LOCUS       NM_001364134           12472 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TAO kinase 1 (Taok1), transcript variant 2, mRNA.
ACCESSION   NM_001364134 XM_006532958
VERSION     NM_001364134.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12472)
  AUTHORS   Wang,J., Li,W., Li,Z., Xue,Z., Zhang,Y., Yuan,Y., Shi,Y., Shan,S.,
            Han,W., Li,F. and Qiu,Z.
  TITLE     Taok1 haploinsufficiency leads to autistic-like behaviors in mice
            via the dorsal raphe nucleus
  JOURNAL   Cell Rep 42 (9), 113078 (2023)
   PUBMED   37656623
  REMARK    GeneRIF: Taok1 haploinsufficiency leads to autistic-like behaviors
            in mice via the dorsal raphe nucleus.
REFERENCE   2  (bases 1 to 12472)
  AUTHORS   Beeman,N., Sapre,T., Ong,S.E. and Yadav,S.
  TITLE     Neurodevelopmental disorder-associated mutations in TAOK1 reveal
            its function as a plasma membrane remodeling kinase
  JOURNAL   Sci Signal 16 (766), eadd3269 (2023)
   PUBMED   36595571
  REMARK    GeneRIF: Neurodevelopmental disorder-associated mutations in TAOK1
            reveal its function as a plasma membrane remodeling kinase.
REFERENCE   3  (bases 1 to 12472)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12472)
  AUTHORS   van Woerden,G.M., Bos,M., de Konink,C., Distel,B., Avagliano
            Trezza,R., Shur,N.E., Baranano,K., Mahida,S., Chassevent,A.,
            Schreiber,A., Erwin,A.L., Gripp,K.W., Rehman,F., Brulleman,S.,
            McCormack,R., de Geus,G., Kalsner,L., Sorlin,A., Bruel,A.L.,
            Koolen,D.A., Gabriel,M.K., Rossi,M., Fitzpatrick,D.R.,
            Wilkie,A.O.M., Calpena,E., Johnson,D., Brooks,A., van
            Slegtenhorst,M., Fleischer,J., Groepper,D., Lindstrom,K.,
            Innes,A.M., Goodwin,A., Humberson,J., Noyes,A., Langley,K.G.,
            Telegrafi,A., Blevins,A., Hoffman,J., Guillen Sacoto,M.J.,
            Juusola,J., Monaghan,K.G., Punj,S., Simon,M., Pfundt,R.,
            Elgersma,Y. and Kleefstra,T.
  TITLE     TAOK1 is associated with neurodevelopmental disorder and essential
            for neuronal maturation and cortical development
  JOURNAL   Hum Mutat 42 (4), 445-459 (2021)
   PUBMED   33565190
REFERENCE   5  (bases 1 to 12472)
  AUTHORS   Zhang,Z., Tang,Z., Ma,X., Sun,K., Fan,L., Fang,J., Pan,J., Wang,X.,
            An,H. and Zhou,J.
  TITLE     TAOK1 negatively regulates IL-17-mediated signaling and
            inflammation
  JOURNAL   Cell Mol Immunol 15 (8), 794-802 (2018)
   PUBMED   29400705
  REMARK    Erratum:[Cell Mol Immunol. 2018 Oct;15(10):940. doi:
            10.1038/s41423-018-0048-5.. PMID: 29844589]
REFERENCE   6  (bases 1 to 12472)
  AUTHORS   Shen,Q., Wang,X., Chen,Y., Xu,L., Wang,X. and Lu,L.
  TITLE     Expression QTL and regulatory network analysis of
            microtubule-associated protein tau gene
  JOURNAL   Parkinsonism Relat Disord 15 (7), 525-531 (2009)
   PUBMED   19233709
REFERENCE   7  (bases 1 to 12472)
  AUTHORS   Draviam,V.M., Stegmeier,F., Nalepa,G., Sowa,M.E., Chen,J.,
            Liang,A., Hannon,G.J., Sorger,P.K., Harper,J.W. and Elledge,S.J.
