaacaactct ttgaaccaca gttgaataaa aggttttctt gccaccaaca gtttagtgtc
     4381 tggagtctta ctggaagaaa aaaaaattct atatcatgac aatgctagaa aagttaaggt
     4441 gacttatgtg ggaagatgca atatagcatt ttcatccttt aaaatttgag tctccaggtg
     4501 ggtgtggtgg cccatgcttt taatcccaga attggtgtaa atgagttgta ggccagctat
     4561 ttccccatct tgaggcaccc tgtcttgcct tgttggaaga gccagttaaa atcaaacatg
     4621 acctttaagg tcagcatctt agcagaagag cagtttattt caggataact tactgttttt
     4681 gatacataag caaatgactg taccttgtac agttacggtt gacttccctg agcccaacgc
     4741 tcacctaaga aaagtgggct gggtatagtg aaacacctgt taaggttttt ggaatgattt
     4801 gctaaattgc ccttgtaaag ggtaaaatgc tgtttcgtgt tctttttatc tgacaatttg
     4861 gtgaatctgg tagaacatgc ctatatccca atattctgga atggacttgg tgttaattta
     4921 atagctgatc taatgtgaag gtcacacacc tgctttccgc ttaccttcca aaaggtattc
     4981 tggaaccact cagaagttac tcagaaagta agagcacttt ctgagctcat taagaccaaa
     5041 tctacacact agacacaaca agccctttgt tggccagaaa tggaaacagc cagtataaaa
     5101 taagtagatt gtagggaatc aaatacaact tgttttttct gtgttggggg ttggccaagc
     5161 actgttaaac acaaatcaaa gctgatattg gcaagtgttt ggacctgtaa caatctcacc
     5221 tgctctgatt ttggggtagg ctgtcattct taggtttgtt actaagcttc ccaggtactt
     5281 ggcgatatga ggaacaatga ttggacgatg caaattagaa attacttatt atgttctcaa
     5341 tccagggaat atagttgatg acttttgtgt agaccccata ctggtctgcc gccccacaat
     5401 taatggaacc ccaggaaact attcctccca caaaccatcg ctgtgtctca ttatctagaa
     5461 acactaatgc ccccccactg tcacctctgc agctgtcctt gccaccagtc tctaagccag
     5521 cacagagcat gttagcgctt actcttactc ctggatagag cttttcatac acggcggtac
     5581 atttttggtg gtcagcaatt ggtatgtcca caaacattag gtttctagca agaagcccct
     5641 tctgggttaa cccccagcca gccacagttc cagtgaagtc tgttctcatt aaggatgcag
     5701 cttcttttcg cggtaggcaa acaggcatga tgcttccgtt gattgtgact ttgttcttga
     5761 gtttaatcaa tgctatatca ttgtcaaaac cagcaccgtg agtgtagcct tcatgtataa
     5821 agatttcctc gggccaggct tgagtgtaat gaggtgagag ccttttgagg atgcccattc
     5881 ggatgttcag ggaggacgct gccattcttt tctcatatac agcatgagcg gctgttagga
     5941 cccaattgtc atgtataagt gcacctgctg ctgctgtagt ttgacccagc aacaagactt
     6001 gccaaggaaa gtcaccaggc tttgcaggct gccctccaac tatgcgtcct cctatagtgt
     6061 gtgtggacag cccacaaact gagggataaa aaacaagtat ttaatgccct acaaattgat
     6121 aggcatcctc cctgttgagt gaggctattt aagtttttgt ttagcctgct cacctccttg
     6181 taaagatcag taagagatct cagagattgt tttgctgaaa gagaacagca tgagggagtc
     6241 tggacaggac ttgtgtgcag gaggacatga cactacttag aggccaaaga caaccccctc
     6301 accacaccct gagctgcttg tttttctctt tttgggctct ctgggaattc tgggaaagca
     6361 ggaactatga tttacaaagt ttctgttgtc tttaaatgta agactctaaa ttacaatgtt
     6421 gcagcaatag ccaaagtgct tctggttcaa aaattggtaa ttttggtctg gtggagccct
     6481 ccaaacactt ttaccgttct ttgcaaactg agggctcagg aatgcaacac atgttcttta
     6541 ttgtggttgt gcactttgat taaaacttgg aagccgcatg tcagccaaat acaaggctag
     6601 aaaactaatt taaaccagct aacacggggg taatgagtgt attattacct ttcaattaaa
     6661 aaaaaagcac tctcaactgt tgttggagcc aattctggta aagaaattta agtactatta
     6721 aaaggcaaat tgcattaatg tttaaaaatc ttgatgtcgt tgaaaacaat tgcttaggga
     6781 aataatgaag ttattagctt tggggtttaa tagcattttt acagagaaga aaagtaacaa
     6841 gagttcttgg ttataaatgt ataaacggtt tgagataatt taagaaatca tttaattttt
     6901 tatgcttgcc tagttataag gtcaaaaaca atcaagtgca tgatgcacct agcttccgtg
     6961 tggaagggga aatgtgagca cactgttggg aaacactaag ctccagcctc agccaagtgc
     7021 tgagctttct gcctccccag ccagaccctg cctattgtct gccagctact ctgtcagcta
     7081 tgaatctctt ttataaatgg cgtccattac caggctcaca aaccgggggg agtttttctc
     7141 ctttggagct cgtccagaat ccatcagcct cacacacata tttacctgca agtcattgga
     7201 aaagcaaaaa tgtttagctg tagttgtcat ttgcttgaat aaccccttga aaaatgttga
     7261 ttcttgagca tctgtggtgg ggagaggtgt gtgaataacc attttacatg atttcataaa
     7321 taggtgtctg cattaccatg tttgcttgca aagtggaaac cttttagatg tgtaacttga
     7381 atatgtatca agatctcaag tgcttaatga taaggttttg acttgttaaa ttaaaccatt
     7441 tggaatatat tgtg
//
