LOCUS       NM_009318               2747 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus TAP binding protein (Tapbp), transcript variant 2,
            mRNA.
ACCESSION   NM_009318
VERSION     NM_009318.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Lv,M., Yao,T., Zhang,Y., Ma,S., Chen,J., Tang,Z., Zang,G. and
            Chen,X.
  TITLE     Exosomes loading Tapasin enhance T cell immune response by
            autophagy to inhibit HBV replication
  JOURNAL   J Med Virol 95 (4), e28746 (2023)
   PUBMED   37185848
  REMARK    GeneRIF: Exosomes loading Tapasin enhance T cell immune response by
            autophagy to inhibit HBV replication.
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Hafstrand,I., Sayitoglu,E.C., Apavaloaei,A., Josey,B.J., Sun,R.,
            Han,X., Pellegrino,S., Ozkazanc,D., Potens,R., Janssen,L.,
            Nilvebrant,J., Nygren,P.A., Sandalova,T., Springer,S.,
            Georgoudaki,A.M., Duru,A.D. and Achour,A.
  TITLE     Successive crystal structure snapshots suggest the basis for MHC
            class I peptide loading and editing by tapasin
  JOURNAL   Proc Natl Acad Sci U S A 116 (11), 5055-5060 (2019)
   PUBMED   30808808
  REMARK    GeneRIF: These results combined with mutation analyses allow us to
            propose a molecular model underlying MHC-I peptide selection by
            tapasin.
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   Doorduijn,E.M., Sluijter,M., Querido,B.J., Seidel,U.J.E.,
            Oliveira,C.C., van der Burg,S.H. and van Hall,T.
  TITLE     T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with
            TAP-Independent Peptides Are Semi-Invariant Lymphocytes
  JOURNAL   Front Immunol 9, 60 (2018)
   PUBMED   29422902
  REMARK    GeneRIF: Qa-1b-restricted CD8+ T cells display characteristics of
            both conventional hypervariable T cells as well as invariant T
            cells and can be classified as semi-invariant T cells, with only
            conserved Valpha usage, positioned between these two known T cell
            subsets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Kanaseki,T., Lind,K.C., Escobar,H., Nagarajan,N., Reyes-Vargas,E.,
            Rudd,B., Rockwood,A.L., Van Kaer,L., Sato,N., Delgado,J.C. and
            Shastri,N.
  TITLE     ERAAP and tapasin independently edit the amino and carboxyl termini
            of MHC class I peptides
  JOURNAL   J Immunol 191 (4), 1547-1555 (2013)
   PUBMED   23863903
  REMARK    GeneRIF: Absence of Tpn or ERAAP independently altered the peptide
            repertoire by causing loss as well as gain of new pMHC I.  Tpn
            defined the characteristic carboxy termini of canonical MHC I
            peptides.
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Li,S., Paulsson,K.M., Sjogren,H.O. and Wang,P.
  TITLE     Peptide-bound major histocompatibility complex class I molecules
            associate with tapasin before dissociation from transporter
            associated with antigen processing
  JOURNAL   J Biol Chem 274 (13), 8649-8654 (1999)
   PUBMED   10085102
REFERENCE   7  (bases 1 to 2747)
  AUTHORS   van Endert,P.M.
  TITLE     Genes regulating MHC class I processing of antigen
  JOURNAL   Curr Opin Immunol 11 (1), 82-88 (1999)
   PUBMED   10047538
  REMARK    Review article
REFERENCE   8  (bases 1 to 2747)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 2747)
  AUTHORS   Grandea,A.G. 3rd, Comber,P.G., Wenderfer,S.E., Schoenhals,G.,
            Fruh,K., Monaco,J.J. and Spies,T.
  TITLE     Sequence, linkage to H2-K, and function of mouse tapasin in MHC
            class I assembly
  JOURNAL   Immunogenetics 48 (4), 260-265 (1998)
   PUBMED   9716645
REFERENCE   10 (bases 1 to 2747)
  AUTHORS   Herberg,J.A., Sgouros,J., Jones,T., Copeman,J., Humphray,S.J.,
            Sheer,D., Cresswell,P., Beck,S. and Trowsdale,J.