  TITLE     A functional genomic screen identifies a role for TAO1 kinase in
            spindle-checkpoint signalling
  JOURNAL   Nat Cell Biol 9 (5), 556-564 (2007)
   PUBMED   17417629
  REMARK    GeneRIF: Functional analysis of the human Tao1 ortholog.
REFERENCE   8  (bases 1 to 12472)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 12472)
  AUTHORS   Hutchison,M., Berman,K.S. and Cobb,M.H.
  TITLE     Isolation of TAO1, a protein kinase that activates MEKs in
            stress-activated protein kinase cascades
  JOURNAL   J Biol Chem 273 (44), 28625-28632 (1998)
   PUBMED   9786855
  REMARK    GeneRIF: Isolation and functional characterization of the rat Taok1
            ortholog, and comparison to human TAOK1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591136.20.
            
            On Jun 8, 2018 this sequence version replaced XM_006532958.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.22074.1,
                                           SRR1660825.175451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               AL591136.20        97792-98399         c
            609-671             AL591136.20        92283-92345         c
            672-893             AL591136.20        75857-76078         c
            894-965             AL591136.20        70358-70429         c
            966-1067            AL591136.20        69310-69411         c
            1068-1113           AL591136.20        67907-67952         c
            1114-1210           AL591136.20        66157-66253         c
            1211-1324           AL591136.20        64280-64393         c
            1325-1416           AL591136.20        62191-62282         c
            1417-1510           AL591136.20        56330-56423         c
            1511-1592           AL591136.20        54248-54329         c
            1593-1760           AL591136.20        50838-51005         c
            1761-1964           AL591136.20        50326-50529         c
            1965-2099           AL591136.20        46148-46282         c
            2100-2336           AL591136.20        44257-44493         c
            2337-2465           AL591136.20        41456-41584         c
            2466-2669           AL591136.20        39856-40059         c
            2670-2909           AL591136.20        35873-36112         c
            2910-3122           AL591136.20        32209-32421         c
            3123-3305           AL591136.20        30638-30820         c
            3306-12472          AL591136.20        19746-28912         c
FEATURES             Location/Qualifiers
     source          1..12472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.64 cM"
     gene            1..12472
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /note="TAO kinase 1"
                     /db_xref="GeneID:216965"
                     /db_xref="MGI:MGI:1914490"
     exon            1..608
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..671
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..893
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             762..3767
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine protein kinase TAO1 homolog;
