LOCUS       NM_001163775            5249 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus TAO kinase 2 (Taok2), transcript variant 2, mRNA.
ACCESSION   NM_001163775
VERSION     NM_001163775.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5249)
  AUTHORS   Henis,M., Rucker,T., Scharrenberg,R., Richter,M., Baltussen,L.,
            Hong,S., Meka,D.P., Schwanke,B., Neelagandan,N., Daaboul,D.,
            Murtaza,N., Krisp,C., Harder,S., Schluter,H., Kneussel,M.,
            Hermans-Borgmeyer,I., de Wit,J., Singh,K.K., Duncan,K.E. and de
            Anda,F.C.
  TITLE     The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and
            modulates translation
  JOURNAL   Sci Adv 10 (15), eadf7001 (2024)
   PUBMED   38608030
REFERENCE   2  (bases 1 to 5249)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5249)
  AUTHORS   Murtaza,N., Cheng,A.A., Brown,C.O., Meka,D.P., Hong,S., Uy,J.A.,
            El-Hajjar,J., Pipko,N., Unda,B.K., Schwanke,B., Xing,S.,
            Thiruvahindrapuram,B., Engchuan,W., Trost,B., Deneault,E., Calderon
            de Anda,F., Doble,B.W., Ellis,J., Anagnostou,E., Bader,G.D.,
            Scherer,S.W., Lu,Y. and Singh,K.K.
  TITLE     Neuron-specific protein network mapping of autism risk genes
            identifies shared biological mechanisms and disease-relevant
            pathologies
  JOURNAL   Cell Rep 41 (8), 111678 (2022)
   PUBMED   36417873
REFERENCE   4  (bases 1 to 5249)
  AUTHORS   Scharrenberg,R., Richter,M., Johanns,O., Meka,D.P., Rucker,T.,
            Murtaza,N., Lindenmaier,Z., Ellegood,J., Naumann,A., Zhao,B.,
            Schwanke,B., Sedlacik,J., Fiehler,J., Hanganu-Opatz,I.L.,
            Lerch,J.P., Singh,K.K. and de Anda,F.C.
  TITLE     TAOK2 rescues autism-linked developmental deficits in a 16p11.2
            microdeletion mouse model
  JOURNAL   Mol Psychiatry 27 (11), 4707-4721 (2022)
   PUBMED   36123424
  REMARK    GeneRIF: TAOK2 rescues autism-linked developmental deficits in a
            16p11.2 microdeletion mouse model.
REFERENCE   5  (bases 1 to 5249)
  AUTHORS   Richter,M., Murtaza,N., Scharrenberg,R., White,S.H., Johanns,O.,
            Walker,S., Yuen,R.K.C., Schwanke,B., Bedurftig,B., Henis,M.,
            Scharf,S., Kraus,V., Dork,R., Hellmann,J., Lindenmaier,Z.,
            Ellegood,J., Hartung,H., Kwan,V., Sedlacik,J., Fiehler,J.,
            Schweizer,M., Lerch,J.P., Hanganu-Opatz,I.L., Morellini,F.,
            Scherer,S.W., Singh,K.K. and Calderon de Anda,F.
  TITLE     Altered TAOK2 activity causes autism-related neurodevelopmental and
            cognitive abnormalities through RhoA signaling
  JOURNAL   Mol Psychiatry 24 (9), 1329-1350 (2019)
   PUBMED   29467497
REFERENCE   6  (bases 1 to 5249)
  AUTHORS   Kapfhamer,D., Taylor,S., Zou,M.E., Lim,J.P., Kharazia,V. and
            Heberlein,U.
  TITLE     Taok2 controls behavioral response to ethanol in mice
  JOURNAL   Genes Brain Behav 12 (1), 87-97 (2013)
   PUBMED   22883308
  REMARK    GeneRIF: disruption of the Taok2 gene alters behavioral response to
            ethanol.
