LOCUS       NM_173764               3508 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane anterior posterior transformation 1
            (Tapt1), mRNA.
ACCESSION   NM_173764
VERSION     NM_173764.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3508)
  AUTHORS   Wang,B., Zhao,Q., Gong,X., Wang,C., Bai,Y., Wang,H., Zhou,J. and
            Rong,X.
  TITLE     Transmembrane anterior posterior transformation 1 regulates BMP
            signaling and modulates the protein stability of SMAD1/5
  JOURNAL   J Biol Chem 298 (12), 102684 (2022)
   PUBMED   36370851
  REMARK    GeneRIF: Transmembrane anterior posterior transformation 1
            regulates BMP signaling and modulates the protein stability of
            SMAD1/5.
            Erratum:[J Biol Chem. 2023 Jul;299(7):104957. doi:
            10.1016/j.jbc.2023.104957.. PMID: 37393648]
REFERENCE   2  (bases 1 to 3508)
  AUTHORS   Ching,Y.H., Munroe,R.J., Moran,J.L., Barker,A.K., Mauceli,E.,
            Fennell,T., Dipalma,F., Lindblad-Toh,K., Abcunas,L.M.,
            Gilmour,J.F., Harris,T.P., Kloet,S.L., Luo,Y., McElwee,J.L., Mu,W.,
            Park,H.K., Rogal,D.L., Schimenti,K.J., Shen,L., Shindo,M.,
            Shou,J.Y., Stenson,E.K., Stover,P.J. and Schimenti,J.C.
  TITLE     High resolution mapping and positional cloning of ENU-induced
            mutations in the Rw region of mouse chromosome 5
  JOURNAL   BMC Genet 11, 106 (2010)
   PUBMED   21118569
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3508)
  AUTHORS   Howell,G.R., Shindo,M., Murray,S., Gridley,T., Wilson,L.A. and
            Schimenti,J.C.
  TITLE     Mutation of a ubiquitously expressed mouse transmembrane protein
            (Tapt1) causes specific skeletal homeotic transformations
  JOURNAL   Genetics 175 (2), 699-707 (2007)
   PUBMED   17151244
  REMARK    GeneRIF: TAPT1 is a downstream effector of HOXC8 that may act by
            transducing or transmitting extracellular information required for
            axial skeletal patterning during development.
REFERENCE   4  (bases 1 to 3508)
  AUTHORS   Wilson,L., Ching,Y.H., Farias,M., Hartford,S.A., Howell,G.,
            Shao,H., Bucan,M. and Schimenti,J.C.
  TITLE     Random mutagenesis of proximal mouse chromosome 5 uncovers
            predominantly embryonic lethal mutations
  JOURNAL   Genome Res 15 (8), 1095-1105 (2005)
   PUBMED   16024820
REFERENCE   5  (bases 1 to 3508)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 3508)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN459607.1 and BC096038.1.