                     thousand and one amino acid protein 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TAO1"
                     /protein_id="NP_001351063.1"
                     /db_xref="CCDS:CCDS36235.1"
                     /db_xref="GeneID:216965"
                     /db_xref="MGI:MGI:1914490"
                     /translation="MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYF
                     ARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAW
                     LVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLT
                     EPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL
                     AERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELL
                     KHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEE
                     QDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMS
                     NSSVIHLKPEEENYQEEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQ
                     MQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFA
                     AEMEKLIKKHQAAMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQL
                     KEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLL
                     GRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQH
                     QTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKAL
                     RNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAEC
                     QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLAL
                     QNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASSWSHNP
                     TGGPGPHWGHPMGGTPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRT
                     ASGGRTEQGMSRSTSVTSQISNGSHMSYT"
     exon            894..965
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1067
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1113
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1210
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1324
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1416
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1510
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1592
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1760
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1964
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2099
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2336
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2465
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2669
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2909
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3122
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3305
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..12472
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12449..12454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /note="hexamer: AATAAA"
     polyA_site      12467
                     /gene="Taok1"
                     /gene_synonym="2810468K05Rik; D130018F14Rik; Map3k16;
                     Markk; Psk2"
                     /note="major polyA site"
ORIGIN      
        1 gggcttggaa ggagagaggg agggtggcga agagagtgag ccggtgccgc cgcccgcttg
       61 aggagagagg aggggtccca ctcgccttgc gcccttcgcg ggctgagagc gcggagcagt
      121 cgcgaacctc ccaggcctct cggcccccgg ggaccccgcc ccgcggcccg acggcccgcg
      181 gcctctcttc tctttgtgag cgcccccttc ccaggggtgg tagtggtggc ggaggggtgc
      241 gcgtgggccc gcccgccaag gggccgcggc gggggaccga cagggcctcg gctgggagga
      301 ccggaggcgg ccgaggcccc ggtccggttc ccccgaggcg gcggcggcgg cgactcccgg
      361 cacttccccc gcgccatctt aactgagccg gagcgttaag ggcgcctcct cgaccccggt
      421 cgtcccctcg tccccccctc cctccccccg gccccttgtc gtagagcctg ggctgggtgg
      481 ctgggggggg ggcggcggtc tgtcgccggg ccccctcctc ctcactcctc gctctccagc
      541 gctgcggcca ccggagcgct ccaggggtct gcgcccgtct gctctgcccc agacctgccg
      601 gcgaaggggt ttctgaactt gttcatggct ggatttttaa aaaatatatt caagatttcc
      661 tgttacgaaa ttttatgcca gcgtggcttc attcatacag atgaaccaag cattgggata
      721 gcagtataaa attagaatca gacagctgac tgctcagcag gatgccatca actaacagag
      781 caggcagtct aaaggaccct gaaattgcag agctcttctt caaagaagat ccggaaaagc
      841 tcttcacaga tctcagagaa atcggccatg ggagctttgg agcagtatat tttgcacgag
      901 atgtgcgtac taatgaagtg gtggccatca agaaaatgtc ttatagtgga aagcagtcta
      961 ctgagaaatg gcaggatatt attaaggaag tcaagtttct acaaagaata aaacatccca
     1021 acagtataga atacaaaggc tgctatttac gtgaacacac agcatggctt gtaatggaat
     1081 attgtttagg atctgcttca gatttattag aagttcataa aaagccatta caagaagtgg
     1141 aaatagcagc aattacacat ggtgctctcc agggactagc ttatttacat tctcatacca
     1201 tgatccatag agatatcaaa gcaggaaata tccttctgac agaaccaggc caagtgaaac
     1261 ttgctgactt tggatctgct tccatggctt cccctgccaa ttcttttgtg ggaacaccat
     1321 attggatggc cccagaagta attttagcca tggatgaagg acagtatgat ggcaaagttg
     1381 atgtatggtc tcttggaata acgtgtattg aattagccga gaggaagcct cctttattta
     1441 atatgaatgc aatgagtgcc ttatatcaca tagcccaaaa tgaatcccct acactacaat
     1501 ctaatgaatg gtctgattat tttcgaaact ttgtagattc ttgcctccag aaaatccctc
     1561 aagatcgccc tacatcagag gaacttttaa agcacatgtt tgttcttcga gagcgccctg
     1621 aaacagtgtt aatagatctt attcaaagga caaaggatgc agtaagagag ctggacaatc
     1681 tgcagtatcg aaagatgaag aaactccttt tccaggaggc acataatggg ccagcggtag
     1741 aagcacagga agaagaggag gagcaagatc atggtgttgg ccgaacagga acagtgaata
     1801 gtgttggaag caatcagtct atccctagta tgtctatcag tgccagcagt caaagcagca
     1861 gtgttaatag tcttccagat gcatcagatg acaagagtga gctagacatg atggagggag
     1921 accatacagt gatgtctaac agttctgtca tccacttaaa acctgaggag gaaaattacc
     1981 aggaagaagg agatcctaga acaagagcat cagacccaca gtctccccct caggtgtctc
     2041 gtcacaagtc acattatcgt aatagagaac actttgcaac catacgaaca gcatcactgg
     2101 ttacaagaca gatgcaagaa catgagcagg actctgaact tagagaacag atgtctggtt
     2161 ataagcggat gaggcgacag catcaaaagc agctgatgac gctggaaaat aaactgaagg
     2221 cagagatgga cgaacatcgg ctcagattag acaaagatct tgaaactcag cgtaacaatt
     2281 tcgctgcaga aatggagaaa cttattaaga aacaccaagc tgctatggaa aaagaggcta
     2341 aagtgatggc caatgaggag aaaaaattcc agcaacacat tcaggctcaa cagaaaaaag
     2401 aactgaatag ctttttggag tctcaaaaaa gagaatataa acttcgcaaa gagcagctta