REFERENCE   7  (bases 1 to 5249)
  AUTHORS   de Anda,F.C., Rosario,A.L., Durak,O., Tran,T., Graff,J.,
            Meletis,K., Rei,D., Soda,T., Madabhushi,R., Ginty,D.D.,
            Kolodkin,A.L. and Tsai,L.H.
  TITLE     Autism spectrum disorder susceptibility gene TAOK2 affects basal
            dendrite formation in the neocortex
  JOURNAL   Nat Neurosci 15 (7), 1022-1031 (2012)
   PUBMED   22683681
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5249)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 5249)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   10 (bases 1 to 5249)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122863.4 and AC124505.4.
            
            On Aug 21, 2018 this sequence version replaced NM_001163775.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085152.1, SRR9219381.184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1062              AC122863.4         24640-25701         c
            1063-1229           AC124505.4         221265-221431       c
            1230-1301           AC124505.4         221016-221087       c
            1302-1403           AC124505.4         220820-220921       c
            1404-1449           AC124505.4         220175-220220       c
            1450-1546           AC124505.4         219959-220055       c
            1547-1660           AC124505.4         219688-219801       c
            1661-1752           AC124505.4         219491-219582       c
            1753-1846           AC124505.4         216794-216887       c
            1847-1928           AC124505.4         216621-216702       c
            1929-2096           AC124505.4         215825-215992       c
            2097-2381           AC124505.4         215417-215701       c
            2382-2540           AC124505.4         215066-215224       c
            2541-2906           AC124505.4         212965-213330       c
            2907-3110           AC124505.4         212674-212877       c
            3111-5249           AC124505.4         210271-212409       c
FEATURES             Location/Qualifiers
     source          1..5249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..5249
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /note="TAO kinase 2"
                     /db_xref="GeneID:381921"
                     /db_xref="MGI:MGI:1915919"
     exon            1..1062
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1229
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1301
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1403
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1449
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1546
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1660
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1752
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1846
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1928
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2096
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2381
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2540
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2906
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3110
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..5249
                     /gene="Taok2"
                     /gene_synonym="1110033K02Rik; B230344N16; MAP3K17;
