LOCUS       NP_001403264             374 aa            linear   ROD 05-MAY-2025
DEFINITION  RISC-loading complex subunit TARBP2 isoform 10 [Mus musculus].
ACCESSION   NP_001403264
VERSION     NP_001403264.1
DBSOURCE    REFSEQ: accession NM_001416335.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 374)
  AUTHORS   Vaughn,L.S., Chukwurah,E. and Patel,R.C.
  TITLE     Opposite actions of two dsRNA-binding proteins PACT and TRBP on
            RIG-I mediated signaling
  JOURNAL   Biochem J 478 (3), 493-510 (2021)
   PUBMED   33459340
  REMARK    GeneRIF: Opposite actions of two dsRNA-binding proteins PACT and
            TRBP on RIG-I mediated signaling.
REFERENCE   2  (residues 1 to 374)
  AUTHORS   Vishlaghi,N. and Lisse,T.S.
  TITLE     Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced
            Anagen Hair Follicle Development
  JOURNAL   Front Cell Dev Biol 8, 338 (2020)
   PUBMED   32478074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 374)
  AUTHORS   Pullagura,S.R.N., Buaas,B., Gray,N., Krening,L.C., Srivastava,A.
            and Braun,R.E.
  TITLE     Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During
            Murine Embryogenesis Does Not Involve miRNA Biogenesis
  JOURNAL   Genetics 208 (4), 1513-1522 (2018)
   PUBMED   29467169
  REMARK    GeneRIF: TARBP2, but not PRKRA, functions in miRNA biogenesis of a
            subclass of miRNAs, and suggesting that functional redundancy
            between TARBP2 and PRKRA does not involve miRNA biogenesis.
REFERENCE   4  (residues 1 to 374)
  AUTHORS   Byun,S.H., Kim,J., Han,D., Kwon,M., Cho,J.Y., Ng,H.X.,
            Pleasure,S.J. and Yoon,K.
  TITLE     TRBP maintains mammalian embryonic neural stem cell properties by
            acting as a novel transcriptional coactivator of the Notch
            signaling pathway
  JOURNAL   Development 144 (5), 778-783 (2017)
   PUBMED   28174252
  REMARK    GeneRIF: TRBP is a novel transcriptional coactivator of the Notch
            signaling pathway, playing an important role in neural stem cell
            regulation during mammalian brain development
REFERENCE   5  (residues 1 to 374)
  AUTHORS   Ding,J., Nie,M., Liu,J., Hu,X., Ma,L., Deng,Z.L. and Wang,D.Z.
  TITLE     Trbp Is Required for Differentiation of Myoblasts and Normal
            Regeneration of Skeletal Muscle
  JOURNAL   PLoS One 11 (5), e0155349 (2016)
   PUBMED   27159388
  REMARK    GeneRIF: study demonstrated that Trbp participates in the
            regulation of muscle differentiation and regeneration
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 374)
  AUTHORS   Delpire,E., Lu,J., England,R., Dull,C. and Thorne,T.
  TITLE     Deafness and imbalance associated with inactivation of the
            secretory Na-K-2Cl co-transporter
  JOURNAL   Nat Genet 22 (2), 192-195 (1999)
   PUBMED   10369265
REFERENCE   7  (residues 1 to 374)
  AUTHORS   Zhong,J., Peters,A.H., Lee,K. and Braun,R.E.
  TITLE     A double-stranded RNA binding protein required for activation of
            repressed messages in mammalian germ cells
  JOURNAL   Nat Genet 22 (2), 171-174 (1999)
   PUBMED   10369260
REFERENCE   8  (residues 1 to 374)
  AUTHORS   Zhong,J., Edelhoff,S., Disteche,C. and Braun,R.E.
  TITLE     The gene encoding PRBP, the mouse homolog of human TRBP, maps to
            distal chromosome 15
  JOURNAL   Mamm Genome 9 (5), 413-414 (1998)
   PUBMED   9545508
REFERENCE   9  (residues 1 to 374)
  AUTHORS   Lee,K., Fajardo,M.A. and Braun,R.E.
  TITLE     A testis cytoplasmic RNA-binding protein that has the properties of
            a translational repressor
  JOURNAL   Mol Cell Biol 16 (6), 3023-3034 (1996)
   PUBMED   8649414
REFERENCE   10 (residues 1 to 374)
  AUTHORS   Kozak,C.A., Gatignol,A., Graham,K., Jeang,K.T. and McBride,O.W.
  TITLE     Genetic mapping in human and mouse of the locus encoding TRBP, a
            protein that binds the TAR region of the human immunodeficiency
            virus (HIV-1)
  JOURNAL   Genomics 25 (1), 66-72 (1995)
   PUBMED   7774957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137156.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.182578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.65 cM"
     Protein         1..374
                     /product="RISC-loading complex subunit TARBP2 isoform 10"
                     /note="RISC-loading complex subunit TARBP2; TAR (HIV) RNA
                     binding protein 2; PRM-1 RNA-binding protein; TAR
                     RNA-binding protein 2; protamine-1 RNA-binding protein"
                     /calculated_mol_wt=39665
     Region          27..98
                     /region_name="DSRM_TARBP2_rpt1"
                     /note="first double-stranded RNA binding motif of the
                     RISC-loading complex subunit TARBP2 and similar proteins;
                     cd19890"
                     /db_xref="CDD:380719"
     Site            order(29..30,32..33,36..37,40..41,48,56..58,60,62,78..81,
                     84)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:380719"
     Region          167..233
                     /region_name="DSRM_TARBP2_rpt2"
                     /note="second double-stranded RNA binding motif of the
                     RISC-loading complex subunit TARBP2 and similar proteins;
                     cd10844"
                     /db_xref="CDD:380681"
     Site            order(167,169..170,173..174,177..178,183..184,194,
                     196..198,200,216..219,222..223)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:380681"
     Region          300..371
                     /region_name="DSRM_TARBP2_rpt3"
                     /note="third double-stranded RNA binding motif of the
                     RISC-loading complex subunit TARBP2 and similar proteins;
                     cd19893"
                     /db_xref="CDD:380722"
     Site            order(300..301,303..304,307..308,311..312,319,329..331,
                     333,335,350..353,356)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:380722"
     Site            order(313..314,324..328,332..334,336,338..340,342..344,
                     346..347,362,365..366,369..371)
                     /site_type="other"
                     /note="Dicer interface [polypeptide binding]"
                     /db_xref="CDD:380722"
     CDS             1..374
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /coded_by="NM_001416335.1:235..1359"
                     /note="isoform 10 is encoded by transcript variant 14"
                     /db_xref="GeneID:21357"
                     /db_xref="MGI:MGI:103027"
ORIGIN      
        1 mseedqgsgt ttgcglpsie qmlaanpgkt pisllqeygt rigktpvydl lkaegqahqp
       61 nftfrvtvgd tsctgqgpsk kaakhkaaev alkhlkggsm lepaledsss fslldssppe
      121 dtpvvaaeaa apvpsavlts tglgpfffrs ppmemqppvs pqqsecnpvg alqelvvqkg
      181 wrlpeymvtq esgpahrkef tmtcrverfi eigsgtskkl akrnaaakml lrvhtvplda
      241 rdgneaepdd dhfsigvssr ldglrnrgpg ctwdslrnsv gekilslrsc svgslgalgs
      301 accsvlsels eeqafhvsyl dieelslsgl cqclvelstq patvcygsat treaargdaa
      361 hralqylrim agsk
//
