LOCUS       NM_001199685            4366 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TAO kinase 3 (Taok3), transcript variant 1, mRNA.
ACCESSION   NM_001199685
VERSION     NM_001199685.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4366)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4366)
  AUTHORS   Poirier,A., Ormonde,J.V.S., Aubry,I., Abidin,B.M., Feng,C.H.,
            Martinez-Cordova,Z., Hincapie,A.M., Wu,C., Perez-Quintero,L.A.,
            Wang,C.L., Gingras,A.C., Madrenas,J. and Tremblay,M.L.
  TITLE     The induction of SHP-1 degradation by TAOK3 ensures the
            responsiveness of T cells to TCR stimulation
  JOURNAL   Sci Signal 17 (817), eadg4422 (2024)
   PUBMED   38166031
  REMARK    GeneRIF: The induction of SHP-1 degradation by TAOK3 ensures the
            responsiveness of T cells to TCR stimulation.
REFERENCE   3  (bases 1 to 4366)
  AUTHORS   Xia,Y., Andersson,E., Caputo,M., Cansby,E., Sedda,F.,
            Font-Girones,F., Ruud,J., Kurhe,Y., Hallberg,B., Marschall,H.U.,
            Asterholm,I.W., Romeo,S., Bluher,M. and Mahlapuu,M.
  TITLE     Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced
            NAFLD development in mice
  JOURNAL   Mol Med 29 (1), 138 (2023)
   PUBMED   37864157
  REMARK    GeneRIF: Knockout of STE20-type kinase TAOK3 does not attenuate
            diet-induced NAFLD development in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4366)
  AUTHORS   Maes,B., Fayazpour,F., Catrysse,L., Lornet,G., Van De Velde,E., De
            Wolf,C., De Prijck,S., Van Moorleghem,J., Vanheerswynghels,M.,
            Deswarte,K., Descamps,B., Vanhove,C., Van der Schueren,B.,
            Vangoitsenhoven,R., Hammad,H., Janssens,S. and Lambrecht,B.N.
  TITLE     STE20 kinase TAOK3 regulates type 2 immunity and metabolism in
            obesity
  JOURNAL   J Exp Med 220 (9) (2023)
   PUBMED   37347461
  REMARK    GeneRIF: STE20 kinase TAOK3 regulates type 2 immunity and
            metabolism in obesity.
REFERENCE   5  (bases 1 to 4366)
  AUTHORS   Poirier,A., Wu,C., Hincapie,A.M., Martinez-Cordova,Z., Abidin,B.M.
            and Tremblay,M.L.
  TITLE     TAOK3 limits age-associated inflammation by negatively modulating
            macrophage differentiation and their production of TNFalpha
  JOURNAL   Immun Ageing 20 (1), 31 (2023)
   PUBMED   37400834
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4366)
  AUTHORS   Hammad,H., Vanderkerken,M., Pouliot,P., Deswarte,K., Toussaint,W.,
            Vergote,K., Vandersarren,L., Janssens,S., Ramou,I., Savvides,S.N.,
            Haigh,J.J., Hendriks,R., Kopf,M., Craessaerts,K., de Strooper,B.,
            Kearney,J.F., Conrad,D.H. and Lambrecht,B.N.
  TITLE     Transitional B cells commit to marginal zone B cell fate by
            Taok3-mediated surface expression of ADAM10
  JOURNAL   Nat Immunol 18 (3), 313-320 (2017)
   PUBMED   28068307
  REMARK    GeneRIF: this study shows that during positive selection in the
            spleen, B-cell receptor signaling causes immature type 1
            transitional B cells to become receptive to Notch ligands via
            Taok3-mediated surface expression of ADAM10
REFERENCE   7  (bases 1 to 4366)
  AUTHORS   Fulcoli,F.G., Franzese,M., Liu,X., Zhang,Z., Angelini,C. and
            Baldini,A.
  TITLE     Rebalancing gene haploinsufficiency in vivo by targeting chromatin
  JOURNAL   Nat Commun 7, 11688 (2016)
   PUBMED   27256596
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4366)
  AUTHORS   Kapfhamer,D., King,I., Zou,M.E., Lim,J.P., Heberlein,U. and
            Wolf,F.W.
