LOCUS       NM_001253795            1394 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus TARBP2, RISC loading complex RNA binding subunit
            (Tarbp2), transcript variant 2, mRNA.
ACCESSION   NM_001253795
VERSION     NM_001253795.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Vaughn,L.S., Chukwurah,E. and Patel,R.C.
  TITLE     Opposite actions of two dsRNA-binding proteins PACT and TRBP on
            RIG-I mediated signaling
  JOURNAL   Biochem J 478 (3), 493-510 (2021)
   PUBMED   33459340
  REMARK    GeneRIF: Opposite actions of two dsRNA-binding proteins PACT and
            TRBP on RIG-I mediated signaling.
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   Vishlaghi,N. and Lisse,T.S.
  TITLE     Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced
            Anagen Hair Follicle Development
  JOURNAL   Front Cell Dev Biol 8, 338 (2020)
   PUBMED   32478074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Pullagura,S.R.N., Buaas,B., Gray,N., Krening,L.C., Srivastava,A.
            and Braun,R.E.
  TITLE     Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During
            Murine Embryogenesis Does Not Involve miRNA Biogenesis
  JOURNAL   Genetics 208 (4), 1513-1522 (2018)
   PUBMED   29467169
  REMARK    GeneRIF: TARBP2, but not PRKRA, functions in miRNA biogenesis of a
            subclass of miRNAs, and suggesting that functional redundancy
            between TARBP2 and PRKRA does not involve miRNA biogenesis.
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Byun,S.H., Kim,J., Han,D., Kwon,M., Cho,J.Y., Ng,H.X.,
            Pleasure,S.J. and Yoon,K.
  TITLE     TRBP maintains mammalian embryonic neural stem cell properties by
            acting as a novel transcriptional coactivator of the Notch
            signaling pathway
  JOURNAL   Development 144 (5), 778-783 (2017)
   PUBMED   28174252
  REMARK    GeneRIF: TRBP is a novel transcriptional coactivator of the Notch
            signaling pathway, playing an important role in neural stem cell
            regulation during mammalian brain development
REFERENCE   5  (bases 1 to 1394)
  AUTHORS   Ding,J., Nie,M., Liu,J., Hu,X., Ma,L., Deng,Z.L. and Wang,D.Z.
  TITLE     Trbp Is Required for Differentiation of Myoblasts and Normal
            Regeneration of Skeletal Muscle
  JOURNAL   PLoS One 11 (5), e0155349 (2016)
   PUBMED   27159388
  REMARK    GeneRIF: study demonstrated that Trbp participates in the
            regulation of muscle differentiation and regeneration
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1394)
  AUTHORS   Delpire,E., Lu,J., England,R., Dull,C. and Thorne,T.
  TITLE     Deafness and imbalance associated with inactivation of the
            secretory Na-K-2Cl co-transporter
  JOURNAL   Nat Genet 22 (2), 192-195 (1999)
   PUBMED   10369265
REFERENCE   7  (bases 1 to 1394)
  AUTHORS   Zhong,J., Peters,A.H., Lee,K. and Braun,R.E.
  TITLE     A double-stranded RNA binding protein required for activation of
            repressed messages in mammalian germ cells
  JOURNAL   Nat Genet 22 (2), 171-174 (1999)
   PUBMED   10369260
REFERENCE   8  (bases 1 to 1394)
  AUTHORS   Zhong,J., Edelhoff,S., Disteche,C. and Braun,R.E.
  TITLE     The gene encoding PRBP, the mouse homolog of human TRBP, maps to
            distal chromosome 15
  JOURNAL   Mamm Genome 9 (5), 413-414 (1998)
   PUBMED   9545508
REFERENCE   9  (bases 1 to 1394)
  AUTHORS   Lee,K., Fajardo,M.A. and Braun,R.E.
  TITLE     A testis cytoplasmic RNA-binding protein that has the properties of
            a translational repressor
  JOURNAL   Mol Cell Biol 16 (6), 3023-3034 (1996)
   PUBMED   8649414
REFERENCE   10 (bases 1 to 1394)
  AUTHORS   Kozak,C.A., Gatignol,A., Graham,K., Jeang,K.T. and McBride,O.W.
  TITLE     Genetic mapping in human and mouse of the locus encoding TRBP, a
            protein that binds the TAR region of the human immunodeficiency
            virus (HIV-1)
  JOURNAL   Genomics 25 (1), 66-72 (1995)
   PUBMED   7774957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137156.3.
            
            On Jan 27, 2023 this sequence version replaced NM_001253795.1.