     2461 aggaggagct gaatgaaaac cagagcacac ctaaaaaaga aaagcaggaa tggctttcaa
     2521 agcagaagga gaatatacag cattttcagg cagaagaaga agctaatctt cttcgacgtc
     2581 aaaggcagta tctagagcta gaatgtcgtc gcttcaaaag aagaatgtta cttgggcgac
     2641 ataacttgga acaggacctt gtcagggagg agttaaacaa aaggcagact caaaaggact
     2701 tggaacatgc aatgctattg cgacagcatg aatcaatgca agaactggag tttcgccatc
     2761 tcaacactat tcagaagatg cgctgtgagt tgatcagact gcagcatcaa actgagctca
     2821 ctaaccagct agagtacaat aagagaaggg aacgggaact gaggcgaaaa catgtcatgg
     2881 aagttcgaca acaacctaag agtctgaagt ctaaagaact ccaaataaaa aagcagtttc
     2941 aggatacctg caaaattcaa accagacagt acaaagcatt aaggaatcac ctactggaga
     3001 ctacaccaaa gagtgagcac aaagctgttt tgaaaagact caaggaggaa cagactcgaa
     3061 agttagccat cttggctgag cagtatgatc atagcattaa tgaaatgctc tccacacaag
     3121 ctctgcgttt ggatgaagca caggaagcag aatgccaggt tctgaagatg cagctgcagc
     3181 aggaactgga gctgctgaat gcttatcaga gcaaaataaa gatgcaagct gaggcccaac
     3241 atgatcgaga gcttcgagag ctggaacaga gggtctccct tcgcagagcg ctcttagaac
     3301 aaaagattga agaagagatg ttggctttgc agaatgaacg cacagaacga atacgtagcc
     3361 tgctcgagcg tcaagccaga gaaattgaag catttgactc tgaaagcatg agattaggtt
     3421 ttagtaacat ggtcctttct aatctctccc ctgaggcatt cagccacagc tacccaggag
     3481 cttctagttg gtctcacaat cctactgggg gtccaggacc tcactggggt catcccatgg
     3541 gtggcacacc acaagcttgg ggtcatccga tgcaaggtgg accccaacca tggggtcatc
     3601 cctcagggcc aatgcaaggg gtacctcgag gtagcagtat gggagtccgc aatagccccc
     3661 aggctttgag gcggacagct tctgggggac ggacggaaca gggcatgagc agaagcacga
     3721 gtgtcacttc acaaatatcc aatgggtcac acatgtctta cacataataa ttgaaagtgg
     3781 caattcctct ggagctgtct gccaaaagaa actgcctaca gacatcatca cagcagcctc
     3841 ctcacttggg tactaccgtg tggaagctgt gcatatggta tattttattt gtctttgtaa
     3901 agcgttatgt tttgtgttta ctaattggga tgtcatagta tttggctgcc ggggtttttg
     3961 tggttggctt tttgtttttg tttaactttt ggaaaatttt taaagtgata atagataagt
     4021 atttcatgta tgtggcaaaa aaaaaaaatt ggcttaatta gaaggggtat tatctgaaca
     4081 atataaaaac agaatgaagc aagctaatct gaatcatcac tttagggtat ccatagccta
     4141 agaaatgtgt cagaagatct aaagccttcc ttcatattcc agttctgtga gtccctaaca
     4201 gcaggcagca tccatgctga agcacataca cctccgctcc tcaccagtgg gttttcttta
     4261 tttatgaatt gatctgattt ctcaacctca tttgaactaa aaaacaagac catgaacatt
     4321 aaaagattgc atttaccttt tcagtggtag aaaatcattt agttctttgc tataaatgat
     4381 tcagaatttt gtcagatttt gtaggttgta tcatcgtaag acggagttgc ataaggagat
     4441 cataagctgt gtggctattg cactaacaag cctgtgagct ttcagagggg aaaaactaga
     4501 gggcgagagg ggcccctgaa agttcctgtg acagggatgc tcagcaggga ggagggaaag
     4561 cctgtatagc tagcctgaca ttttgtttct tgtacaatat ctcatgtgac ccaaacttga
     4621 gactccaaac agtacctttg ctttgtttgt acaaaaatga agacctatag ccaacacaaa
     4681 gcaaatgcca gaggtattgg atgatgccat atttgaactg ccatctatta gcatattcat
     4741 cacactacat agacatagtt ttactgcccc ctttttagct catgggattt cctgtttaca
     4801 ggtagcaata gtcaattatt taactactta gttgccacca ggagtcactg agccaatgac
     4861 tatcagctgc tgactaatct tcacactgta gttattgctt catttacagg tcctctgtgc
     4921 ttaattgctg tttttgttgc tgtagtacct tatgaattct taattcattg agacttagtg