  TITLE     JNK pathway activation is controlled by Tao/TAOK3 to modulate
            ethanol sensitivity
  JOURNAL   PLoS One 7 (12), e50594 (2012)
   PUBMED   23227189
REFERENCE   9  (bases 1 to 4366)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4366)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040531.1, AK042181.1, BC158072.1, AC110234.11 and AA182196.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.4307.1,
                                           SRR7652917.1083985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1360              AK040531.1         2-1361
            1361-2070           AK042181.1         1261-1970
            2071-2922           BC158072.1         2013-2864
            2923-4121           AC110234.11        99443-100641        c
            4122-4366           AA182196.1         1-245
FEATURES             Location/Qualifiers
     source          1..4366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.88 cM"
     gene            1..4366
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /note="TAO kinase 3"
                     /db_xref="GeneID:330177"
                     /db_xref="MGI:MGI:3041177"
     exon            1..211
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            212..296
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            297..507
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..3084
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /EC_number="2.7.11.1"
                     /note="thousand and one amino acid protein 3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TAO3"
                     /protein_id="NP_001186614.1"
                     /db_xref="CCDS:CCDS39233.1"
                     /db_xref="GeneID:330177"
                     /db_xref="MGI:MGI:3041177"
                     /translation="MRKGALKDPEIADLFFKDDPEELFIDLHEIGHGSFGAVYFATNA
                     HTNEVVAVKKMSYSGKQTHEKWQDILKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVME
                     YCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQ
                     VKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERK
                     PPLFNMNAMSALYHIAQNDSPTLQSREWTDSFRRFVDYCLHKIPQERPAAVELLRHDF
                     IRRERPPKVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEEEEDGEQG
                     SNLNREVDSLGSIHSIPSTSVSTGSRSSSVNSMQEVMDESSSELVMMQEDEGTANSSA
                     STVHKKDHVFVRDEAGHGDPRPEPRPTQSVQSRALHYRNRERFATIKSASLVTRQIHE
                     HEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIEL
                     EKLAKKQVATIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEE
                     MNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDRNCRFFKRKIMIKRH
                     EVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTE
                     LENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNH
                     QLEVTPKNEHKAILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQAL
                     RLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKE
                     RSERIKTLLERQERETETFDMESLRMGFGNLVTLDFPKEDYR"
     exon            508..579
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            580..681
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            682..727
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            728..824
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            825..938
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1030
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1124
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1206
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1374
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1581
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1716
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1953
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2082
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2286
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2526
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2739
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2922
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..4351
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4328..4333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4351
                     /gene="Taok3"
                     /gene_synonym="2900006A08Rik; A130052D22; A430105I05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcgggtgcg attggtcacc cctggcggag ccgcacctcg gacagcagca gcggcggcag
       61 ctagggtcct gcgtggagag tggggcgcga cggggactcg cgggcggagg ctgcgcgtgg
      121 ggacccagca cgcgaagacc cagcacgaga gcgactctgg gcacgagtga gaggaggcgg
      181 cggcgccggg gccgcgggtg acagcgctga gacacatcct aagtgcagaa gtgaggagag
      241 actgctgcta caatgttcca gagccactca gtgggggctg tgccatacat caaaaggaac
      301 tgaaggttta taagaaaagt tgtagtcaat gagagagaca aaaggactga gccatccaca
      361 agcaccgtgc ttgccacacc ggccaccatg cgtaaagggg cactgaagga cccagagatt