            
            Transcript Variant: This variant (2) lacks two exons in the 5'
            coding region, which does not affect the reading frame, compared to
            variant 1. The resulting isoform (2) lacks an internal segment in
            the N-terminal region, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144205.1, SRR7345562.967947.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC137156.3         174734-175020
            288-380             AC137156.3         177539-177631
            381-453             AC137156.3         178142-178214
            454-571             AC137156.3         178399-178516
            572-699             AC137156.3         178842-178969
            700-901             AC137156.3         179267-179468
            902-1394            AC137156.3         179603-180095
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.65 cM"
     gene            1..1394
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /note="TARBP2, RISC loading complex RNA binding subunit"
                     /db_xref="GeneID:21357"
                     /db_xref="MGI:MGI:103027"
     exon            1..287
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1059
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RISC-loading complex subunit TARBP2; TAR (HIV) RNA binding
                     protein 2; PRM-1 RNA-binding protein; TAR RNA-binding
                     protein 2; protamine-1 RNA-binding protein"
                     /codon_start=1
                     /product="RISC-loading complex subunit TARBP2 isoform 2"
                     /protein_id="NP_001240724.1"
                     /db_xref="CCDS:CCDS57013.1"
                     /db_xref="GeneID:21357"
                     /db_xref="MGI:MGI:103027"
                     /translation="MSEEDQGSGTTTGCGLPSSFSLLDSSPPEDTPVVAAEAAAPVPS
                     AVLTRSPPMEMQPPVSPQQSECNPVGALQELVVQKGWRLPEYMVTQESGPAHRKEFTM
                     TCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEAEPDDDHFSIGVSSR
                     LDGLRNRGPGCTWDSLRNSVGEKILSLRSCSVGSLGALGSACCSVLSELSEEQAFHVS
                     YLDIEELSLSGLCQCLVELSTQPATVCYGSATTREAARGDAAHRALQYLRIMAGSK"
     exon            288..380
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            381..453
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            454..571
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            572..699
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            700..901
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1394
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /note="hexamer: AATAAA"
     polyA_site      1323
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /note="major polyA site"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="Tarbp2"
                     /gene_synonym="Prbp; TRBP"
                     /note="major polyA site"
ORIGIN      
        1 agaaggcggt gcagatgccc gggcgagtct cgctgagggt tgtggggcgg gtagctcgga
       61 tccataagaa gacacaagga gccgagtggg cgggggactc cagatcccag catgccccgc
      121 ggcgggccct accggccgcg actccgggct tggccccggc cctagctcct cggcggtgta
      181 ctggggtgcg tggaggctgt agtcacggtg gcgcccgcgg ggacggagga gggaatgagt
      241 gaagaggatc agggctccgg cactactaca ggctgcgggc tgcccagttc tttttctctc
      301 ctagactctt caccgcctga ggacactcct gtcgttgctg cagaagctgc tgcccctgtt
      361 ccatctgctg tactaaccag gagccctccc atggagatgc agccccctgt ctctcctcag
      421 cagtctgagt gcaaccccgt cggtgctctg caggagctgg tggtgcaaaa aggctggcgt
      481 ttgccagagt acatggtgac ccaagagtct gggcctgctc accgcaaaga gttcaccatg
      541 acttgccggg tggagcgttt cattgagatt ggcagtggca cttccaaaaa gctggcaaag
      601 cgtaacgcag cagctaagat gctccttcga gtgcacactg tacctctgga tgcccgggat
      661 ggcaatgagg cagagcctga tgacgatcat ttttccattg gcgtgagctc ccgcctggat
      721 ggactgagga atcgtgggcc aggctgcacc tgggattcct tgcggaattc tgtgggagaa
      781 aagatcctat cccttcgcag ttgctccgtg ggctctctag gggctctggg ctctgcctgc
      841 tgcagtgtcc tcagtgagct ctctgaggag caggctttcc atgtcagcta tctggatatt
      901 gaggaactga gcctgagtgg gctctgccag tgcctagtgg aactgtccac ccagccagcc
      961 actgtgtgtt atggttctgc aaccaccagg gaggcagccc gaggtgatgc tgctcaccgc
     1021 gccctacagt acctcaggat catggcgggt agcaagtagc atcccactgc agtgatggat
     1081 atgcatcttt tacttcttgc tccttctgcc cctgggtcca tgtatccacc tagctctggt
     1141 accctccaga ggtgccatct ctacctctga cacagcctgt ctgccttgag actgaggaag
     1201 gcacaggcaa gcaaggagcc atgaaccaca gggccccagc cagcacagga tttgtcctca
     1261 ttccgtgggt gatggatgaa tctattggag tcctgaataa atgctgctct ttggcttcca
     1321 aaaccctgct ctctctggcc ttgggtcatg agggtataag gaataaacat ggtgagcttg
     1381 ttctcctttt gaac
//