            
            On Jul 26, 2005 this sequence version replaced NM_173764.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164135
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               CN459607.1         1-521
            522-3508            BC096038.1         1-2987
FEATURES             Location/Qualifiers
     source          1..3508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 24.24 cM"
     gene            1..3508
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /note="transmembrane anterior posterior transformation 1"
                     /db_xref="GeneID:231225"
                     /db_xref="MGI:MGI:2683537"
     exon            1..193
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1698
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /codon_start=1
                     /product="transmembrane anterior posterior transformation
                     protein 1"
                     /protein_id="NP_776125.2"
                     /db_xref="CCDS:CCDS19270.1"
                     /db_xref="GeneID:231225"
                     /db_xref="MGI:MGI:2683537"
                     /translation="MAGVCDAAAPGEGGGGGADGPERTGRGEAEQPGGGGHGPAPQHT
                     ETLGFYESDRRREKRRGRAELSLLRFLSAELTRGYFLEHNEAKYTERRERVYTCMRIP
                     RELEKLMFFGIFLCLDAFLYVFTLLPLRVFLALFRLLTLPCYGLRDRRLLQPAQVCDI
                     LKGVILVICYFMMHYVDYSMMYHLIRGQSVIKLYIIYNMLEVADRLFSSFGQDILDAL
                     YWTATEPKERKRAHIGVIPHFFMAVLYVFLHAILIMVQATTLNVAFNSHNKSLLTIMM
                     SNNFVEIKGSVFKKFEKNNLFQMSNSDIKERFTNYVLLLIVCLRNMEQFSWNPDHLWV
                     LFPDVCMVIASEIAVDIVKHAFITKFNDITADVYSEYRASLAFDLVSSRQKNAYTDYS
                     DSVARRMGFIPLPLAVLLIRVVTSSIKVQGILSYACVILFYFGLISLKILNSIVLLGK
                     SCQYVKEAKMEEKLFNPPPASTPGKPSSKSQSKGKPSQGLSTEENLSASVTSQPGHQK
                     ENVIPLLVTSNSDQFLTTPDGDEKDITQENSELKHRSSKKDLLEIDRFTICGNRID"
     exon            194..324
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            325..443
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            444..606
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            607..742
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..840
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..910
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            911..991
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1101
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1161
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1230
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1307
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1468
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..3492
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3461..3466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3492
                     /gene="Tapt1"
                     /gene_synonym="4932414K18Rik"
                     /note="major polyA site"
ORIGIN      
        1 aacatggcgg gcgtctgcga cgcggccgcc ccgggagaag gcggcggtgg cggcgcggac
       61 ggccccgagc ggaccggccg cggcgaggcg gagcagccgg gtggtggcgg ccatgggccc
      121 gcgccccaac acaccgagac gctgggcttc tacgagagcg accggcggcg ggagaagcgc
      181 cgcggccgcg cagaactgtc attattgagg ttcctcagtg ctgaactgac aagagggtac
      241 ttccttgaac ataatgaagc caagtataca gagcgaagag aaagggtgta cacttgtatg
      301 cgaataccaa gagaattgga aaagctcatg ttctttggaa tatttttgtg cctcgatgcc
      361 tttctgtatg tgttcaccct gcttccttta agagtctttc tggcgctatt caggctcctc
      421 actctgcctt gctatggctt aagggaccga cgtctgcttc agcccgcaca ggtgtgtgac
      481 attttgaagg gcgtcatctt ggtaatctgc tatttcatga tgcactatgt tgactactcc
      541 atgatgtacc acctgataag aggccagtct gtcatcaagc tctatatcat ctacaacatg