  TITLE     Genomic analysis of the Tapasin gene, located close to the TAP loci
            in the MHC
  JOURNAL   Eur J Immunol 28 (2), 459-467 (1998)
   PUBMED   9521053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF168841.1, AK014566.1, AK054174.1 and CAAA01015907.1.
            
            On Jul 13, 2005 this sequence version replaced NM_009318.1.
            
            Transcript Variant: This variant (2) has an alternate splice site
            in the coding region, compared to variant 1. The resulting isoform
            (2) lacks an internal aa, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169697.1, AK077299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               CF168841.1         1-146
            147-825             AK014566.1         2-680
            826-1752            AK054174.1         1-927
            1753-2747           CAAA01015907.1     5983-6977
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2747
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /note="TAP binding protein"
                     /db_xref="GeneID:21356"
                     /db_xref="MGI:MGI:1201689"
     exon            1..247
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1608
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Tapasin; TPSN; TAP-associated protein"
                     /codon_start=1
                     /product="tapasin isoform 2 precursor"
                     /protein_id="NP_033344.1"
                     /db_xref="CCDS:CCDS89072.1"
                     /db_xref="GeneID:21356"
                     /db_xref="MGI:MGI:1201689"
                     /translation="MKPLLLLVAVALGLATVVSVVSAGPEAIECWFVEDAGGGGLSKK
                     PATLLLRHGPRGPPPRPDLDPKLYFKVDDPAGMLLAAFRRYPAGASAPHCEMSRFIPF
                     PASAKWARSLSPEQNCPRALDGDWLLVSVSSTLFSLSSLLRPQPEPLREPVVITMATV
                     VLTVLTHNPAPRVQLGKDAVLDLRFAYAPSALEGSPSLDAGPPPFGLEWRRQHRGKGH
                     LLLAATPGLAGRMPPAQEKATAFAAWDDDEPWGPWTGNGTFWLPAVKPSQEGVYLATV
                     HLPYLQGQVSLELTVHKAPRVSLTPAPVVWAAPGEAPPELLCLASHFFPAEGLEVKWE
                     LRGGPGGSSRKVEGKTWLSTIRHHSDGSVSQSGHLQLPPVTAKQHGVHYVCRVYHSSL
                     PASGRSADVTLEVAGFSGPSIEDGIGLFLSAFLLLGLLKVLGWLAAYWTIPEVSKEKA
                     TAASLTIPRNSKKSQ"
     exon            248..427
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /inference="alignment:Splign:2.1.0"
     exon            428..688
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /inference="alignment:Splign:2.1.0"
     exon            689..1087
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1429
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1519
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1596
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..2747
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2727..2732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /note="hexamer: AATAAA"
     polyA_site      2747
                     /gene="Tapbp"
                     /gene_synonym="D17Wsu91e; TPN"
                     /note="major polyA site"
ORIGIN      
        1 caagggggtg ggtgcagggc gaggagtggc tggagagcta cagacagggt ttcggcaact
       61 ctgtttggcc cctgtgggcg gcgttcctcc aacgcgcagt cacgccctca cctgaccaga
      121 tcggggaatt tccagttcct caccccagcc ttagaaggaa aatgaaagtg aaaggggaag