     4981 accatctggg tccatgttaa tatcatataa tagcaaattc ctttcagaag tctctagctt
     5041 tagtgctaaa atactactga gaaaggaact aggtagtttg gtgaatgaaa gaaaacaaaa
     5101 tttgaagata ttatgtagtg gtcaaggacc actaatattt ggggagtgtg ttttgtctgt
     5161 tcttcaatga aggatcaatc cagtgttctt catcaatgtt agttaatatc ccattgcttg
     5221 tgtggcgcct tgagttggtg gtagactagg gcaaatgccc tctttagtga gagaccagag
     5281 gttttgtata agttattgtc ctgctccctt ttcagttgtc ttgaagagct cttgctacta
     5341 actttgggtc ctgcttttca tttaggtaga tggtaagcat tctcttaatc ataattagaa
     5401 caaactagtg accaaattgt catctgctag tatggaagtt cttagttttc ttaaccatgc
     5461 tttatgtctt gtccaggtat gtcagtccag tttccatgac gtaccccctt cagaagtttc
     5521 tgacattggt ttgaggtttt ctgacactaa ttaaaagaaa aattagatca gggtgtggta
     5581 gcaaatgcct ataatcccag catttaggag gcagggatag gaatctcagg ttcaaggctg
     5641 cctacaagtg tctcaaaaaa gaaagaacaa aagaaaggta gatgctatag tataggtcct
     5701 ttgaaaatcc aatagaaggt taatagtatt cacacacagg tctaggcagg gttttaaaca
     5761 tattccccat cagtttttag gttaacatat acttgctata gctaatgaaa agggcttttc
     5821 ttttttcttt ttctttctct ttttttcctt tttcactcaa aatactatta aggagtttct
     5881 cagacaaatt gaaaattcta tatgttttga ggaaataagg ggaagcttta gagtttaata
     5941 ggatattcaa aactataaaa gaatatcatc ttaaaaaact gttctggcaa ctatctgcta
     6001 ccagaaggtt agattgagaa agcagatcca atatatgcaa gacatttctt caaactccaa
     6061 actactacca gaaacacatt ttatcaccca ttgtgagagt cacttggtca aatttagtta
     6121 atgagtccat tttgatcata atgcactcac actagtgtgt ttgaatactg actgtctgtc
     6181 tgtccagtaa ggatttctgc ccccatctaa ttgtgtggca cccagttttt ccatgtaggt
     6241 cattatacct ggatgataac atcaatttag ttacaatgca tgtagtttgc acaatgatta
     6301 aaatgaatag gtttgtgttt atagcctata ataactctag ttgaatcatg tacacagcag
     6361 gagtggtcac agtaaaaact ggtagcagga aaatttgaaa gggtttgaaa tgccctgaaa
     6421 tcagggcaag tacttaatgg ggaaaaaaaa gcagaaatgt caacatttga ccaaattaac
     6481 actacctcct ccccagttgt tggtattcat tcattatatg tgtgtttaac aggatgagag
     6541 catggcgagc ttgtagcaca ccagaggttg tagacctata tctggtatcc agaacctgac
     6601 agggaaacag ttcttggtcc cccttttttg gggtcagcat tttaaaaatg caaagcctat
     6661 atgttgagac attgtattcc taattagatt ctctgtcctt tgcacataac tttcttttaa
     6721 acttagttct aaccctaaat cttgacatca gaaagtgttt gcactgtata aacaatgtta
     6781 gctgaaagca tgtttatttt ttaaggagct cctgctcttc tgcacatttc catatctaga
     6841 gatggatagt cctgaacttg acgtcacacc cacaggtgaa acagcccgaa gtcaaggcct
     6901 tgctagtaaa tggagctttg tacatagtca ttgtgatgtc ttggctgccc ggacaccacg
     6961 taaacataac actaaagaaa ctgtcctgga gatcccatcc tgctactaag aagttttctg
     7021 tacatcactt ccaaacattg gaaactttca gatcataagg cagaatttag taattttgtg
     7081 cttctgttaa tgtctagcat tttaaacata ggataacatt gttttggaca ctggaataat
     7141 atgatttatt ttcacctgta aaaatgactt cattgtactt gaacaccttt gcatttctcc
     7201 atttgtgcca tttacaagtg gaaataaatt ttattatacc atgatctact ggcgttttaa
     7261 aactgttaaa tgtgcacatt ttgggtatag ctattttcac ttgtatgtat atattgtata
     7321 tacatataag tgtctgtatg tgtgtataga tggattggta taactcattc taaacgtgtc
     7381 tgccagggct caagttttat tgttcttgcc ccactcccac cccatgttac agcaagactg
     7441 gtcttacaga gtgagtactc tgggtgatgc ttacgggaag gagattggta gatgcagtct