                     mKIAA0881; PSK; PSK1; TAO1; TAO2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgcagcg cgaaagcgtg gcgggcgcat gcgccacagc tctctccacc agcagtcctt
       61 ggaccgcgcg cttgggctcc accccaagca agccaagcct ttctcctctc ctcttcccac
      121 caaggatccg cgtggcgggg cgcgcgcgca cttgggctcg aaggcagctt gtcgtctggg
      181 ccgcggcggc tactggcgag gggcggggct atttcctttg gggccccacc cctttggccc
      241 ggcgtgcata ccgcgcctgc gcgctcccgc ccggtctcca tcttggaatt gggaggaaga
      301 gagagaggga gagagaggga ggccgggacg agagcagggc tgtggtgcgg tgagaagctg
      361 agacgaaaag gaaagggagt gaggcacagg gaccatcagc agcgcctccg ctacagtcct
      421 tcagctgttc cggagagaga ggacgggaaa gggagtaggc cagggctgga gtaggggctg
      481 tcactctcgg accccagcct tagaggggcc gtgcagccgg gcgtcctcgg ggtgggcccc
      541 ttgtcgtggc cgaagacctg gggctcaggc ccctgggtcc caaattttgg ggcttggtcc
      601 cttgtttctc agatacccag gtatcaaacc ctcgtatatc agatatctgg gacccaaagt
      661 cccaaccttt acaaacctgg gtctctgttt tatagaattt aaaatacctg ggattcagga
      721 ccctgtgtgc accaatatcc ggggttcatc ctccaagcga tcagatatcg gactcatttt
      781 tagcccttgc aaatatacgg ggctcagacc ccacaatcgg aaatccggga ttcagcaact
      841 gtcgccctcg agttggggga ggactggacc gcgaggtcag atcaggttgt caccccctcc
      901 cctccagggg aggcttcccg ggcccgcccc tcaggaaggg cgaaagctga ggaagaggtg
      961 gcgaggggga aggtctcctt gcccctctcc ctgcttgtca gagcaactgg agtaccccag
     1021 gcggaagcgg aggcgctggg gcaccatagt gacccctacc aggcaagatc ccaatctcag
     1081 ggccccctgg ggccatcatg ccagctgggg gccgggccgg gagcctgaag gaccctgatg
     1141 tggctgagct cttcttcaag gatgaccctg agaagctctt ctctgacctc cgggagatcg
     1201 gccatggcag ctttggagca gtgtactttg cccgggatgt ccggaacagt gaggtggtgg
     1261 ccatcaagaa gatgtcctat agtgggaagc aatcaaatga gaaatggcag gatatcatca
     1321 aggaagtgcg gttcttacag aagctacggc atcctaatac cattcagtac cggggctgtt
     1381 acctgaggga gcacacagct tggctggtga tggagtattg cctgggctca gcttctgatc
     1441 ttctagaagt gcacaagaaa cccctgcagg aggtagagat tgcagctgtg acccatgggg
     1501 ctcttcaggg cctggcatat ctacactcac acaacatgat ccatagagat gtgaaggctg
     1561 gaaacatctt gctgtcagaa ccaggcttgg taaaactggg ggactttggc tctgcgtcaa
     1621 tcatggcacc tgccaactct tttgtgggta ctccatactg gatggctcca gaggtgatcc
     1681 tagccatgga tgagggacaa tatgatggca aagtggatgt ctggtccttg gggataacct
     1741 gtattgagct agcggagcgg aagccaccac tgttcaacat gaatgcaatg agtgccttat
     1801 accacattgc acagaatgaa tctcctgctc tccagtcagg acactggtct gagtacttcc
     1861 ggaattttgt tgactcctgt cttcagaaaa tccctcaaga cagaccaacc tcagaggttc
     1921 ttttgaagca ccgctttgtg ctccgggagc gaccgcccac agtcatcatg gacctaatcc
     1981 agaggaccaa ggatgctgta cgggaactgg ataacctgca gtaccgaaag atgaagaaga
     2041 tactgttcca agaggcaccc aatggccctg gtgctgaggc cccagaggaa gaggagctca
     2101 caccctgttc ccaggaggca gaaccttaca cgcaccgtgc agggacactg accagtctag
     2161 agagcagcca ttcagtgccc agcatgtcca tcagcgcctc cagccagagc agctcagtca
     2221 acagcctagc agatgcctca gataatgaag aagaggagga agaagaagag gaagaggagg
     2281 aggaggagga ggaagaaggc cctgaatcca gagagatggc catgatgcag gagggggagc
     2341 atacagtcac ttcccacagc tccatcatcc accggctgcc gggctcagac aacctatatg
     2401 atgatcccta ccagccagag atgaccccag gtccactcca gccacctgca gcccctccca
     2461 cctccacctc ctcttctgct cgccgcagag cttattgccg caaccgagac cactttgcta
     2521 ccattcgtac tgcctccctg gtcagccgtc agatccagga gcatgagcag gactcagccc
