LOCUS       NM_013683               2950 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus transporter 1, ATP-binding cassette, sub-family B
            (MDR/TAP) (Tap1), transcript variant 1, mRNA.
ACCESSION   NM_013683
VERSION     NM_013683.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2950)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2950)
  AUTHORS   Middelburg,J., Ghaffari,S., Schoufour,T.A.W., Sluijter,M.,
            Schaap,G., Goynuk,B., Sala,B.M., Al-Tamimi,L., Scheeren,F.,
            Franken,K.L.M.C., Akkermans,J.J.L.L., Cabukusta,B., Joosten,S.A.,
            Derksen,I., Neefjes,J., van der Burg,S.H., Achour,A.,
            Wijdeven,R.H.M., Weidanz,J. and van Hall,T.
  TITLE     The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by
            inflammatory signals, whereas LILRB1/2 receptors are peptide
            indifferent
  JOURNAL   Cell Rep 42 (12), 113516 (2023)
   PUBMED   38048225
REFERENCE   3  (bases 1 to 2950)
  AUTHORS   Garcia-Ferreras,R., Osuna-Perez,J., Ramirez-Santiago,G.,
            Mendez-Perez,A., Acosta-Moreno,A.M., Del Campo,L.,
            Gomez-Sanchez,M.J., Iborra,M., Herrero-Fernandez,B.,
            Gonzalez-Granado,J.M., Sanchez-Madrid,F., Carrasco,Y.R., Boya,P.,
            Martinez-Martin,N. and Veiga,E.
  TITLE     Bacteria-instructed B cells cross-prime naive CD8+ T cells
            triggering effective cytotoxic responses
  JOURNAL   EMBO Rep 24 (7), e56131 (2023)
   PUBMED   37184882
REFERENCE   4  (bases 1 to 2950)
  AUTHORS   Aydin,S., Pareja,J., Schallenberg,V.M., Klopstein,A., Gruber,T.,
            Page,N., Bouillet,E., Blanchard,N., Liblau,R., Korbelin,J.,
            Schwaninger,M., Johnson,A.J., Schenk,M., Deutsch,U., Merkler,D. and
            Engelhardt,B.
  TITLE     Antigen recognition detains CD8+ T cells at the blood-brain barrier
            and contributes to its breakdown
  JOURNAL   Nat Commun 14 (1), 3106 (2023)
   PUBMED   37253744
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2950)
  AUTHORS   Gao,Y., Hong,Y., Huang,L., Zheng,S., Zhang,H., Wang,S., Yao,Y.,
            Zhao,Y., Zhu,L., Xu,Q., Chai,X., Zeng,Y., Zeng,Y., Zheng,L.,
            Zhou,Y., Luo,H., Zhang,X., Zhang,H., Zhou,Y., Fu,G., Sun,H.,
            Huang,T.Y., Zheng,Q., Xu,H. and Wang,X.
  TITLE     beta2-microglobulin functions as an endogenous NMDAR antagonist to
            impair synaptic function
  JOURNAL   Cell 186 (5), 1026-1038 (2023)
   PUBMED   36868208
REFERENCE   6  (bases 1 to 2950)
  AUTHORS   Van Kaer,L., Ashton-Rickardt,P.G., Ploegh,H.L. and Tonegawa,S.
  TITLE     TAP1 mutant mice are deficient in antigen presentation, surface
            class I molecules, and CD4-8+ T cells
  JOURNAL   Cell 71 (7), 1205-1214 (1992)
   PUBMED   1473153
REFERENCE   7  (bases 1 to 2950)
  AUTHORS   Gaskins,H.R., Monaco,J.J. and Leiter,E.H.
  TITLE     Expression of intra-MHC transporter (Ham) genes and class I
            antigens in diabetes-susceptible NOD mice
  JOURNAL   Science 256 (5065), 1826-8 (1992)
   PUBMED   1352067
REFERENCE   8  (bases 1 to 2950)
  AUTHORS   Attaya,M., Jameson,S., Martinez,C.K., Hermel,E., Aldrich,C.,
            Forman,J., Lindahl,K.F., Bevan,M.J. and Monaco,J.J.
  TITLE     Ham-2 corrects the class I antigen-processing defect in RMA-S cells
  JOURNAL   Nature 355 (6361), 647-649 (1992)
   PUBMED   1538753
REFERENCE   9  (bases 1 to 2950)
  AUTHORS   Martinez,C.K. and Monaco,J.J.
  TITLE     Homology of proteasome subunits to a major histocompatibility
            complex-linked LMP gene
  JOURNAL   Nature 353 (6345), 664-667 (1991)
   PUBMED   1681432
REFERENCE   10 (bases 1 to 2950)
  AUTHORS   Cho,S., Attaya,M., Brown,M.G. and Monaco,J.J.
