LOCUS       NM_011530               2490 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus transporter 2, ATP-binding cassette, sub-family B
            (MDR/TAP) (Tap2), mRNA.
ACCESSION   NM_011530
VERSION     NM_011530.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Han,X., Feng,J., Guo,T., Loh,Y.E., Yuan,Y., Ho,T.V., Cho,C.K.,
            Li,J., Jing,J., Janeckova,E., He,J., Pei,F., Bi,J., Song,B. and
            Chai,Y.
  TITLE     Runx2-Twist1 interaction coordinates cranial neural crest guidance
            of soft palate myogenesis
  JOURNAL   Elife 10, e62387 (2021)
   PUBMED   33482080
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Lapenna,A., Omar,I. and Berger,M.
  TITLE     A novel spontaneous mutation in the TAP2 gene unravels its role in
            macrophage survival
  JOURNAL   Immunology 150 (4), 432-443 (2017)
   PUBMED   27861817
  REMARK    GeneRIF: this study show that a new mouse strain with a single
            point mutation (Tap2 knock-out strain) shows impaired survival of
            macrophage survival following peritoneal iflammation
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   Huang,L., Kuhls,M.C. and Eisenlohr,L.C.
  TITLE     Hydrophobicity as a driver of MHC class I antigen processing
  JOURNAL   EMBO J 30 (8), 1634-1644 (2011)
   PUBMED   21378750
REFERENCE   5  (bases 1 to 2490)
  AUTHORS   Theodoratos,A., Whittle,B., Enders,A., Tscharke,D.C., Roots,C.M.,
            Goodnow,C.C. and Fahrer,A.M.
  TITLE     Mouse strains with point mutations in TAP1 and TAP2
  JOURNAL   Immunol Cell Biol 88 (1), 72-78 (2010)
   PUBMED   19721454
  REMARK    GeneRIF: The Rose strain has an A to T substitution in exon 10 of
            TAP1, resulting in an asparagine to valine substitution at position
            643; defective TAP expression mice have very low major
            histocompatibility complex-I cell-surface expression, and few CD8 T
            cells.
REFERENCE   6  (bases 1 to 2490)
  AUTHORS   Van Kaer,L., Ashton-Rickardt,P.G., Ploegh,H.L. and Tonegawa,S.
  TITLE     TAP1 mutant mice are deficient in antigen presentation, surface
            class I molecules, and CD4-8+ T cells
  JOURNAL   Cell 71 (7), 1205-1214 (1992)
   PUBMED   1473153
REFERENCE   7  (bases 1 to 2490)
  AUTHORS   Andria,M.L., Barsh,G.S. and Levy,S.
  TITLE     Expression of TAPA-1 in preimplantation mouse embryos
  JOURNAL   Biochem Biophys Res Commun 186 (3), 1201-1206 (1992)
   PUBMED   1380797
REFERENCE   8  (bases 1 to 2490)
  AUTHORS   Yang,Y., Fruh,K., Chambers,J., Waters,J.B., Wu,L., Spies,T. and
            Peterson,P.A.
  TITLE     Major histocompatibility complex (MHC)-encoded HAM2 is necessary
            for antigenic peptide loading onto class I MHC molecules
  JOURNAL   J Biol Chem 267 (17), 11669-11672 (1992)
   PUBMED   1339432
REFERENCE   9  (bases 1 to 2490)
  AUTHORS   Attaya,M., Jameson,S., Martinez,C.K., Hermel,E., Aldrich,C.,
            Forman,J., Lindahl,K.F., Bevan,M.J. and Monaco,J.J.
  TITLE     Ham-2 corrects the class I antigen-processing defect in RMA-S cells
  JOURNAL   Nature 355 (6361), 647-649 (1992)
   PUBMED   1538753
REFERENCE   10 (bases 1 to 2490)
  AUTHORS   Cho,S., Attaya,M., Brown,M.G. and Monaco,J.J.
  TITLE     A cluster of transcribed sequences between the Pb and Ob genes of
            the murine major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5197-5201 (1991)
   PUBMED   1711220
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ046345.1, M90459.1 and
            BE691532.1.
            
            On Jun 13, 2009 this sequence version replaced NM_011530.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance. The
            protein encoded by this gene is involved in antigen presentation.