     2581 tgcgagagca gctgagtggc tacaagcgga tgcgacgtca gcaccagaag caactgctgg
     2641 ccctggagtc ccgtctgagg ggtgaacgtg aggagcacag tgggcggtta cagcgggagc
     2701 tcgaggcaca gcgggctggc tttgggaccg aggctgagaa gctggcccgg aggcaccagg
     2761 ccattggtga gaaggaggca cgggctgctc aggcggagga gcggaagttc cagcagcaca
     2821 tcctggggca gcagaagaag gagctggccg ccctgctgga ggcgcagaag cgaacctaca
     2881 agctgcggaa ggagcagttg aaagaggagc tccaggagaa ccctagcaca cccaaacgag
     2941 agaaggctga gtggctgttg aggcaaaagg agcagttgca acagtgccag gcagaagagg
     3001 aagcggggct gctgcggagg cagcgccagt actttgaact tcagtgtcgc caatacaagc
     3061 gcaagatgct actggctcgg cacagcctag atcaggacct gcttcgagag gacttgaata
     3121 agaaacagac acagaaggac ttggagtgtg ctctgctgtt acggcagcat gaggctaccc
     3181 gagagctgga gctaagacag ctccaggctg tccagcgcac acgtgctgaa cttacccgcc
     3241 ttcagcacca gacagaacta ggcaaccagc tggagtacaa caagcgacgg gagcaagaat
     3301 tacggcagaa gcacgcggcc caggttcgcc agcagcccaa gagcctcaaa gtacgtgcag
     3361 gccagctacc catgggcctc cctgctactg gggctctggg accactcagc acaggcaccc
     3421 ctagtgaaga gcagccttgc tcatctggcc aggaggcaat cctggaccaa aggatgctgg
     3481 gagaggagga ggaagcagtg ccagagagaa ggattctggg aaaggaaggg actaccttgg
     3541 agccagagga gcagaggatt ctgggggaag aaatgggaac ctttagttcc agcccacaaa
     3601 aacataggag tctggctaat gaggaagatt gggatatatc tgaggagatg aaggagatta
     3661 gagtcccatc actggcatcc caggagagaa atattattgg ccaggaagag gcagcggcat
     3721 ggagtctgtg ggagaaggag ggtgggaacc ttgtggatgt ggagttcaag cttggctggg
     3781 tccagggtcc agttctgact ccagtcccgg aggaggaaga ggaggaggaa gaagagggag
     3841 gggctccaat tggaacccac agggaccctg gagatggctg tccttcccca gatatccccc
     3901 cagagccacc tccatcacat ctgagacagt accctactag ccagctccct ggactcctgt
     3961 ctcatggcct cctggctggc ctatcctttg cagtggggtc ctcctctggc ctcctgcccc
     4021 tactcctcct gctgctactc ccattgctgg cagcccaggg tggaggtggc ttgcaggcag
     4081 cactgctggc ccttgaggta gggctagtgg gcctgggggc ctcctacctg ttcctttgta
     4141 cagctctaca cctgcccccc ggtctgttct tactcctggc tcagggtact gcactgttgg
     4201 ctgtccttag cctgagctgg cgcagaggcc ttatgggtgt gcctctgggc cttggggctg
     4261 cctggctcct agcttggccc agcctggctt tacctctggc agctatggca gctgggggca
     4321 aatgggtacg gcaacaaggc ccccagatgc gtcggggtat ctctcgactc tggttgagga
     4381 ttttgctacg cctgtcaccc atggtctttc gggccctaca gggctgtggg gctgtaggag
     4441 accgggggct gtttgccctg taccctaaga ccaataagaa tggtttccga agtcgactac
     4501 ctgtcccttg gccccgtcag ggaaatcctc gcactactca acacccccta gctcagttaa
     4561 caagagtttg ggctgtgtgc aagggctgga actggcgcct agcacgggct agccacagat
     4621 tagcttcttg cttgcccccc tgggctgttc atatactagc cagctggggc ctgcttaagg
     4681 gtgaacggcc tagtcggatc cctcggctgc tgccacgcag ccaacgccgt cttgggctct
     4741 ctgcttcccg acagctacca ccagggactg tagctgggcg gagatctcag actcgcagga
     4801 ccctgcctcc ctggaggtaa ccagttccaa ttctccaccc aaatttaggg cactgagcac
     4861 tttatctccc atgactcagt aaagtttctc cagtctccca gcctctcctc cccttctgac
     4921 ctttcttcct cagtatgttt tcccaagtcc aatcccggcc ccagatctag gtttttagac
     4981 aggcagcctc ctctgctatg gagtccagaa atgacactct ttgtgttttc cccagtcccc
     5041 taagttattg ctgtcccctg ctgtgtgtgc tcatcctcac cctcattggc tcaggcctgg
     5101 ggccaggggt ggcagggatg gaagtcatgg gggttttccc tctttgattt tgtttttctg
     5161 tctcccttcc aacctgtccc cttcccctcc accaaaaaag aaaaaaaaaa aaaaaagaaa
     5221 aacacaaata aaatatctga gcggaacta
//