  TITLE     A cluster of transcribed sequences between the Pb and Ob genes of
            the murine major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5197-5201 (1991)
   PUBMED   1711220
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK167485.1, AK162731.1 and
            AK152953.1.
            
            On Jun 12, 2009 this sequence version replaced NM_013683.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance. This
            protein forms a heterodimer with Tap2 that transports short
            peptides from the cytosol into the endoplasmic reticulum lumen.
            Mutations in the human gene may be associated with ankylosing
            spondylitis, insulin-dependent diabetes mellitus, and celiac
            disease. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166046.1, AK167485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AK167485.1         4-203
            201-2942            AK162731.1         1-2742
            2943-2950           AK152953.1         2643-2650
FEATURES             Location/Qualifiers
     source          1..2950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2950
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /note="transporter 1, ATP-binding cassette, sub-family B
                     (MDR/TAP)"
                     /db_xref="GeneID:21354"
                     /db_xref="MGI:MGI:98483"
     exon            1..850
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..2499
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /EC_number="7.4.2.14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histocompatibility antigen modifier 1; peptide transporter
                     TAP1; ATP-binding cassette sub-family B member 2;
                     transporter 1, ABC (ATP binding cassette); ATP dependent
                     transport protein family member; ATP-binding cassette,
                     sub-family B (MDR/TAP), member 2; ABC transporter, MHC, 1;
                     peptide supply factor 1; peptide transporter PSF1;
                     transporter, ABC, MHC, 1; antigen peptide transporter 1;
                     transporter associated with antigen processing 1;
                     ATP-binding cassette transporter, major histocompatibility
                     complex, 1; transporter, ATP-binding cassette, major
                     histocompatibility complex, 1; transporter 1 ATP-binding
                     cassette sub-family B"
                     /codon_start=1
                     /product="antigen peptide transporter 1 isoform 1"
                     /protein_id="NP_038711.2"
                     /db_xref="CCDS:CCDS28643.1"
                     /db_xref="GeneID:21354"
                     /db_xref="MGI:MGI:98483"
                     /translation="MAAHVWLAAALLLLVDWLLLRPMLPGIFSLLVPEVPLLRVWVVG
                     LSRWAILGLGVRGVLGVTAGAHGWLAALQPLVAALSLALPGLALFRELAAWGTLREGD
                     SAGLLYWNSRPDAFAISYVAALPAAALWHKLGSLWAPSGNRDAGDMLCRMLGFLGPKK
                     RRLYLVLVLLILSCLGEMAIPFFTGRITDWILQDKTVPSFTRNIWLMSILTIASTALE
                     FASDGIYNITMGHMHGRVHREVFRAVLRQETGFFLKNPAGSITSRVTEDTANVCESIS
                     GTLSLLLWYLGRALCLLVFMFWGSPYLTLVTLINLPLLFLLPKKLGKVHQSLAVKVQE
                     SLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKTLNKKEALAYVAEVWTTS
                     VSGMLLKVGILYLGGQLVIRGAVSSGNLVSFVLYQLQFTQAVQVLLSLYPSMQKAVGS
                     SEKIFEYLDRTPCSPLSGSLAPSNMKGLVEFQDVSFAYPNQPKVQVLQGLTFTLHPGT
                     VTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGQCLVQYDHHYLHTQVAAVGQEPLL
                     FGRSFRENIAYGLNRTPTMEEITAVAVESGAHDFISGFPQGYDTEVGETGNQLSGGQR
                     QAVALARALIRKPLLLILDDATSALDAGNQLRVQRLLYESPKRASRTVLLITQQLSLA
                     EQAHHILFLREGSVGEQGTHLQLMKRGGCYRAMVEALAAPAD"
     exon            851..965
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1096
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1302
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1500
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1629
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1818
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1992
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2155