      601 ctagaggtag ctgatcgtct gttctcctcg tttggacaag atatcttaga tgctctctac
      661 tggacagcca cagagccgaa agaaaggaaa agagcacaca ttggagtcat tcctcacttc
      721 ttcatggctg ttctctatgt ctttctacat gcaattctta tcatggttca agcaacaact
      781 ctcaatgtag cttttaactc tcacaacaag tcactgctta ctatcatgat gtctaataat
      841 tttgttgaaa ttaaaggaag tgtattcaag aagtttgaaa agaataatct ctttcagatg
      901 tcaaatagtg atattaagga gcgattcaca aattacgtgc ttttgttaat agtgtgctta
      961 agaaacatgg agcagttttc ttggaatcca gatcatctct gggtgttgtt tcctgacgtc
     1021 tgtatggtga ttgcatccga aattgctgtg gatattgtaa agcatgcctt tatcaccaaa
     1081 ttcaatgaca tcactgcaga tgtctacagt gaatatagag ccagccttgc ttttgacctt
     1141 gttagcagcc gacagaaaaa tgcatacaca gactacagtg actcggtggc acggaggatg
     1201 gggtttattc ctctcccgct agctgtctta ctcatcagag ttgtaacaag ctcaattaaa
     1261 gtgcaaggaa tcctgtccta cgcctgtgtc atactcttct attttgggtt gatctccttg
     1321 aaaatactta atagcattgt gctgttggga aagtcctgtc aatacgtgaa ggaagccaaa
     1381 atggaagaga agctatttaa tcctcctcca gccagcacac ccggaaaacc ctccagcaaa
     1441 tcccagagca agggcaagcc ctctcaaggc ctttccacag aagaaaacct gtctgcctcc
     1501 gtcaccagcc agcctggtca tcagaaagaa aacgtcatac ctttactcgt gactagcaat
     1561 tctgatcagt tcctgacaac cccagatggt gatgagaagg acataacaca ggaaaattct
     1621 gagttaaagc acagatcctc aaagaaagac ttgttagaaa tagacaggtt cacaatttgc
     1681 gggaaccgga ttgactgagt ttgtgactaa tgagatgaag atgtcaggcc ccgggccaca
     1741 aattctgggt gccaggacac ttgctaaaaa tggcacttaa atatttattt aaaaacttaa
     1801 attattaatg gcaagcaaat cttagtatct ttcttccagt aatgtggcct tgcagaaggg
     1861 cagatcacgg agcagcggtg gcctctggcc ctgactctgg atgctgacac ttgaacactt
     1921 cctcctgcgt ggccaacagc agtgctgctt ccagcacctg gccaagcact gcagaagctc
     1981 ctttccttcg tcagcctggg cttccagatc gtcgggttct cctcaaggcc tcttcaggat
     2041 aaggacacac ctgggaaact gtgacgcttc taccatgagt tccctttcca gcctcagact
     2101 gtctccacac actctttcca gacttgactc catctgccaa agcattgaca agttgctaca
     2161 tctaagtcca gatgacgttc ttaccaccag agtcatcctt ggcaatacat ctgagctagt
     2221 cagaacagaa ggccacttaa ctacaacgtg gtgaatagca gcgtcctatg agaaacagtg
     2281 agctcttggc ccagtcattt actttataaa ggtcatgtgt cactgagaaa tgcttcctgc
     2341 tgcctcggtt actcagggca gagtgtgagc tgtgtgacac gggcccagtg acaataaaag
     2401 gcacagagca atgtcaacag agtaaaaggc acaagtgcag tgtgacctgg ctttgcttta
     2461 aggctaattg cttcattggt tattccaagt taaaggattt ggtgttgaat tggcgaatag
     2521 ccattgcata gctgttgcta gtgccaggct cgtttgttgg gttttgtttt ggtttgagta
     2581 acagttttaa agtattccca gcagattgag cagtgtcacc ttgctgggct tgtaaaatgc
     2641 atttgtctgc ctgtgggtct gttctgtgtg gggaggaaac cctcacatga ccgaccgacc
     2701 gtaagtagag tgtttgggac actgtaacta gcaaccaaaa ggtgctctgg ggttttcatc
     2761 tgagataaag atgttattcc tgcttcatta ctacctatta gcatcccagg acaaattctc
     2821 gacaccctac tttatcttaa gagtctgttc tgcacttctc ttagacagaa agttgaccat
     2881 ttctgatctg aactgtctaa aagatggtac tcttaacttc atttcctatg ctgtcttctg
     2941 aaactcagct ctcatgcaaa tatttgggca cagatggcaa attttaaatg gtttgctgta
     3001 tcctggataa gtataaaact agtttggatg ctttggctta tgcatttgag attcaggagg
     3061 gtttctaatg ttttgcacta acagaatcta aagatagctg ttggagatac tatatattta
     3121 tgccttgtaa agccaggaag caattttaag tttaaaatga acatttttat tcttttgtgt
     3181 atgttttagt ggggccccac ttttaaacta ttctttttac cgaaagagag tgtccatgga
     3241 aaccaggagc cgtgtggaaa aagctttgcc aaacgcagcc ctggtcagaa caagagcacg
     3301 acctaggtgt atctttctgt tccgcttgag ttttctgttt ccgcgctgtt ctctgaagat
     3361 tgcatttcct ttgcagatgc tcttgggagt gtggatgata ctcacttctg tcataatggc
     3421 attcagtact aattttataa gtgcatcttg tgtgaaactc aataaattca attttataat
     3481 cttttttaaa aaaaaaaaaa aaaaaaaa
//