     7501 ttttttcccc cttagcactt gtatgagtga ggagaaagtt aggtaaagat tgaaactata
     7561 aattacagtg cagtaaactg tgctagggaa ggaatcagtt actatttaag tttgttttac
     7621 aatgcaataa aagatacaag ctgcagagaa aagtaaactc tgcaaagaac actggtaata
     7681 attgttctgc aaaggttaag aaagccactg agtcacagtc ttcatggact tttggggttt
     7741 cttagtgttg gatttttggg gtttctcatt tactttttac tcttaatact aatgcttatg
     7801 tgtttcactg agtatcaaaa ctgccaagaa gggtaactaa ggttcctaaa ctgtaagatg
     7861 agcaggagat gatcactggg agagaaagca tactggattg aaggaagggc tgtctccttt
     7921 taacttcttg ttgatagttg caagttcttt atgcaccttc taccccttct gagccactac
     7981 tattcaagca gagattttgt ctaatagaac atgcctttct tgcttttgct tcttttcttt
     8041 tgagacatgt accctttctg attggataat tgatgtttag ccaaggctgg cctcaaaata
     8101 ctagtaatct ttctgtaagc ctctcaagta ctgggattac aggcatgaac caccatgcct
     8161 atagccacag caacccattc ttttggaggt tttatagttc tccatttgtc tcatgttccg
     8221 aatgtgaagt gtcctaatgt gtattaaagt cagaaaataa tatatttaag gtatactaag
     8281 tatgaatctg ctatgataaa agaaattctc acttctcaaa tagtcttctt gtaaggagca
     8341 ttgggctgtc atctttgagc tgcttatcaa aatacagatc attattgcat atatgcaaat
     8401 tctgttttat tttatcccta ataacagaag tctcccttcc atggttttag cgttgccttt
     8461 ttaaaaaggc actcaccctg agttgttaag aactggacct gccccaccct cagattcctt
     8521 aaaggatgaa gagtgtgctg tacactcagc atatgtgcct cttgtatgca aggactactg
     8581 attgaagtct gttttgctgt gtctggttat gttgtctgca cttttatgaa atcactacaa
     8641 tagatctacg ttggaaataa ctatcaattt gtaaagaaat ttttattaaa cactgtagaa
     8701 aaagtgaagc tgagaactct tttgtgcatt tatatttcct actgaattct ggtagcccac
     8761 ttttaacatt gtattgactt tttttttttt tttttgatta tattcagatt tccaaacaag
     8821 tgctggcctt cagatcataa gtataagaaa tatgcatcat atctgcctat tgcaggcttc
     8881 tgaaacttgc actgcccatc catgcaaaaa taagtatctt aaataaaagc agagagcaaa
     8941 aactggggag ccatgtacta tgtcaccaca tctgttaact gtttcctgca atctaaactg
     9001 aagtgtgtgt gtgggtgtgt gtatgtgtat tgggggtttt gttttgcttt gcttttaaat
     9061 atacaagggg ttcttcttta aatagaggaa aaggttaatc ctctccagca ggatgcccac
     9121 tggatatatt aacatctgta ggtagttgga agtgtagaga gaagagaagg taagacttct
     9181 cagtgaatgg aaggatgtct tgatgctcaa gagtccccgc ccccaaagta cgggtaattc
     9241 agcctgcaca gtttcctttc actcatagtt tcacaattac gagtgaaaaa tcatgtaatt
     9301 atctgtaaat atgtagctaa caaattgacc tagtttctgt acttttttgg ttttgtacta
     9361 aagtttatag gtctgtgcca gctagagagg agttgctgtc attgctagtc gtgctctagc
     9421 atacaaccct gaaaccatcc taggtgacat tttagaatta atacttaagt gttgttaaat
     9481 ggggacatgg agcttaatca ttggtcaggt ttgaagtctt ttgaagctaa gtaattttat
     9541 ttaatatgat tacatgtcgt cagtcatgag tgaggtgtag ggagtctccc tccccaagtg
     9601 gccatgttta cagagtgttg tctacaaagt gcaagtgtgt taatgtttat gtaaattatg
     9661 caggtgataa ctttatggtt tgggactgtt tatgggctct tttaagtgaa ttttcaaatg
     9721 aaatgaacta tgcttattgc tggcacattg atcccatttc tggaacattt cctacttcca
     9781 gaattccgta tgttccttag acattacccc cacttaacct cccttcctct gatatgcctt
     9841 gtagctaaga tttaaaagac tgttgaacat agatgagggg tatgcatttc ttaaaaatcc
     9901 atgaaccctc aattgtatgc tttcagtatt gtgttatatg tttctatggc aactttgaag