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2292
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2950
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2926..2931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /note="hexamer: AATAAA"
     polyA_site      2950
                     /gene="Tap1"
                     /gene_synonym="ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1;
                     PSF1; RING4; TAP; Tap-1; Y3"
                     /note="major polyA site"
ORIGIN      
        1 gaggagaatg agattcatgg agaagaacac gacaggccag ggctgctagg cagaactcca
       61 actacagctt cagcggcagc ttccagaaca gcctgagcaa gccagtctca gaaggaggcg
      121 tgtctagtga ttcgaggtcg gctttcggtt tcttcttcct ctaaacgcca gcacttctag
      181 tcagctccac cagctcgagc gggttcccgg gactttacgc gcacgccctc ggacccgccc
      241 ttcttccttc cccacggaga ctcctgtgca gcgcggacgt cgagagtccc aggctaggac
      301 cagactctgg acagctcacg ctcgatggct gcgcacgtct ggctggcggc cgccctgctc
      361 cttctggtgg actggctgct gctgcggccc atgctcccgg gaatcttctc cctgttggtt
      421 cccgaggtgc cgctgctccg ggtctgggtg gtgggcctga gtcgctgggc catcctagga
      481 ctaggggtcc gcggggtcct cggggtcacc gcaggagccc atggctggct ggctgctttg
      541 cagccgctgg tggccgcact gagtttggcc ctgcctggac ttgccttgtt ccgagagctg
      601 gccgcctggg gaacactccg ggagggtgac agcgctggat tactgtactg gaacagtcgt
      661 ccagatgcct tcgctatcag ttatgtggca gcattgcccg cagccgccct gtggcacaag
      721 ttggggagcc tctgggcgcc cagcggcaac agggacgctg gagacatgct gtgtcggatg
      781 ctgggcttcc tgggccctaa gaagagacgt ctctacctgg ttctggttct cttgattctc
      841 tcttgccttg gggaaatggc cattcccttc ttcacgggcc gcatcactga ctggattctt
      901 caggataaga cagttcctag cttcacccgc aacatatggc tcatgtccat tctcaccata
      961 gccagcacag cgctggagtt tgcaagtgat ggaatctaca acatcaccat gggacacatg
     1021 cacggccgtg tgcacagaga ggtgtttcgg gccgtccttc gccaggagac agggtttttc
     1081 ctgaagaacc cagcaggttc catcacatct cgggtgactg aggacacagc caacgtgtgc
     1141 gagtccatta gtggcacgct gagcctgctg ctgtggtacc tggggcgagc cctgtgtctc
     1201 ttggtgttca tgttttgggg gtcaccgtac ctcactctgg tcaccctgat caacctgccc
     1261 ctgctttttc ttttgcctaa gaagctggga aaagtgcatc agtcactggc agtgaaggtg
     1321 caggagtctc tagcaaagtc cacgcaggtg gcccttgagg ccttatcggc gatgcctact
     1381 gtgcggagct ttgccaacga ggagggtgag gcccagaagt tcaggcagaa gttggaagaa
     1441 atgaagactc taaacaagaa ggaggccttg gcttacgtgg ctgaagtctg gaccacgagt
     1501 gtctcgggaa tgctgctgaa ggtgggaatt ctgtacctgg gcgggcagct ggtgatcaga
     1561 ggggctgtca gcagcggcaa ccttgtctca ttcgttctct accagcttca gttcacccag
     1621 gctgttcagg tcctgctctc cctctacccc tccatgcaga aggctgtggg ctcctcagag
     1681 aaaatattcg aatacttgga ccggactcct tgctctccac tcagtggctc gttggcaccc
     1741 tcaaacatga aaggccttgt ggagttccaa gatgtctctt ttgcctaccc aaaccagccc
     1801 aaagtccagg tgcttcaggg gctgacgttc accctgcatc ctggaacggt gacagcgttg
     1861 gtgggaccca atggatcagg gaagagcacc gtggctgccc tgctgcagaa cctgtaccag
     1921 cccaccgggg gccagctgct gctggatggc cagtgcctgg tccagtatga tcaccattac
     1981 ctgcacactc aggtggccgc agtgggacaa gagccgctgc tatttggaag aagctttcga
     2041 gaaaatattg cgtatggcct gaaccggact ccaaccatgg aggaaatcac agctgtggcc
     2101 gtggagtctg gagcccacga tttcatctct gggttccctc agggctatga cacagaggta
     2161 ggtgagactg ggaaccagct gtcaggaggt cagcgacagg cagtggcctt ggcccgagcc
     2221 ttgatccgga agccactcct gcttatcttg gatgatgcca ccagtgccct ggatgctggc
     2281 aaccagctac gggtccagcg gctcctgtat gagagcccca agcgggcttc tcggacggtt
     2341 cttcttatca cccagcagct cagcctggca gagcaggccc accacatcct ctttctcaga
     2401 gaaggctctg tcggcgagca gggcacccac ctgcagctca tgaagagagg agggtgctac
     2461 cgggccatgg tagaggctct tgcggctcct gcagactgac aaggcctctg gactgcacac
     2521 tgcgtgctgt ccccctcctg tcctctactc tgtgtgacag agaacctggg agcaaagata
     2581 ttaccacacc cacggagaca gttgaggagc ggaggtgctt gttacatgag aaaatgtaaa
     2641 ctctaggaga tacccggaat ttaccacgaa tgtgtttccc cgacccgctc cctattagac
     2701 ggggtttcag gtacctcaca ccaacactga gctgctaaat ctccggtctc caccctcccg
     2761 gtgctgagct tgtatcacag catgcacaca caaacctggt ttatgtggcg ttgtgataga
     2821 atgagaagaa acgcccaaag tgtacagaga gaaaggacaa gcagcttgca attaaccaaa
     2881 ggcataggct ggcatttggg tgttctatgg gtgtttgata tttgtaataa aactggtgtt
     2941 ttgtactgtg
//