      181 aaaagacttg gtaggagaga tcgtagcacc atgaagcctc tgctcctgct cgtcgctgtg
      241 gcactgggcc tagcgaccgt cgtctccgtc gtctcggctg gaccagaggc gatcgagtgc
      301 tggttcgtgg aggatgcagg tgggggtggc ctgtctaaga aacctgccac actgctactg
      361 cgccatggac ccaggggacc gccgccccgg ccagatcttg acccaaagct atacttcaag
      421 gtggatgacc cggcgggaat gctcctggcc gccttcaggc ggtaccccgc aggcgcctcc
      481 gccccacact gcgagatgag ccgcttcatc ccgttccctg cctcggcgaa gtgggctaga
      541 agtctgagtc cggagcagaa ctgcccgcgg gccctggacg gggattggct gctggtcagc
      601 gtatccagca ctctcttcag cctctccagc ctgctgcgac cacagccgga gcctctgcgg
      661 gagcctgtcg tcatcaccat ggcaacagtg gtgctgaccg tcctcaccca taaccctgcc
      721 cctcgagtcc agctgggaaa ggatgcagtg ctggacctgc gcttcgccta cgcaccctcc
      781 gccctggaag gttctccctc tctggacgca ggccctcctc cctttgggct ggagtggcga
      841 cgccagcaca ggggaaaggg tcacctgctg ttggctgcca cccccgggct ggccgggaga
      901 atgccaccag cccaggaaaa ggctacggca tttgcagctt gggatgacga tgagccctgg
      961 ggcccgtgga ctgggaatgg gaccttctgg cttccagccg tgaagccttc tcaggagggt
     1021 gtctacctgg ctacggtaca cctgccctac ctgcaaggac aggtctccct ggagctgact
     1081 gtgcacaagg cccccagagt gtctctaaca ccagcacccg ttgtgtgggc tgccccagga
     1141 gaggcacccc cagaactgct ctgtcttgca tcccacttct tccctgcgga gggtctggag
     1201 gtcaagtggg agctcagagg cggcccagga ggaagttcta gaaaggttga ggggaagacg
     1261 tggctctcca ccatccgcca ccattccgat ggctctgtca gccagtctgg gcacctgcag
     1321 ctacctccag tcactgccaa gcagcatgga gttcactatg tctgtcgggt gtaccactct
     1381 agcctgccag catcggggcg cagtgctgac gtcaccctgg aggtggcagg cttctcaggg
     1441 ccctccatcg aggacggcat cggcctgttc ctgtctgctt ttctcctcct cggactcctc
     1501 aaggtgctag gctggctggc tgcctactgg accattcctg aagtctcaaa ggagaaggcc
     1561 acagctgcca gcctgaccat tcccaggaac tcaaagaagt cacagtaaag aagttctcgt
     1621 ctgtggaagc caccctcatc tctggcccag atgactccag tagcccctgc cccagaacaa
     1681 cagccttctt ctcttcttct ccctccattg aatagctcgg attttttttt ttaaggtttt
     1741 tttgtttgtt tcaatctttc ttgttttgtt cttgttttta gacaaggtct ctctatgtag
     1801 ccttggctgg ctgtcctgaa ccctcaccaa gccaaccagg ctggcctcga agtcccagag
     1861 atccacctgt ccctctgcct cggagtgaca aacggcactg gacaccatgc ctagaggtct
     1921 tttttttttt tggtttttgg agacaggatt tctctgtata gtcccggctg tcctggaact
     1981 cactctgtag accaggctgg cctcgaactc agaaatccgc ctgcctctgc ctcccaggtg
     2041 ctgggattaa aggcgtgcgc caccaccgct ggactcgaac taaactttta agatgagaaa
     2101 aaagcgagac ttagcgccac actcatttga tgcccacagt cgggaggcag aggcagtgga
     2161 tctctgacat ttccatgcca gcctgatcta caaataggga gtttcaggtc agtcggggtt
     2221 acttggcggg gctttgttga gagaactaaa tataagaaca cacatgcgta gagtcccagg
     2281 gttgagaaga accagtgtat gcgccagaga ggcgggttca taacctgtgg ctcacaaccc
     2341 cctttaagtc catcggaaat accagacatt aggattcaca acagtagtaa aggcagttac
     2401 gaagtagcaa agaaaataat tttacaactt gaactgcgtt aatgttaaga aggttgagaa
     2461 ccactggcca ggggattagg acgaaaggtc ttcatagcat cttaagattc tagagacctc
     2521 agggacagcc cacagcagta gtctagagac ggaaaggtcc atgtgtctcc ctcgcggact
     2581 aaagcctacc tctccagctc tccattccta ccacagcttt tcttttgcct ggtccacctt
     2641 taccatctcc gggcctggtg ggtctcggcc ctttacgaat gtccccgtgt ggttcgtcct
     2701 ctcctgttcg ccggtcctcg tgagctaata aagtctttcc gagtttc
//