     9961 tcagtggttt agaaatgaga taccaatgtt aatgaaaagt atgtactctt tgcttttgca
    10021 tggcttggct tagtatccaa ggtatattag agccacttga aagcatgaag accagttata
    10081 tggaaacagg tttctctcag tggcacattt tgctttttct tagccctcaa atacattgcc
    10141 tcggcatgaa cattattgtt aatataaatt gcacatggtc atcgagtgaa ttataaaatt
    10201 ttgaaaagat gcagctgccc aatattaaca gttttagttg gtctctatct caaataacag
    10261 tgtaggtatt ggaacccttg tagccctttt gggggtcaaa caggtatatg gatttatcaa
    10321 ggagggcatt ggctgcccct ggggtattgc cacgctgttg tcttgctgcc cattcactcc
    10381 atgtgctgct gtccttcctt cacttcatac tctcaaagaa accatcaccc tttcttccta
    10441 tttttttttg tcttttattc cacattaaat gggaattgtg cctatttaga ttgcccctcc
    10501 agttaaatac acatgtaatc caagccagag ataagatgga agaacatttt tttttcaagt
    10561 tcacttggcc agtaacttat ctaacaaact gttttaccac actatcttga cacttgatag
    10621 aagagcctat taggagtcac agtggtttcg tagagtaaaa cccaagtgag gagggatgtg
    10681 tggggtttcc attaggaaat aatttcgttc ttggtttact ctttaagatc cttctctgct
    10741 agtttagaat aggttaattt ttttttaatt tttttaggga aatttttaca aaaataatgg
    10801 tctgatgtaa ataccatttt aaagtacagt gcacataact ccctaggctg ttccaacctg
    10861 actatttgta aatgctttag agttttaaat taacacttct gttgctaaat actatttatg
    10921 taagtctgaa aaggttttta acccatataa aacatttaaa taatgcaggt tattatgagc
    10981 aagttagctt tgagaaccct ccttttagta tatgaaaaag cctaatgcgc attcatgagg
    11041 ttggagagac tatgagaaat atgtatagtg tatattttaa acagctttgc ttgtattgtg
    11101 aagatttaag aacaaacttg agatttttaa agttaactat taacacagtt ttaacataag
    11161 ttatcccact gggtttaaaa gcatcttgaa tgtataaccc ttctgtaacc caggctggtc
    11221 tttgctttta ctgaacatcc aaacgttatt tatattttaa ttttatgtac tcatttcttt
    11281 ttgttttcct caaacagcat gttgttgttg gggtgttttg ttttgttttt gtttgttttg
    11341 ggtttttttt tttttttgca catgtagaaa ttttttaaaa gaaggaaatt aagacatgat
    11401 ttttctctag attttcttca cttcagtctt tctactaacc tcgtaaaaac catggcttcc
    11461 atttgcttta tttgtgcaaa tgccagggtt ggtttttatt tttatttttg ctatttacct
    11521 aaaaagaaaa agagacaatg cttcagtcaa ctgctttttt atttaaaatt taaagaaaaa
    11581 aaaaagaaaa aaaaagctgt aaccttatca tttctgagta gaccattaag agaaatgcac
    11641 acctgtcagc ccaggaccag ctttggtggc taaagggaat attttaactc gcaaggtgat
    11701 gttctgtaca aaacgtggta tatgttaccc acagtccatt tcagttattc ccacaagtca
    11761 ggtccagata aatgagggtt atcagctaac tgatatgtta tcattgaggt tcgtcaatga
    11821 atttgtacat ttctagttcc ctttggtgaa gggaaaaatg attttgcaag acctagattt
    11881 tggcttggtt tcttgcctcc ttttttggca gccttcatct tttcctaaag cccttgagcc
    11941 tgtagggttt tcatagtgga caaaggactt aaatggtctt ttaaaactgg gatagttttt
    12001 ggggaaaggg caaaagatta tcatattgaa catgtagtat cccaatactc tcaacagtgg
    12061 ataattatga gtaaacccgg tcctttcgat gtttagagta agcagaggcc cacagtggag
    12121 gcttaccaaa ggttgcaatg aggaagaggc ctctccctca ctgtcagcac cagctggtaa
    12181 aggtgactgt gcagatgtgc attttccttt tggtagaaat ggtccacagc actaactggt
    12241 aaggcttatt gtacagtata ttgtcagtat tcttctggtt cagcatacct tatagttcgt
    12301 atataacctg tattaattgt atagattgtg catttaaagc tgttaccaag ttgtcagaac
    12361 cctaagaatg aaaacaggtc atatgtaata ttttgtttgt aagtatcctt tgtatcatag
    12421 caaaggaaat gtttaaaaga tcaactgtaa taaaagtaat tttagtacac ag
//