      421 gctgatctgt tcttcaagga tgaccccgaa gagcttttta tcgatttgca tgaaattgga
      481 catgggagct ttggagccgt gtactttgcg acaaatgcgc acaccaacga ggtggtcgct
      541 gttaagaaaa tgtcctacag tgggaagcag acccatgaga aatggcaaga tatccttaag
      601 gaagttaagt ttctgcagca gctgaagcat cctaacacca tcgagtacaa aggctgttat
      661 ttaaaggagc acactgcatg gttggtgatg gagtactgcc taggttcagc ctctgacttg
      721 ttagaagttc ataagaaacc acttcaggaa gtggagatcg ctgctatcac ccatggtgcc
      781 ttgcaggggc tggcctacct ccactttcac tccctgattc acagggacat taaagcaggg
      841 aacatcctcc tcacagagcc aggtcaggtg aagctggctg acttcggatc tgcctccatg
      901 gcttctcccg ccaactcctt tgtggggact ccttactgga tggccccaga ggtaatctta
      961 gctatggacg aagggcagta cgacgggaaa gttgacatct ggtcgcttgg catcacctgc
     1021 atagagttgg cggagcggaa gccccccctc ttcaacatga acgccatgag cgccctctac
     1081 cacatcgctc agaatgactc ccccacgcta cagtccaggg aatggacaga ctccttcagg
     1141 agattcgttg attactgctt gcacaaaata cctcaggaaa gaccagccgc ggtggagctg
     1201 ttgcggcatg acttcattcg gagggagcgg ccaccgaagg tcctcattga tctcatacag
     1261 aggacaaaag atgctgtccg agagctggac aacctgcagt acaggaaaat gaagaagatc
     1321 ctcttccagg agactcggaa cggacccttg aatgagtcgc aagaagaaga agaagatggt
     1381 gagcaaggaa gcaacctgaa ccgagaggtg gacagtctgg gcagcatcca ctccattccc
     1441 agcacatcag tgagcacagg cagccggagc agcagtgtga acagcatgca ggaggtcatg
     1501 gatgagagca gctctgagct cgtcatgatg caggaggatg aaggcacagc caactccagc
     1561 gcctccacgg tacacaagaa ggatcatgta ttcgtaaggg atgaggcggg ccacggcgat
     1621 cccaggcctg agccgcggcc tacccagtca gttcagagcc gggccctcca ctatcggaac
     1681 cgagagcgct ttgccacgat caaatccgcg tctttggtta cacggcagat ccatgagcat
     1741 gagcaggaga acgagctgcg ggaacagatg tcaggttata agcggatgcg gcgccagcac
     1801 cagaagcagc tgatcgccct ggagaacaag ctgaaggctg agatggatga gcaccgcctc
     1861 aagctccaga aggaggtgga gacgcacgcc aacaactcgt ccatcgagct ggagaagctg
     1921 gccaagaagc aagtggctac catagaaaag gaggcaaagg tagccgcagc ggatgagaag
     1981 aagttccagc agcagatcct ggcccagcag aagaaggact tgacaacttt cttagaaagt
     2041 cagaagaagc agtacaagat ttgtaaggag aaaataaaag aggaaatgaa cgaggaccat
     2101 agcacaccca agaaggagaa gcaggagcgg atatcgaagc ataaagaaaa cctgcagcac
     2161 acgcaggccg aggaggaagc ccacctgctc actcaacaga ggctgtacta cgacagaaac
     2221 tgccgcttct tcaaacggaa aataatgatc aagcgccacg aggtggaaca gcagaacatt
     2281 cgggaggaat taaataagaa gaggacccag aaggaaatgg agcacgccat gctgatccgg
     2341 catgatgaat ccacccgaga gctggagtac aggcagctgc acaccctgca gaagctccgc
     2401 atggatctga tccggctgca gcaccagacg gaactggaga accagctgga gtacaataag
     2461 aggcgggagc gggagctgca ccggaagcac gtcatggagc ttcggcaaca gccgaaaaac
     2521 ttaaaggcca tggaaatgca aattaaaaaa cagtttcagg acacttgcaa agtacagacc
     2581 aaacagtaca aagccctcaa aaatcaccag ttggaagtca ctccaaagaa tgagcacaaa
     2641 gcaatcctaa agacactgaa ggacgagcag acgaggaagc tggccatttt ggccgagcag
     2701 tatgaacaga gtataaacga gatgatggcc tctcaagcgt tacggctaga cgaggcacaa
     2761 gaggcagagt gccaggcctt gagactacag ctccagcagg agatggagct gctcaacgcc
     2821 taccagagca aaatcaagat gcaaacggag gcccagcacg agcgcgagct acagaagcta
     2881 gagcagaggg tgtccctgcg cagagcgcat cttgagcaga agattgaaga ggagctggct
     2941 gccctgcaga aggaacgcag tgagaggatc aagactctcc tggagagaca agagcgagag
     3001 accgagactt ttgacatgga gagcctcaga atgggctttg ggaatttggt gacattagat
     3061 tttcctaagg aggactatag atgagattaa atttttttgc catttacaaa aaaaaaatga
     3121 aaaaaagaaa acaaaaaaat tcagaccctg cgaaactaca ttccccatct taacgggcgc
     3181 tgctctctct ctctctctct ctctctctct ctctctctct ctttctttct ctcttcctcc
     3241 ctctctctcc tcccccttat ctccctccct ctctctgccc ctctctctcc ctccctgcct
     3301 cctccctctc tctacccctc cctctctctc tcccctcacc tctctctctc cctctctctc
     3361 tctccctgac accgtgtcgc actagtgcct gttgattctt actccatcag gggccctttc
     3421 ctccccccca tgtcaacttt cagtgctggc cgagacccgg ccgcccctgc cgtccaccac
     3481 ctgcattgcg gtgccggcga cgacgcggtt ccggatgtcc tgctgaaaac cttggaggtg
     3541 gttttagggt ctgtcaacca acaaacggcg atggaacaca gatggatgtt gctttgagca
     3601 atccctcgtt gtcaccaacc agtgaaagta aagcaaaaaa aagagaaaat acctaaagaa
     3661 acctaaataa acaatacatg ccaaggggga gagagacaca aaatccgcag ccttacacct
     3721 taaccagctg ctgcataact ttattttatt ttattttttt ggtatttatt catcaggaat
     3781 taaaaaaaaa acaaagtttt attaaagatt gaaaatttga tacattttac aggaactaat
     3841 tgtgatgtac atacgaagtg gtaacatatt attactattt tggggccggg gtgggtggga
     3901 ggggtgaaga gatcttgtgg tttttaagaa cctgccggca agagtttgcc ttgccgtcag
     3961 cctggtctac tgtatcccag catcctctgc ggttgcagat ggtgcgagga cacttaaagg
     4021 agctcacaga atcccagtag cacaaaattg ggctttggca aatcatgtat tttgtgtata
     4081 gagggaatct aaggagagga attgcttatt ttcatattgt attttaactg tttctctgat
     4141 cagaattttt ttacttcctc ctcctgttcc tcccctgccc cccacgccca ctccccactc
     4201 cagtctctgg agttcaatgt cttctctgcc aatcatctct gtttatttct ccttcccttc
     4261 cccacgcccc ctatctgtgg tcataaatat tgcattatcc atcctttcaa actgtgtatt
     4321 ttcttacaat aaaaaatgat gacgagaaaa aaaaaaaaaa aaaaaa
//