            This protein forms a heterodimer with Tap1 in order to transport
            peptides from the cytoplasm to the endoplasmic reticulum. Mutations
            in the human gene may be associated with ankylosing spondylitis,
            insulin-dependent diabetes mellitus, and celiac disease. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051257.1, AK159200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               CJ046345.1         2-154
            154-2262            M90459.1           1-2109
            2263-2490           BE691532.1         1-228               c
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2490
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /note="transporter 2, ATP-binding cassette, sub-family B
                     (MDR/TAP)"
                     /db_xref="GeneID:21355"
                     /db_xref="MGI:MGI:98484"
     exon            1..145
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..643
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..758
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..889
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1095
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1293
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1422
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1611
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1785
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1945
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2082
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2490
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /note="hexamer: AATAAA"
     regulatory      2471..2476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /note="hexamer: TATAAA"
     polyA_site      2487
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /note="major polyA site"
     polyA_site      2490
                     /gene="Tap2"
                     /gene_synonym="ABC18; Abcb3; APT2; Ham-2; Ham2; jas; MTP2;
                     PSF2; RING11; Tap-2; Y1"
                     /note="major polyA site"
ORIGIN      
        1 accgcgacca cggcagtgaa gtgaaagcga aagccgcggg acccaggcgc gctccccgcg
       61 agggcgtcgc tgcgcaccca ggagatccag tttgagaaga agcagattcc agaagctctc
      121 ctgagctgcc gctccgcagc cgcagaaccc accatggcgc tgtcctacct gaggccctgg
      181 gtctctctgc tgctggcgga catggcttta cttgggttgc tacaaggatc tctgggaaat
      241 ctgcttcccc aggggctgcc aggactctgg atagagggca ccctgcgact tggagtgctg
      301 tggggactgc taaaagtggg agagctgctg ggacttgtgg ggacccttct gcccttgctc
      361 tgccttgcca ctcccctgtt tttctcgcta agagctctgg tgggaggcac cgcgagcacc
      421 tcagtagtcc gagtggcttc tgcctcttgg ggctggctgc tggctggcta tggggctgtt
      481 gcgctgagct gggccgtgtg ggctgtgctg agcccggctg gagtccagga gaaggaacca
      541 ggccaggaga acagaacact gatgaagcgg ttgctgaagc tgtccaggcc ggacctgcct
      601 ttcctcatag ctgccttctt cttccttgtg gtggctgtgt ggggggagac attaatccct
      661 cgctattcgg gtcgtgtaat tgacatcctg ggaggtgatt tcgaccccga cgcctttgca
      721 agcgccatct ttttcatgtg cctgttctct gttgggagct ccttctctgc aggctgtaga
      781 ggaggctcct tcctcttcac catgtccagg atcaacctgc ggatacgaga gcagcttttc
      841 tcatctttgt tgcgccaaga ccttggattc ttccaggaga ccaagacagg ggagctgaac
      901 tcgaggctga gctctgacac ctctctgatg agccgctggc tccctttcaa tgccaatatc
      961 ctgctgcgga gcctggtgaa ggtggtgggg ctctacttct tcatgctcca ggtatcgccc
     1021 cgactcacct tcctctccct gctggacctg cccctcacga tagcagctga gaaggtgtac
     1081 aacccccgcc atcaggcggt gctaaaggag atccaggatg cagtggccaa ggcggggcag
     1141 gtggtgcgcg aggcggtagg agggctgcag actgtgcgaa gctttggggc cgaggagcag
     1201 gaagtcagcc actacaagga ggccctggag cgatgtagac agctgtggtg gcgccgagac
     1261 ctggaaaaag acgtgtatct agtcatacgg agggtgatgg ccttgggcat gcaggtgctg
     1321 attctgaact gcggcgtgca gcagattctg gctggagagg tcacccgggg tggcctgctc
     1381 tccttcctgc tgtaccagga ggaagtggga caatatgtcc ggaacctggt ttacatgtac
     1441 ggggatatgc tgagcaacgt gggcgctgct gaaaaggtgt tttcctacct ggaccgaaag
     1501 ccgaatctgc cccagcctgg gatcctggcc cctccctggc tggaggggcg cgtggaattc
     1561 caagacgtct ccttttcgta tcccaggcgc cccgagaagc ctgtgctcca gggtctgacg
     1621 ttcaccctgc atcctggaac ggtgacagcg ttggtgggac ccaatggatc agggaagagc
     1681 accgtggccg ccctgctgca gaacctgtac cagcccactg ggggccagct gctgctggat
     1741 ggcgagcccc tgaccgagta tgatcaccac tacctgcacc gccaggtggt tctggtgggg
     1801 caggagcctg tgctgttctc gggttctgtc aaggacaata ttgcctatgg cctgagggac
     1861 tgtgaggacg ctcaagtgat ggcagctgcc caggcggcct gtgcagacga cttcataggg
     1921 gaaatgacta atggaataaa cacagaaatc ggggaaaaag ggggccagtt agctgtggga
     1981 cagaagcaac gtctggccat tgcccgggcc cttgtgcgga acccacgggt cctcatcctg
     2041 gatgaggcta ccagcgccct ggacgcccag tgtgaacagg ccctacagaa ctggagatcg
     2101 cagggggaca ggacgatgct ggtgattgcc cacaggctgc acacggttca gaatgctgac
     2161 caagttctgg tgctcaagca gggacgtctg gtggagcatg accagctcag ggacggccag
     2221 gatgtctacg cccacctggt acagcagcgg ctggaggcat gaggcctcca gaccctgagc
     2281 ccctctcagg actgtggcca ggatcagacc cacagggacc gtgccggagg aggctagggt
     2341 caggataaag attgggaccg ttttggactt tgtgtgtttt tgtggccttg atgggtgagg
     2401 gttgggggag tgggtggttt gtggttctag aaacattatt tttttgctga atataaaaat
     2461 aataaatata tataaaatgc ttttccttaa
//
